The difference in severity and management between children and adult's cases of COVID-19
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Vol. 5 No. 1 (2021)
October 13, 2020
January 4, 2021
January 26, 2021
Abstract
Abstract
COVID-19 (Coronavirus Disease 2019) has been started in Wuhan, China, and spread worldwide and resulting in many cases of death. COVID-19 attacks the respiratory tract acutely and infected both children and adults. The number of cases in children is less than in adults. By seeing from the clinical aspect, the COVID-19 case in children is milder. There are differences in immunology responses in children and adults where children have higher immunology response of COVID-19 than adults. Meanwhile, if the immunology response is slow in adults, it may cause them infected by COVID-19 with severe symptoms. There are some relations between immunization with immunology response to SARS-CoV-2 where children who already have BCG vaccination has lower infection rates of acute respiratory tract case. This study aims to know the difference between COVID-19 cases that infected adults and children seen in various aspects.
Keywords                    : COVID-19,SARS-CoV-2, children, adult, severity, management
Correspondence        : mohammad_husin@yahoo.com
References
Andarini, I. (2020). Diagnosis dan Tata Laksana Kasus COVID-19 pada Anak dan Bayi. 1–22. Jawa Tengah.
Bandi, S., Nevid, M. Z., & Mahdavinia, M. (2020). African American children are at higher risk of COVIDâ€19 infection. Pediatric Allergy and Immunology, pai.13298. https://doi.org/10.1111/pai.13298
Castagnoli, R., et al. (2020). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review. JAMA Pediatrics, 174(9), 882. https://doi.org/10.1001/jamapediatrics.2020.1467
CDC COVID-19. (2020). Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020. MMWR. Morbidity and Mortality Weekly Report, 69(14), 422–426. https://doi.org/10.15585/mmwr.mm6914e4
Chen, J., et al. (2020). The clinical and immunological features of pediatric COVID-19 patients in China. ScienceDirect. https://doi.org/10.1016/j.gendis.2020.03.008
Cristiani, L., Mancino, E., Matera, L., Nenna, R., Pierangeli, A., Scagnolari, C., & Midulla, F. (2020). Will children reveal their secret? The coronavirus dilemma. European Respiratory Journal, 55(6), 2001617. https://doi.org/10.1183/13993003.01617-2020
de Wit, E., van Doremalen, N., Falzarano, D., & Munster, V. J. (2016). SARS and MERS: recent insights into emerging coronaviruses. Nature Reviews Microbiology, 14(8), 523–534. https://doi.org/10.1038/nrmicro.2016.81
Dhochak, N., Singhal, T., Kabra, S. K., & Lodha, R. (2020). Pathophysiology of COVID-19: Why Children Fare Better than Adults? The Indian Journal of Pediatrics, 87(7), 537–546. https://doi.org/10.1007/s12098-020-03322-y
Dong, Y., et al. (2020). Epidemiology of COVID-19 Among Children in China. Pediatrics, 145(6), 20200702. https://doi.org/10.1542/peds.2020-0702
Frieden, T. R., & Lee, C. T. (2020). Identifying and Interrupting Superspreading Events—Implications for Control of Severe Acute Respiratory Syndrome Coronavirus 2. Emerging Infectious Diseases, 26(6), 1059–1066. https://doi.org/10.3201/eid2606.200495
Hoffmann, M., et al. (2020). SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 181(2), 271-280.e8. https://doi.org/10.1016/j.cell.2020.02.052
Huang, C., et al. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395(10223), 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5
IDAI. (2020). Panduan Klinis Tata Laksana COVID-19 pada Anak IKATAN DOKTER ANAK INDONESIA. https://www.idai.or.id/about-idai/idai-statement/panduan-klinis-tata-laksana-covid-19-pada-anak
Istituto Superiore di Sanità . (2020). Epidemia COVID-19 Aggiornamento nazionale: 19 marzo 2020. roma: Istituto Superiore di Sanità .
Jawetz, E., Melnick, J. L., & Adelberg, E. A. (2013). Jawetz, Melnick & Adelberg’s medical microbiology (28th ed.). United States: McGraw-Hill.
Kementerian Kesehatan RI. (2020). Pedoman Pencegahan dan Pengendalian COVID-19. Kementrian Kesehatan Repbulik Indonesia, 0–115.
Lee-Archer, P., & von Ungern-Sternberg, B. S. (2020). Paediatric Anaesthetic implications of COVID-19 - A Review of Current Literature. Paediatric Anaesthesia. https://doi.org/10.1111/pan.13889
Liguoro, I., et al. (2020). SARS-COV-2 infection in children and newborns: a systematic review. European Journal of Pediatrics. https://doi.org/10.1007/s00431-020-03684-7
Liu, K., et al. (2020). Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. Journal of Infection, 80(6), e14–e18. https://doi.org/10.1016/j.jinf.2020.03.005
Lu, X., et al. (2020). SARS-CoV-2 Infection in Children. New England Journal of Medicine, 382(17), 1663–1665. https://doi.org/10.1056/NEJMc2005073
Melgosa, M., et al. (2020). SARS-CoV-2 infection in Spanish children with chronic kidney pathologies. Pediatric Nephrology, 35(8), 1521–1524. https://doi.org/10.1007/s00467-020-04597-1
Miller, A., et al. (2020). Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study. MedRxiv, 03(24), 085201. https://doi.org/10.1101/2020.03.24.20042937
Netea, M. et al. (2020). Defining trained immunity and its role in health and disease. Nature Reviews Immunology, 20(6), 375–388. https://doi.org/10.1038/s41577-020-0285-6
PDPI (Perhimpunan Dokter Paru Indonesia). (2020). Panduan Praktik Klinis: Pneumonia 2019-nCoV. In PDPI (p. 5). JAKARTA: PDPI.
Rothan, H. A., & Byrareddy, S. N. (2020). The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Journal of Autoimmunity, 109(February), 102433. https://doi.org/10.1016/j.jaut.2020.102433
Satgas COVID-19. 2020. Situasi Virus COVID-19 di Indonesia. Retrieved from Peta Sebaran | Satgas Penanganan COVID-19
Setiabudi, D. (2020). Dampak Pandemi COVID-19 terhadap Kesehatan Anak. JAWA BARAT.
Shahid, Z., et al. (2020). COVIDâ€19 and Older Adults: What We Know. Journal of the American Geriatrics Society, 68(5), 926–929. https://doi.org/10.1111/jgs.16472
Singh, T., et al. (2020). Lessons From COVID-19 in Children: Key Hypotheses to Guide Preventative and Therapeutic Strategies. Clinical Infectious Diseases, 22(3), 282–289. https://doi.org/10.1093/cid/ciaa547
Sun, D., et al. (2020). Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World Journal of Pediatrics, 16(3), 251–259. https://doi.org/10.1007/s12519-020-00354-4
Susilo, A., et al. (2020). Coronavirus Disease 2019: Tinjauan Literatur Terkini. Jurnal Penyakit Dalam Indonesia, 7(1), 45. https://doi.org/10.7454/jpdi.v7i1.415
Wang, Z., Qiang, W., & Ke, H. (2020). A Handbook of 2019-nCoV Pneumonia Control and Prevention. In Hubei Science and technology press. Retrieved from http://fpmpam.org/files/Handbook_2019nCoV.pdf
Wardhana, Datau., et al. (2011). The efficacy of Bacillus Calmette-Guerin vaccinations for the prevention of acute upper respiratory tract infection in the elderly. Acta Medica Indonesiana, 43(3), 185–190. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21979284
Wiersinga, W. J., Rhodes, A., Cheng, A. C., Peacock, S. J., & Prescott, H. C. (2020). Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA - Journal of the American Medical Association, 324(8), 782–793. https://doi.org/10.1001/jama.2020.12839
World Health Organization (WHO). (2020). Clinical Management of COVID-19 Interim Guidance. Retrieved from. Clinical management of COVID-19 (who.int)
World Health Organization (WHO). (2020). Coronavirus disease COVID-2019 (Vol. 8). Retrieved from https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200607-covid-19-sitrep-139.pdf?sfvrsn=79dc6d08_2
Wu, Z., & McGoogan, J. M. (2020). Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China. JAMA, 323(13), 1239. https://doi.org/10.1001/jama.2020.2648
Xia, W., et al. (2020). Clinical and CT features in pediatric patients with COVIDâ€19 infection: Different points from adults. Pediatric Pulmonology, 55(5), 1169–1174. https://doi.org/10.1002/ppul.24718
Zhang, H., Penninger, J. M., Li, Y., Zhong, N., & Slutsky, A. S. (2020). Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Medicine, 46(4), 586–590. https://doi.org/10.1007/s00134-020-05985-9
Zhao, W., Zhong, Z., Xie, X., Yu, Q., & Liu, J. (2020). Relation Between Chest CT Findings and Clinical Conditions of Coronavirus Disease (COVID-19) Pneumonia: A Multicenter Study. American Journal of Roentgenology, 214(5), 1072–1077. https://doi.org/10.2214/AJR.20.22976
Zhou, P., et al. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–273. https://doi.org/10.1038/s41586-020-2012-7
Zhu, N., et al. (2020). A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine, 382(8), 727–733. https://doi.org/10.1056/NEJMoa2001017
Authors
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