Acute kidney injury induced by beta-lactam antibiotics in children: A scoping review
Abstract
Antibiotics are the agents that cause Acute Kidney Injuries (AKI) in children. A recent study has shown the incidence of nephrotoxicity by antibiotics reaches 16% in children. Beta-lactam types are not widely known for their nephrotoxic effect. This study aims to examine beta-lactam antibiotics' role in inducing children's renal failure. This search for a scoping review on the effect of beta-lactam antibiotics in children was carried out in December-January 2022-2023. We used some search engines with the year of publication 2012-2022 then extracted. The keyword combinations used are: “beta-lactams” OR “β-lactams” AND “acute renal failure” OR “acute renal injury” OR “nephrotoxic” OR “nephrotoxicity” AND “children” OR “pediatric” OR “neonate” NOT “adult”. Studies were excluded if the: (i) adult; (ii) were a review, systematic review, or meta-analysis; (iii) written in a language other than English; (iv) not available in full text; (v) have kidney disease before (vi) in vitro or in vivo. The article selection process was based on PRISMA-ScR. From 4032 articles that met the search criteria, 3 studies met the inclusion criteria. The result shows that beta-lactam increases the risk of acute renal injury in children. This review emphasizes the importance of choosing kidney-safe antibiotics for children.
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References
Al-Jebawi, Y., Karalic, K., Shekhawat, P., & Mhanna, M. J. (2022). The concomitant use of vancomycin and piperacillin-tazobactam is associated with acute kidney injury (AKI) in extremely low birth weight infants (ELBW). Journal of Neonatal-Perinatal Medicine, 15(2), 303–309. https://doi.org/10.3233/NPM-210866
André, P., Diezi, L., Dao, K., Crisinel, P. A., Rothuizen, L. E., Chtioui, H., … Buclin, T. (2022). Ensuring Sufficient Trough Plasma Concentrations for Broad-Spectrum Beta-Lactam Antibiotics in Children with Malignancies: Beware of Augmented Renal Clearance! Frontiers in Pediatrics, 9, 1599. https://doi.org/10.3389/FPED.2021.768438/BIBTEX
Avci, Z., Koktener, A., Uras, N., Catal, F., Karadag, A., Tekin, O., … Baskin, E. (2004). Nephrolithiasis associated with ceftriaxone therapy: a prospective study in 51 children. Archives of Disease in Childhood, 89(11), 1069–1072. https://doi.org/10.1136/adc.2003.044156
Bellos, I., Karageorgiou, V., Pergialiotis, V., & Perrea, D. N. (2020). Acute kidney injury following the concurrent administration of antipseudomonal β-lactams and vancomycin: a network meta-analysis. Clinical Microbiology and Infection, 26(6), 696–705. https://doi.org/10.1016/J.CMI.2020.03.019/ATTACHMENT/FF1C1C5B-12FC-4B20-996C-0B2691FC374F/MMC1.DOCX
Bhojani, S., Stojanovic, J., Melhem, N., Maxwell, H., Houtman, P., Hall, A., … Milford, D. v. (2020). The Incidence of Paediatric Acute Kidney Injury Identified Using an AKI E-Alert Algorithm in Six English Hospitals. Frontiers in Pediatrics, 8, 29. https://doi.org/10.3389/FPED.2020.00029/BIBTEX
Bjornstad, E. C., Muronya, W., Smith, Z. H., Gibson, K., Mottl, A. K., Charles, A., … Gower, E. W. (2020). Incidence and epidemiology of acute kidney injury in a pediatric Malawian trauma cohort: A prospective observational study. BMC Nephrology, 21(1), 1–12. https://doi.org/10.1186/S12882-020-01755-3/TABLES/5
Black, M. J., Sutherland, M. R., Gubhaju, L., Kent, A. L., Dahlstrom, J. E., & Moore, L. (2013). When birth comes early: effects on nephrogenesis. Nephrology (Carlton, Vic.), 18(3), 180–182. https://doi.org/10.1111/NEP.12028
Brummer, H., & Brophy, P. D. (2023). Pediatric Acute Kidney Injury: Decreasing Incidence and Improving Mortality Disparities Worldwide. Pediatrics, 151(2). https://doi.org/10.1542/PEDS.2022-059906
Cataldi, L., Leone, R., Moretti, U., De Mitri, B., Fanos, V., Ruggeri, L., … Cuzzolin, L. (2005). Potential risk factors for the development of acute renal failure in preterm newborn infants: a case-control study. Archives of Disease in Childhood. Fetal and Neonatal Edition, 90(6), F514-519. https://doi.org/10.1136/adc.2004.060434
Cies, J. J., Ii, W. S. M., Shankar, V., & Chopra, A. (2014). Antimicrobial Renal Injury in a Pediatric Intensive Care Unit: β-Lactams vs. Vancomycin. Pharmacy, 2(4), 276–286. https://doi.org/10.3390/pharmacy2040276
Cleto-Yamane, T. L., Gomes, C. L. R., Suassuna, J. H. R., & Nogueira, P. K. (2019). Acute Kidney Injury Epidemiology in pediatrics. Jornal Brasileiro de Nefrologia, 41(2), 275. https://doi.org/10.1590/2175-8239-JBN-2018-0127
Clifford, K. M., Selby, A. R., Reveles, K. R., Teng, C., Hall, R. G., McCarrell, J., & Alvarez, C. A. (2022). The Risk and Clinical Implications of Antibiotic-Associated Acute Kidney Injury: A Review of the Clinical Data for Agents with Signals from the Food and Drug Administration’s Adverse Event Reporting System (FAERS) Database. Antibiotics, 11(10), 1367. https://doi.org/10.3390/antibiotics11101367
Dursun, M., Otunctemur, A., & Ozbek, E. (2013). KIDNEY STONES AND CEFTRIAXONE. Iranian Journal of Pediatrics. Retrieved from http://files/126/Dursun et al. - KIDNEY STONES AND CEFTRIAXONE.pdf
Hambrick, H. R., Pavia, K., Tang Girdwood, S., Lazear, D., Taylor, J. M., & Benoit, S. (2022). Cefepime-Associated Neurotoxicity in a Pediatric Patient with Stage V Chronic Kidney Disease. Journal of Pharmacy Practice, 8971900221125000. https://doi.org/10.1177/08971900221125000
Hammond, D. A., Smith, M. N., Li, C., Hayes, S. M., Lusardi, K., & Bookstaver, P. B. (2017). Systematic Review and Metaanalysis of Acute Kidney Injury Associated With Concomitant Vancomycin and Piperacillin/Tazobactam. Clinical Infectious Diseases, 64(5), 666–674. https://doi.org/10.1093/CID/CIW811
Hanna, M. H., Askenazi, D. J., Selewski, D. T., Askenazi, D., Opin, C., & Author, P. (2016). Drug Induced Acute Kidney Injury in Neonates HHS Public Access Author manuscript. Curr Opin Pediatr, 28(2), 180–187. https://doi.org/10.1097/MOP.0000000000000311
Horster, M. F., Braun, G. S., & Huber, S. M. (1999). Embryonic renal epithelia: Induction, nephrogenesis, and cell differentiation. Physiological Reviews, 79(4), 1157–1191. https://doi.org/10.1152/PHYSREV.1999.79.4.1157/ASSET/IMAGES/LARGE/9J0490039015.JPEG
Imani, S., Buscher, H., Marriott, D., Gentili, S., & Sandaradura, I. (2017). Too much of a good thing: a retrospective study of β-lactam concentration–toxicity relationships. Journal of Antimicrobial Chemotherapy, 72(10), 2891–2897. https://doi.org/10.1093/jac/dkx209
Joyce, E. L., Kane-Gill, S. L., Priyanka, P., Fuhrman, D. Y., & Kellum, J. A. (2019). Piperacillin/Tazobactam and Antibiotic-Associated Acute Kidney Injury in Critically Ill Children. Journal of the American Society of Nephrology: JASN, 30(11), 2243–2251. https://doi.org/10.1681/ASN.2018121223
Kirita, Y., Kami, D., Ishida, R., Adachi, T., Tamagaki, K., Matoba, S., … Gojo, S. (2016). Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates. Scientific Reports 2016 6:1, 6(1), 1–14. https://doi.org/10.1038/srep26792
Li, N., Zhou, X., Yuan, J., Chen, G., Jiang, H., & Zhang, W. (2014). Ceftriaxone and acute renal failure in children. Pediatrics, 133(4). https://doi.org/10.1542/PEDS.2013-2103
Linden, P. (2007). Safety Profile of Meropenem. Drug Safety, 30(8), 657–668. https://doi.org/10.2165/00002018-200730080-00002
Patzer, L. (2008). Nephrotoxicity as a cause of acute kidney injury in children. Pediatric Nephrology, 23(12), 2159–2173. https://doi.org/10.1007/S00467-007-0721-X/TABLES/2
Rutter, W. C., Cox, J. N., Martin, C. A., Burgess, D. R., & Burgess, D. S. (2017). Nephrotoxicity during Vancomycin Therapy in Combination with Piperacillin-Tazobactam or Cefepime. Antimicrobial Agents and Chemotherapy, 61(2), e02089-16. https://doi.org/10.1128/AAC.02089-16
Seely, J. C. (2017). A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy. Journal of Toxicologic Pathology, 30(2), 125. https://doi.org/10.1293/TOX.2017-0006
Shabaan, A. E., Nour, I., Elsayed Eldegla, H., Nasef, N., Shouman, B., & Abdel-Hady, H. (2017). Conventional Versus Prolonged Infusion of Meropenem in Neonates With Gram-negative Late-onset Sepsis: A Randomized Controlled Trial. The Pediatric Infectious Disease Journal, 36(4), 358–363. https://doi.org/10.1097/INF.0000000000001445
Shen, X., Liu, W., Fang, X., Jia, J., Lin, H., Xu, M., & Geng, H. (2014). Acute kidney injury caused by ceftriaxone-induced urolithiasis in children: a single-institutional experience in diagnosis, treatment and follow-up. International Urology and Nephrology, 46(10), 1909–1914. https://doi.org/10.1007/S11255-014-0742-X
Stojanovic, V., & Djuric Vijatov, G. (2009). Nephrolithiasis Caused by Ceftriaxone in a 3-Year-Old Child with Ureteropelvic Junction Obstruction. Case Reports in Medicine, 2009, 1–3. https://doi.org/10.1155/2009/365962
Sulemanji, M., & Vakili, K. (2013). Neonatal renal physiology. Seminars in Pediatric Surgery, 22(4), 195–198. https://doi.org/10.1053/J.SEMPEDSURG.2013.10.008
Tamma, P. D., Turnbull, A. E., Harris, A. D., Milstone, A. M., Hsu, A. J., & Cosgrove, S. E. (2013). Less Is More: Combination Antibiotic Therapy for the Treatment of Gram-Negative Bacteremia in Pediatric Patients. JAMA Pediatrics, 167(10), 903–910. https://doi.org/10.1001/jamapediatrics.2013.196
Tang Girdwood, S., Pavia, K., Paice, K., Hambrick, H. R., Kaplan, J., & Vinks, A. A. (2022). β-lactam precision dosing in critically ill children: Current state and knowledge gaps. Frontiers in Pharmacology, 13. Retrieved from https://www.frontiersin.org/articles/10.3389/fphar.2022.1044683
Tune, B. M. (1997). Nephrotoxicity of beta-lactam antibiotics: Mechanisms and strategies for prevention. Pediatric Nephrology, 11(6), 768–772. https://doi.org/10.1007/S004670050386/METRICS
Tune, B. M., & Hsu, C. Y. (1990). Mechanisms of beta-lactam antibiotic nephrotoxicity. Toxicology Letters, 53(1–2), 81–86. https://doi.org/10.1016/0378-4274(90)90098-7
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