Acute kidney injury induced by beta-lactam antibiotics in children: A scoping review

Astalitha Lorel Tania (1), Alya (2)
(1) Aisyiyah Hospital Bojonegoro, Indonesia,
(2) RSUD 45 Kuningan, Indonesia

Abstract

Antibiotics are the agents that cause Acute Kidney Injuries (AKI) in children. A recent study has shown the incidence of nephrotoxicity by antibiotics reaches 16% in children. Beta-lactam types are not widely known for their nephrotoxic effect. This study aims to examine beta-lactam antibiotics' role in inducing children's renal failure. This search for a scoping review on the effect of beta-lactam antibiotics in children was carried out in December-January 2022-2023. We used some search engines with the year of publication 2012-2022 then extracted. The keyword combinations used are: “beta-lactams” OR “β-lactams” AND “acute renal failure” OR “acute renal injury” OR “nephrotoxic” OR “nephrotoxicity” AND “children” OR “pediatric” OR “neonate” NOT “adult”. Studies were excluded if the: (i) adult; (ii) were a review, systematic review, or meta-analysis; (iii) written in a language other than English; (iv) not available in full text; (v) have kidney disease before (vi) in vitro or in vivo. The article selection process was based on PRISMA-ScR. From 4032 articles that met the search criteria, 3 studies met the inclusion criteria. The result shows that beta-lactam increases the risk of acute renal injury in children. This review emphasizes the importance of choosing kidney-safe antibiotics for children.

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References

Al-Jebawi, Y., Karalic, K., Shekhawat, P., & Mhanna, M. J. (2022). The concomitant use of vancomycin and piperacillin-tazobactam is associated with acute kidney injury (AKI) in extremely low birth weight infants (ELBW). Journal of Neonatal-Perinatal Medicine, 15(2), 303–309. https://doi.org/10.3233/NPM-210866

André, P., Diezi, L., Dao, K., Crisinel, P. A., Rothuizen, L. E., Chtioui, H., … Buclin, T. (2022). Ensuring Sufficient Trough Plasma Concentrations for Broad-Spectrum Beta-Lactam Antibiotics in Children with Malignancies: Beware of Augmented Renal Clearance! Frontiers in Pediatrics, 9, 1599. https://doi.org/10.3389/FPED.2021.768438/BIBTEX

Avci, Z., Koktener, A., Uras, N., Catal, F., Karadag, A., Tekin, O., … Baskin, E. (2004). Nephrolithiasis associated with ceftriaxone therapy: a prospective study in 51 children. Archives of Disease in Childhood, 89(11), 1069–1072. https://doi.org/10.1136/adc.2003.044156

Bellos, I., Karageorgiou, V., Pergialiotis, V., & Perrea, D. N. (2020). Acute kidney injury following the concurrent administration of antipseudomonal β-lactams and vancomycin: a network meta-analysis. Clinical Microbiology and Infection, 26(6), 696–705. https://doi.org/10.1016/J.CMI.2020.03.019/ATTACHMENT/FF1C1C5B-12FC-4B20-996C-0B2691FC374F/MMC1.DOCX

Bhojani, S., Stojanovic, J., Melhem, N., Maxwell, H., Houtman, P., Hall, A., … Milford, D. v. (2020). The Incidence of Paediatric Acute Kidney Injury Identified Using an AKI E-Alert Algorithm in Six English Hospitals. Frontiers in Pediatrics, 8, 29. https://doi.org/10.3389/FPED.2020.00029/BIBTEX

Bjornstad, E. C., Muronya, W., Smith, Z. H., Gibson, K., Mottl, A. K., Charles, A., … Gower, E. W. (2020). Incidence and epidemiology of acute kidney injury in a pediatric Malawian trauma cohort: A prospective observational study. BMC Nephrology, 21(1), 1–12. https://doi.org/10.1186/S12882-020-01755-3/TABLES/5

Black, M. J., Sutherland, M. R., Gubhaju, L., Kent, A. L., Dahlstrom, J. E., & Moore, L. (2013). When birth comes early: effects on nephrogenesis. Nephrology (Carlton, Vic.), 18(3), 180–182. https://doi.org/10.1111/NEP.12028

Brummer, H., & Brophy, P. D. (2023). Pediatric Acute Kidney Injury: Decreasing Incidence and Improving Mortality Disparities Worldwide. Pediatrics, 151(2). https://doi.org/10.1542/PEDS.2022-059906

Cataldi, L., Leone, R., Moretti, U., De Mitri, B., Fanos, V., Ruggeri, L., … Cuzzolin, L. (2005). Potential risk factors for the development of acute renal failure in preterm newborn infants: a case-control study. Archives of Disease in Childhood. Fetal and Neonatal Edition, 90(6), F514-519. https://doi.org/10.1136/adc.2004.060434

Cies, J. J., Ii, W. S. M., Shankar, V., & Chopra, A. (2014). Antimicrobial Renal Injury in a Pediatric Intensive Care Unit: β-Lactams vs. Vancomycin. Pharmacy, 2(4), 276–286. https://doi.org/10.3390/pharmacy2040276

Cleto-Yamane, T. L., Gomes, C. L. R., Suassuna, J. H. R., & Nogueira, P. K. (2019). Acute Kidney Injury Epidemiology in pediatrics. Jornal Brasileiro de Nefrologia, 41(2), 275. https://doi.org/10.1590/2175-8239-JBN-2018-0127

Clifford, K. M., Selby, A. R., Reveles, K. R., Teng, C., Hall, R. G., McCarrell, J., & Alvarez, C. A. (2022). The Risk and Clinical Implications of Antibiotic-Associated Acute Kidney Injury: A Review of the Clinical Data for Agents with Signals from the Food and Drug Administration’s Adverse Event Reporting System (FAERS) Database. Antibiotics, 11(10), 1367. https://doi.org/10.3390/antibiotics11101367

Dursun, M., Otunctemur, A., & Ozbek, E. (2013). KIDNEY STONES AND CEFTRIAXONE. Iranian Journal of Pediatrics. Retrieved from http://files/126/Dursun et al. - KIDNEY STONES AND CEFTRIAXONE.pdf

Hambrick, H. R., Pavia, K., Tang Girdwood, S., Lazear, D., Taylor, J. M., & Benoit, S. (2022). Cefepime-Associated Neurotoxicity in a Pediatric Patient with Stage V Chronic Kidney Disease. Journal of Pharmacy Practice, 8971900221125000. https://doi.org/10.1177/08971900221125000

Hammond, D. A., Smith, M. N., Li, C., Hayes, S. M., Lusardi, K., & Bookstaver, P. B. (2017). Systematic Review and Metaanalysis of Acute Kidney Injury Associated With Concomitant Vancomycin and Piperacillin/Tazobactam. Clinical Infectious Diseases, 64(5), 666–674. https://doi.org/10.1093/CID/CIW811

Hanna, M. H., Askenazi, D. J., Selewski, D. T., Askenazi, D., Opin, C., & Author, P. (2016). Drug Induced Acute Kidney Injury in Neonates HHS Public Access Author manuscript. Curr Opin Pediatr, 28(2), 180–187. https://doi.org/10.1097/MOP.0000000000000311

Horster, M. F., Braun, G. S., & Huber, S. M. (1999). Embryonic renal epithelia: Induction, nephrogenesis, and cell differentiation. Physiological Reviews, 79(4), 1157–1191. https://doi.org/10.1152/PHYSREV.1999.79.4.1157/ASSET/IMAGES/LARGE/9J0490039015.JPEG

Imani, S., Buscher, H., Marriott, D., Gentili, S., & Sandaradura, I. (2017). Too much of a good thing: a retrospective study of β-lactam concentration–toxicity relationships. Journal of Antimicrobial Chemotherapy, 72(10), 2891–2897. https://doi.org/10.1093/jac/dkx209

Joyce, E. L., Kane-Gill, S. L., Priyanka, P., Fuhrman, D. Y., & Kellum, J. A. (2019). Piperacillin/Tazobactam and Antibiotic-Associated Acute Kidney Injury in Critically Ill Children. Journal of the American Society of Nephrology: JASN, 30(11), 2243–2251. https://doi.org/10.1681/ASN.2018121223

Kirita, Y., Kami, D., Ishida, R., Adachi, T., Tamagaki, K., Matoba, S., … Gojo, S. (2016). Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates. Scientific Reports 2016 6:1, 6(1), 1–14. https://doi.org/10.1038/srep26792

Li, N., Zhou, X., Yuan, J., Chen, G., Jiang, H., & Zhang, W. (2014). Ceftriaxone and acute renal failure in children. Pediatrics, 133(4). https://doi.org/10.1542/PEDS.2013-2103

Linden, P. (2007). Safety Profile of Meropenem. Drug Safety, 30(8), 657–668. https://doi.org/10.2165/00002018-200730080-00002

Patzer, L. (2008). Nephrotoxicity as a cause of acute kidney injury in children. Pediatric Nephrology, 23(12), 2159–2173. https://doi.org/10.1007/S00467-007-0721-X/TABLES/2

Rutter, W. C., Cox, J. N., Martin, C. A., Burgess, D. R., & Burgess, D. S. (2017). Nephrotoxicity during Vancomycin Therapy in Combination with Piperacillin-Tazobactam or Cefepime. Antimicrobial Agents and Chemotherapy, 61(2), e02089-16. https://doi.org/10.1128/AAC.02089-16

Seely, J. C. (2017). A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy. Journal of Toxicologic Pathology, 30(2), 125. https://doi.org/10.1293/TOX.2017-0006

Shabaan, A. E., Nour, I., Elsayed Eldegla, H., Nasef, N., Shouman, B., & Abdel-Hady, H. (2017). Conventional Versus Prolonged Infusion of Meropenem in Neonates With Gram-negative Late-onset Sepsis: A Randomized Controlled Trial. The Pediatric Infectious Disease Journal, 36(4), 358–363. https://doi.org/10.1097/INF.0000000000001445

Shen, X., Liu, W., Fang, X., Jia, J., Lin, H., Xu, M., & Geng, H. (2014). Acute kidney injury caused by ceftriaxone-induced urolithiasis in children: a single-institutional experience in diagnosis, treatment and follow-up. International Urology and Nephrology, 46(10), 1909–1914. https://doi.org/10.1007/S11255-014-0742-X

Stojanovic, V., & Djuric Vijatov, G. (2009). Nephrolithiasis Caused by Ceftriaxone in a 3-Year-Old Child with Ureteropelvic Junction Obstruction. Case Reports in Medicine, 2009, 1–3. https://doi.org/10.1155/2009/365962

Sulemanji, M., & Vakili, K. (2013). Neonatal renal physiology. Seminars in Pediatric Surgery, 22(4), 195–198. https://doi.org/10.1053/J.SEMPEDSURG.2013.10.008

Tamma, P. D., Turnbull, A. E., Harris, A. D., Milstone, A. M., Hsu, A. J., & Cosgrove, S. E. (2013). Less Is More: Combination Antibiotic Therapy for the Treatment of Gram-Negative Bacteremia in Pediatric Patients. JAMA Pediatrics, 167(10), 903–910. https://doi.org/10.1001/jamapediatrics.2013.196

Tang Girdwood, S., Pavia, K., Paice, K., Hambrick, H. R., Kaplan, J., & Vinks, A. A. (2022). β-lactam precision dosing in critically ill children: Current state and knowledge gaps. Frontiers in Pharmacology, 13. Retrieved from https://www.frontiersin.org/articles/10.3389/fphar.2022.1044683

Tune, B. M. (1997). Nephrotoxicity of beta-lactam antibiotics: Mechanisms and strategies for prevention. Pediatric Nephrology, 11(6), 768–772. https://doi.org/10.1007/S004670050386/METRICS

Tune, B. M., & Hsu, C. Y. (1990). Mechanisms of beta-lactam antibiotic nephrotoxicity. Toxicology Letters, 53(1–2), 81–86. https://doi.org/10.1016/0378-4274(90)90098-7

Authors

Astalitha Lorel Tania
lastalitha@gmail.com (Primary Contact)
Alya
Tania, A. L., & Alya Ayu Tazkia. (2024). Acute kidney injury induced by beta-lactam antibiotics in children: A scoping review . Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya, 8(02). https://doi.org/10.30651/jqm.v8i02.20376

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