Acute kidney injury induced by beta-lactam antibiotics in children: A scoping review

Astalitha Lorel Tania (1), Alya (2)
(1) Aisyiyah Hospital Bojonegoro, Indonesia,
(2) RSUD 45 Kuningan, Indonesia

Abstract

Antibiotics are the agents that cause Acute Kidney Injuries (AKI) in children. A recent study has shown the incidence of nephrotoxicity by antibiotics reaches 16% in children. Beta-lactam types are not widely known for their nephrotoxic effect. This study aims to examine beta-lactam antibiotics' role in inducing children's renal failure. This search for a scoping review on the effect of beta-lactam antibiotics in children was carried out in December-January 2022-2023. We used some search engines with the year of publication 2012-2022 then extracted. The keyword combinations used are: “beta-lactams” OR “β-lactams” AND “acute renal failure” OR “acute renal injury” OR “nephrotoxic” OR “nephrotoxicity” AND “children” OR “pediatric” OR “neonate” NOT “adult”. Studies were excluded if the: (i) adult; (ii) were a review, systematic review, or meta-analysis; (iii) written in a language other than English; (iv) not available in full text; (v) have kidney disease before (vi) in vitro or in vivo. The article selection process was based on PRISMA-ScR. From 4032 articles that met the search criteria, 3 studies met the inclusion criteria. The result shows that beta-lactam increases the risk of acute renal injury in children. This review emphasizes the importance of choosing kidney-safe antibiotics for children.

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References

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Authors

Astalitha Lorel Tania
lastalitha@gmail.com (Primary Contact)
Alya
Tania, A. L., & Alya Ayu Tazkia. (2024). Acute kidney injury induced by beta-lactam antibiotics in children: A scoping review . Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya, 8(02). https://doi.org/10.30651/jqm.v8i02.20376

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