Rethinking Patient Safety Culture: A Systematic Review of Its Multilevel Impact on Adverse Events in Hospital Settings

Penulis

  • Surya Prihatini STIKES Amanah Makassar
  • Aulya Kartini Dg. Karra
  • Kurniawati
  • Nurafni Suid
  • Dewi Sartika MS

Kata Kunci:

patient safety culture; adverse events; hospital; patient safety; systematic literature review.

Abstrak

Background: Patient safety culture (PSC) is an important factor in improving healthcare quality and preventing adverse events in hospitals. However, previous studies have reported inconsistent findings regarding the relationship between patient safety culture and adverse events.

Objective: This study aimed to examine how patient safety culture at the individual, team, organizational, and system levels influences adverse events in hospital settings.
Methods: This study used a systematic review method following the PRISMA 2020 guideline. Literature searches were conducted through PubMed, Scopus, and Google Scholar databases for articles published between 2021 and 2026. Articles were selected using the PICOS framework. A total of seven articles that met the inclusion criteria were analyzed using narrative synthesis.

Results: The findings showed that patient safety culture is influenced by several factors, including communication, teamwork, leadership, incident reporting systems, and staffing adequacy. Hospitals with a strong patient safety culture tend to have lower rates of adverse events. In addition, infection prevention practices, open communication, and non-punitive reporting systems play important roles in improving patient safety. However, previous studies have reported inconsistent findings the association between patient safety culture and adverse events.

Conclusion: Patient safety culture plays an important role in reducing the risk of adverse events in hospitals. Efforts to improve safety culture should be implemented comprehensively through organizational support, effective communication, and safe clinical practices.

Referensi

Aires-Moreno, G. T., Marques, L. G., Ramos, S. F., de Castro Araújo-Neto, F., de Oliveira Santos Silva, R., Fernandes, B. D., dos Santos Alcântara, T., Mesquita, A. R., Chemello, C., & Lyra, D. (2025). Improving patient safety culture in hospitals: A scoping review. Research in Social and Administrative Pharmacy, 21(10), 765–783. https://doi.org/10.1016/j.sapharm.2025.05.010

Alabdullah, H., & Karwowski, W. (2024). Patient Safety Culture in Hospital Settings Across Continents: A Systematic Review. Applied Sciences, 14(18), 8496. https://doi.org/10.3390/app14188496

Aouicha, W., Tlili, M. A., Sahli, J., Mtiraoui, A., Ajmi, T., Said Latiri, H., Chelbi, S., Ben Rejeb, M., & Mallouli, M. (2022). Patient safety culture as perceived by operating room professionals: a mixed-methods study. BMC Health Services Research, 22(1), 1–12. https://doi.org/10.1186/s12913-022-08175-z

Aryanto, E., Indrawati, L., & Rosa, T. (2023). Faktor-Faktor yang Mempengaruhi Tingkat Kepatuhan Perawat dalam Penerapan Kewaspadaan Standar di RSUP Persahabatan Tahun 2023. Jurnal Manajemen Dan Administrasi Rumah Sakit Indonesia (MARSI), 7(4), 379–388. https://doi.org/10.52643/marsi.v7i4.3567

Azyabi, A., Karwowski, W., & Davahli, M. R. (2021). Assessing Patient Safety Culture in Hospital Settings. International Journal of Environmental Research and Public Health, 18(5), 2466. https://doi.org/10.3390/ijerph18052466

Chirinos Muñoz, M. S., Orrego, C., Montoya, C., & Sunol, R. (2023). Relationship between adverse events prevalence, patient safety culture and patient safety perception in a single sample of patients: a cross-sectional and correlational study. BMJ Open, 13(8), 1–10. https://doi.org/10.1136/bmjopen-2021-060695

Choi, J. J. (2024). What is diagnostic safety? A review of safety science paradigms and rethinking paths to improving diagnosis. Diagnosis, 11(4), 369–373. https://doi.org/10.1515/dx-2024-0008

Cui, Y., Wang, Y., Liu, H., Xu, S., & Zhang, X. (2025). Exploring the Correlation Between Patient Safety Culture and Adverse Medical Events Using Failure Mode and Effect Analysis (FMEA). Risk Management and Healthcare Policy, 18(April), 1367–1376. https://doi.org/10.2147/RMHP.S502725

Fan, R., Yan, Z., Wang, A., Gao, S., Wang, L., & Mao, S. (2024). The influence of adverse events on inpatient outcomes in a tertiary hospital using a diagnosis-related group database. Scientific Reports, 14(1), 1–11. https://doi.org/10.1038/s41598-024-69283-w

Ghabayen, F., ALBashtawy, M., Abdelkader, R. H., Jarrah, S., Eshah, N., Abdalrahim, A., Saifan, A., Alkhawaldeh, A., Rayan, A., Ayed, A., Al-Amer, R., Mohammad, K. I., Al-Dwaikat, T., Omari, O. Al, ALBashtawy, S., ALBashtawy, B., & Dameery, K. Al. (2023). Knowledge and Compliance With Standard Precautions Among Nurses. SAGE Open Nursing, 9. https://doi.org/10.1177/23779608231189966

Gurková, E., Kalánková, D., Kurucová, R., & Žiaková, K. (2020). Assessment of patient safety climate by nurses in Slovak Public and private hospitals. Journal of Nursing Management, 28(7), 1644–1652. https://doi.org/10.1111/jonm.13120

Hafezi, A., Babaii, A., Aghaie, B., & Abbasinia, M. (2022). The relationship between patient safety culture and patient safety competency with adverse events: a multicenter cross-sectional study. BMC Nursing, 21(1), 1–8. https://doi.org/10.1186/s12912-022-01076-w

Hessels, A. J., Guo, J., Johnson, C. T., & Larson, E. (2023). Impact of patient safety climate on infection prevention practices and healthcare worker and patient outcomes. American Journal of Infection Control, 51(5), 482–489. https://doi.org/10.1016/j.ajic.2023.01.021

Hunt, J., Gammon, J., Williams, S., Daniel, S., Rees, S., & Matthewson, S. (2022). Patient safety culture as a space of social struggle: understanding infection prevention practice and patient safety culture within hospital isolation settings - a qualitative study. BMC Health Services Research, 22(1), 1–11. https://doi.org/10.1186/s12913-022-08703-x

Jury, D., & Noguera, E. (2023). Infection Control. In A. Abd-Elsayed (Ed.), Advanced Anesthesia Review (pp. 886-C355.S7). Oxford University PressNew York. https://doi.org/10.1093/med/9780197584521.003.0354

Kakemam, E., Gharaee, H., Rajabi, M. R., Nadernejad, M., Khakdel, Z., Raeissi, P., & Kalhor, R. (2021). Nurses’ perception of patient safety culture and its relationship with adverse events: a national questionnaire survey in Iran. BMC Nursing, 20(1), 1–10. https://doi.org/10.1186/s12912-021-00571-w

Kanjia, M. K., Kurth, C. D., Hyman, D., Williams, E., & Varughese, A. (2024). Perspectives on Anesthesia and Perioperative Patient Safety: Past, Present, and Future. Anesthesiology, 141(5), 835–848. https://doi.org/10.1097/ALN.0000000000005164

Krasovska, K. O., & Globina, N. I. (2025). Importance of infection control in increasing patient safety and preventing infections during healthcare (literature review). Inter Collegas, 12(2), 64–74. https://doi.org/10.35339/ic.2025.12.2.krg

Lee, S. E., & Dahinten, V. S. (2020). The Enabling, Enacting, and Elaborating Factors of Safety Culture Associated With Patient Safety: A Multilevel Analysis. Journal of Nursing Scholarship, 52(5), 544–552. https://doi.org/10.1111/jnu.12585

Lee, S. E., Scott, L. D., Dahinten, V. S., Vincent, C., Lopez, K. D., & Park, C. G. (2019). Safety Culture, Patient Safety, and Quality of Care Outcomes: A Literature Review. Western Journal of Nursing Research, 41(2), 279–304. https://doi.org/10.1177/0193945917747416

Leyci, F., & Pourasghar, F. (2025). Causes of Medical Errors and Their Relative Importance: Systematic Review. Health Scope, 14(4). https://doi.org/10.5812/healthscope-162224

Liu, C., Chen, H., Cao, X., Sun, Y., Liu, C. Y., Wu, K., Liang, Y. C., Hsu, S. E., Huang, D. H., & Chiou, W. K. (2022). Effects of Mindfulness Meditation on Doctors’ Mindfulness, Patient Safety Culture, Patient Safety Competency and Adverse Event. International Journal of Environmental Research and Public Health, 19(6), 1–15. https://doi.org/10.3390/ijerph19063282

Lomotey, S. A. A. (2025). Work Related Safety behaviour in Occupational Safety and Health-Evaluating the Outcomes of Work Related Safety behaviour on Culture of the Organization Predominantly and Accident in Industry. International Journal of Human Research and Social Science Studies, 02(11), 783–791. https://doi.org/10.55677/ijhrsss/03-2025-vol02i11

Luke Slawomirski, N. K. (2022). The economics of patient safety from analysis to action. Organisation for Economic Co-Operation and Development (OECD), 145, 1–74. http://www.oecd.org/health/health-systems/Economics-of-Patient-Safety-October-2020.pdf

Mistri, I. U., Badge, A., & Shahu, S. (2023). Enhancing Patient Safety Culture in Hospitals. Cureus, 15(12), 1–7. https://doi.org/10.7759/cureus.51159

Musyoki, R. M., Kimuhu, D. S., & Warutere, D. P. (2021). Adherence To Infection Prevention Standard Precautions Among Health Care Workers In Embu Level 5 Hospital-Embu County Kenya. International Journal of Advances in Scientific Research and Engineering, 07(07), 18–27. https://doi.org/10.31695/ijasre.2021.34038

Natt, N., Michael, F., Michael, H., Dubois, S., & Al Mazrou’i, A. (2022). ERCP-Related Adverse Events in Primary Sclerosing Cholangitis: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology, 2022, 1–14. https://doi.org/10.1155/2022/2372257

Ortner, J., Moya, D., Manzanera, R., Torres, M., Vives, A., Farrus, X., Grau, N., & Mira, J. J. (2023). Adverse events in the global healthcare practice of an Occupational Mutual Insurance Company in Spain. Work, 76(3), 1157–1165. https://doi.org/10.3233/WOR-220203

Panagioti, M., Khan, K., Keers, R. N., Abuzour, A., Phipps, D., Kontopantelis, E., Bower, P., Campbell, S., Haneef, R., Avery, A. J., & Ashcroft, D. M. (2019). Prevalence, severity, and nature of preventable patient harm across medical care settings: Systematic review and meta-analysis. The BMJ, 366. https://doi.org/10.1136/bmj.l4185

Reyes Ramos, M. J., & Costa Abós, S. (2024). Patient Safety Culture: Nurses’ Perspective in the Hospital Setting. Healthcare (Switzerland), 12(10). https://doi.org/10.3390/healthcare12101010

San Jose-Saras, D., Valencia-Martín, J. L., Vicente-Guijarro, J., Moreno-Nunez, P., Pardo-Hernández, A., & Aranaz-Andres, J. M. (2022). Adverse events: an expensive and avoidable hospital problem. Annals of Medicine, 54(1), 3157–3168. https://doi.org/10.1080/07853890.2022.2140450

Shi, H., Chen, Z., Du, X., Jiang, J., Peng, Y., Wang, C., Zheng, S., Huang, Q., Xiao, M., Zhao, Q., & Huang, H. (2025). Revisiting hospital patient safety culture in China: a nationwide network analysis. Archives of Public Health, 83(1), 118. https://doi.org/10.1186/s13690-025-01612-5

Tyler, E. R., Yalden, O., Fan, L., Ji, S., Kirchner, J., Yount, N. D., Sorra, J., & Rockville, W. (2024). Surveys on Patient Safety Culture Hospital Survey 2.0: 2024 User Database Report Part 1. www.ahrq.gov

Vikan, M., Haugen, A. S., Bjørnnes, A. K., Valeberg, B. T., Deilkås, E. C. T., & Danielsen, S. O. (2023). The association between patient safety culture and adverse events – a scoping review. BMC Health Services Research, 23(1), 1–27. https://doi.org/10.1186/s12913-023-09332-8

Vinet, L., & Zhedanov, A. (2021). Towards eliminating avoidable harm in health care. In Global patient safety action plan 2021–2030 (pp. 1689–1699). https://doi.org/10.1088/1751-8113/44/8/085201

Weber, D. J., Babcock, H., Hayden, M. K., Wright, S. B., Murthy, A. R., Guzman-Cottrill, J., Haessler, S., Rock, C., Van Schooneveld, T., Forde, C. A., Logan, L. K., Malani, A., & Henderson, D. K. (2020). Universal pandemic precautions - An idea ripe for the times. Infection Control and Hospital Epidemiology, 41(11), 1321–1322. https://doi.org/10.1017/ice.2020.327

Widyastuti, R. D., Arso, S. P., & Suryoputro, A. (2025). Keselamatan pasien sebagai pilar penting dalam mencegah kesalahan medis: Tinjauan sistematik. Holistik Jurnal Kesehatan, 19(2), 277–285. https://doi.org/10.33024/hjk.v19i2.639

Wu, A. W., & Kachalia, A. B. (2023). Creating a “just culture”: More work to be done. Journal of Patient Safety and Risk Management, 28(2), 56–58. https://doi.org/10.1177/25160435231168152

Yilma, M., Taye, G., & Abebe, W. (2024). Magnitude of standard precautions practices among healthcare workers in health facilities of Low and Middle Income Countries: A systematic review and meta-analysis. PLoS ONE, 19(4 April), 1–22. https://doi.org/10.1371/journal.pone.0302282

Zadow, A., Loh, M. Y., Dollard, M. F., Mathisen, G. E., & Yantcheva, B. (2023). Psychosocial safety climate as a predictor of work engagement, creativity, innovation, and work performance: A case study of software engineers. Frontiers in Psychology, 14. https://doi.org/10.3389/fpsyg.2023.1082283

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2026-09-27