Aktifitas Zat Aktif Berbasis Tanaman Tradisional Indonesia Dalam Penyembuhan Luka
DOI:
https://doi.org/10.30651/jkm.v4i2.2121Kata Kunci:
Penyembuhan Luka, Tanaman TradisionalAbstrak
Background:Â Wound healing is a series of complex events that are interrelated and depend on one another. Wound healing can be accelerated using traditional medicine. Traditional medicine is one of the efforts to overcome health problems that have been passed down from generation to generation, the use of traditional plants in Indonesia is part of national culture and has been widely used by people since centuries ago. Purpose: Information about traditional plants that can be used in wound healing. Method: Literature obtained based on scientific databases such as Science direct, and Google Scholar with current pharmacological evidence. Result: Traditional medicine has the activity as an antioxidant, anti-inflammatory, antibacterial in wound healing reported from various studies at this time. Therefore, their research can be introduced as something natural and can be used as a remedy for wound healing. Conclusion: Traditional plants can heal wounds through a mechanism.
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Referensi
Ardiana, t., kusuma, a. P. K., & firdausy, m. D. (2015). Efektivitas pemberian gel binahong (adredera cordifolia) 5% terhadap jumlah sel fibroblast pada soket pasca pencabutan gigi marmut (cavia cobaya). Odonto dental journal, 2, 64–70.
Bestari, z. A., saraswati, i., & adespin, d. A. (2016). Pengaruh bawang putih (allium sativum l) terhadap penyembuhan luka bakar derajat ii dangkal pada tikus wistar. Jurnal kedokteran diponegoro, 5(4), 1955–1961.
Bigoniya, p., agrawal, s., & verma, n. K. (2013). Potential wound healing activity of euphorbia hirta linn total flavonoid fraction. International journal of pharmaceutical sciences review and research, 22(2), 149–156.
Ch muntiaha, m., y yamlean, p. V, & widya astuti lolo, dan. (2014). Uji efektivitas sediaan krim getah jarak cina (jatropha multifida l.) Untuk pengobatan luka sayat yang terinfeksi bakteri staphylococcus aureus pada kelinci (orytolagus cuniculus). Pharmacon jurnal ilmiah farmasi – unsrat agustus, 3(3), 2302–2493.
Childs, d. R., & murthy, a. S. (2017). Overview of wound healing and management. Surgical clinics of north america, 97(1), 189–207. Https://doi.org/10.1016/j.suc.2016.08.013
Enoch, s., & leaper, d. J. (2005). Basic science of wound healing. Surgery (oxford), 23(2), 37–42. Https://doi.org/10.1383/surg.23.2.37.60352
Geethalakshmi, r., sakravarthi, c., kritika, t., kirubakaran, m. A., & sarada, d. V. L. (2013). Evaluation of antioxidant and wound healing potentials of sphaeranthus amaranthoides burm . F ., 2013.
Gurib-fakim, a. (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular aspects of medicine, 27(1), 1–93. Https://doi.org/10.1016/j.mam.2005.07.008
Han, s. (2016). Innovations and advances in wound healing (second). Korea: springer london. Https://doi.org/10.1007/978-3-662-46587-5
Hosseinzadeh, s., jafarikukhdan, a., hosseini, a., & armand, r. (2015). The application of medicinal plants in traditional and modern medicine: a review of <i>thymus vulgaris</i> international journal of clinical medicine, 6(9), 635–642. Https://doi.org/10.4236/ijcm.2015.69084
Kementrian kesehatan republik indonesia. (2016). Peraturan menteri kesehatan repuplik indonesia nomor 6 tahun 2016 tentang formularium obat herbal asli indonesia, 1–226.
Krafts, k. P. (2010). Tissue repair: the hidden drama. Organogenesis, 6(4), 225–233. Https://doi.org/10.4161/org.6.4.12555
Mulholland, e. J., dunne, n., & mccarthy, h. O. (2017). Microrna as therapeutic targets for chronic wound healing. Molecular therapy - nucleic acids, 8(september), 46–55. Https://doi.org/10.1016/j.omtn.2017.06.003
Ningsih, a. P., & agustien, a. (2013). Uji aktivitas antibakteri ekstrak kental tanaman pisang kepok kuning ( musa paradisiaca linn .) Terhadap staphylococcus aureus dan escherichia coli antibacterial activity of crude extracts of pisang kepok kuning ( musa paradisiaca linn .) Against staphylo. Jurnal biologi universitas andalas, 2(september), 207–213.
Oktora, l., & kumala. (2006). Pemanfaatan obat tradisional dan keamanannya. Majalah ilmu kefarmasian, iii(1), 1–7. Https://doi.org/10.7454/psr.v3i1.3394
Paju, n., yamlean, p. V. Y., & kojong, n. (2013). Uji efektivitas salep ekstrak daun binahong (anredera cordifolia (ten.) Steenis) pada kelinci (oryctolagus cuniculus) yang terinfeksi bakteri staphylococcus aureus. Pharmacon jurnal ilmiah farmasi – unsrat, 2(1), 2302–2493.
Puti, i., sabirin, r., maskoen, a. M., & hernowo, b. S. (2011). Peran ekstrak etanol topikal daun mengkudu ( morinda citrifolia l .) Pada penyembuhan luka ditinjau dari imunoekspresi cd34 dan kolagen pada tikus galur wistar role of noni ( morinda citrifolia l .) Leaf ethanolic extract topical application on wound heal, 45(4), 226–233.
Rayhan mahbub, k., & mojibulhoq, m. (1998). In vitro antibacterial activity of crescentia cujete and moringa oleifera. Invitroantibacterialactivityofcrescentiacujeteandmoringaoleifera.bangladeshres.pub.j, 5(44), 337–343.
Singh, m., govindarajan, r., nath, v., kumar, a., rawat, s., & mehrotra, s. (2006). Antimicrobial , wound healing and antioxidant activity of, 107, 67–72. Https://doi.org/10.1016/j.jep.2006.02.007
Sugianti, b. (2005). Pemanfaatan tumbuhan obat tradisional dalam pengendalian penyakit ikan, 1–37.
Tahir, t., bakri, s., patellongi, i., aman, m., & upik, a. (2017). Evaluation of topical red dragon fruit extract effect ( hylocereus polyrhizus ) on tissue granulation and epithelialization in diabetes mellitus ( dm ) and non-dm wistar rats : pre eliminary study. International journal of science : basic and applied research, 4531(january), 309–320.
Taye, b., giday, m., animut, a., & seid, j. (2011). Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in ethiopia. Asian pacific journal of tropical biomedicine, 1(5), 370–375. Https://doi.org/10.1016/s2221-1691(11)60082-8
Wijonarko, b. (2016). Efektvitas topikal salep ekstrak binahong ( anredera cordifolia ( tenore ) steenis ) terhadap proses penyembuhan luka ulkus diabetik pada tikus wistar ( rattus novergicus ) diabetes melitus ( dm ) me-rupkan suatu penyakit menahun yang ditandai oleh kadar , ix(2).
Yunanda, v., & rinanda, t. (2017). Aktivitas penyembuhan luka sediaan topikal ekstrak bawang merah (allium cepa) terhadap luka sayat kulit mencit (mus musculus) (the activity of topical extract of onions (allium cepa) on wound healing process in mice (mus musculus)). Jurnal veteriner, 17(4), 606–614. Https://doi.org/10.19087/jveteriner.2016.17.4.606
Zuhdan, f. M., & nugroho, t. (2014). Pengaruh salep ekstrak etanol daun sirih ( piper betle ) terhadap penyembuhan luka iris, 6(1), 19–27.
ardiana, t., kusuma, a. P. K., & firdausy, m. D. (2015). Efektivitas pemberian gel binahong (adredera cordifolia) 5% terhadap jumlah sel fibroblast pada soket pasca pencabutan gigi marmut (cavia cobaya). Odonto dental journal, 2, 64–70.
Bestari, z. A., saraswati, i., & adespin, d. A. (2016). Pengaruh bawang putih (allium sativum l) terhadap penyembuhan luka bakar derajat ii dangkal pada tikus wistar. Jurnal kedokteran diponegoro, 5(4), 1955–1961.
Bigoniya, p., agrawal, s., & verma, n. K. (2013). Potential wound healing activity of euphorbia hirta linn total flavonoid fraction. International journal of pharmaceutical sciences review and research, 22(2), 149–156.
Ch muntiaha, m., y yamlean, p. V, & widya astuti lolo, dan. (2014). Uji efektivitas sediaan krim getah jarak cina (jatropha multifida l.) Untuk pengobatan luka sayat yang terinfeksi bakteri staphylococcus aureus pada kelinci (orytolagus cuniculus). Pharmacon jurnal ilmiah farmasi – unsrat agustus, 3(3), 2302–2493.
Childs, d. R., & murthy, a. S. (2017). Overview of wound healing and management. Surgical clinics of north america, 97(1), 189–207. Https://doi.org/10.1016/j.suc.2016.08.013
Enoch, s., & leaper, d. J. (2005). Basic science of wound healing. Surgery (oxford), 23(2), 37–42. Https://doi.org/10.1383/surg.23.2.37.60352
Geethalakshmi, r., sakravarthi, c., kritika, t., kirubakaran, m. A., & sarada, d. V. L. (2013). Evaluation of antioxidant and wound healing potentials of sphaeranthus amaranthoides burm . F ., 2013.
Gurib-fakim, a. (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular aspects of medicine, 27(1), 1–93. Https://doi.org/10.1016/j.mam.2005.07.008
Han, s. (2016). Innovations and advances in wound healing (second). Korea: springer london. Https://doi.org/10.1007/978-3-662-46587-5
Hosseinzadeh, s., jafarikukhdan, a., hosseini, a., & armand, r. (2015). The application of medicinal plants in traditional and modern medicine: a review of <i>thymus vulgaris</i> international journal of clinical medicine, 6(9), 635–642. Https://doi.org/10.4236/ijcm.2015.69084
Kementrian kesehatan republik indonesia. (2016). Peraturan menteri kesehatan repuplik indonesia nomor 6 tahun 2016 tentang formularium obat herbal asli indonesia, 1–226.
Krafts, k. P. (2010). Tissue repair: the hidden drama. Organogenesis, 6(4), 225–233. Https://doi.org/10.4161/org.6.4.12555
Mulholland, e. J., dunne, n., & mccarthy, h. O. (2017). Microrna as therapeutic targets for chronic wound healing. Molecular therapy - nucleic acids, 8(september), 46–55. Https://doi.org/10.1016/j.omtn.2017.06.003
Ningsih, a. P., & agustien, a. (2013). Uji aktivitas antibakteri ekstrak kental tanaman pisang kepok kuning ( musa paradisiaca linn .) Terhadap staphylococcus aureus dan escherichia coli antibacterial activity of crude extracts of pisang kepok kuning ( musa paradisiaca linn .) Against staphylo. Jurnal biologi universitas andalas, 2(september), 207–213.
Oktora, l., & kumala. (2006). Pemanfaatan obat tradisional dan keamanannya. Majalah ilmu kefarmasian, iii(1), 1–7. Https://doi.org/10.7454/psr.v3i1.3394
Paju, n., yamlean, p. V. Y., & kojong, n. (2013). Uji efektivitas salep ekstrak daun binahong (anredera cordifolia (ten.) Steenis) pada kelinci (oryctolagus cuniculus) yang terinfeksi bakteri staphylococcus aureus. Pharmacon jurnal ilmiah farmasi – unsrat, 2(1), 2302–2493.
Puti, i., sabirin, r., maskoen, a. M., & hernowo, b. S. (2011). Peran ekstrak etanol topikal daun mengkudu ( morinda citrifolia l .) Pada penyembuhan luka ditinjau dari imunoekspresi cd34 dan kolagen pada tikus galur wistar role of noni ( morinda citrifolia l .) Leaf ethanolic extract topical application on wound heal, 45(4), 226–233.
Rayhan mahbub, k., & mojibulhoq, m. (1998). In vitro antibacterial activity of crescentia cujete and moringa oleifera. Invitroantibacterialactivityofcrescentiacujeteandmoringaoleifera.bangladeshres.pub.j, 5(44), 337–343.
Singh, m., govindarajan, r., nath, v., kumar, a., rawat, s., & mehrotra, s. (2006). Antimicrobial , wound healing and antioxidant activity of, 107, 67–72. Https://doi.org/10.1016/j.jep.2006.02.007
Sugianti, b. (2005). Pemanfaatan tumbuhan obat tradisional dalam pengendalian penyakit ikan, 1–37.
Tahir, t., bakri, s., patellongi, i., aman, m., & upik, a. (2017). Evaluation of topical red dragon fruit extract effect ( hylocereus polyrhizus ) on tissue granulation and epithelialization in diabetes mellitus ( dm ) and non-dm wistar rats : pre eliminary study. International journal of science : basic and applied research, 4531(january), 309–320.
Taye, b., giday, m., animut, a., & seid, j. (2011). Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in ethiopia. Asian pacific journal of tropical biomedicine, 1(5), 370–375. Https://doi.org/10.1016/s2221-1691(11)60082-8
Wijonarko, b. (2016). Efektvitas topikal salep ekstrak binahong ( anredera cordifolia ( tenore ) steenis ) terhadap proses penyembuhan luka ulkus diabetik pada tikus wistar ( rattus novergicus ) diabetes melitus ( dm ) me-rupkan suatu penyakit menahun yang ditandai oleh kadar , ix(2).
Yunanda, v., & rinanda, t. (2017). Aktivitas penyembuhan luka sediaan topikal ekstrak bawang merah (allium cepa) terhadap luka sayat kulit mencit (mus musculus) (the activity of topical extract of onions (allium cepa) on wound healing process in mice (mus musculus)). Jurnal veteriner, 17(4), 606–614. Https://doi.org/10.19087/jveteriner.2016.17.4.606
Zuhdan, f. M., & nugroho, t. (2014). Pengaruh salep ekstrak etanol daun sirih ( piper betle ) terhadap penyembuhan luka iris, 6(1), 19–27.
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