Subchronic exposure to Chlorpyrifos, Carbofuran, and Cypermethrin increase sciatic nerve damage and degeneration in adolescent rats
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Pesticide, Chlorpyrifos, Carbofuran, Cypermethrin, Peripheral nerve
Abstract
Several types of pesticides that are often used are chlorpyrifos (organophosphate), carbofuran (carbamate), and cypermethrin (pyrethroid). Â Pesticides can kill pests but also can cause toxic effects on humans when exposed. Â One of the adverse effects of pesticide exposure is a disturbance in the peripheral nervous system. Â Age is an essential factor in peripheral nerve damage. Â Nerve injury is one of the most common injuries in children and adolescents and is estimated at 10% to 15% of all exceptional unit cases. Â However, the outcome of peripheral nerve injury is known better in subjects who sustain the injury at a younger age. Â This study aims to determine the subchronic exposure effect of chlorpyrifos, carbofuran, and cypermethrin to sciatic nerve histopathology in juvenile rats. Â This study used 30 male Wistar rats (Rattus norvegicus) which were divided into 5 groups, normal group (N), control group (K), chlorpyrifos group (P1), carbofuran group (P2) and cypermethrin group (P3). Â Subcutaneous injection of pesticides was carried out for 21 days. Â Rats were sacrificed using the cervical dislocation method, and the right sciatic nerve was taken for histopathological observation. Â Assessment of the degree of ischiatic nerve histopathological damage is using the Jensen et al., (2018) method. Â Data were analyzed using the Kruskal-Wallis test and continued with the Mann-Whitney test. Â This study showed a significantly increased degree of histopathological damage in the chlorpyrifos group, carbofuran group, and cypermethrin group compared to the control group and the normal group (p<0.05). Â It can be concluded that exposure to chlorpyrifos, carbofuran, and cypermethrin pesticides increased damage and degeneration of the ischiadicus nerve in juvenile rats.
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