Analysis of Neutrophil, Leukocyte, Lymphocyte, and NLR Cell Profiles in Patients Diagnosed with Chronic Gastritis Affected by Helicobacter pylori and Non-Helicobacter pylori Infection at Dr. Soetomo Hospital in Surabaya, Indonesia
Abstract
Helicobacter pylori (HP) is a prevalent cause of bacterial infections, particularly chronic gastritis in the human body. The diagnosis of gastritis relied on gastric biopsy examination, where inflammation is characterized by an increase in various inflammatory cells, including macrophage, neutrophil, lymphocyte, or plasma cells. Therefore, this research aimed to determine the profiles of neutrophil, leukocyte, lymphocyte, and neutrophil lymphocyte ratio (NLR) in chronic gastritis patients, distinguishing between those with Helicobacter pylori and non-Helicobacter pylori infection at Dr. Soetomo Hospital in Surabaya. This research adopted a retrospective method, using medical records for chronic gastritis patients at Dr. Soetomo Hospital between 2018 and 2022. The variables analyzed included Helicobacter pylori infections and values of neutrophil, leukocyte, lymphocyte, and NLR cells. The obtained data were subjected to analysis using descriptive statistics. The results showed that the majority of participants were females (61.9%), senior high school graduates (52.38%), and aged 45-59 (pre-elderly) (32.14%). In non-Helicobacter pylori group, the average values of neutrophil, leukocyte, lymphocyte, and NLR cells were 62.29 (SD = 12.17), 8.155 (SD = 4.02), 29.165 (SD = 12.31), and 3.68 (SD=4.865), respectively. In conclusion, females showed a propensity for chronic gastritis with Helicobacter pylori. It was observed that non-Helicobacter pylori chronic gastritis tended to have elevated neutrophil and leukocyte values. Meanwhile, Helicobacter pylori-related chronic gastritis tended to show increased lymphocyte and NLR values due to systemic inflammation. Helicobacter pylori was associated with conditions such as iron deficiency anemia, cardiovascular disease, diabetes, thyroid disease, and malnutrition.
References
Atayan, Y., & Hacisalihoglu, P. (2017). The correlation between tissue Helicobacter pylori severity and the increase in serum neutrophil/lymphocyte ratio in patients with active chronic gastritis. Biomed. Res, 28, 4874-4877.
Boyuk, B., Saydan, D., Mavis, O., & Erman, H. (2020). Evaluation of Helicobacter pylori Infection, Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio in Dyspeptic Patients. Gastroenterology Insights, 11(1), 2-9.
Crowe, S. E. (2019). Helicobacter pylori infection. New England Journal of Medicine, 380(12), 1158-1165.
Deyuga, M. R., Lubis, A. D., Fujiati, I. I., Ramayani, O. R., & Evalina, R. (2022). Relationship between Neutrophil Lymphocyte Ratio in Children with H. Pylori and Non H. Pylori Gastritis. Medicine, Health & Food, 92(1), 10-10.
Farah, R., & Khamisy-Farah, R. (2014). Association of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infection. J Clin Lab Anal, 28(3), 219-223. https://doi.org/10.1002/jcla.21669
Guclu, M., & Faruq Agan, A. (2017). Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume. Euroasian J Hepatogastroenterol, 7(1), 11-16. https://doi.org/10.5005/jp-journals-10018-1204
Iida, M., Ikeda, F., Ninomiya, T., Yonemoto, K., Doi, Y., Hata, J., Matsumoto, T., Iida, M., & Kiyohara, Y. (2012). White blood cell count and risk of gastric cancer incidence in a general Japanese population: the Hisayama study. Am J Epidemiol, 175(6), 504-510. https://doi.org/10.1093/aje/kwr345
Kim, D. H., Son, B. K., Min, K. W., Han, S. K., Na, J. U., Choi, P. C., Kim, H. L., Kwon, M. J., Oh, Y. H., Jung, W. Y., Moon, J. Y., Hong, S., Oh, K. W., & Kim, Y. S. (2020). Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System. J Clin Med, 9(6). https://doi.org/10.3390/jcm9061856
Koç, S., & Gedikli, M. A. (2022). The Role of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratios in Predicting H Pylori Positivity and Severity in Patients with Chronic Gastritis. Cumhuriyet Medical Journal, 44(1).
Miftahussurur, M. (2020). Noninvasive Helicobacter pylori Diagnostic Methods in Indonesia. Gut Liver, 14(5), 553-559. https://doi.org/10.5009/gnl19264
Monica, T. (2019). Hubungan Antara Pengetahuan Dan Tingkat Stres Terhadap Kambuh Ulang Gastritis Di Wilayah Kerja Puskesmas Kota Sungai Penuh Tahun 2018. Menara Ilmu, 13(5).
Muna, U. L., & Kurniawati, T. (2023). Hubungan Stres dengan Kejadian Gastritis: Literatur Review. Jurnal Ilmu Psikologi dan Kesehatan (SIKONTAN), 1(4), 277-282.
Prakoeswa, F. R. (2020). Peranan Sel Limfosit Dalam Imunulogi: Artikel Review. Jurnal Sains Dan Kesehatan, 2(4), 525-537.
Raintung, E. P., Kaunang, W. P., & Malonda, N. S. (2019). Faktor-faktor yang Memengaruhi Kejadian Gastritis di Puskesmas Ranotana Weru Kota Manado. EBiomedik, 7(2).
Rodríguez-García, J. L., & Carmona-Sánchez, R. (2016). Functional dyspepsia and dyspepsia associated with Helicobacter pylori infection: Do they have different clinical characteristics? Revista de Gastroenterología de México (English Edition), 81(3), 126-133. https://doi.org/https://doi.org/10.1016/j.rgmxen.2016.06.017
Sağlam, N., & Civan, H. A. (2023). Impact of chronic Helicobacter pylori infection on inflammatory markers and hematological parameters. Eur Rev Med Pharmacol Sci, 27(3), 969-979. https://doi.org/10.26355/eurrev_202302_31190
Săsăran, M. O., Meliţ, L. E., Mocan, S., Ghiga, D. V., & Dobru, E. D. (2020). Pediatric gastritis and its impact on hematologic parameters. Medicine (Baltimore), 99(35), e21985. https://doi.org/10.1097/md.0000000000021985
Sharma, P. K., Salaria, S., Manrai, M., Srivastava, S., Kumar, D., & Singh, A. R. (2022). Helicobacter pylori infection in non-ulcer dyspepsia: A cross-sectional study. Medical Journal Armed Forces India, 78(2), 180-184. https://doi.org/https://doi.org/10.1016/j.mjafi.2020.11.020
Syam, A. F., Miftahussurur, M., Makmun, D., Nusi, I. A., Zain, L. H., Zulkhairi, Akil, F., Uswan, W. B., Simanjuntak, D., Uchida, T., Adi, P., Utari, A. P., Rezkitha, Y. A., Subsomwong, P., Nasronudin, Suzuki, R., & Yamaoka, Y. (2015). Risk Factors and Prevalence of Helicobacter pylori in Five Largest Islands of Indonesia: A Preliminary Study. PLoS One, 10(11), e0140186. https://doi.org/10.1371/journal.pone.0140186
Tussakinah, W., Masrul, M., & Burhan, I. R. (2018). Hubungan Pola Makan dan Tingkat Stres terhadap Kekambuhan Gastritis di Wilayah Kerja Puskesmas Tarok Kota Payakumbuh Tahun 2017. Jurnal Kesehatan Andalas, 7(2), 217-225.
Uwa, L. F., Milwati, S., & Sulasmini, S. (2019). Hubungan antara stres dan pola makan dengan kejadian gastritis yang terjadi di puskesmas dinoyo. Nursing News: Jurnal Ilmiah Keperawatan, 4(1).
Yulida, E., Oktaviyanti, I. K., & Rosida, L. (2013). Gambaran derajat infiltrasi sel radang dan infeksi Helicobacter pylori pada biopsi lambung pasien gastritis: di RSUD Ulin Banjarmasin tahun 2009-2011. Berkala Kedokteran, 9(1), 51-65.
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