DUTCH (Dried Urine Test for Comprehensive Hormones) In Preventing Diseases Related Hormonal Function
Abstract
Hormones released and absorbed by the human body in a balanced state will help create balance and health, while changes in hormone levels can cause various severe and chronic health problems. Hormone test is a method of measuring hormone levels in the body that can be used to diagnose and treat diseases, monitor patient health as a whole, or prevent the growth of certain health problems. This research might be the information about. the functional hormone test (DUTCH). This study presented a case of a 47 years old woman with history of chronic dysmenorrhea. The functional hormone testing was carried out on days 19-22 of the menstrual cycle in women with a regular period of 28 days. The result of DUTCH test in this patient were dominant 2-OH that she safe from the symptoms of estrogen dominance and low production of 4-OH, the methylation process was fluent so that the risk of cancer-related to estrogen dominance syndrome was low. Hormone examination through urine is intended to see metabolites (metabolic waste) hormones released through urine. By witnessing the estrogen & progesterone metabolites, it can be seen how much risk a person has Estrogen Dominance Syndrome.
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References
Bédard, Nancy J. Martin, Paul Krueger, Kevin Brazil, M., 2000. Assessing reproducibility of data obtained with instruments based on continuous measurements. Experimental Aging Research, 26(4), pp.353-365.
Black, C.N., Bot, M., Scheffer, P.G., Cuijpers, P. and Penninx, B.W., 2015. Is depression associated with increased oxidative stress? A systematic review and meta-analysis. Psychoneuroendocrinology, 51, pp.164-175.
Blasco, H., Garrigue, M.A., De Vos, A., Antar, C., Labarthe, F., Maillot, F., Andres, C.R. and Nadal-Desbarats, L., 2010. Filter paper saturated by urine sample in metabolic disorders detection by proton magnetic resonance spectroscopy. Analytical and bioanalytical chemistry, 396(3), pp.1205-1211.
Direito, A., Bailly, S., Mariani, A. and Ecochard, R., 2013. Relationships between the luteinizing hormone surge and other characteristics of the menstrual cycle in normally ovulating women. Fertility and sterility, 99(1), pp.279-285.
Groenewoud, E.R., Macklon, N.S., Cohlen, B.J., Al-Oraiby, A., Brinkhuis, E.A., Broekmans, F.J., de Bruin, J.P., van der Dool, G., Fleisher, K., Friederich, J. and Goddijn, M., 2017. The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles. Reproductive biomedicine online, 34(5), pp.546-554.
de Jong, W.H., Buitenwerf, E., Pranger, A.T., Riphagen, I.J., Wolffenbuttel, B.H., Kerstens, M.N. and Kema, I.P., 2018. Determination of reference intervals for urinary steroid profiling using a newly validated GC-MS/MS method. Clinical Chemistry and Laboratory Medicine (CCLM), 56(1), pp.103-112.
Klein, D.A., Paradise, S.L. and Reeder, R.M., 2019. Amenorrhea: a systematic approach to diagnosis and management. American family physician, 100(1), pp.39-48.
Krone, N., Hughes, B.A., Lavery, G.G., Stewart, P.M., Arlt, W. and Shackleton, C.H., 2010. Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS). The Journal of steroid biochemistry and molecular biology, 121(3-5), pp.496-504.
Marcos, J., Renau, N., Casals, G., Segura, J., Ventura, R. and Pozo, O.J., 2014. Investigation of endogenous corticosteroids profiles in human urine based on liquid chromatography tandem mass spectrometry. Analytica chimica acta, 812, pp.92-104.
McCann, M.T., Thompson, M.M., Gueron, I.C., Lemieux, B., Giguere, R. and Tuchman, M., 1996. Methylmalonic acid quantification by stable isotope dilution gas chromatography-mass spectrometry from filter paper urine samples. Clinical chemistry, 42(6), pp.910-914.
Newman, M., Pratt, S.M., Curran, D.A. and Stanczyk, F.Z., 2019. Evaluating urinary estrogen and progesterone metabolites using dried filter paper samples and gas chromatography with tandem mass spectrometry (GC–MS/MS). BMC chemistry, 13(1), pp.1-12.
Newman, M. and Curran, D.A., 2021. Reliability of a dried urine test for comprehensive assessment of urine hormones and metabolites. BMC chemistry, 15(1), pp.1-13.
Rezvanpour, A. and Don-Wauchope, A.C., 2017. Clinical implications of estrone sulfate measurement in laboratory medicine. Critical reviews in clinical laboratory sciences, 54(2), pp.73-86.
Roos, J., Johnson, S., Weddell, S., Godehardt, E., Schiffner, J., Freundl, G. and Gnoth, C., 2015. Monitoring the menstrual cycle: Comparison of urinary and serum reproductive hormones referenced to true ovulation. The European Journal of Contraception & Reproductive Health Care, 20(6), pp.438-450.
Sampson, J.N., Falk, R.T., Schairer, C., Moore, S.C., Fuhrman, B.J., Dallal, C.M., Bauer, D.C., Dorgan, J.F., Shu, X.O., Zheng, W. and Brinton, L.A., 2017. Association of estrogen metabolism with breast cancer risk in different cohorts of postmenopausal women. Cancer research, 77(4), pp.918-925.
Sansone, A., Sansone, M., Selleri, R., Schiavo, A., Gianfrilli, D., Pozza, C., Zitzmann, M., Lenzi, A. and Romanelli, F., 2019. Monitoring testosterone replacement therapy with transdermal gel: when and how?. Journal of endocrinological investigation, 42(12), pp.1491-1496.
Savkovic, S., Lim, S., Jayadev, V., Conway, A., Turner, L., Curtis, D., Goebel, C. and Handelsman, D.J., 2018. Urine and serum sex steroid profile in testosterone-treated transgender and hypogonadal and healthy control men. The Journal of Clinical Endocrinology & Metabolism, 103(6), pp.2277-2283.
Schiffer, L., Barnard, L., Baranowski, E.S., Gilligan, L.C., Taylor, A.E., Arlt, W., Shackleton, C.H. and Storbeck, K.H., 2019. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review. The Journal of steroid biochemistry and molecular biology, 194, p.105439.
Shackleton, C., 2010. Clinical steroid mass spectrometry: a 45-year history culminating in HPLC–MS/MS becoming an essential tool for patient diagnosis. The Journal of steroid biochemistry and molecular biology, 121(3-5), pp.481-490.
Stanczyk, F.Z. and Clarke, N.J., 2010. Advantages and challenges of mass spectrometry assays for steroid hormones. The Journal of steroid biochemistry and molecular biology, 121(3-5), pp.491-495.
Authors
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