Understanding Pacing-Induced Cardiomyopathy: a mini review
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Vol. 5 No. 2 (2021)
September 14, 2020
July 24, 2021
Abstract
Patients with total atrioventricular block or sinus node dysfunction will need pacemaker implantation to improve the physiologic function of the heart. It is known that chronic pacing such as right ventricular pacing could deteriorate the cardiac function (decreased left ventricular ejection fraction) due to dyssynchrony. This condition is knows as pacing-induced cardiomyopathy (PICM). The incidence of PICM could reach 19.5% during 3 years follow-up. The right ventricle is one of the locations for implantation. Chronic right ventricular pacing may cause interventricular dyssynchrony and disrupt the contraction mechanism in the heart. These will lead to cardiac remodeling and eventually impair the left ventricular function. Therapy is needed in patients with PICM to improve the symptoms and maintain the cardiac function. This article will further highlight the definition, mechanism, risk factor, treatment and preventive strategy for patients with PICM.
References
Bank, A. J., Gage, R. M., & Burns, K. V. (2012). Right ventricular pacing, mechanical dyssynchrony, and heart failure. Journal of Cardiovascular Translational Research, 5(2), 219–231.
Bank, A. J., Kaufman, C. L., Burns, K. V, Parah, J. S., Johnson, L., Kelly, A. S., … Kaiser, D. R. (2010). Intramural dyssynchrony and response to cardiac resynchronization therapy in patients with and without previous right ventricular pacing. European Journal of Heart Failure, 12(12), 1317–1324.
Buja, G., Estes III, N. A. M., Wichter, T., Corrado, D., Marcus, F., & Thiene, G. (2008). Arrhythmogenic right ventricular cardiomyopathy/dysplasia: risk stratification and therapy. Progress in Cardiovascular Diseases, 50(4), 282.
Burns, K. V, Kaufman, C. L., Kelly, A. S., Parah, J. S., Dengel, D. R., & Bank, A. J. (2011). Torsion and dyssynchrony differences between chronically paced and non-paced heart failure patients. Journal of Cardiac Failure, 17(6), 495–502.
Cho, S. W., Gwag, H. Bin, Hwang, J. K., Chun, K. J., Park, K., On, Y. K., … Park, S. (2019). Clinical features, predictors, and longâ€term prognosis of pacingâ€induced cardiomyopathy. European Journal of Heart Failure, 21(5), 643–651.
Cicchitti, V., Radico, F., Bianco, F., Gallina, S., Tonti, G., & De Caterina, R. (2016). Heart failure due to right ventricular apical pacing: the importance of flow patterns. Ep Europace, 18(11), 1679–1688.
Cook, S., Togni, M., Schaub, M. C., Wenaweser, P., & Hess, O. M. (2006). High heart rate: a cardiovascular risk factor? European Heart Journal, 27(20), 2387–2393.
Cornacchia, D., Fabbri, M., Puglisi, A., Moracchini, P., Bernasconi, M., Nastasi, M., … De Seta, F. (2000). Latest generation of unipolar and bipolar steroid eluting leads: long-term comparison of electrical performance in atrium and ventricles. EP Europace, 2(3), 240–244.
Curtis, A. B., Worley, S. J., Adamson, P. B., Chung, E. S., Niazi, I., Sherfesee, L., … St John Sutton, M. (2013). Biventricular pacing for atrioventricular block and systolic dysfunction. N Engl J Med, 368, 1585–1593.
Curtis, A. B., Worley, S. J., Chung, E. S., Li, P., Christman, S. A., & Sutton, M. S. J. (2016). Improvement in clinical outcomes with biventricular versus right ventricular pacing: the BLOCK HF study. Journal of the American College of Cardiology, 67(18), 2148–2157.
Diaz, A., Bourassa, M. G., Guertin, M.-C., & Tardif, J.-C. (2005). Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease. European Heart Journal, 26(10), 967–974.
Doust, J., Lehman, R., & Glasziou, P. (2006). The role of BNP testing in heart failure. American Family Physician, 74(11), 1893–1898.
Dreger, H., Maethner, K., Bondke, H., Baumann, G., & Melzer, C. (2012). Pacing-induced cardiomyopathy in patients with right ventricular stimulation for> 15 years. Europace, 14(2), 238–242.
Elliott, P., Andersson, B., Arbustini, E., Bilinska, Z., Cecchi, F., Charron, P., … McKenna, W. J. (2008). Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases. European Heart Journal, 29(2), 270–276.
Fox, K., Borer, J. S., Camm, A. J., Danchin, N., Ferrari, R., Sendon, J. L. L., … Tendera, M. (2007). Resting heart rate in cardiovascular disease. Journal of the American College of Cardiology, 50(9), 823–830.
Gebauer, R. A., Tomek, V., Salameh, A., Marek, J., Chaloupecký, V., Gebauer, R., … Janoušek, J. (2009). Predictors of left ventricular remodelling and failure in right ventricular pacing in the young. European Heart Journal, 30(9), 1097–1104.
Gwag, H. Bin, Chun, K. J., Hwang, J. K., Park, K.-M., On, Y. K., Kim, J. S., & Park, S.-J. (2017). Comparison of de novo versus upgrade cardiac resynchronization therapy; focused on the upgrade for pacing-induced cardiomyopathy. Yonsei Medical Journal, 58(4), 703–709.
Hussain, M. A., FURUYAâ€KANAMORI, L., Kaye, G., Clark, J., & Doi, S. A. R. (2015). The effect of right ventricular apical and nonapical pacing on the shortâ€and longâ€term changes in left ventricular ejection fraction: a systematic review and metaâ€analysis of randomizedâ€controlled trials. Pacing and Clinical Electrophysiology, 38(9), 1121–1136.
Jouven, X., Empana, J. P., Escolano, S., Buyck, J. F., Tafflet, M., Desnos, M., & Ducimetière, P. (2009). Relation of heart rate at rest and long-term (> 20 years) death rate in initially healthy middle-aged men. The American Journal of Cardiology, 103(2), 279–283.
Kadish, A. H., Buxton, A. E., Kennedy, H. L., Knight, B. P., Mason, J. W., … Boone, A. W. (2001). ACC/AHA clinical competence statement on electrocardiography and ambulatory electrocardiography: A report of the ACC/AHA/ACP–ASIM Task Force on Clinical Competence (ACC/AHA Committee to Develop a Clinical Competence Statement on Electrocardiography and Am. Circulation, 104(25), 3169–3178.
Kaye, G., Ng, J. Y., Ahmed, S., Valencia, D., Harrop, D., & Ng, A. C. T. (2019). The Prevalence of Pacing-Induced Cardiomyopathy (PICM) in Patients With Long Term Right Ventricular Pacing− Is it a Matter Of Definition? Heart, Lung and Circulation, 28(7), 1027–1033.
Khurshid, S., Epstein, A. E., Verdino, R. J., Lin, D., Goldberg, L. R., Marchlinski, F. E., & Frankel, D. S. (2014). Incidence and predictors of right ventricular pacing-induced cardiomyopathy. Heart Rhythm, 11(9), 1619–1625.
Khurshid, S., Obeng-Gyimah, E., Supple, G. E., Schaller, R., Lin, D., Owens, A. T., … Frankel, D. S. (2018). Reversal of pacing-induced cardiomyopathy following cardiac resynchronization therapy. JACC: Clinical Electrophysiology, 4(2), 168–177.
Kiehl, E. L., Makki, T., Kumar, R., Gumber, D., Kwon, D. H., Rickard, J. W., … Varma, N. (2016). Incidence and predictors of right ventricular pacing-induced cardiomyopathy in patients with complete atrioventricular block and preserved left ventricular systolic function. Heart Rhythm, 13(12), 2272–2278.
Kim, J. H., Kang, K.-W., Chin, J. Y., Kim, T.-S., Park, J.-H., & Choi, Y. J. (2018). Major determinant of the occurrence of pacing-induced cardiomyopathy in complete atrioventricular block: a multicentre, retrospective analysis over a 15-year period in South Korea. BMJ Open, 8(2), e019048.
Kotsakou, M., Kioumis, I., Lazaridis, G., Pitsiou, G., Lampaki, S., Papaiwannou, A., … Karapantzos, I. (2015). Pacemaker insertion. Annals of Translational Medicine, 3(3).
Kusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., … Kim, R. J. (2019). 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Journal of the American College of Cardiology, 74(7), e51–e156.
Lazar, S., Huang, H., & Wissner, E. (2017). Pacemaker and ICD Troubleshooting. Interpreting Cardiac Electrograms: From Skin to Endocardium, 77.
Lee, S.-A., Cha, M.-J., Cho, Y., Oh, I.-Y., Choi, E.-K., & Oh, S. (2016). Paced QRS duration and myocardial scar amount: predictors of long-term outcome of right ventricular apical pacing. Heart and Vessels, 31(7), 1131–1139.
Lu, D., Zhang, H., Chen, C., Wang, K., & Shan, Q. (2018). Clinical outcomes with biventricular versus right ventricular pacing in patients with atrioventricular conduction defects. Heart Failure Reviews, 23(6), 897–906.
Makita, S., Onoda, T., Ohsawa, M., Tanno, K., Tanaka, F., Omama, S., … Sakata, K. (2014). Bradycardia is associated with future cardiovascular diseases and death in men from the general population. Atherosclerosis, 236(1), 116–120.
Marcus, F. I., McKenna, W. J., Sherrill, D., Basso, C., Bauce, B., Bluemke, D. A., … Daubert, J. P. (2010). Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Circulation, 121(13), 1533–1541.
Maron, B. J., Towbin, J. A., Thiene, G., Antzelevitch, C., Corrado, D., Arnett, D., … Young, J. B. (2006). Contemporary definitions and classification of the cardiomyopathies: an American Heart Association scientific statement from the council on clinical cardiology, heart failure and transplantation committee; quality of care and outcomes research and functional genomics and translational biology interdisciplinary working groups; and council on epidemiology and prevention. Circulation, 113(14), 1807–1816.
Merchant, F. M., Hoskins, M. H., Musat, D. L., Prillinger, J. B., Roberts, G. J., Nabutovsky, Y., & Mittal, S. (2017). Incidence and time course for developing heart failure with high-burden right ventricular pacing. Circulation: Cardiovascular Quality and Outcomes, 10(6), e003564.
Merchant, F. M., & Mittal, S. (2020). Pacing induced cardiomyopathy. Journal of Cardiovascular Electrophysiology, 31(1), 286–292.
Mollazadeh, R., Mohimi, L., Zeighami, M., Fazelifar, A., & Haghjoo, M. (2012). Hemodynamic effect of atrioventricular and interventricular dyssynchrony in patients with biventricular pacing: Implications for the pacemaker syndrome. Journal of Cardiovascular Disease Research, 3(3), 200–203.
Nauman, J., Janszky, I., Vatten, L. J., & Wisløff, U. (2011). Temporal changes in resting heart rate and deaths from ischemic heart disease. Jama, 306(23), 2579–2587.
Riahi, S., Nielsen, J. C., Hjortshøj, S., Thomsen, P. E. B., Højberg, S., Møller, M., … Friis, E. V. (2012). Heart failure in patients with sick sinus syndrome treated with single lead atrial or dual-chamber pacing: no association with pacing mode or right ventricular pacing site. Europace, 14(10), 1475–1482.
Sarvari, S. I., Sitges, M., Sanz, M., Tolosana Viu, J. M., Edvardsen, T., Stokke, T. M., … Bijnens, B. (2017). Left ventricular dysfunction is related to the presence and extent of a septal flash in patients with right ventricular pacing. EP Europace, 19(2), 289–296.
Semelka, M., Gera, J., & Usman, S. (2013). Sick sinus syndrome: a review. American Family Physician, 87(10), 691–696.
Semsarian, C., Ingles, J., Maron, M. S., & Maron, B. J. (2015). New perspectives on the prevalence of hypertrophic cardiomyopathy. Journal of the American College of Cardiology, 65(12), 1249–1254.
Shan, P., Su, L., Zhou, X., Wu, S., Xu, L., Xiao, F., … Huang, W. (2018). Beneficial effects of upgrading to His bundle pacing in chronically paced patients with left ventricular ejection fraction< 50%. Heart Rhythm, 15(3), 405–412.
Swerdlow, C. D., Wang, P. J., Zipes, D. P. (2015). Pacemaker and implantable cardioverter-defibrillators. 10th edition Braunwald’s Heart Disease. a textbook of cardiovascular, 721-747
Tops, L. F., Schalij, M. J., & Bax, J. J. (2009). The effects of right ventricular apical pacing on ventricular function and dyssynchrony: implications for therapy. Journal of the American College of Cardiology, 54(9), 764–776.
Vijayaraman, P., Herweg, B., Dandamudi, G., Mittal, S., Bhatt, A. G., Marcantoni, L., … Zanon, F. (2019). Outcomes of His-bundle pacing upgrade after long-term right ventricular pacing and/or pacing-induced cardiomyopathy: Insights into disease progression. Heart Rhythm, 16(10), 1554–1561.
Wexler, R., Elton, T., Pleister, A., & Feldman, D. (2009). Cardiomyopathy: an overview. American Family Physician, 79(9), 778.
Authors
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