Association Between Diabetic Neuropathy and Fall Risk in Patients with Type 2 Diabetes Mellitus at Siti Khodijah Hospital Sepanjang
Abstract
Diabetic neuropathy has been recognized as a prevalent complication of type 2 diabetes mellitus, correlated with diminished balance function and an elevated likelihood of falls, which may be associated with substantial morbidity and reduced quality of life. The present study was undertaken to investigate the association between diabetic neuropathy and fall risk in patients with type 2 diabetes mellitus at Siti Khodijah Hospital, Sepanjang, using a cross-sectional design among 56 patients selected through purposive sampling. Diabetic neuropathy status was ascertained from medical record documentation reflecting clinical diagnoses established by internal medicine and neurology specialists, whereas fall risk was evaluated by administering the Timed Up and Go (TUG) test. Of participants with diabetic neuropathy, 26 of 35 patients (74.3%) were identified as higher fall risk, compared to 8 of 21 patients (38.1%) without diabetic neuropathy. Chi-square analysis yielded a statistically significant association between diabetic neuropathy and TUG-based fall risk classification (p = 0.007, r = 0.338), with an odds ratio of 4.694 (95% CI: 1.469–15.005). These results suggest that early detection of diabetic neuropathy and prompt initiation of preventive interventions may be warranted to reduce fall-related outcomes in this population.
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References
Alam, U., Riley, D. R., Jugdey, R. S., Azmi, S., Rajbhandari, S., D’Août, K., & Malik, R. A. (2017). Diabetic Neuropathy and Gait: A Review. In Diabetes Therapy (Vol. 8, Number 6, pp. 1253–1264). Springer Healthcare. https://doi.org/10.1007/s13300-017-0295-y
Batool, S. (2019). Association between diabetic neuropathy, fall risks and balance in diabetes type 2 patients. Rawal Medical Journal, 45.
Centers for Disease Control and Prevention. (2017). Timed Up & Go (TUG). National Center for Injury Prevention and Control. https://www.cdc.gov/steadi/media/pdfs/STEADI-Assessment-TUG-508.pdf
Chatterjee, S., Khunti, K., & Davies, M. J. (2017). Type 2 diabetes. The Lancet, 389(10085), 2239–2251. https://doi.org/10.1016/S0140-6736(17)30058-2
Damanik, J., & Yunir, E. (2021). Type 2 Diabetes Mellitus and Cognitive Impairment. In Acta Med Indones-Indones J Intern Med • (Vol. 53, Number 2).
Dani Safitri, E., Nurdian Asnindari, L., Murni Setiawati Program Studi Keperawatan, E., Ilmu Kesehatan, F., & Yogyakarta, A. (2025). Hubungan neuropati diabetik perifer dengan risiko jatuh pasien diabetes tipe 2 Puskesmas Godean 1 Sleman (Vol. 3).
Feldman, E. L., Callaghan, B. C., Pop-Busui, R., Zochodne, D. W., Wright, D. E., Bennett, D. L., Bril, V., Russell, J. W., & Viswanathan, V. (2019). Diabetic neuropathy. In Nature Reviews Disease Primers (Vol. 5, Number 1). Nature Publishing Group. https://doi.org/10.1038/s41572-019-0092-1
Freire, L. B., Brasil-Neto, J. P., da Silva, M. L., Miranda, M. G. C., de Mattos Cruz, L., Martins, W. R., & da Silva Paz, L. P. (2024a). Risk factors for falls in older adults with diabetes mellitus: systematic review and meta-analysis. BMC Geriatrics, 24(1). https://doi.org/10.1186/s12877-024-04668-0
IDF Diabetes Atlas. (2021). IDF Diabetes Atlas 2021 _ IDF Diabetes Atlas. In IDF official website. https://diabetesatlas.org/atlas/tenth-edition/%0Ahttps://diabetesatlas.org/data/en/world/
Kardm, S. M., Kardm, A. S., Alanazi, Z. A., Alnakhli, H. H., Alkhamis, B. A., & Reddy, R. S. (2025). Sensorimotor dysfunction and postural instability in older adults with type 2 diabetes mellitus: the role of proprioception and neuropathy. Frontiers in Aging Neuroscience, 17. https://doi.org/10.3389/fnagi.2025.1615399
Kelly, C., Fleischer, A., Yalla, S., Grewal, G. S., Albright, R., Berns, D., Crews, R., & Najafi, B. (2016). Fear of Falling Is Prevalent in Older Adults with Diabetes Mellitus But Is Unrelated to Level of Neuropathy.
Khan, K. S., & Andersen, H. (2022). The Impact of Diabetic Neuropathy on Activities of Daily Living, Postural Balance and Risk of Falls - A Systematic Review. Journal of Diabetes Science and Technology, 16(2), 289–294. https://doi.org/10.1177/1932296821997921
Kim, Y. J., Lee, N. Y., Lee, K. A., Park, T. S., & Jin, H. Y. (2022). Influence of Glucose Fluctuation on Peripheral Nerve Damage in Streptozotocin-Induced Diabetic Rats. Diabetes and Metabolism Journal, 46(1), 117–128. https://doi.org/10.4093/DMJ.2020.0275
Lee, B.-W., Kim, J. H., Ko, S.-H., Hur, K.-Y., Kim, N.-H., Rhee, S. Y., Kim, H. J., Moon, M. K., Park, S.-O., & Choi, K. M. (2017). Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association, 2017. Diabetes Metab J, 41, 367–373. https://doi.org/10.4093/dmj.2017.41.5.367
Mustapa, A., Justine, M., Mohd Mustafah, N., Jamil, N., & Manaf, H. (2016). Postural Control and Gait Performance in the Diabetic Peripheral Neuropathy: A Systematic Review. In BioMed Research International (Vol. 2016). Hindawi Limited. https://doi.org/10.1155/2016/9305025
Parasoglou, P., Rao, S., & Slade, J. M. (2017). Declining Skeletal Muscle Function in Diabetic Peripheral Neuropathy. In Clinical Therapeutics (Vol. 39, Number 6, pp. 1085–1103). Excerpta Medica Inc. https://doi.org/10.1016/j.clinthera.2017.05.001
Reeves, N. D., Orlando, G., & Brown, S. J. (2021). Sensory-motor mechanisms increasing falls risk in diabetic peripheral neuropathy. In Medicina (Lithuania) (Vol. 57, Number 5). MDPI AG. https://doi.org/10.3390/medicina57050457
Reynolds, E. L., Russman, D., Baskozos, G., Feldman, E. L., Bennett, D. L., & Callaghan, B. C. (2025). The Association Between Detailed Obesity Measurements and Peripheral Neuropathy in Persons With Diabetes. European Journal of Neurology, 32(12). https://doi.org/10.1111/ene.70447
Scarton, A., Jonkers, I., Guiotto, A., Spolaor, F., Guarneri, G., Avogaro, A., Cobelli, C., & Sawacha, Z. (2017). Comparison of lower limb muscle strength between diabetic neuropathic and healthy subjects using OpenSim. Gait and Posture, 58(July), 194–200. https://doi.org/10.1016/j.gaitpost.2017.07.117
Sina, M. I., Fithrie, A., & Iqbal, K. M. (2019). INTERNATIONAL JOURNAL OF RESEARCH SCIENCE & MANAGEMENT ASSOCIATION BETWEEN DIABETIC NEUROPATHY SYMPTOM AND DIABETIC NEUROPATHY EXAMINATION WITH BERG BALANCE SCALEIN DIABETIC NEUROPATHY PATIENTS. 6(5). https://doi.org/10.5281/zenodo.2673435
Sloan, G., Selvarajah, D., & Tesfaye, S. (2021). Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. In Nature Reviews Endocrinology (Vol. 17, Number 7, pp. 400–420). Nature Research. https://doi.org/10.1038/s41574-021-00496-z
Son, S. M. (2016). Influence of Obesity on Postural Stability in Young Adults. Osong Public Health and Research Perspectives, 7(6), 378–381. https://doi.org/10.1016/j.phrp.2016.10.001
Strini, V., Schiavolin, R., & Prendin, A. (2021). Fall risk assessment scales: A systematic literature review. In Nursing Reports (Vol. 11, Number 2, pp. 430–443). MDPI. https://doi.org/10.3390/nursrep11020041
Susanti, I., Maria Seraph, N., Natasya Edward, M., & Burhan, A. (2025). National Trends in the Prevalence of Diabetic Peripheral Neuropathy Among Diabetes Mellitus Patients in Indonesia (2010–2024): A Pooled Meta-Analysis of 46 Studies with 2,808 Participants. Java Nursing Journal, 3(2), 124–146. https://doi.org/10.61716/jnj.v3i2.103
Tilahun, E., Workina, A., Habtamu, A., Tufa, H., Abebe, F., Fikadu, A., & Atomsa, F. (2024). Survival, incidence, and predictors of diabetic neuropathy among type 2 diabetic patients in hospitals of Addis Ababa. Frontiers in Clinical Diabetes and Healthcare, 5. https://doi.org/10.3389/fcdhc.2024.1386426
Timar, B., Timar, R., Gaiță, L., Oancea, C., Levai, C., & Lungeanu, D. (2016). The impact of diabetic neuropathy on balance and on the risk of falls in patients with type 2 diabetes mellitus: A cross-sectional study. PLoS ONE, 11(4). https://doi.org/10.1371/journal.pone.0154654
Umegaki, H. (2015). Sarcopenia and diabetes: Hyperglycemia is a risk factor for age-associated muscle mass and functional reduction. In Journal of Diabetes Investigation (Vol. 6, Number 6, pp. 623–624). https://doi.org/10.1111/jdi.12365
Wettasinghe, A. H., Dissanayake, D. W., Katulanda, P., & Lord, S. R. (2020). Timed up and go performance in older people with diabetes mellitus: Association with sensorimotor, function , balance, cognition, and falls. International Journal of Physiotherapy, 7(2). https://doi.org/10.15621/ijphy/2020/v7i2/655
Wettasinghe, A. H., Dissanayake, D. W. N., Allet, L., Katulanda, P., & Lord, S. R. (2020). Falls in older people with diabetes: Identification of simple screening measures and explanatory risk factors. Primary Care Diabetes, 14(6), 723–728. https://doi.org/10.1016/j.pcd.2020.05.006
Yang, Y., Hu, X., Zhang, Q., & Zou, R. (2016). Diabetes mellitus and risk of falls in older adults: A systematic review and meta-analysis. In Age and Ageing (Vol. 45, Number 6, pp. 761–767). Oxford University Press. https://doi.org/10.1093/ageing/afw140
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