Breaking the Delay: Stage III HIV Diagnosis and Successful Recovery at the Primary Healthcare Level

Sahika Nisandi Ayudelvi (1), Ronald Pratama Adiwinoto (2), Diadema Dicky Fansia (3), Muzna Anisah (4), Khakan Baguna (5), Iriyadi (6), Eltari Primasari (7)
(1) Hang Tuah University, Indonesia,
(2) Hang Tuah University, Indonesia,
(3) Diponegoro University, Indonesia,
(4) University of Indonesia, Indonesia,
(5) Malahayati University, Indonesia,
(6) Primary Health Center of Prabumulih Timur, Indonesia,
(7) Primary Health Center of Prabumulih Timur, Indonesia

Abstract

Human Immunodeficiency Virus (HIV) remains a major public health problem, particularly when diagnosis occurs at an advanced stage. This case report describes a 24-year-old male diagnosed with WHO stage III HIV infection at a primary health care facility in the absence of CD4 count and baseline viral load due to resource limitations. The patient presented with oral candidiasis, chronic diarrhea, prolonged fever, and significant weight loss, alongside high-risk sexual behavior. HIV and syphilis serology were reactive, while tuberculosis was excluded despite strong clinical suspicion. The patient was managed with antifungal therapy, syphilis treatment, and first-line antiretroviral therapy (ART). Significant clinical improvement was observed within one month, and viral load decreased to 60 copies/mL at six months, indicating near-complete virological suppression. This case highlights missed opportunities for early HIV diagnosis, supports the use of WHO clinical staging as a surrogate in resource-limited settings, and demonstrates that effective HIV management can be achieved at the primary care level.

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References

Baker, S., Hijazi, M. and Nandakumar, A.K. (2025) ‘Innovative approaches to HIV/AIDS financing: lessons learned from the Sustainable Financing Initiative (SFI)’, BMC health services research, 24(Suppl 1). Available at: https://doi.org/10.1186/S12913-025-12529-8.

Beyrer, C. et al. (2025) ‘The HIV/AIDS pandemic: where are we now?’, AIDS (London, England), 39(11), pp. 1497–1504. Available at: https://doi.org/10.1097/QAD.0000000000004308.

Chang, J. et al. (2025) ‘Integrating HIV/AIDS services into financial protection systems to increase sustainability of the HIV/AIDS response’, BMC health services research, 24(Suppl 1). Available at: https://doi.org/10.1186/S12913-025-12528-9.

Chéret, A. (2025) ‘Acute HIV-1 Infection : Paradigm and Singularity’, pp. 1–23.

Chun, H.M. et al. (2023) ‘ Vital Signs : Progress Toward Eliminating HIV as a Global Public Health Threat Through Scale-Up of Antiretroviral Therapy and Health System Strengthening Supported by the U.S. President’s Emergency Plan for AIDS Relief — Worldwide, 2004–2022 ’, MMWR. Morbidity and Mortality Weekly Report, 72(12), pp. 317–324. Available at: https://doi.org/10.15585/mmwr.mm7212e1.

Cribbs, S.K. et al. (2025) ‘Pathogenesis Of Hiv-Related Lung Disease : Immunity, Infection, and Infammation’, American Physiological Society, 100, pp. 603–632. Available at: https://doi.org/10.1152/physrev.00039.2018.

Fatokun, B.S. et al. (2025) ‘Psychiatric comorbidities in HIV/AIDS patients and its overlap with neurological disorders’, Discover mental health, 5(1). Available at: https://doi.org/10.1007/S44192-025-00308-0.

Fauci, A.S. and Folkers, G.K. (2025) ‘Treatment and prevention of HIV/AIDS: Unfinished business’, PLoS medicine, 22(12), p. e1004806. Available at: https://doi.org/10.1371/JOURNAL.PMED.1004806.

Hanum, N. et al. (2025) ‘HIV incidence and adherence after pre-exposure prophylaxis initiation in key populations in Indonesia: Findings from a real-world pilot program 2021-2023’, IJID Regions, 14(July 2024), p. 100573. Available at: https://doi.org/10.1016/j.ijregi.2025.100573.

Haorah, J. et al. (2025) ‘Neurological impact of HIV/AIDS and substance use alters brain function and structure’, Frontiers in medicine, 11. Available at: https://doi.org/10.3389/FMED.2024.1505440.

Hareru, H.E. et al. (2025) ‘Satisfaction with HIV/AIDS treatment and care services and its associated factors among adult people receiving antiretroviral therapy in Ethiopia: a systematic review and meta-analysis’, BMJ open, 15(2). Available at: https://doi.org/10.1136/BMJOPEN-2024-085169.

Kemenkes (2022) ‘Kementerian Kesehatan Republik Indonesia’, Kementrian Kesehatan RI, p. Available at: https://www.kemkes.go.id/article/pri.

Kemenkes RI (2019) ‘PEDOMAN NASIONAL PELAYANAN KEDOKTERAN TATA LAKSANA HIPERBILIRUBINEMIA’.

Kemenkes RI (2023) ‘Mengenal HIV dan AIDS serta Tanda-tanda Gejalanya’, Kementerian Kesehatan Republik Indonesia [Preprint]. Available at: https://ayosehat.kemkes.go.id/mengenal-hiv-dan-aids-serta-tanda-tanda-gejalanya.

Kemenkes RI (2025) ‘Berani Tes, Berani Lindungi Diri, Kemenkes Targetkan Eliminasi HIV dan IMS Tahun 2030’, Kementerian Kesehatan Republik Indonesia [Preprint]. Available at: https://kemkes.go.id/id/berani-tes-berani-lindungi-diri-kemenkes-targetkan-eliminasi-hiv-dan-ims-tahun-2030.

Menteri Kesehatan Republik Indonesia (2022) ‘Pedoman Nasional Pelayanan Kedokteran Tata Laksana Rinosinusitis Kronik’, Kemenkes RI, pp. 1–106.

Menteri, P. et al. (2022) ‘Peraturan Kementrian Kesehatan’, (831).

Murchu, E.O. et al. (2022) ‘Oral pre-exposure prophylaxis (PrEP) to prevent HIV: A systematic review and meta-analysis of clinical effectiveness, safety, adherence and risk compensation in all populations’, BMJ Open, 12(5). Available at: https://doi.org/10.1136/bmjopen-2020-048478.

Orlando, S. et al. (2025) ‘The global response to HIV/AIDS in sub-Saharan Africa: achievements, challenges, and perspectives for the future’, Frontiers in public health, 13. Available at: https://doi.org/10.3389/FPUBH.2025.1665666.

Patel, P. et al. (2022) ‘Public Health Implications of Adapting HIV Pre-exposure Prophylaxis Programs for Virtual Service Delivery in the Context of the COVID-19 Pandemic: Systematic Review’, JMIR Public Health and Surveillance, 8(6). Available at: https://doi.org/10.2196/37479.

Pitchumoni, C.S. and Brun, A. (2024) ‘HIV and AIDS’, Geriatric Gastroenterology, pp. 659–666. Available at: https://doi.org/10.1007/978-1-4419-1623-5_71.

Pitchumoni, C.S. and Brun, A. (2025) ‘HIV and AIDS’, Geriatric Gastroenterology, pp. 659–666. Available at: https://www.ncbi.nlm.nih.gov/books/NBK534860/.

Rutstein, S.E. et al. (2025) ‘Multilevel Intervention to Support Tailored and Responsive HIV Pre-Exposure Prophylaxis Care in Rural North Carolina: Protocol for a Randomized Controlled Trial.’, JMIR research protocols, 14, p. e68085. Available at: https://doi.org/10.2196/68085.

Shen, J. et al. (2025) ‘The reasons of late diagnosis in patients with HIV/AIDS: a Meta-synthesis’, Asian Nursing Research [Preprint]. Available at: https://doi.org/10.1016/j.anr.2025.10.005.

Wang, H. and Lu, X. (2025) ‘Editorial: HIV/AIDS: pathogenesis and vaccine’, Frontiers in cellular and infection microbiology, 15. Available at: https://doi.org/10.3389/FCIMB.2025.1584301.

WHO (2025) ‘HIV data and statistics’, World Health Organization [Preprint]. Available at: https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/hiv/strategic-information/hiv-data-and-statistics.

Wong, K. et al. (2020) ‘Pathogenesis of Human Immunodeficiency Virus- Mycobacterium tuberculosis Co-Infection’, Journal of Clinical Medicine, 9(3537), pp. 1–23.

Zhang, H. et al. (2025) ‘Targeting inflammasomes as a therapeutic potential for HIV/AIDS’, Cellular and molecular life sciences : CMLS, 82(1). Available at: https://doi.org/10.1007/S00018-025-05685-X.

Authors

Sahika Nisandi Ayudelvi
sahikaaydlv@gmail.com (Primary Contact)
Ronald Pratama Adiwinoto
Diadema Dicky Fansia
Muzna Anisah
Khakan Baguna
Iriyadi
Eltari Primasari
Author Biographies

Sahika Nisandi Ayudelvi, Hang Tuah University

Dear Editor,

We would like to submit our manuscript entitled “Clinical Characteristics and Risk Factors among Patients with Stage III Human Immunodeficiency Virus (HIV) Infection at Prabumulih Timur Primary Health Center” for your kind consideration for publication in your journal.

This manuscript presents a clinically relevant description of HIV stage III cases identified at the primary health care level. The study highlights the importance of recognizing clinical indicator conditions and risk factors for HIV infection in resource-limited settings, where access to advanced diagnostic tools may be limited.

The findings provide valuable insights into the clinical spectrum and behavioral risk factors associated with stage III HIV infection in a primary health center context, which remains underreported in the literature, particularly in developing countries. This manuscript may contribute to improving early detection, timely referral, and appropriate management of HIV patients at the primary care level.

We believe that this manuscript fits well within the scope of the journal and will be of interest to clinicians, public health practitioners, and researchers focusing on HIV/AIDS, primary health care, and infectious diseases. The authors confirm that this manuscript is original, has not been published previously, and is not under consideration for publication elsewhere.

Sincerely,
The Authors

Ronald Pratama Adiwinoto, Hang Tuah University

Dear Editor,

We would like to submit our manuscript entitled “Clinical Characteristics and Risk Factors among Patients with Stage III Human Immunodeficiency Virus (HIV) Infection at Prabumulih Timur Primary Health Center” for your kind consideration for publication in your journal.

This manuscript presents a clinically relevant description of HIV stage III cases identified at the primary health care level. The study highlights the importance of recognizing clinical indicator conditions and risk factors for HIV infection in resource-limited settings, where access to advanced diagnostic tools may be limited.

The findings provide valuable insights into the clinical spectrum and behavioral risk factors associated with stage III HIV infection in a primary health center context, which remains underreported in the literature, particularly in developing countries. This manuscript may contribute to improving early detection, timely referral, and appropriate management of HIV patients at the primary care level.

We believe that this manuscript fits well within the scope of the journal and will be of interest to clinicians, public health practitioners, and researchers focusing on HIV/AIDS, primary health care, and infectious diseases. The authors confirm that this manuscript is original, has not been published previously, and is not under consideration for publication elsewhere.

Sincerely,
The Authors

Diadema Dicky Fansia, Diponegoro University

Dear Editor,

We would like to submit our manuscript entitled “Clinical Characteristics and Risk Factors among Patients with Stage III Human Immunodeficiency Virus (HIV) Infection at Prabumulih Timur Primary Health Center” for your kind consideration for publication in your journal.

This manuscript presents a clinically relevant description of HIV stage III cases identified at the primary health care level. The study highlights the importance of recognizing clinical indicator conditions and risk factors for HIV infection in resource-limited settings, where access to advanced diagnostic tools may be limited.

The findings provide valuable insights into the clinical spectrum and behavioral risk factors associated with stage III HIV infection in a primary health center context, which remains underreported in the literature, particularly in developing countries. This manuscript may contribute to improving early detection, timely referral, and appropriate management of HIV patients at the primary care level.

We believe that this manuscript fits well within the scope of the journal and will be of interest to clinicians, public health practitioners, and researchers focusing on HIV/AIDS, primary health care, and infectious diseases. The authors confirm that this manuscript is original, has not been published previously, and is not under consideration for publication elsewhere.

Sincerely,
The Authors

Muzna Anisah, University of Indonesia

Dear Editor,

We would like to submit our manuscript entitled “Clinical Characteristics and Risk Factors among Patients with Stage III Human Immunodeficiency Virus (HIV) Infection at Prabumulih Timur Primary Health Center” for your kind consideration for publication in your journal.

This manuscript presents a clinically relevant description of HIV stage III cases identified at the primary health care level. The study highlights the importance of recognizing clinical indicator conditions and risk factors for HIV infection in resource-limited settings, where access to advanced diagnostic tools may be limited.

The findings provide valuable insights into the clinical spectrum and behavioral risk factors associated with stage III HIV infection in a primary health center context, which remains underreported in the literature, particularly in developing countries. This manuscript may contribute to improving early detection, timely referral, and appropriate management of HIV patients at the primary care level.

We believe that this manuscript fits well within the scope of the journal and will be of interest to clinicians, public health practitioners, and researchers focusing on HIV/AIDS, primary health care, and infectious diseases. The authors confirm that this manuscript is original, has not been published previously, and is not under consideration for publication elsewhere.

Sincerely,
The Authors

Khakan Baguna, Malahayati University

Dear Editor,

We would like to submit our manuscript entitled “Clinical Characteristics and Risk Factors among Patients with Stage III Human Immunodeficiency Virus (HIV) Infection at Prabumulih Timur Primary Health Center” for your kind consideration for publication in your journal.

This manuscript presents a clinically relevant description of HIV stage III cases identified at the primary health care level. The study highlights the importance of recognizing clinical indicator conditions and risk factors for HIV infection in resource-limited settings, where access to advanced diagnostic tools may be limited.

The findings provide valuable insights into the clinical spectrum and behavioral risk factors associated with stage III HIV infection in a primary health center context, which remains underreported in the literature, particularly in developing countries. This manuscript may contribute to improving early detection, timely referral, and appropriate management of HIV patients at the primary care level.

We believe that this manuscript fits well within the scope of the journal and will be of interest to clinicians, public health practitioners, and researchers focusing on HIV/AIDS, primary health care, and infectious diseases. The authors confirm that this manuscript is original, has not been published previously, and is not under consideration for publication elsewhere.

Sincerely,
The Authors

Iriyadi, Primary Health Center of Prabumulih Timur

Dear Editor,

We would like to submit our manuscript entitled “Clinical Characteristics and Risk Factors among Patients with Stage III Human Immunodeficiency Virus (HIV) Infection at Prabumulih Timur Primary Health Center” for your kind consideration for publication in your journal.

This manuscript presents a clinically relevant description of HIV stage III cases identified at the primary health care level. The study highlights the importance of recognizing clinical indicator conditions and risk factors for HIV infection in resource-limited settings, where access to advanced diagnostic tools may be limited.

The findings provide valuable insights into the clinical spectrum and behavioral risk factors associated with stage III HIV infection in a primary health center context, which remains underreported in the literature, particularly in developing countries. This manuscript may contribute to improving early detection, timely referral, and appropriate management of HIV patients at the primary care level.

We believe that this manuscript fits well within the scope of the journal and will be of interest to clinicians, public health practitioners, and researchers focusing on HIV/AIDS, primary health care, and infectious diseases. The authors confirm that this manuscript is original, has not been published previously, and is not under consideration for publication elsewhere.

Sincerely,
The Authors

Eltari Primasari, Primary Health Center of Prabumulih Timur

Dear Editor,

We would like to submit our manuscript entitled “Clinical Characteristics and Risk Factors among Patients with Stage III Human Immunodeficiency Virus (HIV) Infection at Prabumulih Timur Primary Health Center” for your kind consideration for publication in your journal.

This manuscript presents a clinically relevant description of HIV stage III cases identified at the primary health care level. The study highlights the importance of recognizing clinical indicator conditions and risk factors for HIV infection in resource-limited settings, where access to advanced diagnostic tools may be limited.

The findings provide valuable insights into the clinical spectrum and behavioral risk factors associated with stage III HIV infection in a primary health center context, which remains underreported in the literature, particularly in developing countries. This manuscript may contribute to improving early detection, timely referral, and appropriate management of HIV patients at the primary care level.

We believe that this manuscript fits well within the scope of the journal and will be of interest to clinicians, public health practitioners, and researchers focusing on HIV/AIDS, primary health care, and infectious diseases. The authors confirm that this manuscript is original, has not been published previously, and is not under consideration for publication elsewhere.

Sincerely,
The Authors

Ayudelvi, S. N., Adiwinoto, R. P., Fansia, D. D., Anisah, M., Baguna, K., Iriyadi, I., & Primasari, E. (2026). Breaking the Delay: Stage III HIV Diagnosis and Successful Recovery at the Primary Healthcare Level. Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya, 10(02). https://doi.org/10.30651/jqm.v10i02.30290

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