Understanding the Side Effects of the Plastic Storage Bags Used for Breast Milk and the Environment: A Narrative Review
Abstract
The widespread use of plastic breastmilk storage bags raises concerns about microplastic (MP) exposure in infants, particularly during storage and heating. This review aimed to summarize evidence on MPs' release from storage bags, infant exposure pathways, potential health effects, and environmental implications. A narrative review was conducted using PubMed, Scopus, ScienceDirect, and Google Scholar for studies published between January 2015 and June 2025. Keywords related to MPs, breast milk, storage bags, and infant exposure were used. Six eligible studies were included. Plastic storage bags can release MPs, especially with heat exposure, prolonged storage, and repeated use. MPs have been detected in breastmilk and infant feces, indicating early-life exposure. Small particles may cross the gastrointestinal barrier, with experimental studies suggesting potential effects such as oxidative stress, inflammation, and microbiota disruption. However, clinical evidence in infants remains limited. In conclusion, Breastmilk storage bags may be a modifiable source of infant exposure to MPs. Although clinical impacts are not yet established, safer storage practices and further human studies are needed.
Full text article
References
Andrady, A. L. (2011). Microplastics in the marine environment. Marine Pollution Bulletin, 62(8), 1596–1605. https://doi.org/10.1016/j.marpolbul.2011.05.030
Campanale, C., Massarelli, C., Savino, I., Locaputo, V., & Uricchio, V. F. (2020). A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health. International Journal of Environmental Research and Public Health, 17(4). https://doi.org/10.3390/ijerph17041212
Chen, G., Shan, H., Xiong, S., Zhao, Y., van Gestel, C. A., Qiu, H., & Wang, Y. (2024). Polystyrene nanoparticle exposure accelerates ovarian cancer development in mice by altering the tumor microenvironment. Science of the Total Environment, 906, 167592.
Chia, R. W., Atem, N. V., Lee, J.-Y., & Cha, J. (2025). Microplastic and human health with focus on pediatric well-being: A comprehensive review and call for future studies. Clinical and Experimental Pediatrics, 68(1), 1–15. https://doi.org/10.3345/cep.2023.01739
Deng, Y., Chen, H., Huang, Y., Wang, Q., Chen, W., & Chen, D. (2022). Polystyrene microplastics affect the reproductive performance of male mice and lipid homeostasis in their offspring. Environmental Science & Technology Letters, 9(9), 752–757.
Ding, R., Chen, Y., Shi, X., Li, Y., Yu, Y., Sun, Z., & Duan, J. (2024). Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: Oxidative stress related-DNA damage and potential carcinogenicity. Science of The Total Environment, 912, 169514. https://doi.org/10.1016/j.scitotenv.2023.169514
Fackelmann, G., & Sommer, S. (2019). Microplastics and the gut microbiome: How chronically exposed species may suffer from gut dysbiosis. Marine pollution bulletin, 143, 193–203.
Liu, L., Zhang, X., Jia, P., He, S., Dai, H., Deng, S., & Han, J. (2023). Release of microplastics from breastmilk storage bags and assessment of intake by infants: A preliminary study. Environmental Pollution, 323, 121197. https://doi.org/10.1016/j.envpol.2023.121197
Liu, S., Guo, J., Liu, X., Yang, R., Wang, H., Sun, Y., Chen, B., & Dong, R. (2023). Detection of various microplastics in placentas, meconium, infant feces, breastmilk and infant formula: A pilot prospective study. Science of The Total Environment, 854, 158699. https://doi.org/10.1016/j.scitotenv.2022.158699
Mammo, F. K., Amoah, I. D., Gani, K. M., Pillay, L., Ratha, S. K., Bux, F., & Kumari, S. (2020). Microplastics in the environment: Interactions with microbes and chemical contaminants. Science of The Total Environment, 743, 140518. https://doi.org/10.1016/j.scitotenv.2020.140518
Mišľanová, C., Valachovičová, M., & Slezáková, Z. (2024). An Overview of the Possible Exposure of Infants to Microplastics. Life (Basel, Switzerland), 14(3). https://doi.org/10.3390/life14030371
Osman, A. I., Hosny, M., Eltaweil, A. S., Omar, S., Elgarahy, A. M., Farghali, M., Yap, P.-S., Wu, Y.-S., Nagandran, S., Batumalaie, K., Gopinath, S. C. B., John, O. D., Sekar, M., Saikia, T., Karunanithi, P., Hatta, M. H. M., & Akinyede, K. A. (2023). Microplastic sources, formation, toxicity and remediation: A review. Environmental Chemistry Letters, 1–41. https://doi.org/10.1007/s10311-023-01593-3
Priya, A. K., Muruganandam, M., Imran, M., Gill, R., Vasudeva Reddy, M. R., Shkir, M., Sayed, M. A., AlAbdulaal, T. H., Algarni, H., Arif, M., Jha, N. K., & Sehgal, S. S. (2023). A study on managing plastic waste to tackle the worldwide plastic contamination and environmental remediation. Chemosphere, 341, 139979. https://doi.org/10.1016/j.chemosphere.2023.139979
Ragusa, A., Notarstefano, V., Svelato, A., Belloni, A., Gioacchini, G., Blondeel, C., Zucchelli, E., De Luca, C., D’Avino, S., Gulotta, A., Carnevali, O., & Giorgini, E. (2022). Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk. Polymers, 14(13). https://doi.org/10.3390/polym14132700
Saraluck, A., Techarang, T., Bunyapipat, P., Boonchuwong, K., Pullaput, Y., & Mordmuang, A. (2024). Detection of Microplastics in Human Breast Milk and Its Association with Changes in Human Milk Bacterial Microbiota. Journal of Clinical Medicine, 13(14). https://doi.org/10.3390/jcm13144029
Wei, Z., Wang, Y., Wang, S., Xie, J., Han, Q., & Chen, M. (2022). Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice. Toxicology, 465, 153059.
Xu, M., Halimu, G., Zhang, Q., Song, Y., Fu, X., Li, Y., Li, Y., & Zhang, H. (2019). Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell. Science of the Total Environment, 694, 133794.
Yan, J., Pan, Y., He, J., Pang, X., Shao, W., Wang, C., Wang, R., He, Y., Zhang, M., & Ye, J. (2023). Toxic vascular effects of polystyrene microplastic exposure. Science of the Total Environment, 905, 167215.
Yang, H., Chen, G., & Wang, J. (2021). Microplastics in the marine environment: Sources, fates, impacts and microbial degradation. Toxics, 9(2), 41.
Yang, S., Cheng, Y., Chen, Z., Liu, T., Yin, L., Pu, Y., & Liang, G. (2021). In vitro evaluation of nanoplastics using human lung epithelial cells, microarray analysis and co-culture model. Ecotoxicology and environmental safety, 226, 112837.
Zhao, L., Shi, W., Hu, F., Song, X., Cheng, Z., & Zhou, J. (2021). Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL/6J mice through polarization of macrophages and increased infiltration of natural killer cells. Ecotoxicology and environmental safety, 227, 112882.
Zheng, H., Wang, J., Wei, X., Chang, L., & Liu, S. (2021). Proinflammatory properties and lipid disturbance of polystyrene microplastics in the livers of mice with acute colitis. Science of the Total Environment, 750, 143085.
Ziani, K., Ioniță-Mîndrican, C.-B., Mititelu, M., Neacșu, S. M., Negrei, C., Moroșan, E., Drăgănescu, D., & Preda, O.-T. (2023). Microplastics: A Real Global Threat for Environment and Food Safety: A State of the Art Review. Nutrients, 15(3). https://doi.org/10.3390/nu15030617
Authors
Copyright (c) 2026 Annisa Amelia Gusvania, Corinna Faustina, Azizah Qayla Asmarani

This work is licensed under a Creative Commons Attribution 4.0 International License.

Qanun Medika by FK UM Surabaya is liscence under Lisensi Creative Commons Atribusi 4.0 Internasional.