Multiple Large Atrial Thrombus Due To Rheumatic Heart Disease And Present Of Atrial Fibrillation With No Sign Of Stroke: How Is It Possible?
Abstract
ABSTRACTÂ
Atrial fibrillation is the most common arrhythmia associated with stroke and in the rheumatic heart disease patient’s atrial fibrillation can easily cause thromboembolism. Thromboembolism is the major complication also in patients of mitral stenosis with atrial fibrillation. A 54-year-old woman with uncontrollable movements in the right arm, stomach, right leg and painful swelling at right ankle joint was admitted to the emergency department. Transesophageal echocardiogram revealed rheumatic heart disease affecting two valves and thrombus in left atrial extending towards left atrial appendage. Heart rate was 120 beats per minute. ECG showed atrial fibrillation. A patient has undergone mitral and aortic valves replacement surgery and left atrial thrombus evacuation. Despite the involvement of two heart valves and the presence of large thrombus, the patient did not show any sign of brain infarction. This is a contradiction with a theory which implies that atrial fibrillation is the most common arrhythmia associated with stroke and in the rheumatic heart disease patient’s atrial fibrillation can easily cause thromboembolism and become stroke. This study evaluates many factors founded in the patient that make this anomaly may happen.
Keywords                  : atrial fibrillation, rheumatic heart disease, thromboembolism stroke
Correspondence to     : rickyindraalfaray@gmail.com
ABSTRAKÂ
Atrial fibrilasi merupakan jenis aritmia yang berkaitan erat dengan stroke dan cenderung menyebabkan thromboembolism. Thromboembolism merupakan komplikasi mayor dari mitral stenosis dengan atrial fibrilasi. Seorang wanita berusia 54 tahun masuk ke unit gawat darurat dengan keluhan utama gerakan tak terkendali pada lengan kanan, perut, kaki kanan, serta bengkak yang menyakitkan di sendi pergelangan kaki kanan. Echocardiogram transesophageal menunjukan gambaran penyakit jantung rematik pada dua katup dan trombus di atrium kiri meluas menuju valve atrium kiri. Detak jantung 120 kali per menit. EKG menunjukkan fibrilasi atrium. Pasien menjalani operasi penggantian katup mitral dan aorta serta evakuasi trombus pada atrium. Meskipun terdapat abnormalitas pada dua katup jantung ditambah dengan ditemukan adanya trombus besar pada atrium, pasien tidak menunjukkan tanda-tanda infark otak. Ini bertentangan dengan teori yang mengimplikasikan bahwa atrial fibrilasi adalah aritmia paling umum yang berhubungan dengan stroke dan pada penyakit jantung reumatik. Pasien dengan fibrilasi atrium dapat dengan mudah terjadi tromboemboli hingga bermanifestasi stroke. Studi ini mengevaluasi berbagai faktor yang memungkinkan anomali kasus seperti ini dapat terjadi.
Kata kunci                : fibrilasi atrium, penyakit jantung rematik, stroke thromboemboli
Korespondensi            : rickyindraalfaray@gmail.com
Â
Full text article
References
Ahmad, S & Wilt, H 2016. Stroke Prevention in Atrial Fibrillation and Valvular Heart Disease. Open Cardiovasc Med J, 10, 110-6.
Arboix, A. & Alio, J. 2010. Cardioembolic stroke: clinical features, specific cardiac disorders and prognosis. Curr Cardiol Rev, 6, 150-61.
Camm, A. J., Kirchhof, P., Lip, G. Y., Schotten, U., Savelieva, I., Ernst, S., van Gelder, I. C., Al-attar, N., Hindricks, G., Prendergast, B., Heidbuchel, H., Alfieri, O., Angelini, A., Atar, D., Colonna, P., de Caterina, R., de Sutter, J., Goette, A., Gorenek, B., Heldal, M., Hohloser, S. H., Kolh, P., le Heuzey, J. Y., Ponikowski, p., Rutten, f. H. & Guidelines, e. S. C. C. F. P. 2010. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Europace, 12, 1360-420.
Camm, A. J., Lip, G. Y., de Caterina, R., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P., Guidelines-CPG, e. S. C. C. F. P. & document, r. 2012. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation--developed with the special contribution of the European Heart Rhythm Association. Europace, 14, 1385-413.
Deora, S., Gurmukhani, S., Shah, S. & Patel, T. 2014. Left Atrial Thrombus Causing Stroke and Syncope: Does Size Matters? Heart India, 2, 112-114.
Gupta, A., Bhatia, R., Sharma, G., Prasad, K., Singh, M. B. & Vibha, d. 2015. Predictors of Ischemic Stroke in Rheumatic Heart Disease. J Stroke Cerebrovasc Dis, 24, 2810-5.
Ha, A. C., Verma, A. & Verma, S. 2017. Oral anticoagulation for stroke prevention amongst atrial fibrillation patients with valvular heart disease: an update. Curr Opin Cardiol, 32, 174-180.
Healey, J. S., Oldgren, J., Ezekowitz, M., Zhu, J., Pais, P., Wang, J., Commerford, P., Jansky, P., Avezum, A., Sigamani, A., Damasceno, A., Reilly, P., Grinvalds, A., Nakamya, J., Aje, A., Almahmeed, W., Moriarty, A., Wallentin, L., Yusuf, S., Connolly, S. J., Registry, R.-l. A. F. & cohort study, i. 2016. Occurrence of death and stroke in patients in 47 countries 1 year after presenting with atrial fibrillation: a cohort study. Lancet, 388, 1161-9.
Helgason, C. M. 1992. Cardioembolic stroke: topography and pathogenesis. Cerebrovasc Brain Metab Rev, 4, 28-58.
Lee, R. J., Bartus, K. & Yakubov, S. J. 2010. Catheter-based left atrial appendage (LAA) ligation for the prevention of embolic events arising from the LAA: initial experience in a canine model. Circ Cardiovasc Interv, 3, 224-9.
Petersen, P & Godtfredsen, J. 1988. Risk factors for stroke in chronic atrial fibrillation. Eur Heart J, 9, 291-4.
Phankingthongkum, R., Opartkiattikul, N., Chotinaiwattarakul, C., Panchavinnin, P., Tresukosol, D., Jakrapanichakul, D., Krittayaphong, R., Kitrattana, B. & Thongtang, V. 2004. An abnormal systemic and regional hypercoagulable state in patients with mitral stenosis. J Med Assoc Thai, 87, 158-65.
Pradhan, R. R., Jha, A., Nepal, G. & Sharma, M. 2018. Rheumatic Heart Disease with Multiple Systemic Emboli: A Rare Occurrence in a Single Subject. Cureus, 10, e2964.
Topcuoglu, M. A., Liu, L., Kim, D. E. & Gurol, M. E. 2018. Updates on Prevention of Cardioembolic Strokes. J Stroke, 20, 180-196.
Wang, D., Liu, M., Hao, Z., Tao, W., Lin, S., Zhang, S., Wu, B., Ma, Z. & Dong, W. 2012. Features of acute ischemic stroke with rheumatic heart disease in a hospitalized Chinese population. Stroke, 43, 2853-7.
Yusuf, J., Goyal, M., Mukhopadhyay, S., Mehta, V., Dhaiya, S., Saxena, R. & Trehan, V. 2015. Effect of heart rate control on coagulation status in patients of rheumatic mitral stenosis with atrial fibrillation--A pilot study. Indian Heart J, 67 Suppl 2, S40-5.
Authors
Qanun Medika by FK UM Surabaya is liscence under Lisensi Creative Commons Atribusi 4.0 Internasional.