Positive Effect of Konjac Glucomannan on Lowering Blood Pressure in Hypertensive Wistar Rats
Abstrak
Latar Belakang: Hipertensi merupakan penyakit tidak menular (PTM) yang saat ini menjadi prioritas utama kesehatan global, Penyakit ini ditandai dengan peningkatan tekanan darah sistolik >140 mmHg dan diastolik >90 mmHg. Pengobatan hipertensi melalui herbal telah mendapatkan banyak perhatian akhir-akhir ini, karena diketahui tidak memiliki efek samping dalam pengunaan jangka panjang. Tujuan penelitian ini adalah untuk mengevaluasi efektivitas Konjac Glucomannan (KGM) dalam menurunkan tekanan darah pada tikus wistar yang telah diinduksi NaCl. Metode: Penelitian ini melibatkan 10 ekor tikus wistar jantan dengan tekanan darah sistolik normal, diberi diet tinggi NaCl total 10% selama 14 hari. Tekanan darah tinggi dicapai pada hari ke 14. Hewan coba dibagi menjadi 1 kelompok, kelompok perlakuan P1 mendapat glucomannan 50 mg/kg BB. Tekanan darah diukur sebelum tikus wistar mendapat induksi, setelah induksi (hari ke-14) dan setelah mendapat intervensi (6 jam) setelahnya. Data diastolik (dBP) digunakan sebagai kriteria eksklusi. Analisis data dilakukan dengan menggunakan uji t-test berpasangan. Hasil: Tekanan darah masing-masing kelompok mengalami penurunan yang signifikan setelah 6 jam intervensi. Pembahasan: Glucomannan dapat menurunkan tekanan darah melalui mekanisme ACE-i. Namun, sebenarnya mekanisme ini harus dikaji secara spesifik, karena hanya spekulasi dan tidak menarik kesimpulan berdasarkan bukti yang konkrit. Kesimpulan: Temuan ini menunjukkan bahwa glucomannan dapat menurunkan tekanan darah dan sangat potensial untuk anti-hipertensi pengganti obat konvensional yang sekarang.
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Penulis
Hak Cipta (c) 2024 Bryan Anggara Putra, Sugeng Mashudi, Alfia Pradita Sari, Fany Risma Afriani, Yaya Sulthon Aziz, Tukimin bin Sansuwito
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