Exploring cytokine levels in pregnancy, preeclampsia, and sepsis-complicated preeclampsia

Mira Kusuma Wardhani (1), Harry Kurniawan Gondo (2)
(1) a:1:{s:5:"en_US";s:34:"Universitas Wijaya Kusuma Surabaya";}, Indonesia,
(2) , Indonesia

Abstract

Around the world, preeclampsia (PE) influences five to  eight percent of pregnancies and  contributes significantly to maternal mortality. This study applies a scientific observational cross-sectional review to examine how TNF-α, TNF-R1, and TNF-R2 play their roles in normal pregnancy, preeclampsia, and  preeclampsia associated with  sepsis. Blood tests were gathered from subjects  at a  local medical clinic in Malang, Indonesia, and  TNF-α, TNF-R1, and TNF-R2 levels were surveyed utilizing the Enzyme-linked Immunosorbent Assay (ELISA) strategy. The results demonstrate raised TNF-α levels in both preeclampsia and preeclampsia with sepsis, along with expanded TNF-R1 and TNF-R2 receptor levels, signifying their association in these circumstances. Validation through bigger scope studies is basic, possibly situating TNF-α as an early indicative biomarker for sepsis. This study highlights the importance of TNF-α in pregnant mothers with preeclampsia and preeclampsia muddled by sepsis, uncovering possible analytic and remedial avenues.


 

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Authors

Mira Kusuma Wardhani
uwks.dosen@gmail.com (Primary Contact)
Harry Kurniawan Gondo
Wardhani, M. K., & Gondo, H. K. (2024). Exploring cytokine levels in pregnancy, preeclampsia, and sepsis-complicated preeclampsia. Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya, 8(02). https://doi.org/10.30651/jqm.v8i02.20427

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