Ocular manifestations in COVID-19 Patients at Dr. Wahidin Sudiro Husodo General Hospital Mojokerto during January – June 2021

Rini Kusumawar Dhany (1), Gusti Ratu Azzahra (2)
(1) Dr. Wahidin Sudiro Husodo Mojokerto General Hospital. Faculty of Medicine, Muhammadiyah Surabaya University., Indonesia,
(2) Faculty of Medicine, Muhammadiyah Surabaya University., Indonesia

Abstract

Coronavirus Disease (COVID-19) is a respiratory infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). SARS-CoV-2 can be found in ocular organs through direct inoculation, migration via the nasolacrimal duct, or hematogenous. This study aims to determine the clinical manifestations of eye disease in COVID-19 patients at Dr. Wahidin Sudiro Husodo Mojokerto General Hospital from January-June 2021. A cross-sectional retrospective observational study by collecting secondary data on patient medical records. The research sample was all outpatients and inpatients with a positive PCR test for COVID-19 who were consulted by an ophthalmologist at Dr. Wahidin Sudiro Husodo General Hospital Mojokerto in January-June 2021. A total of 861 cases of patients with positive PCR tests for COVID-19, a total of 67 patients were consulted to eye specialists with a median age of 42.6 years. Among 67 patients, 59 (88%) showed symptoms of conjunctival injection, 8 patients (12%) ciliary infusion with 7 patients diagnosed with keratitis, and 1 patient with ulcer redness. In conclusion, the main eye manifestation most commonly found in COVID-19 patients is conjunctivitis which is characterized by conjunctival hyperemia.

Full text article

Generated from XML file

References

Aggarwal K, Agarwal A, Jaiswal N, Dahiya N, Ahuja A, Mahajan S, Tong L, Duggal M, Singh M, Agrawal R, Gupta V. Ocular surface manifestations of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. PLoS One. 2020 Nov 5;15(11):e0241661. doi: 10.1371/journal.pone.0241661. PMID: 33151999; PMCID: PMC7643964.

Durak, S. et al., 2021, 'Potency of SARS-CoV-2 on Ocular Tissues', in A. Rodriguez-Garcia, J. C. Hernandez-Camarena (eds.), Infectious Eye Diseases - Recent Advances in Diagnosis and Treatment, IntechOpen, London. 10.5772/intechopen.97055.

Hoffman-La Roche, 2020. Provides an update on the phase III COVACTA trial of Actemra /Ro Actemra in hospitalized patients with severe COVID-19 associated pneumonia. Journal Update for COVID-19

Gennaro, F, Pizzol D, Marotta, C, Antunes M, RacalbutoV, Veronese N, Smith, L, 2020. Corona virus Diseases ( COVID-19 ) Current Status and Future Perspectives : A Narrative Review. International Journal of Environmental Researchand Public Health Environmental Research and Public Health, 17(2690), 1–11.

Güemes-Villahoz N, Burgos-Blasco B, Arribi-Vilela A, Arriola-Villalobos P, Rico- Luna CM, Cuiña-Sardiña R, Delgado-Iribarren A, García-Feijoó J. Detecting SARS-CoV-2 RNA in conjunctival secretions: Is it a valuable diagnostic method of COVID-19? J Med Virol. 2021 Jan;93(1):383-388. doi: 10.1002/jmv.26219. Epub 2020 Jul 6. PMID: 32579256; PMCID: PMC7361904.

Jaiswal Vinod, Prashant Nasa, May Raouf, Megha Gupta, Hany Dewedar, Hozaifah Mohammad, Mahmoud Marashi, 2021. Therapeutic plasma exchange

followed by convalescent plasma transfusion in critical COVID-19: An exploratory study. International Journal of Infectious Diseases 102 (2021) 332–334

Li G, He X, Zhang L, Ran Q, Wang J, Xiong A, Wu D, Chen F, Sun J, Chang C. Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID- 19. J Autoimmun. 2020 Aug;112:102463. doi: 10.1016/j.jaut.2020.102463. Epub 2020 Apr 13. PMID: 32303424; PMCID: PMC7152872.

Ni, W., Yang, X., Yang, D. et al. Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. Crit Care 24, 422 (2020). https://doi.org/10.1186/s13054-020-03120-0.

Seah I, Agrawal R. Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals. Ocul Immunol Inflamm. 2020 Apr 2;28(3):391-395. doi: 10.1080/09273948.2020.1738501. Epub 2020 Mar 16. PMID: 32175797; PMCID: PMC7103678.

Sen, Mrittika; Honavar, Santosh G; Sharma, Namrata1; Sachdev, Mahipal S2. COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19. Indian Journal of Ophthalmology: March 2021 - Volume 69 - Issue 3 - p 488-509 doi: 10.4103/ijo.IJO_297_21.

Zhou L, Xu Z, Castiglione GM, Soiberman US, Eberhart CG, Duh EJ. ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection. Ocul Surf. 2020 Oct;18(4):537-544. doi: 10.1016/j.jtos.2020.06.007. Epub 2020 Jun 13. PMID: 32544566; PMCID: PMC7293510.

Authors

Rini Kusumawar Dhany
rininugroho@gmail.com (Primary Contact)
Gusti Ratu Azzahra
Author Biographies

Rini Kusumawar Dhany, Dr. Wahidin Sudiro Husodo Mojokerto General Hospital. Faculty of Medicine, Muhammadiyah Surabaya University.

Head of Ophtalmology department at Dr. Wahidin Sudiro Husodo Mojokerto General Hospital.
Lecturer from the Faculty of Medicine, Muhammadiyah Surabaya University.

Gusti Ratu Azzahra, Faculty of Medicine, Muhammadiyah Surabaya University.

Student from the Faculty of Medicine, Muhammadiyah Surabaya University
Dhany, R. K., & Azzahra, G. R. (2023). Ocular manifestations in COVID-19 Patients at Dr. Wahidin Sudiro Husodo General Hospital Mojokerto during January – June 2021. Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya, 7(2). https://doi.org/10.30651/jqm.v7i2.17356

Article Details

No Related Submission Found