The effect of ginger (Zingiber officinale) extract on the neutrophil level and CAT (COPD Assessment Test) scores in workers with COPD due to dust exposure

Susilo Budi Pratama, Yuliani Setyaningsih, Daru Lestyanto




Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airflow limitation that does not fully return to normal and is associated with the increased inflammatory response in the airways due to exposure to noxious particles or gases. Workers are susceptible to exposure to steam, dust, gases, and fumes in the work environment. Administration of antioxidants can be beneficial in COPD patients by reducing oxidative stress to reduce the inflammatory response. Ginger contains various active ingredients that act as antioxidants. The research design is a quasi-experimental study with a pre-test and post-test approach. The research subjects were 30 subjects workers diagnosed with COPD. Subjects were divided into two groups: the control group was given standard therapy, the treatment group was given standard therapy and ginger extract. The treatment was given for one month, then the neutrophil and the COPD Assessment Test (CAT) scores were checked. The data were analyzed with an unpaired difference test. The treatment group (-5.67 +2.32) experienced more CAT decline than the control group (-0.73 +1.28) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = <0.001). The treatment group (-4.93 +4.43) experienced more neutrophil decline than the control group (0.27 +1.10) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = < 0.001). Administration of ginger extract can reduce neutrophil levels and CAT scores in COPD workers due to dust exposure.


Keywords             : COPD, CAT score, neutrophil, ginger

Correspondence   : 


COPD, CAT score, neutrophil, ginger

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Aisanov, Z. R., Chuchalin, A. G., & Kalmanova, E. N. (2019). Chronic obstructive pulmonary disease and cardiovascular comorbidity. Kardiologiia, 59(8), 24–36.

Asri, A. A. M., Anua, S. M., Safuan, S., Shakri, S. F. M., Hussein, N. S. M., Ishak, N. S., & Zin, R. A. M. (2020). Inhalable dust exposure and lung function among rice mill, sawmill and furniture factory workers. Malaysian Journal of Medicine and Health Sciences, 16(8), 49–55.

Barbu, C., Iordache, M., & Man, M. G. (2011). Inflammation in COPD: Pathogenesis, local and systemic effects. Romanian Journal of Morphology and Embryology, 52(1), 21–27.

Barnes PJ, Drazen JM, Rennard S, T. N. (2529). Asthma and COPD basic mechanisms and clinical management. 2nd.

Cho, Y. M., Lee, J., Choi, M., Choi, W. S., Myong, J. P., Kim, H. R., & Koo, J. W. (2015). Work-related COPD after years of occupational exposure. Annals of Occupational and Environmental Medicine, 27(1), 4–8.

Desai, U., Gothi, D., & Joshi, J. M. (2012). COPD Exacerbations: Clinical Management Options. Indian Journal of Clinical Medicine, 3(January), IJCM.S5476.

Feliz-Rodriguez, D., Zudaire, S., Carpio, C., Martínez, E., Gómez-Mendieta, A., Santiago, A., Alvarez-Sala, R., & García-Río, F. (2013). Evolution of the COPD Assessment Test score during chronic obstructive pulmonary disease exacerbations: Determinants and prognostic value. Canadian Respiratory Journal, 20(5), 92–98.

Fishwick, D., Sen, D., Barber, C., Bradshaw, L., Robinson, E., Sumner, J., & Standard, T. C. (2015). Occupational chronic obstructive pulmonary disease : a standard of care. 270–282.

Global Initiative for Chronic Obstructive Lung Disease. (n.d.). GOLD-REPORT-2021-v1.1-25Nov20_WMV.pdf.

GOLD. (2014). GOLD Report 2014.

Hansel, T. T., & Barnes, P. J. (2009). New drugs for exacerbations of chronic obstructive pulmonary disease. The Lancet, 374(9691), 744–755.

Koh, E. M., Kim, H. J., Kim, S., Choi, W. H., Choi, Y. H., Ryu, S. Y., Kim, Y. S., Koh, W. S., & Park, S.-Y. (2009). Modulation of macrophage functions by compounds isolated from Zingiber officinale. In Planta medica (Vol. 75, Issue 2, pp. 148–151).

Löfstedt, H., Hagström, K., Bryngelsson, I. L., Holmström, M., & Rask-Andersen, A. (2017). Respiratory symptoms and lung function in relation to wood dust and monoterpene exposure in the wood pellet industry. Upsala Journal of Medical Sciences, 122(2), 78–84.

Mao, Q. Q., Xu, X. Y., Cao, S. Y., Gan, R. Y., Corke, H., Beta, T., & Li, H. Bin. (2019). Bioactive compounds and bioactivities of ginger (Zingiber officinale roscoe). Foods, 8(6), 1–21.

Molen, H. F. Van Der, Groene, G. J. De, & Hulshof, C. T. J. (2018). Association between Work and Chronic Obstructive Pulmonary Disease ( COPD ).

Oemiati, R. (2013). KAJIAN EPIDEMIOLOGIS PENYAKIT PARU. 23(2), 82–88.

Perhimpunan Dokter Paru Indonesia. (2016). Pedoman Diagnosis dan Penatalaksanaan PPOK. In Perhimpunan Dokter Paru Indonesia. Universitas Indonesia Press.

Report, A. (2009). GSK is changing. Growth (Lakeland), 8–9.

Roca, M., Verduri, A., Corbetta, L., Clini, E., Fabbri, L. M., & Beghé, B. (2013). Mechanisms of acute exacerbation of respiratory symptoms in chronic obstructive pulmonary disease. European Journal of Clinical Investigation, 43(5), 510–521.

Shetkar, N. R., & Pyati, A. (2018). Available Online through OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN. March.

Stockley, R. A. (1999). Neutrophils and Protease / Antiprotease Imbalance. 8(9).