Management and quality of life extranodal non hodgkin lymphoma of testis

Bagus Aulia Mahdi; Pradana Zaky Romadhon; Ugroseno Yudho Bintoro; Merlyna Savitri; Putu Niken Ayu Amrita; Muhammad Noor Diansyah; Ami Ashriati Prayoga; Kartika Prahasanti

doi:10.30651/jqm.v6i1.7610

Bagus Aulia Mahdi ⁽¹⁾, Pradana Zaky Romadhon ⁽²⁾, Ugroseno Yudho Bintoro ⁽³⁾, Merlyna Savitri ⁽⁴⁾, Putu Niken Ayu Amrita ⁽⁵⁾, Muhammad Noor Diansyah ⁽⁶⁾, Ami Ashriati Prayoga ⁽⁷⁾, Kartika Prahasanti ⁽⁸⁾

(1) FACULTY OF MEDICINE AIRLANGGA UNIVERSITY SURABAYA, Indonesia,

(2) FACULTY OF MEDICINE AIRLANGGA UNIVERSITY SURABAYA, Indonesia,

(3) FACULTY OF MEDICINE AIRLANGGA UNIVERSITY SURABAYA, Indonesia,

(4) FACULTY OF MEDICINE AIRLANGGA UNIVERSITY SURABAYA,

(5) FACULTY OF MEDICINE AIRLANGGA UNIVERSITY SURABAYA,

(6) FACULTY OF MEDICINE AIRLANGGA UNIVERSITY SURABAYA,

(7) FACULTY OF MEDICINE AIRLANGGA UNIVERSITY SURABAYA, Indonesia,

(8) Faculty of Medicine, Universitas Muhammadiyah Surabaya, Indonesia

https://doi.org/10.30651/jqm.v6i1.7610

Issue
Vol. 6 No. 1 (2022): Journal Qanun Medika Vol 6 No 01

Submitted
Maret 8, 2021

Published
Januari 12, 2022

Keywords:

extranodal, lymphoma non hodgkin, testicular, chemotherapy, quality of life

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Abstract

Extranodal non-Hodgkin lymphoma still seems to be a rare case and an issue to discuss a lot. Clinical evidence and guidelines on treatment have not yet been widely published and accessible. We present a case of a forty-five-year-old male with the chief complaint of a bulky and huge right mass in the testis with an ulcer on it. The patient underwent an orchiectomy, and the biopsy showed a malignant round cell tumor, suspected as non-Hodgkin lymphoma. The patient then received the following treatment: chemotherapy with R-CHOP regiment every three weeks, consisting of 6 cycles showing shrinkage size of the testis by day 7 and final complete response after 4th cycle with ADE grade 0 no sexual activity disorder after chemotherapy. This raises hope in developing treatment modalities that the right choice on chemotherapy regimen with complete control on the drug effects may improve clinical outcome and patientâ€™s quality of life.

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References

Cheah, C. Y., Wirth, A., & Seymour, J. F. (2014). Primary testicular lymphoma. Blood, 123(4), 486-493. doi:10.1182/blood-2013-10-530659

Deng, L., Xu-Monette, Z. Y., Loghavi, S., Manyam, G. C., Xia, Y., Visco, C., . . . Young, K. H. (2016). Primary testicular diffuse large B-cell lymphoma displays distinct clinical and biological features for treatment failure in rituximab era: a report from the International PTL Consortium. Leukemia, 30(2), 361-372. doi:10.1038/leu.2015.237

Eckardt, A. M., Lemound, J., Rana, M., & Gellrich, N. C. (2013). Orbital lymphoma: diagnostic approach and treatment outcome. World J Surg Oncol, 11, 73. doi:10.1186/1477-7819-11-73

Ellatif, M., Kumar, R., Weller, A., Katz, D., & Vrentzou, E. (2019). Two Cases of Primary Testicular Lymphoma Presenting with Direct Spread along the Spermatic Cord and Gonadal Vessels. Case Rep Radiol, 2019, 5953618. doi:10.1155/2019/5953618

Jia, B., Shi, Y., Dong, M., Feng, F., Yang, S., Lin, H., . . . He, X. (2014). Clinical features, survival and prognostic factors of primary testicular diffuse large B-cell lymphoma. Chin J Cancer Res, 26(4), 459-465. doi:10.3978/j.issn.1000-9604.2014.08.12

Kiserud, C. E., Fossa, A., Bjoro, T., Holte, H., Cvancarova, M., & Fossa, S. D. (2009). Gonadal function in male patients after treatment for malignant lymphomas, with emphasis on chemotherapy. Br J Cancer, 100(3), 455-463. doi:10.1038/sj.bjc.6604892

Kumar, K., Lewis, S., Vinci, S., Riera-Escamilla, A., Fino, M. G., Tamburrino, L., . . . Krausz, C. (2018). Evaluation of sperm DNA quality in men presenting with testicular cancer and lymphoma using alkaline and neutral Comet assays. Andrology, 6(1), 230-235. doi:10.1111/andr.12429

Kuper-Hommel, M. J., Janssen-Heijnen, M. L., Vreugdenhil, G., Krol, A. D., Kluin-Nelemans, H. C., Coebergh, J. W., & van Krieken, J. H. (2012). Clinical and pathological features of testicular diffuse large B-cell lymphoma: a heterogeneous disease. Leuk Lymphoma, 53(2), 242-246. doi:10.3109/10428194.2011.607528

Ma, R. Z., Tian, L., Tao, L. Y., He, H. Y., Li, M., Lu, M., . . . Lu, J. (2018). The survival and prognostic factors of primary testicular lymphoma: two-decade single-center experience. Asian J Androl, 20(6), 615-620. doi:10.4103/aja.aja_73_18

Marcus, R., Sweetenham, J. W., & Williams, M. (2014). Lymphoma : Pathology, Diagnosis, and Treatment (Second ed.): Cambridge University Press.

Nanthakwang, N., Rattarittamrong, E., Rattanathammethee, T., Chai-Adisaksopha, C., Tantiworawit, A., Norrasethada, L., & Ya-In, C. (2019). Clinicopathological study and outcomes of primary extranodal lymphoma. Hematol Rep, 11(4), 8227. doi:10.4081/hr.2019.8227

Niitsu, N. (2011). [Point of diagnosis and treatment of extranodal diffuse large B-cell lymphoma]. Rinsho Ketsueki, 52(10), 1637-1644. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21971241

Niitsu, N., & Umeda, M. (1998). Clinical features of testicular non-Hodgkin's lymphoma--focus on treatment strategy. Acta Oncol, 37(7-8), 677-680. doi:10.1080/028418698430034

Sahu, K. K., Mishra, A. K., Lal, A., & Oshea, J. (2020). Testicular Lymphoma: A Rare Cause of a Testicular Mass. J Coll Physicians Surg Pak, 30(5), 556. doi:10.29271/jcpsp.2020.05.556

Shahab, N., & Doll, D. C. (1999). Testicular lymphoma. Semin Oncol, 26(3), 259-269. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10375083

Shih, H. J., Shih, L. Y., Chang, H., Wang, P. N., Wu, J. H., Kuo, M. C., . . . Dunn, P. (2014). Clinical features of testicular lymphoma. Acta Haematol, 131(3), 187-192. doi:10.1159/000353379

Skeel, T. R., & Khleif, S. N. (2011). Handbook of Cancer Chemotherapy (Eighth Edition ed.). Philadelphia, PA 19103: Lippincott Williams & Wilkins, a Wolters Kluwer business.

Vannata, B., & Zucca, E. (2015). Primary extranodal B-cell lymphoma: current concepts and treatment strategies. Chin Clin Oncol, 4(1), 10. doi:10.3978/j.issn.2304-3865.2014.12.01

Xu, H., & Yao, F. (2019). Primary testicular lymphoma: A SEER analysis of 1,169 cases. Oncol Lett, 17(3), 3113-3124. doi:10.3892/ol.2019.9953

Zhou, Bao, C., Ye, X., Zhu, L., Zhu, J., Li, L., . . . Xie, W. (2017). Clinical and histological features of primary testicular diffuse large B-cell lymphoma: a single center experience in China. Oncotarget, 8(68), 112384-112389. doi:10.18632/oncotarget.19736