Perbedaan Pengaruh Pemberian Ekstrak Zingiber Officinale dengan Insulin terhadap Jumlah Anak Hidupa, Mati atau Resorbsi dan Cacat pada Rattus Norvegicus Model Diabetes Melitus Pragestasional

yasinta siskaningtia


Diabetes mellitus was metabolic disease which had chronic hyperglycemic characteristic  .The risk of fetal death and malformation which were higher in pregestational diabetes. The complications could be suppressed through insulin therapy. The reasons about insulin side effect made herbal therapy began to develop, such as ginger (Zingiber officinale). This research aimed to prove the difference effect of Zingiber officinale extract and insulin on the number of fetal dead or resorbsion, and malformations in Rattus novergicus model of pregestational diabetes mellitus. Thirty rats were divided into 1 negative control group and 4 groups which were modeled with type 1 DM with streptozotocin (STZ) i.p dose 50mg/kgBB in citrate buffer 0,05M pH 4,5. Rat with blood glucose levels >200mg/dL after 2 days of induction, were sampled and bundled. The treatment groups were given 1IU insulin, ginger extract 500mg/kgBB, and 1IU insulin plus ginger extract 500mg / kgBB. The 17th day of pregnancy fetal sample was observed macroscopically. Analysis data with One Way ANOVA and Post Hoc with LSD. There were significant differences in fetal malformation with p value was 0,012 and death or resorbsion were 0,001. Ginger extract could be used as a single therapy or combination therapy to reduced the number of fetal death or malformation.


pregestational diabetes mellitus, Zingiber officinale extract, insulin, fetal death malformation


Societies (US) Toward brighter future of endocrinology-metabolic care in asean region: from bench to clinical practice. The 17th ASEAN Federation of Endocrine Societies (AFES) congress. Jakarta on 13-16 November 2013.

Gabbay-Benziv, R., Reece, E.A., Wang, F., Yang, P. (2015) Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis. World J Diabetes; 6(3): 481-488

Hermanto, H.T. dan Pranoto, A. (2004) Konsensus pedoman diagnosis dan terapi diabetes melitus dalam kehamilan.

Karmakar, D. and Sharma, J.B. (2010) Diabetes mellitus in pregnancy. JIMSA; Vol 23 No.4

Langer, O. (2015) The Diabetes in pregnancy dilemma: Leading Change with Proven Solutions, 2e. USA: PMPH USA. Copyright Li, Y., Tran, V.H., Duke, C.C.,

Roufogalis, B.D. (2012) Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review. Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 516870.

Robson, S. and Nolan, C. (2013) ‘Diabetes and stillbirth’. Obstetry Gynecology Magazine; Vol 15 No 4:36-38

Wahabi, H.A., Alzeidan, R.A. dan Esmaeil, S.A. (2012) Pre-pregnancy care for women with pre-gestational diabetes mellitus: a systematic review and meta-analysis. Public Health; 12:792

Zahibi, S. (2008) Fetal outcome in experimental diabetic pregnancy. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine. Uppsala University