P-selectin levels in women with endometriosis and non-endometriosis

Tonny Simarmata

Abstract

The discovery of a decline in the cellular immune system in endometrial tissue of women with endometriosis triggers the idea that immunologic factors may play a role in the process of endometriosis. This study was conducted to determine differences in blood plasma P-selectin levels in women with endometriosis and non endometriosis. This cross-sectional study was conducted at the Department of Obstetrics and Gynecology of the Faculty of Medicine, University of North Sumatra (FK USU) from April to August 2014. P-selectin levels were measured through blood plasma of women with endometriosis (cases) and non-endometriosis (control) ELISA. Diagnosis of endometriosis is confirmed by histopathologic examination with hematoxylin eosin staining. Statistical tests were performed with t-test and anova. Each of 28 cases of endometriosis and control with age 30-39 years (endometriosis 42.9% and control 57.1%). The endometriosis group is entirely with 0 (100%) parity, while the control with parity is ≥3 (92.9%). Most cases of endometriosis in stage 4 (46.4%). P-selectin levels in endometriosis were clinically higher when compared with non endometriosis (30.89 ± 8.27 vs. 28.36 ± 7.78 ng / ml), but no statistically significant difference was found (p> 0.05). There was an average difference of P-selectin levels based on endometriosis stage but statistically no significant difference was found (p> 0.05). P-selectin levels in endometriosis were clinically higher when compared with non-endometriosis but there was no statistically significant difference.

Keywords

p-selectin, endometriosis, non endometriosis.

References

Schorge JO, Schaffer JI, Halvorson LM, Ed et al. Williams Gynecology. McGraw-Hill’s. 2008

Mounsey Al, Wilgus A, Slawson DC. Diagnosis and Management of Endometriosis. Am Fam Physician 2006;74(4):594-600

Berek JS, ed. Berek and Novak’s Gynecology. 14th ed. Lippincott Williams and Wilkins. California. 2007.

Overton C, Davis C, McMillan L, Shaw RW. An Atlas of Endometriosis. 3rd ed. Informa healthcare. UK. 2007.pp 89-96

Chapron C, Vercellini P, Barakat H, Vieira M, Dubuisson J. Management of ovarian endometrioma. Human Reproduction Update 2011;8(6):591-7

Berbic M, Fraser I.S. Regulatory T cells and other leukocytes in the pathogenesis of endometriosis.J Reprod Immunol 2011;88(2):149-55

Ley K, Laudanna C, Cybulsky MI, Noursharqh. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nature review-immunology 2007;7(9):678-89

Schmidt M, Regidor P, Engel K, Regidor M, Winterhager E, Scotti S, et al. E- and P-selectin expression in endometriotic tissues and the corresponding endometria. Gynecol Endocrinol 2000;14:111-7.

Ley K. The role of selectins in inflammation and disease. Trends Mol Med 2003;9(6):263-8

Carlos TM, Harlan JM. Leukocyte-Endothelial Adhesion Molecules. Bloodjournal.1994;84:2068-2101.

Ozkan S, Murk W, Arici A. Endometriosis and infertility: epidemiology and evidence-based treatments. Ann N Y Acad Sci 2008;1127:92-100

Ballard K, Lane H, Hudelist G, Banerjee S, Wright J. Can specific pain symptoms help in the diagnosis of endometriosis? A cohort study of women with chronic pelvic pain. Fertil Steril 2010;94(1):20-7

Giudice L, Evers JLH, Healy DL. Endometriosis: Science and Practice. Chichester, Blackwell Publising; 2012. DOI: 10.1002/9781444398519

Koninckx PR, Kennedy SH, Barlow DH. Endometriotic disease: the role of peritoneal fluid. Hum Reprod Update 1998;4(5):741-51

Daniel Y, Baram A, Faith G, Lessing JB, Geva E, Amit A et al. Do soluble cell adhesion molecules play a role in endometriosis? American Journal of Reproductive Immunology 2000;43(3):160-6


DOI: http://dx.doi.org/10.30651/qm.v1i02.492