Potential of Anti Breast Cancer Black Ethanol Rice Extract (Oryza sativa L). indica) In Decreasing Levels of CA 15-3 Serum in the White Mice Sprague dawley in Induction 7.12-Dimethylbenz (α) Antracene (DMBA) and Estrogen

Zanuar Abidin

Abstract

Breast cancer is cancer that has the high incidence in Indonesia. Black rice (Oryza sativa L. indica) is a plant that has an anticancer potency. This research aim is to prove black rice as a potential anticancer by using experimental animals, 20 Sprague Dawley female rats aged 7-8 weeks induced breast cancer by using the combination of 7,12-dimethylbenz (α) anthracene (DMBA) and estrogen. Rats were divided into two groups, namely the K-induced breast cancer and a group of P-induced cancer and treated with black rice. Black rice is given in the form of ethanol extract at a dose of 75 mg / kg / day for six weeks. Levels of CA 15-3 serum are used as a parameter. The result showed that the differences in levels of serum CA 15-3 are significant (p <0.05). Serum CA 15-3 level in P group is lower than in K group. This study proved that the ethanol extract of black rice (Oryza sativa L. indica) has potential as an anticancer breast as indicated by decreased level of serum CA 15-3

Keywords

beras hitam,antikanker payudara,CA 15-3 serum

References

Akinleye, A., Awaru, P., Furqan, M., Song, Y., Liu, D. (2013) Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics, J Hemato Onco. 6 pp.88

Fresco, P., Borges, F., Diniz, C., Marques, MP. (2006) New insights on the anticancer properties of dietary polyphenols, Med. Res. Rev. 26 pp.747-66

Gioia, DD., Dresse, M., Mayr, D., Nagel, D., Heinemann, V., Stieber, P. (2015) Serum HER2 in combination with CA 15-3 as a parameter for prognosis in patients with early breast cancer, Clinica Chimica Acta.440, pp.16-22

Hauptman et al .(2013) ‘Micro RNAs and long non-coding RNAs’ : prospects in diagnostics and therapy of cancer. J Radiol Oncol.47, pp.311-318.

Joshi, Y., Goyal, B. (2011) Anthocyanins : ‘a lead for anticancer drugs’, Intl J of Research in Pharmacy. 1(4), pp.1119–1126

Kementerian Kesehatan Republik Indonesia, (2015). ‘Panduan nasional penanganan kanker payudara’. Komite Nasional Penanggulangan Kanker Kementerian Kesehatan Republik Indonesia. Jakarta

Kubatka, P., Ahlersova, E., Ahlers, I., Bojkova, B., Kalicka, K., Adamekova, E., Markova, M., Chamilova, M., Cermakova, M (2002) ‘Variability of mammary carcinogenesis induction in female sprague dawley and wistar’ : han rats : the effect of season and age, Physiol. Res. J.51,pp.633-640

Lewandowska, U., Gorlach, S., Owczarek, K., Hrabec, E., Szewczyk, K. (2014) Synergistic interaction between anticancer chemo-therapeutics and phenolic compounds and anticancer synergy between poly-phenols, Postepy Hig Med Dosw. 68, pp.528-540

McDonald, Gail Theresa. (2008).

Thesis : ‘Inhibition Phosphatidyl-Inositol-3-Kinase (PI3K) Signalling Leads to Resistance to Chemotherapeutic Agents in Human Cancer Cells’. Ontario, Canada : Department of Anatomy and Cell Biology Queen’s University.

Pengkumsri, N., Chaiyasut, C., Saenjum, C., Sirilun, S., Peerajan, S., Suwannalert, P., Sirisatha, S., Sivamaruthi, BS. (2015) Physicochemical and antioxidative properties of black, brown and red rice varieties of northern Thailand, Food Sci. Technol Campinas. 35(2), pp.331-338

Pratiniyata, S., Roosdiana, A., Oktavianie, DA. (2013) ‘Pengaruh induksi DMBA (7,12-dimethylbenz(α) antracene) multiple low dose (MLD) terhadap estrogen pada serum darah tikus (Rattus norvegicus)’. Laporan Penelitian Fakultas Kedokteran Hewan Universitas Brawijaya, Malang,

Ramos, S. (2008) Cancer chemo-prevention and chemo-therapy: dietary polyphenols and signaling pathways, Mol. Nutr. Food Res. 52, pp.507-526

Sadeghi-Aliabadi, H., Mosavi, H., Mirian, M., Kakhki, S., Zarghi, A. (2012) The cytotoxic and synergistic effects of flavonoid derivates on doxorubicin cytotoxicity in Hela, MDA-MB-231, and HT-29 cancer cells, Iranian J Toxicology. 5(15).

Sudiana, IK. (2011) Patobiologi Molekuler Kanker. Jakarta : Salemba Empat.


DOI: http://dx.doi.org/10.30651/qm.v1i01.378