2026-05-18T11:17:31Z https://journal.um-surabaya.ac.id/qanunmedika/oai

oai:journal.um-surabaya.ac.id:article/378 2021-01-26T03:22:11Z qanunmedika:AR

Potential of Anti Breast Cancer Black Ethanol Rice Extract (Oryza sativa L). indica) In Decreasing Levels of CA 15-3 Serum in the White Mice Sprague dawley in Induction 7.12-Dimethylbenz (α) Antracene (DMBA) and Estrogen Abidin, Zanuar beras hitam antikanker payudara CA 15-3 serum Breast cancer is cancer that has the high incidence in Indonesia. Black rice (Oryza sativa L. indica) is a plant that has an anticancer potency. This research aim is to prove black rice as a potential anticancer by using experimental animals, 20 Sprague Dawley female rats aged 7-8 weeks induced breast cancer by using the combination of 7,12-dimethylbenz (α) anthracene (DMBA) and estrogen. Rats were divided into two groups, namely the K-induced breast cancer and a group of P-induced cancer and treated with black rice. Black rice is given in the form of ethanol extract at a dose of 75 mg / kg / day for six weeks. Levels of CA 15-3 serum are used as a parameter. The result showed that the differences in levels of serum CA 15-3 are significant (p <0.05). Serum CA 15-3 level in P group is lower than in K group. This study proved that the ethanol extract of black rice (Oryza sativa L. indica) has potential as an anticancer breast as indicated by decreased level of serum CA 15-3 Universitas Muhammadiyah Surabaya 2017-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/378 10.30651/qm.v1i01.378 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 01 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 01 (2017) 2548-9526 2541-2272 10.30651/qm.v1i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/378/286 Copyright (c) 2017 Qanun Medika - Jurnal FK UM Surabaya

oai:journal.um-surabaya.ac.id:article/379 2021-01-26T03:22:11Z qanunmedika:AR

Effects of Ginger Extract (Zingiber officinale L) on Glycogen Levels Liver on Mice with Hyperglycaemia Triastuti, Nenny Basori, Achmad Zakaria, Sunarni diet tinggi lemak STZ ekstrak jahe kadar glikogen hati This study aims to prove the effect of ginger extract on rat liver glycogen levels in hyperglycemic. The design of this study is the post-test only control group design with independent variables (free) include a high-fat diet, injections of streptozotocin, the ethanol extract of ginger doses of 300, 400, 500 mg / kg and the dependent variable (dependent) include blood glucose levels ( GTTO II), glycogen levels. Based on this study, the results of different test GTTO end shows significant differences between negative control group and a positive control, a positive control and P1. Besides, also, there is a significant difference between P1 to P2. This suggests that, dosing higher ginger extract can increase the amount of glycogen levels to near normal. Effect of ginger extract on levels of glycogen in the liver of mice were exposed to a high-fat diet and STZ Universitas Muhammadiyah Surabaya 2017-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/379 10.30651/qm.v1i01.379 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 01 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 01 (2017) 2548-9526 2541-2272 10.30651/qm.v1i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/379/287 Copyright (c) 2017 Qanun Medika - Jurnal FK UM Surabaya

oai:journal.um-surabaya.ac.id:article/380 2021-01-26T03:22:11Z qanunmedika:AR

Laporan Kasus Serial Variasi Terapi pada Kelainan Vaskular Jatmiko, Sigit Wahyu Budi, Agus Santoso anomali vaskuler klasifikasi embolisasi eksisi. Secara klinis berbagai kelainan vaskuler memiliki kemiripan, flat atau noduler dengan variasi bentuk, variasi warna darikebiruan, pinkish sampai kemerahan. Pemeriksaan yang teliti dapat menjadi kunci utama untuk membedakan anomali vaskuler, hemangioma atau malformasi.Terapi anomali vaskuler memiliki banyak modalitas, mulai dari hanya observasi / konservatif,  farmakoterapi, kemoterapi,injeksi corticosteroid, embolisasi,  eksisi sampai dengan terapi kombinasi antara embolisasi dan eksisi. Kami melaporkan perbandingan terapi dari beberapa kasushemangiomadan arteriovenous malformations (AVM), yang diterapi dengan injeksi corticosteroid, embolisasi, pada kasus yang lain dilakukan eksisi, namun ada pula yang dilakukan kombinasi keduanya serta satu kasus yang hanya dilakukan observasi. Pengambilan keputusan untuk dilakukan terapi tersebut  berdasarkan hasil diskusi beberapa departemen terkait.Semuanya memiliki hasil akhir yang berbeda dan  tetap diperlukan follow up terhadap pasien-pasien tersebut. (QM 2017;01:23-35) Universitas Muhammadiyah Surabaya 2017-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/380 10.30651/qm.v1i01.380 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 01 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 01 (2017) 2548-9526 2541-2272 10.30651/qm.v1i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/380/288 Copyright (c) 2017 Qanun Medika - Jurnal FK UM Surabaya

oai:journal.um-surabaya.ac.id:article/381 2021-01-26T03:22:11Z qanunmedika:AR

Laporan Kasus Operasi Transeksual pada Kelainan Sex Ambigua dan Hukumnya dalam Agama Islam Primadina, Nova sex ambigua transeksual kelainan genetik Sex Ambigua adalah suatu kelainan yang ditandai dengan adanya kelainan bentuk genitalia eksterna / fenotip yang tidak jelas laki atau perempuan yang disebabkan oleh segala hal yang dapat mengganggu proses perkembangan/ differensiasi sel-sel organ seksual intrauterin. Penatalaksanaannya melibatkan multidisiplin ilmu dan pada tahan akhir dilakukan operasi transeksual. Melaporkan suatu kasus Sex Ambigua pada satu keluarga, dimana terdapat kelainan sex ambigua pada setiap generasi keluarga tersebut ,dan diambil satu kasus penanganan Sex Ambigua ini pada salah satu anggota keluarga mereka, Laki-laki, 29 tahun diikuti hingga selesai melaksanakan operasi transeksual (operasi ganti kelamin) menjadi seorang wanita, serta akan dibahas bagaimana pandangan hukum Islam terhadap operasi ganti kelamin (transeksual) ini. (QM 2017;01:36-43) Universitas Muhammadiyah Surabaya 2017-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/381 10.30651/qm.v1i01.381 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 01 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 01 (2017) 2548-9526 2541-2272 10.30651/qm.v1i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/381/289 Copyright (c) 2017 Qanun Medika - Jurnal FK UM Surabaya

oai:journal.um-surabaya.ac.id:article/382 2021-01-26T03:22:11Z qanunmedika:AR

Neurofibroma Type 1 with Intracranial Infiltration A Case Report Rahmania, Dinar Budi, Agus Santoso Neurofibroma type 1 intracranial neurofibroma Neurofibromatosis (NF) is an AD dysplasi of mesoderm and ectoderm characterized by numerous neurofibromas and cafe-au-lait spot. It can develop on cranial and cavum orbita. Additional abnormalities such as episode of seizure, learning disabilities, and speech difficultie may present.  Presented a rare case that has underwent surgery by multidisciplinary team consist of neuro surgeon, plastic surgeon, and ophthalmologist. A 31 years old female patient admitted to Dr.Soetomo Hospital with mass at left face since she was 3 years old. Clinical examination shows a large plexiform mass at left hemifacial, distopia left oculi, and facial deformity. Radiological  examination shows a soft tissue mass destructing the left temporal and maxillary bone, a temporal lobe herniation to frontobasal, and a suppression on left optical nerve. In the present time, the patient is satisfied with her performance and vision. The result of surgery is satisfying. (QM 2017;01:44-47) Universitas Muhammadiyah Surabaya 2017-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/382 10.30651/qm.v1i01.382 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 01 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 01 (2017) 2548-9526 2541-2272 10.30651/qm.v1i01 ind eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/382/290 https://journal.um-surabaya.ac.id/qanunmedika/article/view/382/306 Copyright (c) 2017 Qanun Medika - Jurnal FK UM Surabaya

oai:journal.um-surabaya.ac.id:article/405 2021-01-26T03:22:11Z qanunmedika:AR

The Relationship Between Glucosamine Supplementation and Increased Intraocular Pressure in Patients With Open Angle Glaucoma (at Dr. Wahidin Soediro Husodo Hospital) Kusumawardhany, Rini glucosamine supplement intra ocular pressure pressure glaucoma open angle glaucoma rs dr wahidin Introduction and Objective Researchers postulate that excessive deposits of GAG in the trabecular meshwork restrict outflow. Another theory suggests that increased release of GAG into the aqueous causes an osmotic effect, drawing more water into the anterior chamber, thus causing swelling, a decrease in pore size, and eventually increased resistance to outflow.Either of these proposed mechanisms could lead to an increased thickness of the pore lining and/or decreased outflow, resulting in increased intraocular pressure (IOP). Methods A total of 13 patients (26 eyes) 6 men, 7 women, with average age 62 years were included in this experimental study. IOP was measured before, on 7th day after they began glucosamine supplementation and after discontinuation. Patients had been selected who established the diagnosis of open-angle glaucoma, willingness to using glucosamine, IOP measurements at least 3 times within 2 years, and no associated changes in glaucoma medications or eye surgery.Result  Based on the parametric repeat measure general linear model test, the IOP decreased significantly from during glucosamine supplementation to discontinuation of glucosamine.(P= 0,013, or P< 0,05).  The IOP was increased during glucosamine supplementation compared with before glucosamine supplementation, but the difference statistically not significant. (P= 0,527).The IOP decreased after discontinuation compared with before supplementation, but the difference also statistically not significant. (P=1). There was no significant difference between the left and right eyes in each patient.       Universitas Muhammadiyah Surabaya 2017-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/405 10.30651/qm.v1i02.405 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 02 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 02 (2017) 2548-9526 2541-2272 10.30651/qm.v1i02 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/405/460 Copyright (c) 2017 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/490 2021-01-26T03:22:11Z qanunmedika:AR

Pengaruh Pemberian Alga Coklat (Sargassum sp.) Terhadap Enzim Katalase Kelenjar Submandibularis Tikus Rattus Norvegicus Strain Wistar Akibat Iradiasi Linear Energy Transfer (LET) Rendah ferni, sariano Brown algae catalase enzyme irradiation low LET Background: Background: Intraoral radiography use some lower LET (Linear Energy Transfer) and could penetrate submandibular salivary gland. Radiography have negative impact which is decrease catalase enzyme of human body. Brown algae (Sargassum sp.) has a flavonoid antioxidant, polysaccharides as Fucoidan and alginat (Na-alginat) can be used for immunomodulator, antioxidative and activation modulation of immune. Purpose: To knowing effectiveness of brown algae (Sargassum sp.) on activity catalase enzyme submandibular salivary gland Rattus Novergicus strain Wistar with irradiation low LET. Material and Methods: 28 samples of Rattus Novergicus strain Wistar, weight 200gr, age 2-3months, gender male, sample divide into 4 groups, K1 (control with brown algae dosage 0,018mg/kgbw) K2 (use brown algae and irradiation 4 times), K3 (use brown algae and irradiation 8 times), K4 (use brown algae and irradiation 14 times). Brown algae been given 7days before apply irradiotion on day 8, then did euthanasia and took submandibular salivary gland. After that did measurement activity of catalase enzyme and counted by spectrophotometer with 240 λ. Result: Data were analyze by Shapiro-wilk, One Way ANOVA and Bonferroni. The activity of catalase enzyme have increased; 0,2586 ± 0,1050 (K1), 0,2595 ± 0,0630 (K2), 0,3252 ± 0,1663 (K3), 0,3668 ± 0,0852 (K4) but theres no significant differences  activity of catalase enzyme between one group to other group. Conclusion: Brown algae dosage 0,018mg/kgbw can’t increase activity of catalase enzyme on Rattus Novergicus strain Wistar. Universitas Muhammadiyah Surabaya 2017-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/490 10.30651/qm.v1i02.490 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 02 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 02 (2017) 2548-9526 2541-2272 10.30651/qm.v1i02 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/490/461 Copyright (c) 2017 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/491 2021-01-26T03:22:11Z qanunmedika:AR

Maternal Mortality Determinants in Refferal Hospital : Three Years Retrospective Study Sembiring, Morel maternal mortality remote determinant intermediate determinant outcome determinant Background: Maternal mortality rate is one indicator used to assess overall women health status. According to the WHO, 99% of maternal deaths are delivery related and dominantly occur in developing countries. Objective: To determine the causes of maternal deaths at H. Adam Malik General Hospital Medan based on the following factors: remote determinants, the intermediate determinants, and outcome determinants as a risk factor of maternal deaths. Methods: This retrospective analytical study reviewed medical records of women who underwent delivery at H. Adam Malik General Hospital, Medan from January 1st 2010 until December 31th 2012. Data were statiscally analysed using a descriptive and inferential approach. Univariate, bivariate, and multivariate logistic regression analysis were used. Results: This study obtained as much as 681 complete medical records for 3 years, with 37 maternal deaths. Pre-eclampsia / eclampsia is the most common cause of death by 20 cases (54.1%). Maternal education degree, referral systems, facilities for delivery, history of systemic diseases, pregnancy and postpartum related complications were significantly correlated to the outcome of labor with OR of 1.97; 10.11; 41.36; 5.818; 3.49; and 685.7, respectively and p<0.05. Based on the multiple logistic regression test, maternal history of systemic diseases, pregnancy and postpartum related complications were the three factors that most significantly correlated to maternal mortality with p <0.05. Conclusion: Delivery outcomes were significantly associated with the followingfacrors: formal education, referral status, facilities for delivery, history of systemic diseases, mode of delivery, pregnancy and postpartum related complications. Maternal history of systemic diseases, pregnancy and postpartum related complicationswere the three factors that most significantly correlated to maternal mortality. Universitas Muhammadiyah Surabaya 2017-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/491 10.30651/qm.v1i02.491 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 02 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 02 (2017) 2548-9526 2541-2272 10.30651/qm.v1i02 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/491/459 Copyright (c) 2017 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/492 2021-01-26T03:22:11Z qanunmedika:AR

P-selectin levels in women with endometriosis and non-endometriosis Simarmata, Tonny p-selectin endometriosis non endometriosis. The discovery of a decline in the cellular immune system in endometrial tissue of women with endometriosis triggers the idea that immunologic factors may play a role in the process of endometriosis. This study was conducted to determine differences in blood plasma P-selectin levels in women with endometriosis and non endometriosis. This cross-sectional study was conducted at the Department of Obstetrics and Gynecology of the Faculty of Medicine, University of North Sumatra (FK USU) from April to August 2014. P-selectin levels were measured through blood plasma of women with endometriosis (cases) and non-endometriosis (control) ELISA. Diagnosis of endometriosis is confirmed by histopathologic examination with hematoxylin eosin staining. Statistical tests were performed with t-test and anova. Each of 28 cases of endometriosis and control with age 30-39 years (endometriosis 42.9% and control 57.1%). The endometriosis group is entirely with 0 (100%) parity, while the control with parity is ≥3 (92.9%). Most cases of endometriosis in stage 4 (46.4%). P-selectin levels in endometriosis were clinically higher when compared with non endometriosis (30.89 ± 8.27 vs. 28.36 ± 7.78 ng / ml), but no statistically significant difference was found (p> 0.05). There was an average difference of P-selectin levels based on endometriosis stage but statistically no significant difference was found (p> 0.05). P-selectin levels in endometriosis were clinically higher when compared with non-endometriosis but there was no statistically significant difference. Universitas Muhammadiyah Surabaya 2017-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/492 10.30651/qm.v1i02.492 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 02 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 02 (2017) 2548-9526 2541-2272 10.30651/qm.v1i02 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/492/455 Copyright (c) 2017 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/516 2021-01-26T03:22:11Z qanunmedika:AR

Histopathology of Left Ventricular Mice Presented with Electrical Cigarettes (ENDS) and Conventional Tursinawati, Yanuarita Tursinawati Yazid, Noor Yazid Purnawati, Findi Wira penelitian ABSTRACTElectric Cigarette (ENDS) and conventional contains carbon monoxide (CO) which is a major cause of cardiovascular disease. CO is a dangerous substance since as free radicals it have high affinity for hemoglobin. Thus affinity could lead to tissue hypoxia resulting in cell death (necrosis) started by the cell nucleus pyknosis. In order to further study about the effect, this experiment is conducted to identify the histopathological appearence  of the left ventricle rat against exposure to electric cigarette (ENDS) and conventional. This study was conducted with a post test only control group design method. Samples contained 18 Rattus novergicus rat which was divided in 3 groups: control group (K) as a negative control,  P1 group were exposed by conventional cigarretes, and P2 group were exposed by ENDS. The treatment had been maintained for 30 days, followed by termination to perform the heart organ dissection and HE staining in order to made preparat. Preparat was observed by 400x lens of microscope to identify the pyknosis of the nuclei in 5 field of view. Data were analyzed with oneway ANOVA test with p<0,05 and  CI=95%. This study proved that there was a significant differences of pycnotic nuclei amount among the group (p-value=0,008). There was significant difference between group K with P1 (p=0,004), group K with group P2 (p=0,012). There was no significant difference between group P1 and P2 (p=0,567).It can be conluded that exposure to either electric cigarette (ENDS) or conventional cigarette gives significant effect to cell nucleus pycnosis. Meanwhile, the effect comes from exposure of electric cigarette smoke (ENDS) has no significant difference with conventional cigarette. Keywords:  histopathological appearance of  left ventricle, electrical cigarette, ENDS, conventional cigarette ABSTRAKRokok elektrik (ENDS) dan konvensional mengandung karbonmonoksida (CO) yang diduga berperan utama menyebabkan penyakit kardiovaskuler.CO merupakan zat yang berbahaya karena sebagai radikal bebas dan sifatnya yang memiliki afinitas yang tinggi terhadap Hemoglobin. Hal ini dapat menyebabkan hipoksia jaringan yang mengakibatkan kematian sel (nekrosis) ditandai dengan inti sel yang piknosis. Tujuan penelitian ini untuk mengidentifikasi gambaran histopatologi ventrikel kiri tikus terhadap paparan rokok elektrik (ENDS) dan konvensional. Penelitian ini merupakan penelitian eksperimental dengan rancangan post test only control group design. Sampel adalah tikus Rattus norvegicus dengan jumlah 18 ekor dibagi dalam 3 kelompok, yakni kelompok K sebagai kontrol negatif, kelompok P1 diberikan paparan Rokok Konvensional dan kelompok P2 diberikan paparan rokok elektrik (ENDS). Sampel diperlakukan selama 30 hari, kemudian diterminasi untuk pengambilan organ jantung dan dibuat preparat dengan pengecatan HE. Pembacaan preparat dengan mikroskop perbesaran 400x untuk melihat inti sel piknotik pada 5 lapang pandang. Data dianalisis menggunakan uji Oneway ANOVA dengan p<0,05 dan CI=95%. Dari hasil penelitian didapatkan perbedaan yang bermakna jumlah inti sel piknotik pada ketiga kelompok (p-value=0,008). Terdapat perbedaan yang signifikan antara kelompok K dan P1 (p=0,004), kelompok K dan P2 (p=0,012). Namun antar kelompok P1 dan P2 tidak terdapat perbedaan bermakna (p=0,567).Paparan rokok elektrik dan konvensional memiliki efek yang signifikan dibanding kontrol terhadap jumlah inti piknotik. Namun, Jumlah inti sel piknotik ventrikel kiri tikus tidak mengalami perbedaan bermakna antara paparan asap rokok elektrik (ENDS) dan konvensional. Kata kunci: Histopatologi ventrikel kiri, rokok elektrik,ENDS, rokok konvensional.   Universitas Muhammadiyah Surabaya 2017-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/516 10.30651/qm.v1i02.516 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 02 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 02 (2017) 2548-9526 2541-2272 10.30651/qm.v1i02 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/516/458 Copyright (c) 2017 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/545 2021-01-26T03:22:11Z qanunmedika:AR

Peran Jalur Phosphatidyl-Inositol-3-kinase (PI3K) dalam Resistensi Kemoterapi pada Kanker Abidin, Zanuar PI3K resistensi kemoterapi kanker Cancer has the ability to develop resistance to chemotherapy and increased prevalence of this drug-resistant cancer requires further research and development of treatment. There are several mechanisms that can stimulate chemotherapy resistance, such as drug inactivation, drug effectiveness mechanism, HER2 role, PI3K pathway, DNA damage repair, and apoptotic inhibition. The PI3K pathway is an important signal transduction pathway in the growth and development of cancer. This pathway plays a role in several functions, such as proliferation, cell growth, and tumor survival. PI3K activation has been identified in some cases of cancer, including breast cancer. This pathway undergoes excessive activation resulting in resistance to chemotherapy and increased metastasis. Universitas Muhammadiyah Surabaya 2018-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/545 10.30651/qm.v2i01.545 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 01 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 01 (2018) 2548-9526 2541-2272 10.30651/qm.v2i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/545/835 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/550 2021-01-26T03:22:11Z qanunmedika:AR

Femur Pathological Fracture Caused by Metastatic Bone Disease Derived from Foot Squamous Cell Carcinoma ., Ferdiansyah Edward, Mouli Basuki, Muhammad Hardian Aryawan, Deny Mory Squamous Cell Carcinoma metastatic Femur pathological fracture Metastatic Bone Disease Background : Bone is an organ and the most common site that prone to metastatic cancer and cause serious morbidity. Besides, metastatic cancer to bone will limit skeletal function so that decrease quality of life and even death that most of them caused by its complication.Objective : Reporting a rare case about Squamous Cell Carcinoma that cause femur pathological fracture caused by Metastatic Bone Disease.Material and Method : Case report in women patients 55 years old with femur close fracture one-third middle caused by Metastatic Bone Disease in RSUD Soetomo Surabaya, period May 2015-March 2016.Data is taken retrospectively from medical record through interview, physical examination, radiological examination, and laboratory.Result and Discussion : Patients are treated in hospital because of femur close fracture one-third middle caused by Metastatic Bone Disease.  Based on physical and radiological examination, it is decided being done by skin traction first. The next plan is surgery. Patients are treated with interlocking nail left femur. Evaluation after surgery is done with medical rehabilitation, that is ROM exercise. Until now, 9 months after surgery, patients still control routinely to be done chemotherapy and there is improvement in patient’s condition.Conclusion : Metastatic process in bone often cause pathological fracture. Bone Metastatic is common from Breast, Lung, Prostate and Kideney Cancer. There was no publication before about Bone Metastatic Disease come from Squamous Cell Cancer. Mirel’s score is used as guiding in fixation prior to the next treatment. Decision of surgery is considered through patient’s objective and subjective appraisal that can be calculated in Abdurrahman score system. Universitas Muhammadiyah Surabaya 2017-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/550 10.30651/qm.v1i02.550 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 02 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 02 (2017) 2548-9526 2541-2272 10.30651/qm.v1i02 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/550/462 Copyright (c) 2017 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/555 2021-01-26T03:22:11Z qanunmedika:AR

Profile of Syndromic Kraniosinostosis for 5 Years in RSUD dr.Soetomo Surabaya Profil PAsien Sindromik Kraniosinostosis selama 5 Tahun di dr.Soetomo Hospital Surabaya Widita, Adinda Hutagalung, Magda Putri, Indri Lakhsmi syndromic craniosinostosis apert syndrome Crouzon syndrome Pfeiffer Syndrome Sindromik Kraniosinostosis Apert Syndrome Crouzon Syndrome Pfeiffer Syndrome Craniosynostosis is a premature cover of one or more sutures, which may occur as part of syndrome (syndromic) or as a separate defect / isolated defect (nonsyndromic). Cohen and Kreirborg state the incidence of Apert and Crouzon syndromes of 15.5: 1,000,000 and 16.5: 1,000,000 per birth. The incidence of craniosynostosis in Indonesia still not handled properly, as well as low recognition in this disorder. RSUD Dr. Soetomo as an eastern referral hospital, which has one of the centers of plastic surgery education in Indonesia, where craniosynostosis syndromic often occurs, so we have the most total cases handled in Indonesia. This is a retrospective descriptive study discusses more about the profile of patients syndromic craniosinostosis for 5 years in dr. Soetomo Surabaya, performed on twenty-four first syndromic craniosinostosis patients at Dr. Soetomo Surabaya period 1 January 2008 - 31 December 2013. Out of 24 total patients, 12 cases of apert (29%), 6 crouzon cases (54%) and 3 cases of pfeiffer (17%) were obtained. Based on sex, more commonly found in women (54%). With the most common age the patient comes first is aged 5-10 years (37%). Each patient has an average of 2 surgeries, with a type of surgical action on cranial vault remodeling patients. Abnormalities of syndromic craniosinostosis found the most common in women and apert syndrome in RSUD dr.Sutomo. Where the most common age when the arrival of 5-10 years, caused by the late diagnosis of the disorder Craniosynostosis is a premature cover of one or more sutures, which may occur as part of syndrome (syndromic) or as a separate defect / isolated defect (nonsyndromic). Cohen and Kreirborg state the incidence of Apert and Crouzon syndromes of 15.5: 1,000,000 and 16.5: 1,000,000 per birth. The incidence of craniosynostosis in Indonesia still not handled properly, as well as low recognition in this disorder. RSUD Dr. Soetomo as an eastern referral hospital, which has one of the centers of plastic surgery education in Indonesia, where craniosynostosis syndromic often occurs, so we have total cases handled in Indonesia. This is a retrospective descriptive study discusses more about the profile of patients syndromic craniosynostosis for 5 years in dr. Soetomo Surabaya, performed on twenty-four first syndromic craniosynostosis patients at Dr. Soetomo Surabaya period 1 January 2008 - 31 December 2013. Out of 24 total patients, 12 cases of apert (29%), 6 crouton cases (54%) and 3 cases of Pfeiffer (17%) were obtained. Based on sex, more commonly found in women (54%). With the most common age, the patient comes first is aged 5-10 years (37%). Each patient has an average of 2 surgeries, with a type of surgical action on cranial vault remodeling patients. Abnormalities of syndromic craniosinostosis found the most common in women and apert syndrome in RSUD dr.Sutomo. Where the most common age when the arrival of 5-10 years, caused by the late diagnosis of the disorder. Universitas Muhammadiyah Surabaya 2017-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/555 10.30651/qm.v1i02.555 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 02 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 02 (2017) 2548-9526 2541-2272 10.30651/qm.v1i02 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/555/463 Copyright (c) 2017 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/631 2021-01-26T03:22:11Z qanunmedika:AR

Rekomendasi Upaya Pemasaran dengan Model Value-Based Matrix pada Marketing 3.0 untuk Meningkatkan Hunian Unit Obsgyn RS ‘Aisyiyah Bojonegoro Rosyida, Fahtia Nur Penelituan ABSTRACTThe occupancy rate of obsgyn ward ‘Aisyiyah Bojonegoro Hospital is still very low (33,5%) compared to occupancy target (50.0%) in last five years. The purpose of this study was to identify the expectations of consumers to 4Ps (Product, Price, Place, Promotion) obsgyn inpatient services in mind, heart, spirit and the mission, vision, and values ‘Aisyiyah Bojonegoro hospital. Further arranged on marketing efforts with Value-Based Matrix models on marketing 3.0 for an alternative answer to the problems of dwelling of obsgyn ward ‘Aisyiyah Bojonegoro Hospital. This is a descriptive with cross-sectional approach study. The data was taken in January-August 2016. The data used are primary and secondary data. Primary data was taken with a questionnaire guidance to 152 patients respondent from obsgyn clinic specialist and 22 patients respondent from Maternal and Child Health (MCH) outpatient 'Aisyiyah Bojonegoro Hospital. The sampling method was accidental sampling. Secondary data such as mission, vision, and values are taken from the profile hospital hospital. Analysis of the respondents expectations and the hospitals mission, vision, and values are taken to be FGD material with hospital management to explore alternative marketing efforts that will be done. The researchers analysis from FGD results lead to the conclusion in the form of 19 marketing efforts recommendations based on value-based matrix in marketing 3.0 by identifying consumer expectations and the mission, vision, values hospital. These marketing efforts recommendations is expected to increase the occupancy rate of obsgyn ward ‘Aisyiyah Bojonegoro Hospital.Keywords:Marketing Efforts, Value Based Matrix, Marketing 3.0. Universitas Muhammadiyah Surabaya 2018-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/631 10.30651/qm.v2i01.631 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 01 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 01 (2018) 2548-9526 2541-2272 10.30651/qm.v2i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/631/832 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/632 2021-01-26T03:22:11Z qanunmedika:AR

Laporan Kasus : Thymik Karsinoma dengan Efusi Perikard Subkhan, Mohammad thymic carcinoma pericard effusion Thymoma and thymic carcinoma are anterior mediastinal tumors derived from the thymus gland. Thymoma generally provides a benign picture although histologically it has been invasive. The causes of thymoma is often found without typical symptoms and difficult to detect by physical examination. Thymic carcinoma is a malignant tumor, faster to grow and spread to other parts of the body and more difficult to treat, it is the most common tumor found in anterior mediastinum is about 47%. A male 29 years old, complained of chest pain since 1 month and getting heavier in 2 weeks. In lateral AP thoracic image founded opasitas mass density with a firm margin of the regular edge on the lateral projection lies in the anterior mediastinum. Echocardiography results was Pericard effusion. FOB Examination was extraluminal mass accumulation of the main carina. CT Scan Thorax founded Impresses mass in anterior mediastinum inherent / masking superior vena cava, suspicious of a thymoma, teratodermoid tumor, ascendent thoracic aorta within normal limits. In these patients, thymectomy was performed with debulking and histology results from mass with non-Thymic carcinoma Keratinizing epidermoid carcinoma. The patient's condition after surgery improved with normal chest radiograph picture and subsequent outpatient. Universitas Muhammadiyah Surabaya 2017-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/632 10.30651/qm.v1i02.632 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 02 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 02 (2017) 2548-9526 2541-2272 10.30651/qm.v1i02 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/632/464 Copyright (c) 2017 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/633 2021-01-26T03:22:11Z qanunmedika:AR

Diagnosis dan Tatalaksana Tromboemboli pada Kehamilan Airlangga, Muhammad Perdana deep vein thrombosis pulmonary embolism pregnancy Venous thromboembolism is both more common and more complex to diagnose in patients who are pregnant than in those who are not pregnant. Pulmonary embolism and deep-vein thrombosis are the two components of a single disease called venous thromboembolism. Pulmonary embolism is the leading cause of maternal death in the developed world. Delayed diagnosis, delayed or inadequate treatment, and inadequate thromboprophylaxis account for many of the deaths due to venous thromboembolism. Successful strategies for the management of venous thromboembolism in nonpregnant patients have been established. However, many of the recommendations for the treatment of pregnant patients who have venous thromboembolism are not based on high-quality data; rather, they are derived from observational studies and extrapolation from studies involving nonpregnant patients. The purpose of this review is to provide a practical approach to the diagnosis, management, and prevention of venous thromboembolism in pregnant patients. Universitas Muhammadiyah Surabaya 2017-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/633 10.30651/qm.v1i02.633 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 02 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 02 (2017) 2548-9526 2541-2272 10.30651/qm.v1i02 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/633/465 Copyright (c) 2017 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/634 2021-01-26T03:22:11Z qanunmedika:AR

Tinjauan Anatomi Klinik dan Manajemen Bell's Palsy Mujaddidah, Nur Bell's palsy facial nerve self-limited Bell's Palsy is a peripheral facial nerve weakness (facial nerve) with acute onset on one side of the face. This condition causes the inability of the patient to move half of his face consciously (volunter) on the affected side. The Bell's Palsy incidence is 20-30 cases out of 100.000 people and accounts for 60-70% of all cases of unilateral facial paralysis. The disease is self-limited, but causes great suffering for patients who are not treated properly. Controversy in the management is still debated, and the cause is still unknown. The underlying hypothesis is ischemic, vascular, viral, bacterial, hereditary, and immunologic. Therapy done so far is to improve facial nerve function and healing process. The management of the therapy used will be closely related to the structure of the anatomy and its functions and associated abnormalities. The modalities of Bell's Palsy therapy are with corticosteroids and antivirals, facial exercises, electrostimulation, physiotherapy and decompression operations. Approximately 80-90% of patients with Bell's palsy recover completely within 6 months, even in 50-60% of cases improved within 3 weeks. Approximately 10% experienced persistent facial muscle asymmetry, and 5% experienced severe sequelae, and 8% of cases were recurrent. Universitas Muhammadiyah Surabaya 2017-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/634 10.30651/qm.v1i02.634 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 1 No. 02 (2017) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 1 No 02 (2017) 2548-9526 2541-2272 10.30651/qm.v1i02 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/634/466 Copyright (c) 2017 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/640 2021-01-26T03:22:11Z qanunmedika:AR

Perbedaan Pengaruh Pemberian Insulin dan Ekstrak Zingiber officinale Terhadap Berat Badan Lahir Anak Rattus Norvegicus Model Diabetes Melitus Pragestasional Septiasari, Ratih Mega Penelitian Diabetes during pregnancy can be divided into pregestational diabetes and gestational diabetes. The risk of fetal Diabetes Mellitus pregestational (DMpG) patients can be either macrosomia or low birth weight. The purpose of this study was to investigate the differences in the administration effect of insulin and Zingiber officinale extract on birth weight of Rattus norvegicus pregestational diabetes mellitus model. This research is an experimental research using post test only control group design. Samples contained 30 pregnant Rattus norvegicus and divided into 5 groups, where K0 (negative control group) and K1 (positive control group) given aquadest 1cc, K2 given insulin 1IU, K3 given ginger extract 500mg/ kg BW, K4 given insulin 1IU and ginger extract 500mg/ kg BW. Treatment was administered during the first 16 days of pregnancy. On the 17th day, the rats were terminated and then the birth weight was measured with the scale. Data analysis using One-way ANOVA test followed by Tamhane test. The results showed that there was a difference of birth weight in the insulin treatment group and ginger extract treatment group (p-value = 0,037 < α =0,05). The conclusion of this study was Zingiber officinale can be used as a single therapy or combination with insulin of Rattus norvegicus pregestational diabetes mellitus model.  Universitas Muhammadiyah Surabaya 2018-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/640 10.30651/qm.v2i01.640 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 01 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 01 (2018) 2548-9526 2541-2272 10.30651/qm.v2i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/640/805 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/641 2021-01-26T03:22:11Z qanunmedika:AR

Pengaruh Insulin, Jahe dan Kombinasi Keduanya Terhadap Jumlah Sel Trofoblas Rattus Norvegicus Model Diabetes Pragestasional Zahrotin, Alif penelitian Diabetes mellitus (DM) is a metabolic disease with characteristics of hyperglycemia that has an effect on increasing morbidity and mortality in the mother. One of the complications of pregestational DM (pGDM) is preeclampsia (PE). The perinatal mortality rate increases 20x in pGDM women with PE complication. Exposure to hyperglycemia causes an increase in oxidative stress that increases apoptosis of trophoblast cells which in turn causes the decrease of proliferation and the number of trophoblastic cells and leads to endothelial dysfunction and hypoxia. The purpose of this study was to distinguish the effect of insulin administration and ginger extract on the number of trophoblast cells of R. norvegicus. This research was an experimental research using post-test only control group design. The population used were pregnant R. norvegicus. The sampling technique was simple random sampling with independent variables are insulin and Z. officinale extract and the dependent variable is the number of trophoblast cells. Data analysis of the number of trophoblast cells used wereKruskal-Wallis and Mann-Whitney test. The result showed that there was a significant difference in the trophoblast cell number with p-value <0,05 (p = 0,001) on positive control with insulin treatment group. The conclusion of this study was the presence of ginger extract can be used as a single therapy or combination with insulin for pregestational diabetes. Universitas Muhammadiyah Surabaya 2018-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/641 10.30651/qm.v2i01.641 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 01 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 01 (2018) 2548-9526 2541-2272 10.30651/qm.v2i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/641/806 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/642 2021-01-26T03:22:11Z qanunmedika:AR

Perbandingan Pengaruh Pemberian Ekstrak Zingiber officinale dengan Insulin terhadap Berat Plasenta pada Rattus norvegicus Model Diabetes Mellitus Pragestasional Aftabuddin, Sepfrita Katerine penelitian Diabetes mellitus is a chronic disease that occurs in the community, with 1.9% prevalence of in the world is and the seventh leading cause of death in the world. It is estimated to increase up to 21.3 million by 2030 if the pattern of Diabetes management is not well developed. In 2007, the prevalence of Pregestational Diabetes Mellitus in Indonesia was 12% and had an impact on placental development that was important during pregnancy for fetal survival with placental weight as the indicator. Diabetes Mellitus pregestational therapy is insulin, however, it often causes complications. Oral hyperglycemic drugs with ginger dose extract of 500mg/kgBW significantly decreased serum glucose levels in diabetic-induced rats. Ginger extract is expected to decrease blood glucose levels so as to increase the weight of placenta. The purpose of this study was to determine the effect of insulin and ginger extract on the weight of placenta Rattus norvegicus model of diabetes mellitus. This research is an experimental research using post test only control group design. The population used in this study was pregnant Rattus norvegicus with simple random sampling. The independent variables are insulin and ginger extract and the dependent variable is the weight of placenta. Data analysis for placental weight using Kruskal Wallis was continued by Post Hoc Bonferroni test. Test results for placental weight p>α (0.63 > 0.05) mean that there is no difference in placental weight between negative control, positive control, and treatment group. The conclusion of this study is there is no significant difference between groups, however, based on mean data the weight of placenta Rattus norvegicus model of diabetes mellitus with insulin and ginger extract therapy are higher than the control group Universitas Muhammadiyah Surabaya 2018-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/642 10.30651/qm.v2i01.642 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 01 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 01 (2018) 2548-9526 2541-2272 10.30651/qm.v2i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/642/759 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/650 2021-01-26T03:22:11Z qanunmedika:AR

Perbedaan Pengaruh Pemberian Ekstrak Zingiber Officinale dengan Insulin terhadap Jumlah Anak Hidupa, Mati atau Resorbsi dan Cacat pada Rattus Norvegicus Model Diabetes Melitus Pragestasional siskaningtia, yasinta pregestational diabetes mellitus Zingiber officinale extract insulin fetal death malformation Diabetes mellitus was metabolic disease which had chronic hyperglycemic characteristic  .The risk of fetal death and malformation which were higher in pregestational diabetes. The complications could be suppressed through insulin therapy. The reasons about insulin side effect made herbal therapy began to develop, such as ginger (Zingiber officinale). This research aimed to prove the difference effect of Zingiber officinale extract and insulin on the number of fetal dead or resorbsion, and malformations in Rattus novergicus model of pregestational diabetes mellitus. Thirty rats were divided into 1 negative control group and 4 groups which were modeled with type 1 DM with streptozotocin (STZ) i.p dose 50mg/kgBB in citrate buffer 0,05M pH 4,5. Rat with blood glucose levels >200mg/dL after 2 days of induction, were sampled and bundled. The treatment groups were given 1IU insulin, ginger extract 500mg/kgBB, and 1IU insulin plus ginger extract 500mg / kgBB. The 17th day of pregnancy fetal sample was observed macroscopically. Analysis data with One Way ANOVA and Post Hoc with LSD. There were significant differences in fetal malformation with p value was 0,012 and death or resorbsion were 0,001. Ginger extract could be used as a single therapy or combination therapy to reduced the number of fetal death or malformation. Universitas Muhammadiyah Surabaya 2018-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/650 10.30651/qm.v2i01.650 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 01 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 01 (2018) 2548-9526 2541-2272 10.30651/qm.v2i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/650/760 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/652 2021-01-26T03:22:11Z qanunmedika:AR

Hemangioma Pedis and Tuberculoma Pedis Sinistra in Children MD, Ferdiansyah Edward, Mouly Basuki, Muhammad Hardian Amrullah, Ahmad Hannan Hemangioma pedis Tuberculoma pedis oncologi orthopaedics HISTORY: The girl 15 years old, had main complaint, there was a mass in her pedis since she got 2 years old, look red, no pain although in walk, size equal with the skin. The mass got bigger and pain in walk. The mass get bleedy after had crushed by stone, after that bleedy always happen when there was a contact, although soft touch. Patient had history contact with tuberculosis patient.INTERESTING POINTS FOR DISCUSSION: Tuberculoma is a mass that happened because infected bacil mycobacterium tuberculosis, hemangioma is a soft tissue mass that formed by vascular. hemangioma commonly happened in children about 4-10% in children’s tumor. It happened in a girl 3-5 more times than in a boy. Both of them are rare happen in the same time, especially in pedis. From this case, we  can found both type in the same patient.SOLUTION AND RATIONALE: For this case of soft tissue tumor,we use open biopsy. After we found the result , the best treatment for hemangioma and tuberculoma of the pedis for this case is below knee amputation.FINAL OUTCOME: For this case, the best treatment is amputation, and after amputation, the patient never complain about pain anymore, she feel satisfied and overall her quality of life is improving. Universitas Muhammadiyah Surabaya 2018-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/652 10.30651/qm.v2i01.652 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 01 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 01 (2018) 2548-9526 2541-2272 10.30651/qm.v2i01 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/652/817 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/654 2021-01-26T03:22:11Z qanunmedika:AR

CD4 T-lymphocyte cell counts and pneumonia in HIV children Masri, Siti Habsyah Penelitian CD4 T-lymphocyte cell counts and pneumonia in HIV-infected childrenAbstractBackground Pneumonia is a major cause of morbidity and the most common cause of mortality in infants and children who are infected with Human Immunodeficiency Virus (HIV). For HIV-infected children, the risk for developing pneumonia has been closely related to an individual’s having a lower CD4 T-lymphocyte cell count.Objective To evaluate for an association between CD4 T-lymphocyte cell count and pneumonia in HIV-infected childrenMethods. A cross sectional study was conducted among all children diagnosed with and without pneumonia who had HIV at Adam Malik Hospital, Medan. Data were taken from patients’ medical records between January 2008 to December 2015. We studied demographic, clinical, radiological and CD4 T-lymphocyte cell counts on admission, as well as mortality outcomes.Results  A total of 174 HIV-infected children were included in this study. Pneumonia was found in 47 children with 39 months as the median age of onset. The mean difference in CD4 levels was 0.912 cells/mm3 units (95% CI to -5.79 to 7.62) with higher mean in the pneumonia group than in the non-pneumonia group, but no significant difference. In addition, no significant association were found between nutritional status and incidence of pneumonia [OR 1,050; 95% CI 0,537 to 2,053); P = 0.886) or between immunodeficiency status and pneumonia, [OR 0.986;(95% CI 0,25 to 3.885);P= 0,984]. The common opportunistic infection in our subjects besides pneumonia were diarrhea, oral candidiasis and pulmonary TB, or some combination there of.  Severe malnutrition was also present in some subjects.Conclusions There is no significant association between CD4 T-lymphocyte cell count and pneumonia in HIV-infected children Key words CD4, HIV, pneumonia, children  Universitas Muhammadiyah Surabaya 2018-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/654 10.30651/qm.v2i01.654 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 01 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 01 (2018) 2548-9526 2541-2272 10.30651/qm.v2i01 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/654/833 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/655 2021-01-26T03:22:11Z qanunmedika:AR

Kemampuan Konsentrasi Berhubungan dengan Waktu Reaksi tetapi Tidak Berhubungan dengan Pola Tidur di Pondok Pesantren -, Handayani Sufriyana, Herdiantri Firdaus, Abraham Ahmad Ali Concentration ability reaction time sleep pattern kemampuan konsentrasi waktu reaksi pola tidur pesantren Pesantren as dormitory-based educational institutions familiarize their students with sleep patterns and certain activities, including sports that increase reaction time. This study aims to prove the relationship between sleep patterns and reaction time with the ability of concentration in adolescent girls. This cross-sectional study was conducted on 27 Wachid Hasyim boarding school students whose average age was 17.49 years (IK 95% 17.33-17,66). Subjects filled out the Pittsburgh Sleep Quality Index (PSQI) and Krawietz Concentration Scale (KCS) questionnaires and underwent the Ruler Drop Test. All three consecutively measured sleep patterns, concentration ability and reaction time. The KCS questionnaire assessed four components: 1) Control of Focus (CF); 2) Uncontrolled Focus (UF); 3) Reading and Listening Focus (RLF); And 4) Control of Focus Before Sleep (CFBS). The results show that the subject has a PSQI score of 6.41 (95% IK 5.29-7.52) that exceeds the normal limit. However, subjects had a rapid reaction time (55.6%) and a KCS score of 216.78 (95% IO 958.06-225.49; p = 0.044) higher than their mean value. There was no relationship between sleep patterns with concentration ability (p = 0.487). There is a negative correlation trend between sleep patterns and CFBS (r = -322; p = 0.050) or with reaction time (r = -394; p = 0.069). There was a relationship between reaction time and overall concentration (p = 0.048) and partially on RLF + CFBS (p = 0.029). There is a positive correlation between the reaction time in the form of the catch distance response with CFBS (r = 0.326; p = 0.049). The effort of pesantren in maximizing the use of time that caused poor sleep pattern was found did not decrease the ability of student concentration. Exercise that increases reaction time is found to reduce their ability to start sleeping Universitas Muhammadiyah Surabaya 2018-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/655 10.30651/qm.v2i01.655 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 01 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 01 (2018) 2548-9526 2541-2272 10.30651/qm.v2i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/655/774 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/874 2021-01-26T03:22:11Z qanunmedika:AR

Korelasi Rasio Kolesterol Total Terhadap HDL dengan Prediksi Outcome Stroke Iskemik Akut yuziani, yuziani Stroke is the leading cause of death in Indonesia with the significant increase in prevalence each year. The dominant stroke is ischemic stroke which is often caused by abnormal blood lipid profile which is the increase of total cholesterol to High-Density Lipoprotein (HDL) ratio that is an increase of total cholesterol and decrease of HDL. The risk of ischemic stroke will increase if there is an increase of total cholesterol to HDL ratio because it can stimulate the formation of atherosclerosis. The increase of total cholesterol and the low of HDL level after stroke attack will inhibit the recovery, both of them can influence outcomes and increase mortality in ischemic stroke. This study aim is to determine the correlation between total cholesterol to HDL ratio with outcomes prediction of acute ischemic stroke.This study is an analytic study using cross-sectional study design. Sampling studied are all of the acute ischemic stroke patients at General Hospital of Cut Meutia North Aceh District from May to August 2017 used total sampling that met inclusion and exclusion criteria. Analysis of the correlation between total cholesterol to HDL ratio with outcomes prediction of acute ischemic stroke uses Spearman correlation test with a significant degree (α) of 0,01. The result of this study showed that the mean of total cholesterol to HDL ratio was 3,7 (moderate risk) and outcomes prediction of acute ischemic stroke was good. There is a correlation between total cholesterol to HDL ratio with outcomes prediction of acute ischemic stroke (r=- 0,623;p=0,000). Lower total cholesterol to HDL ratio was correlated with better outcomes of acute ischemic stroke. Total cholesterol to HDL ratio can be used as a predictor of ischemic stroke outcomes. Universitas Muhammadiyah Surabaya 2018-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/874 10.30651/qm.v2i01.874 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 01 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 01 (2018) 2548-9526 2541-2272 10.30651/qm.v2i01 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/874/834 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/975 2021-01-26T03:22:11Z qanunmedika:AR

Triple Curve Scoliosis Presented with Developmental Dysplasia of the Left Hip in Marfan Syndrome Widhiyanto, Lukas Martanto, Tri Wahyu Brahmana, Febrian Introduction: Marfan syndrome is an autosomal dominant disorder of connective tissue, and skeletal system involvements are the cardinal features.  Triple rigid large major curve in conjunction with developmental dysplasia of the hip in Marfan syndrome is rare then sagittal and coronal imbalance correction on this case is challengingCase Presentation: We reported a case of 12 years old female with Marfan syndrome presented triple rigid large Major curve scoliosis on left cervico-thoracal, right main  thoracal and left thorakolumbal, also developmental dysplasia of the left hip has been done correction surgery consist of open reduction following cast immobilization of the left hip, multiple ponte osteotomy and asymetrical pedicle substraction osteotomy to correct sagittal and coronal imbalance.Discussion: the treatment of scoliosis in patients with Marfan syndrome parallels that in patients with idiopathic scoliosis and spinal fusion and instrumentation should be considered for curves greater than 45 to 50 degrees. Posterior technique, Ponte osteotomy correct 10 to 20 degrees and pedicle substraction osteotomy correct 30 to 40 degrees at each segment are effective for managing sagittal and coronal imbalance in scoliosis. Open reduction developmental dysplasia of the hip to overcome complicated coronal balance correction.Conclusion : Detailed planning scoliosis surgery is needed to correct a rare the sagittal and coronal imbalance due to scoliosis complicated with developmental dysplasia of the hip in Marfan syndrome. Universitas Muhammadiyah Surabaya 2018-07-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/975 10.30651/jqm.v2i2.975 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 2 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 2 (2018) 2548-9526 2541-2272 10.30651/jqm.v2i2 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/975/1388 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1089 2021-01-26T03:22:11Z qanunmedika:AR

Autopsi Verbal pada Kasus Kematian Mendadak di Instalasi Kedokteran Forensik RSUD Dr. Soetomo pada 1 November 2017 - 30 November 2017 Pratiwi, Ambarini Isa ABSTRAKKematian mendadak biasanya terjadi pada orang-orang yang merasa sehat dan tidak memiliki keluhan sebelumnya. Sebab kematian pada kasus kematian mendadak perlu dikonfirmasi oleh dokter secara legal pada surat keterangan kematian. Dalam rangka menentukan sebab kematian kasus kematian mendadak harus melakukan autopsi. Namun, pelaksanaan autopsi pada kasus kematian mendadak sangat kecil. Berdasarkan data di Instalasi  Kedokteran Forensik RSUD Dr. Soetomo periode 2014-2016, hanya sekitar 12% kasus kematian mendadak yang dilakukan autopsi. Autopsi verbal dikembangkan untuk menentukan sebab kematian jenazah tanpa autopsi. Penggunaan autopsi verbal diharapkan dapat digunakan untuk menentukan sebab kematian yang valid sehingga pencatatan kematian di rumah sakit akan semakin baik. Penelitian ini menggunakan desain deskriptif observasional berdasarkan data primer hasil wawancara kepada keluarga 20 sampel jenazah yang memenuhi kriteria inklusi dan eksklusi. Penelitian ini dilakukan pada jenazah kasus kematian mendadakdi Instalasi Kedokteran Forensik pada 1 November 2017 – 30 November 2017. Dari 20 jenazah kasus kematian mendadak, 75% jenazah merupakan jenazah laki-laki. Kejadian kematian mendadak didominasi kelompok usia 40-60 tahun (50%). Sebab kematian mendadak didominasi sebab kematian terkait sistem kardiovaskular (55%). Pada penelitian autopsi verbal pada kasus kematian mendadak, laki-laki mempunyai risiko lebih tinggi dibandingkan perempuan dan angka kejadian akan meningkat seiring bertambahnya usia. Penyebab kematian pada kasus kematian mendadak banyak ditemukan pada kematian terkait sistem kardiovaskular, sistem respiratori, sistem saraf pusat, sistem pencernaan dan SIDS.Kata kunci: Kematian mendadak, autopsi verbal, sebab kematian. ABSTRACTSudden death is common and usually happen to a people who are feeling healthy and having no symptom before. Any suspicions about the cause of sudden death are need to be confirmed by the doctor with the legal cause of death written in the letter of death. In order to confirm the cause of sudden death the doctor has to held an autopsy. Unluckily, there is only little number of an autopsy are held in the case of sudden death. Based on the data in Instalasi Kedokteran Forensik RSUD Dr. Soetomo, an autopsy are held only about 12% from all the case of sudden death in the periode 2014-2016. Autopsy verbal are developed in order to define the cause of death without an autopsy. The used of an autopsy verbal expected to define a valid cause of death therefore the death registration in the hospital will be good. This research used observasional descriptive study which use primary data collected from the interview records with the family of the dead body involving a sample of 20 dead body after considering the inclusion and exclusion criteria. The study was conducted in the dead body who were on sudden death case admitted to Instalasi Kedokteran Forensik from November, 1st 2017-November, 30st 2017. Out of 20 patients with sudden death case, 75% was male. The incidence of sudden death was dominated by 40-60 years age group (50%). The cause of the sudden death was dominated by the cardiovascular system (55%). In this study of the autopsy verbal on sudden death, males were more at risk than females where the incidence was increased by the increasing of the age. The cause of sudden death were mostly found in the cardiovascular system, followed by respiratory system, central nervous system, digestive system, and SIDS. Keywords: Sudden Death, Autopsy Verbal, Cause of death. Correspondence: Ambarini Isa Pratiwi, Jln. Serayu BH-12, Wisma Troposo, Waru, Sidoarjo Phone: 085785406614; E-mail: ambrnsprtw@gmail.com Universitas Muhammadiyah Surabaya 2018-07-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1089 10.30651/jqm.v2i2.1089 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 2 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 2 (2018) 2548-9526 2541-2272 10.30651/jqm.v2i2 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/1089/1383 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1232 2021-01-26T03:22:11Z qanunmedika:AR

Comparing Effectiveness of Hay Infusion and Sugar Fermentation Solution as Ovitrap's Attractans to Aedes aegypti Widoretno, Nastiti Dengue Hemorrhagic Fever (DHF) is still one of the major public health problems in the world and Indonesia. There are several methods of mosquito vector control, one of them is the use of ovitrap and the addition of attractants which is a compound that may attract gravid mosquitoes to lay eggs. Some examples of attractants are hay infusion and sugar fermentation solution. This research aimed to compare effectiveness of hay infusion  and sugar fermentation solution as Aedes aegypti attractants. This research type was true experimental laboratory with complete randomized design which is divided into 3 groups of ovitrap containing aquades as control, 20% hay infusion and 20% sugar fermentation solution. Ovitraps with those attractants were put into a mosquito coop containing 25 gravid female mosquitoes. Mosquito’s eggs counting was done after 2 days with 9 times repetition. The data were then analyzed using Kruskal-Wallis and Mann-Whitney test. It was found that the difference of mosquito’s eggs number in the ovitrap containing the fermentation solution of sugar and hay infusion had a significance value of 0.000 (p> 0,05). It means that hay infusion is more effective compared with sugar fermentation. Keywords                   : DHF, ovitrap, attractant, hay infusion, sugar fermentation solution Universitas Muhammadiyah Surabaya 2018-07-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1232 10.30651/jqm.v2i2.1232 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 2 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 2 (2018) 2548-9526 2541-2272 10.30651/jqm.v2i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/1232/1385 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1237 2021-01-26T03:22:11Z qanunmedika:AR

Analisis Histopatologi Pembuluh Darah Tikus Berdasarkan Jarak Luka Masuk Pasca Paparan Listrik Djunaedy, Annisa Sarfina Elfiah, Ulfa Fatmawati, Heni Electrical injury merupakan suatu kerusakan pada jaringan atau organ tubuh akibat adanya aliran arus listrik yang melewati tubuh. Pembuluh darah merupakan salah satu jaringan yang mengalami kerusakan ketika terjadi electrical injury. Salah satu kerusakan pada pembuluh darah adalah adanya trombus yang dapat mengganggu aliran darah sehingga menyebabkan  tatalaksana electric injury menjadi kurang baik. Tujuan umum dari penelitian ini adalah menganalisis histopatologi pembuluh darah tikus berdasarkan jarak luka masuk pasca paparan listrik. Jenis penelitian yang digunakan adalah penelitian eksperimental sebenarnya dengan  rancangan post test only control group design. Penelitian ini menggunakan 25 ekor tikus wistar yang dibagi menjadi lima kelompok. Perlakuan yang diberikan berupa paparan listrik sebesar 140 V selama 17 detik. Kelompok kontrol merupakan kelompok yang tidak diberi paparan listrik, kelompok H0 diterminasi pada hari ke-0 pasca paparan listrik, kelompok  H3 diterminasi pada hari ke-3 pasca paparan listrik, kelompok H7 diterminasi pada hari ke-7 pasca paparan listrik, kelompok H10 diterminasi pada hari ke-10 pasca paparan listrik. Pada penelitian ini, hal yang diamati yaitu persentase trombus pada arteri saphena dekstra berdasaran jarak dari luka masuk. Hipotesis diterima apabila hasil analisis data menggunakan One Way Anova atau Kruskall Wallis menghasilkan p<0.05. Secara garis besar, pada hasil penelitian didapatkan bahwa bahwa persentase trombus semakin berkurang ketika semakin jauh dari luka masuk, kecuali pada kelompok H7. Selain itu, hasil penelitian  menunjukkan bahwa secara garis besar persentase trombus  bertambah  seiring berjalannya waktu dan menurun pada waktu tertentu. Namun, pada penelitian ini didapatkan bahwa tidak terdapat perbedaan yang signifikan secara statistik pada gambaran histopatologi pembuluh darah, khususnya trombus pasca paparan listrik berdasarkan jarak luka masuk di hari ke-0, ke-3, ke-7, dan ke-10. Universitas Muhammadiyah Surabaya 2018-07-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1237 10.30651/jqm.v2i2.1237 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 2 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 2 (2018) 2548-9526 2541-2272 10.30651/jqm.v2i2 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/1237/1384 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1433 2021-01-26T03:22:11Z qanunmedika:AR

Toksisitas Senyawa Tembaga(II)Klorida Dihidrat Terhadap Sel Kanker Payudara T74D Secara in vitro Sucipto, Teguh Hari Setyawati, Harsasi Martak, Fahimah Cancer is a transformation of normal cells in the body into malignancy due to the induction of carcinogens. Breast cancer is the second leading cause of death in Indonesia. The field of treatment with inorganic compounds has been widely developed and shows better anticancer activity than organic compounds. This research aims to know the toxicity level of copper value of 29.021 μg/ml. The value of IC 50 obtained <100 μg/ml so that the copperCancer is a transformation of normal cells in the body into malignancy due to the induction ofcarcinogens. Breast cancer is the second leading cause of death in Indonesia. The field oftreatment with inorganic compounds has been widely developed and shows better anticanceractivity than organic compounds. This research aims to know the toxicity level ofcoppervalue of 29.021 μg/ml. The value of IC50obtained<100 μg/ml so that the copper Universitas Muhammadiyah Surabaya 2018-07-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1433 10.30651/jqm.v2i2.1433 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 2 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 2 (2018) 2548-9526 2541-2272 10.30651/jqm.v2i2 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/1433/1389 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1446 2021-01-26T03:22:11Z qanunmedika:AR

Insomnia is not a Risk Factor for Impaired Cognitive Function in Elderly sincihu, yudhiakuari Kurniawati, Nita Background: Elderly are often considered as a burden because of their physical limitations. Reduced cognitive function is one of the important causes for this physical limitation. Quality of sleep used to be associated with changes in cognitive function. Methods: A comparative analytic research to assess insomnia as a risk factor for the incidence of cognitive function impairment in the elderly. A case control study in elderly community at the nursing home St.Yosef, Surabaya. Result: Fifty respondents were taken by consecutive sampling and meeting the inclusion criteria. This study also excluded people with depression, schizophrenia, and users of psychotropic drugs. Eighty four percent of respondents with impaired cognitive function. Not much difference in percentage of insomnia disturbance in control group (37,5%) and case group (35,8%). Fisher's Exact Test show Sig.0,609 and OR=0.926 on CI [(0,194),(4,425)]. Conclusion: It was concluded that insomnia alone was not a risk factor for impaired cognitive modalities. Elderly exposed to sleep disorders have the same tendency to suffer cognitive impairment with unexposed. Universitas Muhammadiyah Surabaya 2018-07-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1446 10.30651/jqm.v2i2.1446 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 2 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 2 (2018) 2548-9526 2541-2272 10.30651/jqm.v2i2 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/1446/1390 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1559 2021-01-26T03:22:11Z qanunmedika:AR

Ekstrak Etanol Teh Hijau (Camellia sinensis) Meningkatkan Kadar Folicle Stimulating Hormone (FSH) dan Jumlah Folikel Antral pada Tikus Betina yang Dipapar Sipermetrin Sari, Melati Puspita Winarsih, Sri Raras, Tri Yudani Mardining Mintaroem, Karyono Latar Belakang: Sipermetrin adalah insektisida jenis piretroid sintetik yang dapat menganggu sistem reproduksi. Sipermetrin juga mampu menghasilkan  reactive oxygene species (ROS) sehingga bertanggung jawab menimbulkan terjadinya stres oksidatif. Teh hijau (Camellia sinensis) mengandung polifenol sehingga dapat menghambat radikal hidroksil dan enzim prooksidan. Tujuan: Penelitian ini bertujuan untuk membuktikan pemberian ekstrak etanol teh hijau dapat meningkatkan kadar FSH dan jumlah folikel antral pada tikus betina yang dipapar sipermetrin. Metode: Penelitian yaitu true experimental pada 25 ekor tikus betina galur wistar (Rattus norvegicus) yang dibagi menjadi 5 kelompok; KN: tanpa perlakuan, KP: sipermetrin 20 mg/kgBB/hari, P1: sipermetrin 20 mg/kgBB/hari + ekstrak etanol teh hijau 7 mg/kgBB/hari, P2: sipermetrin 20 mg/kgBB/hari + ekstrak etanol teh hijau 14 mg/kgBB/hari, P3: sipermetrin 20 mg/kgBB/hari + ekstrak etanol teh hijau 28 mg/kgBB/hari per oral selama 28 hari. Kadar FSH diukur dengan metode ELISA dan organ ovarium diambil untuk pemeriksaan jumlah folikel antral dengan metode pewarnaan hematoxylin eosin. Hasil: Kadar FSH dan jumlah folikel antral pada tikus betina menunjukkan hubungan yang positif dan kuat dengan nilai koefisien korelasi 0,742 yang berarti peningkatan kadar FSH diikuti penambahan jumlah folikel antral. Ada perbedaan bermakna pada kadar FSH (p=0,005) dan jumlah folikel antral (p=0,001) antara kelompok kontrol dengan kelompok perlakuan. Kesimpulan: Pemberian ekstrak etanol teh hijau dapat meningkatkan kadar FSH dan jumlah folikel antral pada tikus betina yang dipapar sipermetrin. Universitas Muhammadiyah Surabaya 2018-07-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1559 10.30651/jqm.v2i2.1559 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 2 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 2 (2018) 2548-9526 2541-2272 10.30651/jqm.v2i2 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/1559/1391 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1591 2021-07-25T10:41:15Z qanunmedika:AR

Telaah Sel Basofil Sebagai Sel Penyaji Antigen Pada Manusia Jatmiko, Safari Wahyu ABSTRACTThe discovery of basophils as antigen presenting cells in animals tries to raise a big question about the same role in humans. In order to solve the problem, the references had been searched through the US National Library of Medicine, National Institute of Health with the web site address http://www.ncbi.nlm.nih.gov/pubmed. The search had been done in May 2018 with key words: basophil, antigen presenting cell. Author used filter: publication less than 10 years and free full text article. Author found nine (9) articles that meet the criteria. Discussion from the existing article indicates that basophile cells are incapable of endocytosis of solid particles, unable to process and present antigens through MHC molecules, and basophils cells do not express the accessory molecules either before or after activated. It can be concluded that basophil has no role as antigen-presenting cells in humans.Keywords                   : Basophil, human, antigen presenting cellCorrespondence to       : safari.wahyu@ums.ac.id ABSTRAK Penemuan peran basofil sebagai sel penyaji antigen pada hewan coba menimbulkan pertanyaan besar mengenai peran yang sama pada manusia. Untuk menjawab permasalahan tersebut dilakukan penelusuran artikel melalui US    National    Library    of  Medicine,  National  Institute  of  Health dengan alamat web site  http://www.ncbi.nlm.nih.gov/pubmed. Pencarian sumber pustaka dilakukan pada bulan mei 2018 dengan   kata   kunci   Basophil, antigen presenting cell dengan filter publikasi yang berusia kurang dari 10 tahun dan merupakan free  full  text  article. Hasil pencarian ditemukan 9 artikel yang memenuhi kriteria. Pembahasan dari artikel yang ada menunjukkan bahwa sel basofil tidak mampu melakukan endositosis partikel padat, tidak mampu memproses dan menyajikan antigen melalui molekul MHC, dan sel basofil tidak mengekspresikan molekul asesori baik sebelum maupun setelah diaktifkan. Dapat disimpulkan bahwa basofil tidak mempunyai peran sebagai sel penyaji antigen pada manusia.Kata kunci                  : Basofil, manusia, antigen presenting cellKorespondensi             : safari.wahyu@ums.ac.id Universitas Muhammadiyah Surabaya 2019-01-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1591 10.30651/jqm.v3i1.1591 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 1 (2019); 1-5 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 1 (2019); 1-5 2548-9526 2541-2272 10.30651/jqm.v3i1 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/1591/1715 Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1612 2021-07-25T10:41:15Z qanunmedika:AR

Uji Biokompabilitas pada Implan Orthopedi Antara Implan Impor, Implan Lokal dari Material Impor, dan Prototipe Stainless Steel 316L dari Material Lokal Mahyudin, Ferdiansyah Waskita, Heppy Chandra Utomo, Dwikora Novembri Suroto, Heri Martanto, Tri Wahyu ABSTRACT  Demands of orthopedic implants are increasing in Indonesia, but its production are limited and still imported. Stainless steel, especially 316L is one of metal that is used commonly. This research evaluates biocompatibility of stainless steel 316L implant prototype, local implant manufactured using imported stainless steel, and imported stainless steel implant. Cytotoxicity test used mesenchymal human cell with MTT assay. Irritation test, acute toxicity/pyrogenicity test, and implantation test used 24 Wistar rats respectively which were assigned to 4 groups. We evaluate Draize score, weight and rectal temperature changes, and fibrous capsule ring thickness. Cytotoxicity test shows viable cell percentage in stainless steel 316L implant prototype, local implant, and imported implant are 83.7%, 87.5%, and 83.7% respectively. Comparison test using One Way ANOVA shows no significant difference between 3 groups (p>0.05). Iritation test results in 3 groups are grade 0 (no edema and no erythema). Acute toxicity/pyrogenicity test shows no statistically significant difference (p>0.05) among all groups. There is also no significant difference (p>0.05) of fibrous capsule ring thickness on 1 and 4 weeks after implantation. Based on ISO for medical test guide, stainless steel 316L implant prototype is safe and has similar biocompatibility test result compared to local and imported implant.Keywords                   : stainless steel 316L, biocompatibility, orthopaedic implantCorrespondence to    : ferdiansyah@fk.unair.ac.id ABSTRAKKebutuhan implan orthopedi terus meningkat di Indonesia, namun produksinya terbatas dan sebagian besar masih impor dari luar negeri. Stainless steel, utama 316L adalah salah satu metal yang sering digunakan. Penelitian ini mengevaluasi biokompatibilitas dari prototipe implan stainless steel 316L, implan lokal yang diproduksi menggunakan stainless steel impor, dan implan stainless steel impor. Uji sitotoksisitas menggunakan sel mesenkim human dengan MTT assay. Uji iritasi, uji pirogenositas, dan uji implantasi menggunakan 24 tikus Wistar yang terbagi dalam 4 grup. Kami mengevaluasi skor Draize, perubahan berat dan temperatur rektal, dan ketebalan fibrous capsule ring. Uji sitotoksisitas menunjukkan persentase viabilitas sel pada prototipe stainless steel 316L, implan lokal, dan implan impor berturut-turut adalah 83,7%; 87,5%; dan 83,7%. Uji komparasi dengan One Way Anova tidak menunjukkan perbedaan signifikan diantara 3 grup (p>0,05). Hasil uji iritasi 3 grup menunjukkan grade 0 (tidak ada edema dan eritema). Uji pirogenositas tidak menunjukkan perbedaan signifikan pada semua grup (p>0,05). Tidak ada perbedaan signifikan (p>0,05) pula pada ketebalan fibrous capsule ring di minggu ke 1 dan 4 setelah implantasi. Berdasarkan ISO untuk pedoman uji di bidang medis, prototipe stainless steel 316L aman dan memiliki kesamaan hasil uji biokompatibilitas bila dibandingkan dengan implan lokal dan impor.Kata kunci              : stainless steel 316L, uji biokompatibilitas, implan orthopaediKorespondensi       : ferdiansyah@fk.unair.ac.id Universitas Muhammadiyah Surabaya 2019-01-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1612 10.30651/jqm.v3i1.1612 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 1 (2019); 7-13 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 1 (2019); 7-13 2548-9526 2541-2272 10.30651/jqm.v3i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/1612/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1656 2021-01-26T03:22:11Z qanunmedika:AR

Prediksi Tinggi Badan Ditentukan dari Panjang Rentang Lengan dan Panjang Telapak Kaki Pada Mongoloid Feminina Khususnya Etnis Jawa Mochtar, Nur Mujaddidah Background: There are various circumstances where measurements are not actually possible, replacement parameters can be used to estimate body height. Many characteristics of body height measurement and how to measure it. These include anthropometric measurements that can be used for the identification of medicolegal-forensic processes. Body height in clinical medicine and in the field of scientific research can be easily estimated using various anthropometric parameters such as arm span, knee height, foot length and foot breadth, and others. The arm span and foot length has proved to be one of the most reliable predictors. This study was conducted to estimate of body height from arm span and foot length using the regression equation and to determine the correlation between the body height and arm span and foot length.Methods: This study was conducted at Universitas Muhammadiyah Surabaya with 182 Javanese female students. Stature, arm span and foot length measured directly using anthropometric technique and measuring tape. The data obtained were then analyzed with SPSS version 16. The regression equation was derived for the estimate of body height and the relationship between stature, arm span and foot length determined by the Pearson correlation.               Results: We found that the mean body height of Javanese women was 1534,45 ± 47,623  mm, mean of arm span 1543,25 ± 60,468 mm and the mean of foot length 226,14 ± 9,586 mm. The correlation between stature and arm span was positive and significant (r = 0,715  , p <0,05). The correlation between stature and foot length was positive and significant (r = 0,726 , p <0,05). The correlation between stature and arm span and foot length was positive and significant (r = 0,798, p <0,05).               Conclusion: Body height correlates well with the arm span and foot length so that it can be used as a reliable marker for high estimates using regression equations. Universitas Muhammadiyah Surabaya 2018-07-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1656 10.30651/jqm.v2i2.1656 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 2 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 2 (2018) 2548-9526 2541-2272 10.30651/jqm.v2i2 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/1656/1419 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1657 2021-01-26T03:22:12Z qanunmedika:AR

CA 125 dan Pemakaian Klinis Dalam Penatalaksanaan Kanker Ovarium Dwi ariningtyas, Ninuk Today there are three types of ovarian cancer, namely epithelial cell tumors (70%), which are the largest part of the tumor, Germ cell tumors with a smaller frequency, and sex cord-stroma tumors which is the smallest proportion of about 8% of neoplasm. Ovarian cancer is characterized by unusual early symptoms, real symptoms at advanced stages and low survival rates. Therefore, ovarian cancer is the leading cause of death from gynecological cancer. Over the past decade, several studies have been directed at increasing outcomes of ovarian cancer by performing preclinical screening tests, determining the early stages of disease by using radiological examination or tumor marker serum. The purpose of screening for ovarian cancer is to reduce mortality by detection of stage 1 ovarian invasive epithelial cancer that is potential to be cured. Serum CA 125 measurements are often used to monitor disease status or predict residual disease. A number of cell surface antigens and serum proteins are produced by ovarian tumors and can be tested with monoclonal antibodies. Some of these tests have been clinically applied as a marker of disease and are useful in the detection of subclinical diseases and the diagnosis of recurrent ovarian cancer. Among the multiple biochemical markers in ovarian cancer, the most studied are CA 125. CA 125 is a surface glycoprotein detectable cells in more than 80% of cases of ovarian epithelial cancer. This test is clinically used in the evaluation of mass diagnostics in the ovaries, observation of response to treatment, and further evaluation of patients with ovarian cancer Universitas Muhammadiyah Surabaya 2018-07-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1657 10.30651/jqm.v2i2.1657 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 2 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 2 (2018) 2548-9526 2541-2272 10.30651/jqm.v2i2 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/1657/1386 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1732 2021-01-26T03:22:11Z qanunmedika:AR

The Effectiveness of Scaevola tacada Extract (Gaertn roxb) on the Level of Cytokine IL-10 of Strain Sprague dawly (Female Laboratory Rats) Induced by the Staphylococcus Aureus Bactera Umrah, Andi Sitti Background: Staphylococcus aureus is a sort of bacteria causing mastitis on women, generally found after delivery and during breastfeeding. These bacteria stimulate the immune system to respond, during which Sitikon is released. IL-10 is an anti-inflmation that impedes cell damage on the body, so it is required to do a complementary therapy stemming from the extract of Scaevola Taccada extract (Gaertn Roxb), generally known as sea lettuce. This study aimed to examine the effectiveness of Scaevola Taccada extract (Gaertn Roxb) on the level of Sitokin Il-10 of Strain Strain Sprague Dawly (Female Laboratory Rat) induced by the Staphylococcus Aureus Bacteria.Methods: This true experimental study employing pre- and post-test control design used 18 Sprangue Dawley, laboratory rats, that weighed between 200-250g, and that were divided into three groups, each of which comprised of six rats. The negative control group, positive control group and expiremental group were respectively given 1ml of aqua pro injection/250grBB rats, 9.6mg/ml of antibiotic amoxicillin/250gramBB rats, and 9.6mg of antibiotic amoxicillin/250grBB + 400mg/ml of Scaevola Taccada extract (Gaertn Roxb)/kgBB rats for five days. The sea lettuce plants were taken from the district of Pinrang, South Sulawesi. All groups were induced by staphylococcus aureus 0.2 ml x108 ml/CFU. The level of IL-10 was investigated using R&D method system ELISA Rat, in which the data were analyzed using ANOVA + post hoc test formula with the significant value ρ ≤ 0.05 and CI 95%.Results: The empirical evidence showed that there was no a significant different of Sitokin IL-10 level, either before or after the induction of the bacteria staphylococcus aureus for the length of ± 24 hours of all groups (ρ > 0.05). It was also found that there was a different level of IL-10 after the treatment between all of the groups given the value ρ < 0.05. The increase of IL-10 level was higher in the experimental group (mean ± 72,8 pg/ml) compared to the positive control group (mean ± 41, pg/ml).Conclusions:  This research concluded that giving the extract of Scaevola taccada (Gaertn)Roxb) was effective in the boost of sitokin IL-10 level as an anti inflammation that plays central role in the stimulation of immune responses and the prevention of lichen imunopatologia development. The extract of sea lettuce (Scaevola taccada (Gaertn)Roxb)) can be given as a complementary therapy. Universitas Muhammadiyah Surabaya 2018-07-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1732 10.30651/jqm.v2i2.1732 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 2 No. 2 (2018) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 2 No 2 (2018) 2548-9526 2541-2272 10.30651/jqm.v2i2 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/1732/1393 Copyright (c) 2018 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1760 2021-07-25T10:41:15Z qanunmedika:AR

Pengaruh EkstrakTeh Hijau Terhadap Kadar FSH, MDA Ovarium dan Diameter Folikel pada Tikus yang Dipapar MSG Kamalah, Rizqi Kalsum, Umi ABSTRACT  Monosodium Glutamate (MSG) is a sodium salt of glutamic acid. The main function of glutamate is as a communicator cells, and also control GnRH. Consumption of MSG can causes the amount of glutamate in the plasma to increase so as to trigger the occurrence of oxidative stress To minimize the negative impact is needed endogenous antioxidants one of which is green tea. Polyphenol content in green tea is able to inhibit transcription factors of reduction, inhibit prooxidant enzymes. This study aims to determine the effect of MSG exposure and green tea ethanol extract on the prevention of decreased levels of FSH, prevention of the increasing levels of ovarian Malondialdehyde (MDA) and antral follicle diameter. The methode used in this research is elisa essay, spectrophotometry and haematoxylin eosin (HE). The rats were dividing into 5 grups, namely control grup, positive grup and treatment grups (PI,PII,PIII) treated with 0,7 mg/gBB of MSG and 0,7 mg, 1,4 mg, 2,8 mg of green tea ethanol extract (PI,PII,PIII). The results showed a significant correlation between giving green tea ethanol extract dose 1,4 mg and 2,8 mg can prevent decrease of FSH level and increase of ovarian MDA in rat exposed MSG (p=0,002, r=0,370 dan 0,366, p=0,021, r=0,039 dan 0,040, p=0,474). This study concludes that MSG exposure and green tea ethanol extract can increase FSH levels and decrease MDA ovary level of female rat but can’t prevent decrease diameter of follicle antral in rat with exposed MSGKeywords         : MSG, green tea extract, FSH, MDA ovary, antral follicle diameter.Correspondence to  : tantpopo16@gmail.com ABSTRAK Monosodium Glutamat (MSG) adalah garam natrium dari asam glutamat. Glutamat memiliki fungsi dalam komunikasi antar sel, dan juga dapat mengendalikan GnRH. Konsumsi MSG yang berlebihan dapat menyebabkan jumlah glutamat dalam plasma darah meningkat sehingga memicu terjadinya stres oksidatif. Untuk meminimalisirnya tubuh memerlukan antioksidan, khususnya antioksidan endogen seperti teh hijau. Teh hijau mengandung polifenol yang dapat menghambatan faktor transkripsi reduksi, menghambatan enzim prooksidan. Penelitian ini bertujuan untuk mengetahui pemberian ekstrak etanol teh hijau terhadap kadar FSH, MDA ovarium dan diameter folikel antral pada tikus yang dipapar MSG. Metode yang digunakan dalam penelitian ini elisa essay, spectrophotometry dan Haematoxylin Eosin (HE). Sampel dibagi menjadi 5 kelompok, yaitu kelompok kontrol negatif, kelompok kontrol positif dan perlakuan (PI,PII,PIII) masing-masing mendapat dosis MSG yang sama 0,7 mg/gBB. Dosis ekstrak etanol teh hijau untuk kelompok perlakuan (PI,PII,PIII) masing-masing mendapat dosis 0,7 mg, 1,4 mg dan 2,8 mg. Berdasarkan hasil analisis statistik, didapatkan hubungan yang signifikan bahwa pemberian ekstrak etanol teh hijau dosis dosis 1,4 mg dan 2,8 mg dapat mencegah penurunan kadar FSH, dapat mencegah peningkatan kadar MDA ovarium pada tikus yang dipapar MSG (p=0,002, r=0,370 dan 0,366, p=0,021, r=0,039 dan 0,040, p=0,474 ). Penelitian ini membuktikan bahwa pemberian ekstrak etanol teh hijau dapat mencegah penurunan kadar FSH, mencegah peningkatan kadar MDA ovarium, akan tetapi tidak dapat mencegah penurunan diameter folikel antral pada tikus yang dipapar MSGKata kunci    : MSG, ekstrak teh hijau, FSH, MDA ovarium, diameter folikel antralKorespondensi  :  tantpopo16@gmail.com Universitas Muhammadiyah Surabaya 2019-01-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1760 10.30651/jqm.v3i1.1760 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 1 (2019); 23-30 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 1 (2019); 23-30 2548-9526 2541-2272 10.30651/jqm.v3i1 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/1760/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/1865 2021-07-25T10:41:16Z qanunmedika:AR

The Effect Of Pagoda Leaf Extract (Clerodendrum Paniculatum L) On The IL-10 Level In Mammae Of Female Rats Strain (Sprague Dawley) Induced With Staphylococcus Aureus Bacteria Suriati, Israini Ahmad, Mardiana Siagian, Nurul Aini Prihantono, Prihantono ABSTRACTMastitis is an infectious disease problems of found in breast feeding usually caused by Staphylococcus aureus. When Staphylococcus aureus bacteria enters the body’s tissues, IL-10 immune will active helped prevent cell broken. The immune system will get worse if there is no treatment. So that it takes complementary therapies like pagoda leaves, The content of the pagoda contains tannins, alkaloids and flavonoids, where is this compound can to improve immune system. This study aims to determine the effect of pagoda leaf extract on IL10 levels in rats induced by Staphylococcus aureus bacteria. The type of research used in this study is true experimental with pre and posttest control design. The use of 15 Sprague Dawley strain rats divided into 3 groups: 5 negative control groups (aqua pro injections 1ml/gramBB) five  tails were all given standard feed,  positive control group (Amoxicilin with 9.6ml / 250gramBB ) five tails were all given standard feed, and treatment group (Amoxicilin 9.6ml / 250gramBB plus pagoda leaf extract 50ml/250gramBB) five tails were all given standard feed. All groups were induced bacteria Staphylococcus aureus  (0,2 mlx108ml/CFU). IL-10 levels were examined using the R & D method of the Enzyme Linked Immonosorbent Assay (ELISA) Rat system. Data analysis used ANOVA + post hoc test, with a significant value ρ ≤ 0, 05. This study showed no difference in levels of IL10 cytokines, before induced Staphylococcus aureus bacteria in all groups with values (ρ> 0.05). Whereas after the treatment was given, the value of ρ <0.05) between all groups showed that there was a difference in IL10 levels after treatment between all groups. In the negative control group, IL10 experienced a decrease (mean ± 10.4 pg / ml). While the increase in IL-10 levels was greater in the treatment group (mean ± 58.4 pg / ml), compared to the positive group (mean ± 41.8 pg / ml). The conclusion in this study is that pagoda leaf extract (Clerodendrum Paniculatum L) has an influence in increasing IL-10 levels as an anti-inflammatory. Pagoda leaf extract can be used as a complementary therapyKeywords                    : Staphylococcus aureus , IL-10, Ekstrak Daun PagodaCorrespondence          : israinisuriati@yahoo.com.AbstrakMastitis adalah masalah penyakit infeksi yang ditemukan pada ibu menyusui yang biasanya disebabkan oleh Staphylococcus aureus. Ketika bakteri Staphylococcus aureus masuk ke jaringan tubuh, kekebalan IL-10 akan aktif membantu mencegah sel- sel rusak. Sistem imun akan memburuk jika tidak ada penanganan. Sehingga dibutuhkan terapi komplementer seperti tanaman daun pagoda, kandungan dari tanaman daun pagoda terdiri dari tannins, alkaloids and flavonoids, di mana senyawa ini dapat meningkatkan sistem kekebalan tubuh. Jenis penelitian yang digunakan dalam penelitian ini adalah true experimental dengan rancangan pre dan posttest control design. Yang menggunakan tikus strain Sprague Dawley sebanyak 15 ekor yang dibagi dalam 3 kelompok yaitu kelompok kontrol negatif (aqua pro injections) sebanyak 5 ekor  semuanya  diberikan  pakan  standar,  kelompok  kontrol  positif (Amoxicilin dengan dosis 9,6ml/250gramBB) sebanyak 5 ekor semuanya  diberikan  pakan standar, dan kelompok perlakuan (Amoxicilin 9,6ml/250gramBB ditambah dengan ekstrak daun pagoda (50ml/250gramBB) 5 ekor semuanya diberikan pakan standar. Semua kelompok diinduksisikan bakteri Staphylococcus aureus 0,2 ml/CFU. Pemeriksaan kadar IL-10 menggunakan metode R & D system Enzyme Linked Immonosorbent Assay (ELISA) Rat. Analisis data menggunakan uji ANOVA + post hoc, dengan nilai signifikan ρ ≤ 0, 05. Penelitian ini menunjukkan tidak ada perbedaan kadar sitokin IL-10, sebelum diinduksikan bakteri Staphylococcus aureus pada semua kelompok dengan nilai (ρ > 0,05).. Sedangkan setelah diinduksikan bakteri Staphylococcus aureus ± 24 jam semua kelompok mengalami penurunan kadar IL10 dengan nilai (ρ > 0,05). Setelah diberikan treatment diperoleh nilai ρ < 0,05) antara semua kelompok hal ini menunjukkan ada perbedaan kadar IL-10 setelah diberikan treatment antara semua kelompok. Pada kelompok kontrol negatif kadari IL-10 mengalami penurunan (rerata ± 10,4 pg/ml). Sedangkan peningkatan kadar IL-10 lebih besar pada kelompok perlakuan (rerata ± 58.4 pg/ml), dibandingkan pada kelompok positif (rerata ± 41.8 pg/ml ). Kesimpulan dalam penelitian ini adalah ekstrak daun pagoda (Clerodendrum Paniculatum L) memiliki pengaruh dalam meningkatkan kadar IL-10 sebagai anti-inflamasi. Ekstrak daun pagoda dapat dijadikan terapi komplementer.Kata kunci        : Staphylococcus aureus, IL-10, Ekstrak Daun PagodaKorespondensi : israinisuriati@yahoo.com.   Universitas Muhammadiyah Surabaya 2019-01-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/1865 10.30651/jqm.v3i1.1865 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 1 (2019); 63-74 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 1 (2019); 63-74 2548-9526 2541-2272 10.30651/jqm.v3i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/1865/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2008 2021-07-25T10:41:15Z qanunmedika:AR

Pengaruh Durasi Pneumotorak Terhadap Tingkat Stress Oksidatif Paru Tikus Wistar Muttaqien, Faisal Bermansyah, Bermansyah Saleh, Irsan ABSTRACTLarge pneumothorax with long duration of symptoms can be dangerous. Large pneumothorax can cause hypoxemia and its duration states the duration of hypoxia. This long duration of hypoxia can affect changes in tissue conditions of the lungs, which if it reaches 72 hours can increase the permeability of the alveolar capillaries in the lungs to facilitate pulmonary edema. Large pneumothorax with long duration of symptoms can be a risk factor for re-expansion pulmonary edema (REPE). Meanwhile, hypoxia can also cause increased production of free radicals in lung tissue (pulmonary oxidative stress). This study investigated whether the duration of pneumothorax also affects the level of pulmonary oxidative stress, with experiments in rats. There were 4 groups consisting of 6 rats in each group: 24 hours of pneumothorax (A), 48 hours of pneumothorax (B), 72 hours of pneumothorax (C) and control (D). Pneumothorax is made by injecting air into the right pleural cavity of the chest, then we performed X-ray. All samples were examined for PaO2 to ensure hypoxia status. After that, the rats were examined for malondialdehyde (MDA) levels to express the level of oxidative stress. The result showed that all pneumothorax groups were hypoxemic (PaO2 below 80 mmHg). Mean MDA levels were higher in pneumothorax groups. However, only group C were significantly higher (p=0,031). MDA levels were 1,601 ± 0,739 in group A, 1,585 ±  0,714 in group B, 2,256 ± 0,513 in group C, and 1,243 ± 0,162 in group D.  We concluded that pneumothorax can cause pulmonary oxidative stress if the pneumothorax has a large volume and the duration of symptoms reaches 72 hours.Keywords   : Pneumothorax, REPE, Lung Edema, Free Radicals, Malondialdehyde, Hypoxia.Correspondance to : faisaldanyani@gmail.com ABSTRAKPneumotorak luas dengan durasi gejala yang lama dapat berbahaya. Pneumotorak luas dapat menyebabkan hipoksemia dan durasi gejalanya yang lama menyatakan durasi hipoksia parunya. Durasi hipoksia ini dapat mempengaruhi perubahan kondisi jaringan di paru, yang bila mencapai 72 jam dapat meningkatkan permeabilitas kapiler alveolar di paru sehingga memudahkan terjadinya edema paru. Pneumotorak luas dengan durasi gejala yang lama dapat menjadi faktor resiko reexpansion pulmonary edema (REPE). Sementara itu, hipoksia juga dapat menyebabkan peningkatan produksi radikal bebas di jaringan paru (stress oksidatif paru). Penelitian ini menginvestigasi apakah durasi pneumotorak juga mempengaruhi tingkat stress oksidatif paru, dengan eksperimen pada tikus. Terdapat 4 kelompok yang masing-masing terdiri dari 6 tikus: kelompok pneumotorak 24 jam (A), pneumotorak 48 jam (B), pneumotorak 72 jam (C) dan kontrol (D). Pneumotorak dibuat dengan cara injeksi udara ke rongga pleura dada kanan, lalu di X-ray. Semua sampel diperiksa PaO2 untuk memastikan tingkat hipoksianya. Setelah itu, tikus diperiksa kadar malondialdehid (MDA) parunya untuk mengetahui tingkat stress oksidasi parunya. Hasil penelitian menunjukkan semua kelompok tikus pneumotorak mengalami hipoksemia. Rata-rata kadar MDA lebih tinggi pada kelompok pneumotorak, namun secara statistik hanya bermakna pada kelompok 72 jam (C) dengan p=0,031. Kadar MDA pada masing-masing kelompok adalah 1,601 ± 0,739  pada kelompok A, 1,585 ± 0,714 pada kelompok B, 2,256 ± 0,513 pada kelompok C,  dan 1,243 ± 0,162 pada kelompok D. Kesimpulannya pneumotorak dapat menyebabkan stress oksidatif paru bila pneumotorak bervolume luas dan durasi gejala mencapai 72 jam.Kata kunci: Pneumotorak, REPE, Edema Paru, Radikal Bebas, Malondialdehid, HipoksiaKorespondensi : faisaldanyani@gmail.com Universitas Muhammadiyah Surabaya 2019-01-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2008 10.30651/jqm.v3i1.2008 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 1 (2019); 45-53 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 1 (2019); 45-53 2548-9526 2541-2272 10.30651/jqm.v3i1 ind https://journal.um-surabaya.ac.id/qanunmedika/article/view/2008/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2131 2021-04-27T02:51:00Z qanunmedika:AR

Magnetic resonance cholangiopancreatography as a diagnostic tools to diagnose biliary atresia at Dr.Soetomo hospital Djalilah, Gina Noor Widayanti, Reny Setyoboedi, Bagus Arief, Sjamsul ABSTRACT Cholestasis jaundice results from diminished bile flow and/or excretion, and caused by a number of disorders such as biliary atresia (BA). Magnetic resonance cholangiopancreatography (MRCP) is widely accepted as one of the modalities for biliary system imaging; however, liver biopsy still generally used for BA diagnosis, especially in developing countries. This aim study was to evaluate the diagnostic value of biliary atresia from MRCP compared to the result of a liver biopsy. A cross-sectional for diagnostic study documented of hospitalized patients from June 2014 to June 2015. All patients had MRCP and liver biopsy examination. The collection of data including age, gender, clinical manifestation and the result of MRCP and liver biopsy with ROC to evaluate the sensitivity and specificity was done. Liver biopsy revealed of biliary atresia was made based on proliferation, degeneration, and fibrosis of bile ducts. ROC to evaluate the sensitivity and specificity was done. The sensitivity, specificity, negative predictive value, positive predictive value of MRCP in diagnosing BA were calculated. There were 16 patients enrolled in this study with a median age of diagnosis was 6 months old (range 3-11). There were nine female patients out of the 16 patient. The median age of jaundice onset was 5 days (range 2-14 days). All patients had hepatomegaly and splenomegaly. Histopathology from liver biopsy revealed biliary atresia in 12 patients. From the ROC curve, the sensitivity of MRCP was 87.5% and specificity 62.5% with PPV 70% and NPV 80%. Five patients underwent a Kasai procedure and revealed biliary atresia. MRCP is sensitive but not specific for diagnosing BA, and MRCP has moderate sensitivity and specificity for BA diagnosis.Keyword: biliary atresia, magnetic resonance cholangiopancreatography, liver biopsy, diagnostic test.Correspondence: geendjk@gmail.com ABSTRAKIkterus dikarenakan kolestasis terjadi akibat berkurangnya aliran empedu dan/ atau ekskresi, dan dapat disebabkan oleh sejumlah gangguan seperti atresia biliaris (BA). Magnetic resonance cholangiopancreatography (MRCP) secara luas diterima sebagai salah satu modalitas untuk pencitraan sistem empedu, namun biopsi hati masih secara umum digunakan untuk diagnosis BA, terutama di negara berkembang. Studi ini bertujuan untuk mengevaluasi nilai diagnostik atresia biliaris dari MRCP ke hasil biopsi hati. Sebuah cross sectional untuk studi diagnostik didokumentasikan pasien rawat inap dari Juni 2014 hingga Juni 2015. Semua pasien menjalani MRCP dan pemeriksaan biopsi hati. Data usia, jenis kelamin, manifestasi klinis dan hasil MRCP dan biopsi hati dengan ROC untuk mengevaluasi sensitivitas dan spesifisitas dilakukan. Biopsi hati mengungkapkan atresia biliar dibuat berdasarkan proliferasi, degenerasi dan fibrosis saluran empedu. ROC untuk mengevaluasi sensitivitas dan spesifisitas yang dilakukan. Dilakukan perhitungan sensitivitas, spesifisitas, nilai prediktif negatif, nilai prediksi positif MRCP dalam mendiagnosis BA. Terdapat 16 pasien yang terdaftar dalam penelitian ini dengan median usia diagnosis adalah 6 (kisaran 3-11) bulan. Terdapat 9 perempuan dari 16 pasien tersebut. Usia rata-rata onset penyakit kuning adalah 5 (kisaran 2-14) hari. Semua pasien mengalami hepatomegali dan splenomegali. Histopatologi dari biopsi hati mengungkapkan atresia bilier pada 12 dari 16 pasien. Dari kurva ROC, sensitivitas MRCP adalah 87,5% dan spesifisitas 62,5% dengan PPV 70% dan NPV 80%. Lima pasien menjalani prosedur Kasai dan mengungkapkan atresia bilier. MRCP sensitif namun tidak spesifik untuk mendiagnosis BA dan MRCP memiliki sensitivitas dan spesifisitas sedang untuk diagnosis BA.Kata kunci: biliary atresia, magnetic resonance cholangiopancreatography, liver biopsy, diagnostic test.Korespondensi: geendjk@gmail.com Universitas Muhammadiyah Surabaya 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2131 10.30651/jqm.v3i2.2131 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 2 (2019); 137-142 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 2 (2019); 137-142 2548-9526 2541-2272 10.30651/jqm.v3i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2131/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2191 2021-07-25T10:41:15Z qanunmedika:AR

Studi Epidemiologi Fraktur Vertebra di RSUD Dr.Soetomo Surabaya Pada Tahun 2013-2017 Widhiyanto, Lukas Martiana, I Ketut Airlangga, Primadenny Ariesa Permana, Donny  AbstractThe incidence of spinal trauma in the world is 0.019-0.088% per year. However, the epidemiological data from each country varies according to the specificities of each country. Until now, there have been no reports of epidemiological research for vertebral trauma in Indonesia. This research is a descriptive analytic study. The sample of this study were all patients with vertebral fractures who entered the Dr. Soetomo Hospital in 2013-2017. The data were obtained through medical records and electronic data in hospital databases. The data are displayed in tables and graphs and comparative analysis of variables is carried out. Based on data from 2014-2017, there were a total of 442 patients with vertebral fractures, with male and female ratio of 3.3: 1. The mean age of patients was 43.6 year. The causes of vertebral fractures are due to fall from altitude (38%), traffic accidents (34%), and direct impact / hit burden (10%). Based on fracture level, most fractures were at the lumbar level (153 patients, 34,6%). At the lumbar level, the most fracture subtypes were type A with a percentage of 91.5% and the most mechanism of injury was due to falling from a height. Based on the fracture subtype, type A (compression or burst) fracture is the most common type of fracture. Lumbar vertebral fracture is the most fractured in vertebral fractures. The most common cause of fracture in the vertebrae is trauma with great energy due to falling from a height.Keywords: Epidemiology, vertebral fractures, spinal traumaCorrespondence to : dr.donnypermana@gmail.com Abstrak Insiden trauma spinal di dunia tercatat sebesar 0,019% hingga 0,088% per tahun, namun data epidemiologi dari masing-masing negara adalah berbeda-beda, sesuai dengan kekhususan dari masing-masing negara. Hingga saat ini, belum terdapat laporan penelitian epidemiologi untuk trauma vertebra di Indonesia. Penelitian ini merupakan penelitian deskriptif analitik. Sampel penelitian ini adalah seluruh pasien dengan fraktur vertebra yang masuk di RS Dr. Soetomo Surabaya pada tahun 2013-2017. Data penelitian ini didapatkan melalui data berkas rekam medis dan database elektronik rumah sakit. Data ditampilkan dalam bentuk tabel dan grafik serta dilakukan analisa komparasi dari variabel. Berdasarkan data tahun 2014-2017 didapatkan total 442 pasien dengan fraktur vertebra, dengan perbandingan laki-laki dan perempuan sebesar 3,3:1.  Rerata usia pasien adalah 43,6 tahun. Penyebab fraktur vertebra adalah akibat jatuh dari ketinggian (38%), kecelakaan lalu lintas (34%), dan benturan langsung/ tertimpa beban (10%). Berdasarkan level fraktur, fraktur terbanyak sejumlah 153 pasien (34,6%) pada level lumbal. Pada level lumbal didapatkan subtIpe fraktur terbanyak adalah tipe A dengan persentase 91,5% dan mechanism of injury terbanyak adalah akibat jatuh dari ketinggian. Berdasarkan subtipe frakturnya, fraktur tipe A (kompresi atau burst) merupakan jenis fraktur yang paling banyak terjadi. Fraktur vertebra lumbal adalah fraktur terbanyak pada kasus fraktur pada vertebra. Penyebab terbanyak fraktur pada vertebra adalah trauma dengan energi besar akibat jatuh dari ketinggian. Laki-laki 3 kali lebih banyak mengalami fraktur vertebra dibanding perempuan.Kata kunci: Epidemiologi, fraktur vertebra, trauma spinalKorespondensi  : dr.donnypermana@gmail.com Universitas Muhammadiyah Surabaya 2019-01-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2191 10.30651/jqm.v3i1.2191 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 1 (2019); 15-22 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 1 (2019); 15-22 2548-9526 2541-2272 10.30651/jqm.v3i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2191/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2198 2021-07-25T10:41:15Z qanunmedika:AR

Proses Penyembuhan Luka Ditinjau dari Aspek Mekanisme Seluler dan Molekuler Primadina, Nova Basori, Achmad Perdanakusuma, David S ABSTRACTWound is the discontinue of the anatomical structure of the body tissue, the healing phase consists of 3 stages, they are the inflammatory phase, which is divided into early inflammation, and late inflammation that occurs from day 0 to day 5 after injury. The Proliferation phase, which includes three main processes, namely: Neoangiogenesis, fibroblast formation and re-epithelialization, occurs from day 3 to day 21 after injury. Maturation phase occurs from day 21 to 1 year after injury which aims to maximize the strength and structural integrity of new tissue fillings, epithelial growth and scar tissue formation. These three phases influence each other and many cells and cytokines play a role in each phase. The amount of research on the wound healing process to achieve satisfactory results with a shorter time than the nominal phase results in a theory of the process of wound healing that is increasingly detailed which will be explained from the aspects of cellular and molecular mechanisms.Keywords : wound healing, wound healing process, wound healing mechanism, cellular mechanism of wound healing, molecular mechanism of wound healingCorrespondence to  : novaprimadina@fk.um-surabaya.ac.id ABSTRAKLuka adalah terputusnya kontinuitas struktur anatomi jaringan tubuh, dimana fase penyembuhannya terdiri dari 3 tahap yaitu Fase Inflamasi yang dibagi menjadi early inflammation (Fase haemostasis), dan late inflammation yang terjadi sejak hari ke 0 sampai hari ke 5 pasca terluka. Fase Proliferasi, yang meliputi tiga proses utama yakni: Neoangiogenesis, pembentukan fibroblast dan re-epitelisasi, terjadi dari hari ke-3 sampai hari ke-21 pasca terluka. Fase Maturasi terjadi mulai hari ke-21 sampai 1 tahun pasca luka.yang bertujuan untuk memaksimalkan kekuatan dan integritas struktural jaringan baru pengisi luka, pertumbuhan epitel dan pembentukan jaringan parut. Ketiga fase ini saling mempengaruhi satu sama lain dan banyak sel dan sitokin yang berperan didalam setiap fase. Banyaknya penelitian tentang proses penyembuhan luka untuk mencapai hasil yang memuaskan dengan waktu yang lebih singkat dari fase nomal menghasilkan teori proses penyembuhan luka yang semakin detail yang akan dijelaskan dari aspek mekanisme seluler dan molekuler.Kata kunci  :penyembuhan luka, proses penyembuhan luka, mekanisme penyembuhan luka, mekanisme seluler penyembuhan luka, mekanisme molekuler penyembuhan lukaKorespondensi : novaprimadina@fk.um-surabaya.ac.id Universitas Muhammadiyah Surabaya 2019-01-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2198 10.30651/jqm.v3i1.2198 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 1 (2019); 31-43 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 1 (2019); 31-43 2548-9526 2541-2272 10.30651/jqm.v3i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2198/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2268 2021-07-25T10:41:16Z qanunmedika:AR

Success Of Pulmonary Tuberculosis Treatment Services In Bangetayu Primary Healthcare Semaranga Reviewed From The Aspect Of Quality Of Service Lahdji, Aisyah ABSTRACTPulmonary tuberculosis is a disease that until now has a high morbidity rate, including in Indonesia. Indonesia ranks second with the highest TB burden in the world. From 2013 to 2016, the percentage of the success rate of treatment in Semarang City was 83%, where the lift was still below the target of 90% and in the health profile of the Bangetayu Primary Health Care Semarang, the cure rate was 55% and complete treatment was 34%. One of the controls in TB disease is treatment with the Directly Observed Treatment Short-Course (DOTS) system by monitoring medication. The existence of these efforts still cannot increase the success rate of TB treatment. The purpose of this study was to analyze the scope of achievement of the success of pulmonary TB treatment in Bangetayu Primary Health Care in terms of service quality aspects. This study included descriptive observational research with a qualitative approach. Data collection in this study used interviews and observations by determining the source with the snowball sampling method, namely the head of the health care, the person in charge of the P2P program, the holder of the pulmonary TB program and laboratory officer. This research was conducted at Bangetayu Primary Health Care in November 2018 to December 2018. Assessment of service quality is seen from the aspects of input, process and 5 dimensions of service quality. The results of the study found that the quality of management services from input, process and 5 dimensions of service quality at the Bangetayu Primary Health Care were good. The conclusion of this study is that the Bangetayu Primary Health Care has implemented TB service management well, even though the achievements of TB treatment have not met the target, so that the failure to achieve success in TB treatment in Bangetayu Primary Health Care, Semarang is not caused by health service factors.Keywords                   : Pulmonary tuberculosis, Bangetayu Primary Health Care, service qualityCorrespondence to      : lahdjiaa@yahoo.com   ABSTRAKTuberculosis Paru (TB Paru) adalah  penyakit yang sampai saat ini memiliki angka kesakitan yang tinggi termasuk di Indonesia. Indonesia menduduki peringkat kedua dengan nilai beban TB tertinggi di dunia. Dari tahun 2013 hingga tahun 2016, presentase angka keberhasilan pengobatan di Kota Semarang sebesar 83%, dimana angkat tersebut masih berada dibawah target sebesar 90% . Pada profil kesehatan Puskesmas Bangetayu Semarang, didapatkan angka kesembuhan sebesar 55% dan pengobatan lengkap sebesar 34%. Salah satu pengendalian pada penyakit TB adalah pengobatan dengan system Directly Observed Treatment Short-Course (DOTS) dengan pemantauan minum obat. Adanya upaya tersebut masih belum bisa meningkatkan angka keberhasilan pengobatan TB secara optimal. Tujuan penelitian ini adalah untuk menganalisis  capaian keberhasilan pengobatan TB paru di Puskesmas Bangetayu yang ditinjau dari aspek mutu pelayanan. Penelitian ini termasuk penelitian deskriptif observatif dengan pendekatan kualitatif. Pengumpulan data pada penelitian ini menggunakan wawancara dan observasi dengan penentuan narasumber dengan metode snowball sampling, yaitu kepala puskesmas, penanggungjawab program P2P dan pemegang program TB paru, petugas Laboratorium. Penelitian ini dilakukan di Puskesmas Bangetayu Semarang pada bulan November 2018 hingga Desember 2018. Penilaian mutu pelayanan dilihat dari aspek input, proses dan 5 dimensi mutu pelayanan. Hasil penelitian didapatkan bahwa mutu pelayanan manajemen dari input, proses dan 5 dimensi mutu pelayanan di Puskesmas Bangetayu Semarang sudah baik. Kesimpulan pada penelitian ini adalah Puskesmas Bangetayu sudah  menerapkan manajemen pelayanan TB dengan baik, meskipun capaian keberhasilan pengobatan TB belum memenuhi target, sehingga ketidakberhasilan capaian keberhasilan pengobatan TB di Puskesmas Bangetayu, Semarang tidak disebabkan oleh faktor pelayanan kesehatan.Kata Kunci     : TB Paru, puskesmas bangetayu, mutu pelayananKorespondensi : lahdjiaa@yahoo.com Universitas Muhammadiyah Surabaya 2019-01-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2268 10.30651/jqm.v3i1.2268 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 1 (2019); 55-62 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 1 (2019); 55-62 2548-9526 2541-2272 10.30651/jqm.v3i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2268/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2300 2021-07-25T10:41:16Z qanunmedika:AR

Gambaran Kejadian Infeksi Pada Usia Lanjut Prahasanti, Kartika ABSTRACT Infection in the elderly is the second leading cause of morbidity and death in the world after cardiovascular disease. This event is closely related to the increase in the elderly population in the last few decades caused by an increase in human life expectancy. The causes of infection in elderly due to the presence of considerable chronic comorbidities, decreased resistance or immunity to infection, decreased communication power in the elderly and difficulty recognizing signs of infection early. Infection in the elderly is not only more frequent and more severe, but also have specialties related to clinical, laboratory and microbiological presentations. The purpose of this review is to provide an overview of the predisposition of infectious diseases in the elderly, immunesenescence in the elderly, the appropriate diagnostic and treatment approach in cases of infection in the elderly.Keywords                   : infection, elderly, immunesenescence Correspondence to      : drkartikaprahasanti@gmail.com ABSTRAK  Infeksi pada usia lanjut merupakan penyebab kesakitan dan kematian terbanyak kedua di dunia setelah penyakit kardiovaskuler. Kejadian ini berhubungan erat dengan peningkatan populasi penduduk usia lanjut pada beberapa dekade terakhir yang diakibatkan oleh peningkatan usia harapan hidup manusia. Penyebab terjadinya infeksi pada usia lanjut banyak disebabkan oleh karena adanya adanya penyakit komorbid kronik, penurunan daya tahan atau imunitas tubuh terhadap infeksi, penurunan kemampuan komunikasi pada usia lanjut sehingga jarang didapatkan keluhan serta sulitnya mengenal tanda infeksi secara dini. Infeksi pada usia lanjut tidak hanya lebih sering terjadi dan lebih berat, namun juga memiliki kekhususan terkait presentasi klinis, laboratorium maupun mikrobiologi. Tujuan dari tinjauan ini adalah untuk memberikan gambaran mengenai predisposisi penyakit infeksi pada usia lanjut, gangguan respon imun pada usia lanjut (immunesenescence), pendekatan diagnosis dan tatalaksana yang tepat pada kasus infeksi pada usia lanjut. Kata kunci                  : infeksi, usia lanjut, gangguan respon imunKorespondensi             : drkartikaprahasanti@gmail.com Universitas Muhammadiyah Surabaya 2019-01-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2300 10.30651/jqm.v3i1.2300 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 1 (2019); 81-91 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 1 (2019); 81-91 2548-9526 2541-2272 10.30651/jqm.v3i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2300/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2305 2021-07-25T10:41:16Z qanunmedika:AR

Physical Exercise and Bone Health Sari, Gadis Meinar ABSTRACTExercise was a planned and structured physical activity in which there was a movement repetition to maintain or enhance one or more components of physical fitness. The physical exercise on biological functions gave positive effects such as improving, but in certain circumstances, it could also give a negative effect such as inhibiting or disturbing the level of individual, system, cell, and molecular. Likewise the effect of physical exercise on bones, many factors affected bone both positively and negatively, among others; the dose of physical exercise which included frequency, intensity, type and time. The dosage of physical exercise was individual on each person. Some studies found that moderate intensity physical exercise provided positive benefits on bones. One of them was affecting the process of proliferation and differentiation of osteoblast, which was one of bone cells that had a function to form bone matrix. Moderate intensity physical exercise combined with salmon calcitonin would increase mouse bone density. Moderate-speed walking exercise would cause changes in IL-6 serum levels which had a role in the process of stem cell differentiation into osteoprogenitor and directly affected adult osteoblasts, whereas changes in PTH serum levels in the sub-acute phase of exercise played a role in the positive uncoupling process of bone remodeling directly.Keywords                   : moderate intensity physical exercise, bone healthCorrespondence to      : gadis-m-s@fk.unair.ac.id ABSTRAKOlahraga adalah latihan fisik yang merupakan bagian dari aktivitas fisik yang terencana, terstruktur, terdapat repetisi gerakan, dan mempunyai tujuan mempertahankan atau meningkatkan salah satu atau lebih komponen kebugaran fisik. Pengaruh latihan fisik terhadap fungsi biologis dapat memberi pengaruh positif yaitu bersifat memperbaiki, akan tetapi pada keadaan tertentu dapat pula memberikan pengaruh negatif yaitu menghambat atau mengganggu baik pada tingkat individu, sistem, sel maupun molekul. Demikian juga pengaruh latihan fisik terhadap tulang, banyak faktor yang mempengaruhi tulang secara positif maupun negatif, antara lain adalah dosis latihan fisik yang meliputi frekuensi, intensitas, jenis dan waktu melakukan latihan fisik. Dosis latihan fisik bersifat individual pada setiap orang. Beberapa penelitian menunjukkan bahwa latihan fisik intensitas sedang memberikan manfaat positif pada tulang. Antara lain mempengaruhi proses proliferasi dan diferensiasi sel osteoblas yaitu salah satu sel tulang yang berfungsi membentuk matriks tulang. Latihan fisik intensitas sedang dikombinasikan dengan salmon kalsitonin akan meningkatkan kepadatan tulang tikus. Latihan jalan dengan kecepatan sedang akan menyebabkan perubahan kadar IL-6 serum yang berperan pada proses diferensiasi stem cell menjadi osteoprogenitor dan secara langsung berpengaruh pada osteoblas dewasa, sedangkan perubahan kadar PTH serum pada fase subakut latihan berperan pada proses positive uncoupling remodeling tulang secara langsung.Kata kunci                  : latihan fisik intensitas sedang, kesehatan tulangKorespondensi            : gadis-m-s@fk.unair.ac.id Universitas Muhammadiyah Surabaya 2019-01-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2305 10.30651/jqm.v3i1.2305 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 1 (2019); 75-80 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 1 (2019); 75-80 2548-9526 2541-2272 10.30651/jqm.v3i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2305/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2327 2021-04-27T02:51:00Z qanunmedika:AR

Multiple Large Atrial Thrombus Due To Rheumatic Heart Disease And Present Of Atrial Fibrillation With No Sign Of Stroke: How Is It Possible? Alfaray, Ricky Indra Ayomi, Deisha Laksmitha Sembiring, Yan Efrata ABSTRACT  Atrial fibrillation is the most common arrhythmia associated with stroke and in the rheumatic heart disease patient’s atrial fibrillation can easily cause thromboembolism. Thromboembolism is the major complication also in patients of mitral stenosis with atrial fibrillation. A 54-year-old woman with uncontrollable movements in the right arm, stomach, right leg and painful swelling at right ankle joint was admitted to the emergency department. Transesophageal echocardiogram revealed rheumatic heart disease affecting two valves and thrombus in left atrial extending towards left atrial appendage. Heart rate was 120 beats per minute. ECG showed atrial fibrillation. A patient has undergone mitral and aortic valves replacement surgery and left atrial thrombus evacuation. Despite the involvement of two heart valves and the presence of large thrombus, the patient did not show any sign of brain infarction. This is a contradiction with a theory which implies that atrial fibrillation is the most common arrhythmia associated with stroke and in the rheumatic heart disease patient’s atrial fibrillation can easily cause thromboembolism and become stroke. This study evaluates many factors founded in the patient that make this anomaly may happen.Keywords                   : atrial fibrillation, rheumatic heart disease, thromboembolism strokeCorrespondence to      : rickyindraalfaray@gmail.comABSTRAK Atrial fibrilasi merupakan jenis aritmia yang berkaitan erat dengan stroke dan cenderung menyebabkan thromboembolism. Thromboembolism merupakan komplikasi mayor dari mitral stenosis dengan atrial fibrilasi. Seorang wanita berusia 54 tahun masuk ke unit gawat darurat dengan keluhan utama gerakan tak terkendali pada lengan kanan, perut, kaki kanan, serta bengkak yang menyakitkan di sendi pergelangan kaki kanan. Echocardiogram transesophageal menunjukan gambaran penyakit jantung rematik pada dua katup dan trombus di atrium kiri meluas menuju valve atrium kiri. Detak jantung 120 kali per menit. EKG menunjukkan fibrilasi atrium. Pasien menjalani operasi penggantian katup mitral dan aorta serta evakuasi trombus pada atrium. Meskipun terdapat abnormalitas pada dua katup jantung ditambah dengan ditemukan adanya trombus besar pada atrium, pasien tidak menunjukkan tanda-tanda infark otak. Ini bertentangan dengan teori yang mengimplikasikan bahwa atrial fibrilasi adalah aritmia paling umum yang berhubungan dengan stroke dan pada penyakit jantung reumatik. Pasien dengan fibrilasi atrium dapat dengan mudah terjadi tromboemboli hingga bermanifestasi stroke. Studi ini mengevaluasi berbagai faktor yang memungkinkan anomali kasus seperti ini dapat terjadi.Kata kunci                  : fibrilasi atrium, penyakit jantung rematik, stroke thromboemboliKorespondensi             : rickyindraalfaray@gmail.com  Universitas Muhammadiyah Surabaya 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2327 10.30651/jqm.v3i2.2327 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 2 (2019); 191-198 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 2 (2019); 191-198 2548-9526 2541-2272 10.30651/jqm.v3i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2327/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2534 2021-04-27T02:50:59Z qanunmedika:AR

Diabetes Insipidus In Patients With Traumatic Severe Brain Injury Prabowo, Yudha Adi Airlangga, Prananda Surya Diabetes Insipidus Cedera otak Hipernatremia Desmopresin Osmolaritas ABSTRACTTraumatic severe brain injury is a fatal injury, with a mortality rate of up to 50%. About 1.5 million people experience severe brain injury in the United States. There are more than 50,000 deaths and 500,000 incidents of permanent neurological sequelae. About 85% of mortality occurs in the first 2 weeks after the injury. One complication of a severe brain injury is diabetes insipidus. There are no definitive data on the incidence of diabetes insipidus in patients with traumatic severe brain injury of Indonesia so far. In this case report, a male, 45 years old, was taken to the Emergency Installation (IRD) after experiencing a traffic accident 12 hours before being hospitalized. After surgery, the signs of diabetes insipidus was presented by polyuria of 300cc / hour urine production and 149mmol / L hypernatremia, although the immediate administration of desmopressin, the patients clinical and hemodynamic was not shown any improvements. The patient passed away in the days five of treatment in the Intensive Care Unit (ICU). The main treatments for diabetes insipidus in traumatic severe brain injury are adequate rehydration and administration of desmopressin. Adequate hypovolemic, polyuric and hypernatremia corrections are the keys to the successful treatment of diabetes insipidus. Diabetes insipidus in cases of brain injury requires complicated treatment. Therefore, in the case of being handled improperly, it can bring death. Keywords: Diabetes insipidus, brain injury, hypernatremia, desmopressin, ICUCorrespondence: yud180987@yahoo.com ABSTRAKCedera otak berat traumatis adalah cedera fatal, dengan tingkat kematian hingga 50%. Sekitar 1,5 juta orang mengalami cedera otak berat di Amerika Serikat. Terdapat lebih dari 50.000 kematian dan 500.000 insiden gangguan neurologis permanen. Sekitar 85% kematian terjadi dalam 2 minggu pertama setelah cedera. Salah satu komplikasi dari cedera otak yang parah adalah diabetes insipidus. Tidak ada data pasti tentang kejadian diabetes insipidus pada pasien dengan cedera otak traumatis berat di Indonesia sejauh ini. Pada laporan kasus ini, seorang pria, 45 tahun, dibawa ke Instalasi Rawat Darurat (IRD) setelah mengalami kecelakaan lalu lintas 12 jam sebelum dirawat di rumah sakit. Setelah operasi, tanda-tanda diabetes insipidus ditandai dengan adanya poliuria produksi urin 300cc / jam dan hipernatremia 149 mmol / L, meskipun segera diberikan desmopresin, kondis klinis dan hemodinamik pasien tidak menunjukkan perbaikan. Pasien meninggal pada hari kelima perawatan di Unit Perawatan Intensif (ICU). Perawatan utama untuk diabetes insipidus pada cedera otak berat traumatis adalah rehidrasi dan pemberian desmopresin yang adekuat. Koreksi hipovolemik, poliurik, dan hipernatremia yang adekuat adalah kunci keberhasilan pengobatan diabetes insipidus. Diabetes insipidus dalam kasus cedera otak membutuhkan perawatan yang rumit. Karena itu, jika ditangani dengan tidak tepat, bisa menyebabkan kematian.  Kata kunci: Diabetes insipidus, cedera otak, hipernatremia, desmopressin, ICUKorespondensi: yud180987@yahoo.com Universitas Muhammadiyah Surabaya 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion case report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2534 10.30651/jqm.v3i2.2534 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 2 (2019); 181-190 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 2 (2019); 181-190 2548-9526 2541-2272 10.30651/jqm.v3i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2534/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2590 2021-04-27T02:51:00Z qanunmedika:AR

Clinical Evaluation Of Post High Tibial Osteotomy Patients In Regional General Hospitals Dr. Soetomo Surabaya, Husada Utama Hospital Surabaya, Al-Irsyad Hospital Surabaya In 2010 - 2015 Limbong, Suyenci Utomo, Dwikora Novembri Osteoartritis High Tibial Osteotomy Knee Society Score Knee Injury and Ostoarthritis Outcome Score Modified Hospital For Special Surgery Knee Scoring ABSTRACT Osteoarthritis (OA) of the knee is a disruption in the knee joint which is characterized by pathological changes in the structure in the knee joint that occur progressively. High Tibial Osteotomy (HTO) is a therapeutic option for treating isolated medial compartment OA in varus genu and one of the routine surgical procedures performed in the orthopedic field. As the number of OA cases increases, the number of high tibial osteotomy (HTO) procedures also increases, so clinical evaluation is needed to see whether HTO can meet patient expectations. This study was a retrospective descriptive study with a sample of patients who had undergone the 2010 to 2015 open wedge high tibial osteotomy (OWHTO) procedure. The evaluation used the Knee Society Score, Knee Injury and Osteoarthritis Outcome Score, and Modified Hospital instruments for Special Surgery Knee Scoring. The data obtained are then grouped and analyzed to calculate the average of each instrument. The results showed a sample of 6 knees consisting of 2 male samples (33.3%) and 4 female samples (66.7%). All samples are over 35 years old. The evaluation results using KOOS scores obtained the mean value of the pain component was 77.7; complaint component = 70.3; daily activity component = 76.2; sports and recreation components = 47.9; and components of quality of life = 74.1. On the SSC score, the average knee score was 70.8 and the average functional score was 61.6. Whereas the HSS score obtained by the average functional score is 81.5. This study produced each score with a good average value. This shows that the choice of the High Tibial Osteotomy operating technique provides satisfactory operating results. So that the High Tibial Osteotomy surgery technique can be an option in the case of Osteoarthritis. With the many choices of types of surgery in patients with Osteoarthritis, the High Tibial Osteotomy can be a good choice for patient satisfaction. Keywords: Osteoarthritis, High Tibial Osteotomy, Knee Society Score, Knee Injury and Osteoarthritis Outcome Score, Modified Hospital for Special Surgery Knee ScoringCorrespondence to: liliosanci@gmail.com ABSTRAK Osteoartritis (OA) lutut adalah gangguan pada sendi lutut yang ditandai oleh perubahan patologis pada struktur di dalam sendi lutut yang terjadi secara progresif. High Tibial Osteotomy (HTO) merupakan pilihan terapi untuk penanganan isolated medial compartement OA pada genu varus dan salah satu prosedur operasi yang rutin dilakukan di bidang orthopedi. Dengan meningkatnya jumlah kasus OA meningkat pula jumlah prosedur high tibial osteotomy (HTO), sehingga perlu dilakukan evaluasi klinis untuk melihat apakah HTO dapat memenuhi harapan pasien. Penelitian ini merupakan penelitian deskriptif retrospektif dengan sampel pasien yang telah menjalani prosedur open wedge high tibial osteotomy (OWHTO) 2010 sampai 2015. Evaluasi menggunakan instrument Knee Society Score, Knee Injury and Ostoarthritis Outcome Score, dan Modified Hospital for Special Surgery Knee Scoring. Data yang didapat selanjutnya dikelompokkan dan dianalisa utk menghitung rata-rata dari masing-masing instrumen. Hasil penelitian didapatkan sampel sejumlah 6 lutut yang terdiri dari 2 sampel laki-laki (33,3%) dan 4 sampel perempuan (66,7%). Semua sampel berusia di atas 35 tahun. Hasil evaluasi menggunakan skor KOOS didapatkan nilai rerata komponen nyeri adalah 77,7; komponen keluhan = 70,3; komponen aktivitas harian = 76,2; komponen olahraga dan rekreasi = 47,9; dan komponen kualitas hidup = 74,1. Pada skor KSS didapatkan rerata knee score adalah 70,8 dan  rerata functional score adala 61,6. Sedangkan pada skor HSS didapatkan rerata functional score adalah 81.5. Penelitian ini menghasilkan masing-masing skor dengan nilai rata-rata yang bagus. Hal ini menunjukkan bahwa pilihan teknik operasi High Tibial Osteotomy memberikan hasil operasi yang memuaskan. Sehingga teknik operasi High Tibial Osteotomy dapat menjadi salah satu pilihan pada kasus Osteoarthritis. Dengan banyaknya pilihan macam operasi pada penderita Osteoarthritis maka High Tibial Osteotomy dapat menjadi satu pilihan yang baik untuk kepuasan pasien. Kata kunci: Osteoartritis, High Tibial Osteotomy, Knee Society Score, Knee Injury and Ostoarthritis Outcome Score, Modified Hospital for Special Surgery Knee ScoringKorespondensi: liliosanci@gmail.com Universitas Muhammadiyah Surabaya 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2590 10.30651/jqm.v3i2.2590 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 2 (2019); 144-149 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 2 (2019); 144-149 2548-9526 2541-2272 10.30651/jqm.v3i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2590/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2612 2021-04-27T02:51:00Z qanunmedika:AR

Overview of Survey Results of the Healthy Indonesia Program with a Family Approach In the area of Penggaron Lor, Semarang Lahdji, Aisyah PIS-PK Health Family Penggaron Lor ABSTRACT Health Development Index (HDI) greatly influences health status. Efforts to achieve healthy development are carried out by implementing Healthy Indonesia Program with A Family Approach (Program Indonesia Sehat dengan Pendekatan Keluarga or PIS-PK). The implementation of the PIS-PK was established with 12 main indicators, which aimed at improving the quality of life. The purpose of this study was to find out family health problems by identifying problems and analyzing the causes of health problems in the working area of Bangetayu Public Health Care (RW I, RT 5, 6, 7, 8, and 9) in Penggaron Lor, Semarang. This research is observational descriptive with a cross-sectional approach through interviews and filling in family health profile data in RW I, RT 5, 6, 7, 8, and 9. The problem obtained from the interview was an analysis of the causes of the problem using the L-Green Theory. The survey results showed that the health indexes with healthy categories consisted of 29 families, pre-healthy 113 families, and unhealthy 14 families, with three lowest indicators of PIS-PK are hypertension without regular medication (22%), no family members smoke (39%) and families join the family planning program (37%). In conclusion, there are three problems from 12 healthy family indicators occur in Penggaron Lor, which are families who participate in the family planning program, hypertensive patients who take regular medication, and no family members who are smokers. Keywords                   : PIS-PK, healthy family, Penggaron LorCorrespondence          : lahdjiaa@yahoo.com ABSTRAKDerajat Kesehatan merupakan salah satu unsur penting dalam meningkatkan Indeks Pembangunan Manusia (IPM). Upaya  mencapai pembangunan kesehatan dilakukan dengan melaksanakan Program Indonesia Sehat dengan Pendekatan Keluarga (PIS-PK). Penyelenggaraan PIS-PK ditetapkan dengan adanya 12 indikator utama yang bertujuan untuk meningkatkan kualitas hidup masyarakat Indonesia, dengan mengutamakan pelayanan promotif dan preventif. Tujuan penelitian ini adalah untuk mengetahui masalah kesehatan keluarga dengan mengidentifikasi masalah dan menganalisis penyebab masalah kesehatan di wilayah kerja Puskesmas Bangetayu, RW 1 (RT 5, 6, 7, 8, dan 9), Kelurahan Penggaron Lor, Semarang. Penelitian ini termasuk deskriptif observasional dengan pendekatan cross sectional melalui wawancara dan pengisian data profil kesehatan keluarga di wilayah RW I (RT 5, 6, 7, 8, dan 9). Penyebab pada masalah yang didapatkan dari wawancara dianalisis menggunakan Teori L-Green. Hasil survei menunjukkan warga wilayah RW I (RT 5, 6, 7, 8, dan 9), Kelurahan  Penggaron Lor, Semarang berindeks kesehatan dengan kategori sehat sebanyak 29 Kepala Keluarga (KK), pra sehat 113 KK, dan tidak sehat 14 KK,  dengan 3 indikator terendah PIS-PK yaitu hipertensi yang tidak melakukan pengobatan secara teratur (22 %), anggota keluarga tidak ada yang merokok (39 %) dan keluarga mengikuti program KB (37%).  Kesimpulan penelitian ini adalah terdapat 3 masalah dari 12 indikator keluarga sehat yang terjadi di Kelurahan Penggaron Lor yaitu keluarga mengikuti program KB, penderita hipertensi yang berobat teratur, dan tidak ada anggota keluarga yang merokok. Kata Kunci                 : PIS-PK, Keluarga Sehat, Penggaron LorKorespondensi            : lahdjiaa@yahoo.com Universitas Muhammadiyah Surabaya 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2612 10.30651/jqm.v3i2.2612 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 2 (2019); 151-156 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 2 (2019); 151-156 2548-9526 2541-2272 10.30651/jqm.v3i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2612/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2637 2021-04-27T02:51:00Z qanunmedika:CR

Synovial Chondromatosis in Woman with Symptoms Mimicking Early Stages Osteoarthritis: Case Report Soetojo, Bagus Wibowo Soehadak, Faizal Arifianto Yunus, Yunus Synovial chondromatosis osteoarthritis total synovectomy ABSTRACT  Synovial chondromatosis is a case that rarely found epidemiologically. It is a process which is benign in the synovial lining of joints, synovial sheaths, and bursae. It is the metaplastic process of synovium, which converts it into the cartilage and gets detached to become a loose body. Methods of this study are describing a case report of patient of Airlangga University Hospital that has synovial chondromatosis. A 38 years old woman, with a one-year history of pain, edema, and restriction of the left knee joint. Patient symptoms were insidious in onset, which gradually progressed. Decreased range of motion of her knee. The symptoms were mimicking of osteoarthritis. Considering the extensive involvement with multiple nodule masses inside the knee joint, we planned surgical management and open procedure. Total synovectomy was done, synovium and the masses were sent for histopathological examination which confirmed the diagnosis of synovial chondromatosis. In our case, the patient has clinical symptoms mimicking osteoarthritis of genu. Some study reported similar cases. Although synovium osteochondromatosis is a rare case and it should be kept as a differential diagnosis with chronic knee pain with swelling. Synovial chondromatosis is a rare case in the orthopedic patient. Diagnosis of synovial chondromatosis is often made following a thorough history, physical examination, and radiographic examination and histopathologic. In our case report, we present synovial chondromatosis in woman mimicking osteoarthritis.  Patient treated by surgical removal of the loose bodies followed by total synovectomy. Keywords: Synovial chondromatosis, osteoarthritis, total synovectomy Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion case report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2637 10.30651/jqm.v4i1.2637 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 137-142 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 137-142 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2637/pdf Copyright (c) 2020 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2652 2021-04-27T02:51:00Z qanunmedika:CR

Tumor Mimicking in Musculoskeletal System in Surabaya: A Case Series Hadi, Bayu Antara Edward, Mouli Tumor mimicking osteosarcoma chondroma malignancy. ABSTRACTMusculoskeletal tumors are potential causes of heavy morbidity and economic burdens for patients. There are often cases suspected as musculoskeletal tumors based on a specific diagnostic modality because of overlapping features upon physical examination or a tumor-like appearance from the radiological examination, the more reason for triple diagnosis to be performed for an exact diagnosis.  We report 5 cases of fractures tumor-mimicking lesions. The First patient, a patient with MRI revealing a primary malignant bone tumor, but with plain thorax x-ray and FNAB, the diagnosis was tuberculosis arthritis of the elbow. The second patient shows metastatic proses with plain radiographic, but from open biopsy, the diagnoses fall to chronic osteomyelitis. The third patient had a history of papillary carcinoma thyroid with pathological fracture of proximal of the left femur, but the biopsy shows a hypercalcemic state. The fourth patient, had mass size 20x15 cm at the thigh, but the biopsy shows Non-Specific Chronic Osteomyelitis. The fifth patient with progressive swelling of the left knee for one year, 10x10 cm in size, the biopsy showed no sign of malignancy but tuberculosis of left distal femur. In conclusion, standard comprehensive diagnosis steps consisting of clinical history, imaging, laboratory and histopathological examinations are crucial to differentiate tumor-mimicking lesions from neoplasms, thus ensuring proper treatment.Keywords: Tumour mimicking, osteosarcoma, chondroma, malignancy Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2652 10.30651/jqm.v4i1.2652 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 111-118 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 111-118 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2652/pdf Copyright (c) 2020 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2656 2021-04-27T02:51:00Z qanunmedika:LR

Fiber consumption effect on non-communicable disease: how big is the impact? Indarti, Yuli fiber cardiovascular disease diabetes melitus cancer supplement Abstract  Non-communicable diseases have effects on the quality of human resources because, in addition to causes of death and morbidity, they also reduce productivity. Fiber intake was allegedly affecting the incidence of non-communicable diseases. The purpose of this literature review is to look at the link between fiber intake and the incidence of non-communicable diseases and the effect of fiber supplements to treat non-communicable diseases. Several literature indicate that fiber intake is associated with cardiovascular disease, diabetes mellitus, cancer, and obesity. Research also shows fiber supplementation can improve metabolic profiles, blood sugar, insulin resistance in cardiovascular and diabetes mellitus patients. Fiber supplementation also reduces the risk of breast cancer. Fiber intake is related to the incidence of non-communicable diseases and can overcome some non-communicable diseases Keywords             : fiber, cardiovascular disease, diabetes mellitus, cancer, supplement  Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion lirerature review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2656 10.30651/jqm.v4i1.2656 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 27-34 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 27-34 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2656/pdf Copyright (c) 2020 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2661 2021-04-27T02:51:00Z qanunmedika:CR

Ankle Arthrodesis with Cannulated Screw: Case Series Desnantyo, Andre Triadi Chilmi, Muhammad Zaim Yazid, Hizbillah ankle arthrodesis with cannulated screw fusi sendi pergelangan kaki ABSTRACT Ankle osteoarthritis patients are young and lack of available long last treatment. Ankle arthrodesis remains the gold standard and is the procedure of choice for younger patients who are heavy laborers. These case series evaluate and report five patients undergone ankle arthrodesis at RSUD Dr. Soetomo Surabaya on 2012-2016. The data were collected from patient files, radiographs, and a recent physical examination. The outcome has been assessed with SF-36 score and clinical scoring system Ankle-Hind foot American Foot and Ankle Society. Three male patients and two female patients underwent ankle arthrodesis with cannulated screw, caused by neglected severe ankle dislocation. One patient had open dislocation. Based on SF-36 scoring, the five patients had average score 76,7 with highest and lowest score were 95,9 and 56,7. Based on clinical score ankle-hind foot American Ankle and Foot Society, the average score was 68(51 – 88). The scoring result includes general health, physic, emotional, and social. And clinical scoring ankle-hind foot American Foot and Ankle Society evaluation includes pain, function, and alignment. It shows that there was patient that gains an almost perfect result. Patient with the lowest score also had knee osteoarthritis contralateral from the operated ankle. Early weight bearing on ankle arthrodesis with cannulated screw was the major factor caused unsatisfactory result of this patient. Ankle arthrodesis with cannulated screw has satisfactory result eventhough remain complain on one patient. Nevertheless, ankle arthrodesis with cannulated screw still has an important role in the treatment of choice on ankle reconstruction.Keywords                   : Ankle arthrodesis, cannulated screw, ankle joint fusion  Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion case series application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2661 10.30651/jqm.v4i1.2661 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 87-101 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 87-101 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2661/pdf Copyright (c) 2020 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2706 2021-04-27T02:51:00Z qanunmedika:AR

Elevation of Bcl2 expression in artery spiralis of pregnant Rattus norvegicus infected with Tachyzoite of Toxoplasma gondii with hyperbaric oxygen therapy Nurdianto, Arif Rahman Aryati, Aryati Suryokusumo, Mohammad Guritno Mufasirin, Mufasirin Toxoplasma gondii Tachyzoite Hyperbaric Oxygen Therapy Bcl2 Artery spiralis ABSTRACTSpiral artery apoptosis plays a role in the process of abortion. Low Bcl2 expression found in abortion and in spiral artery. In pregnancy, Toxoplasmosis infection is found to increase apoptosis in spiral arteries. Hyperbaric Oxygen Therapy (HBOT) improves the expression of Bcl-2. This study aims to determine the effects of Hyperbaric Oxygen therapy in enhancing the expressions of Bcl2 in artery spiralis of pregnant rats infected with tachyzoite of Toxoplasma gondii. This is an experiment with a ‘randomized control group of post-test only design’ on 37 Rattus novergicus Sprague Dawley rats. Rats were divided into four groups. The group A is pregnant rats infected with 103 tachyzoites via intraperitoneal injection and received 10 sessions of HBOT 2.4 ATA in 3x30 minutes. Group B is pregnant only and received HBOT. Group C is pregnant and infected with tachyzoite but did not received HBOT. And the last, Group D is pregnant rats with no infection and did not received HBOT. Examinations of Bcl2 expressions were performed on day-5 after HBOT (twice a day). The Bcl2 expression was measured with immunohistochemistry. All data were tested with One-way ANOVA from SPSS 21.  There is an increased expression of Bcl2 spiralis artery in the Group A. There was a significant difference between Group A and Group C with a value of p=0.042. HBOT can increase the expression of Bcl2 from the spiral arteries of rats, in the provision of HBOT 2.4 ATA for 3x30 minutes, 10 times in 5 days.Keywords: Toxoplasma gondii, tachyzoite, Hyperbaric Oxygen Therapy, Bcl2, spiralis arteryCorrespondence to: didins99@gmail.com  ABSTRAK Apoptosis arteri spiralis berperan dalam proses aborsi. Ekspresi Bcl2 rendah ditemukan pada aborsi dan di arteri spiral. Pada kehamilan, infeksi Toxoplasmosis ditemukan meningkatkan apoptosis pada arteri spiralis. Terapi Oksigen Hiperbarik (HBOT) meningkatkan ekspresi Bcl-2. Ini adalah penelitian eksperimental dengan desain post-test only pada 37 hamil Rattus novergicus Sprague Dawley, maka tikus dibagi menjadi 4 kelompok. Grup A HBOT adalah tikus hamil yang terinfeksi tachyzoite yang menerima terapi 10 sesi HBOT 2.4 ATA dalam 3x30 menit; kelompok B adalah Hamil saja dan tidak mendapat HBOT; kelompok C Hamil dan terinfeksi tachyzoite T.gondii tetapi tidak menerima HBOT; dan kelompok D adalah tikus hamil normal. Setiap tikus hamil yang terinfeksi diberi 103 Tachyzoite Toxoplasma gondii melalui intraperitoneal. Pemeriksaan ekspresi Bcl2 dilakukan pada hari ke-5 setelah HBOT (dua kali sehari). Tikus terbunuh dan kadar Bcl2 Arteri spiralis diukur dengan pemeriksaan Immunohistokimia. Semua data dianalisis dengan uji ANOVA dengan Program SPSS 21. Pada studi ini menunjukkan terapi Oksigen Hiperbarik dapat meningkatkan Ekspresi Bcl2 Arteri Spiralis dengan dosis 2.4 ATA selama 3x30 menit dalam 10 sesi selama 5 hari terapi. Studi ini menyimpulkan bahwa HBOT dapat meningkatkan ekspresi Bcl2 dalam arteri spiralis, dalam pemberian HBO 2.4 ATA selama 3x30 menit dalam 10 sesi.Kata kunci: HBOT, Arteri spiralis, Bcl2, Tachyzoite Toxoplasma gondiiKorespondensi: didins99@gmail.com  Universitas Muhammadiyah Surabaya 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2706 10.30651/jqm.v3i2.2706 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 2 (2019); 157-167 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 2 (2019); 157-167 2548-9526 2541-2272 10.30651/jqm.v3i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2706/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2746 2021-04-27T02:51:00Z qanunmedika:AR

Zero Maternal Death with KECUBUNG Featured in SATE Krembung Application (Integrated Queue System) in Krembung Community Health Center in 2017 until 2018 Nurdianto, Arif Rahman SATE Krembung KECUBUNG Maternal Death ABSTRACTThere are some special programs in Maternal and Child Health that have not yet been reached and have a bad trend like the number of Low Birth Weight (LBW), cases of stillbirth, and babies died. There was a congenital defect in babies, increased obstetric complications, and there is one case of maternal death. There were neo-complications in infants and babies. The problem that often results in the death of pregnant women is the lack of early detection at first-level facilities in the Krembung Health center. Early detection and treatment or planning in cases of high-risk pregnant women is lacking, and then we created a SATE Krembung application in 2017. Making SATE Krembung application, socializing to the community, socializing the features of KECUBUNG to report mothers at high risk, and bringing services closer to the community and to evaluate reports from residents. Activities are collected, analyzed, and processed into mature data. The number of people activities collected during the collection of data during this research from 500 users of application from 2017 until 2018. There was a decrease in maternal mortality rates to zero patients in 2017 and 2018. The use of SATE Krembung is quite effective in reducing maternal mortality to zero patients in the Krembung health center work area, but this must be improved with the development of applications. The application of SATE Krembung with KECUBUNG feature can reduce maternal mortality by empowering health cadres and the community to be aware of the environmental conditions surrounding them.Keywords                   : SATE Krembung, KECUBUNG, Maternal Death Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2746 10.30651/jqm.v4i1.2746 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 59-67 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 59-67 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2746/pdf Copyright (c) 2020 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2778 2021-04-27T02:51:00Z qanunmedika:AR

Correlation Between IFNγ+ and CTLA-4+ Tumor Infiltrating Lymphocytes In Luminal And Non-Luminal Breast Carcinoma Parengkuan, Irene Lingkan Mustokoweni, Sjahjenny Kurniasari, Nila research article ABSTRACT The role of tumor infiltrating lymphocytes (TIL) in breast carcinoma depends on the molecular subtype, especially the expression of the estrogen receptor. A greater mutation load in the non-luminal subtype leads to continuous activation of the immune system resulting in exhausted T lymphocytes. Observational research with a cross-sectional approach was conducted on 40 formalin fixed paraffin-embedded tissue from breast carcinoma at the Anatomical Pathology Laboratory of Dr. Soetomo General Hospital Surabaya during January 2017 -  December 2018. Samples were divided into two groups based on their status of ER expression. The parameter was a positive percentage of TIL immunoreactivity against IFNγ and CTLA-4 antibodies. Percentage of IFNγ+ TIL is higher in the luminal subtype (p =0.001), whereas the percentage of CTLA-4+ TIL is higher in the non-luminal (p =0.001). These expressions were significantly correlated with the molecular subtype of breast carcinoma (p=0.001). A significant correlation between IFNγ+ and CTLA-4+ TIL were found (rs=-0.350, p=0.027). Exhausted T lymphocytes express some inhibitor molecules such as CTLA-4. CTLA-4 (Cytotoxic T-Cell Lymphocyte Associated Protein-4) suppresses immune system function including the activity of IFN-γ as an important molecule in anti-tumor immunity and forms an immunosuppressive and pro-tumor microenvironment. Different level of expressions of IFNγ+ (p=0.001) and CTLA-4 + (p=0.001) TIL were proven to be related to the molecular subtype of breast carcinoma (rs=-0.683, p=0.001; rs=0,501, p=0.001, respectively). The negative correlation between IFNγ+ and CTLA-4+ TIL shows the role of CTLA-4 as an inhibitory molecule to the immune system (rs=-0.350, p=0.027).Keywords : tumour infiltrating lymphocytes, IFNγ, CTLA-4, breast carcinoma,  luminal molecular subtypeCorrespondence to: lingkan.parengkuan@gmail.com ABSTRAK Peran tumour infiltrating lymphocytes (TIL) pada karsinoma payudara berhubungan erat dengan subtipe molekuler, terutama ada atau tidaknya ekspresi reseptor estrogen. Beban mutasi yang besar pada subtipe non-luminal menyebabkan pengaktifan sistem imun terjadi terus menerus dengan hasil akhir terbentuknya subset limfosit T yang kelelahan. Penelitian observasional analitik dengan pendekatan potong lintang ini menggunakan sampel 40 blok parafin dari penderita karsinoma payudara di Laboratorium Patologi Anatomi RSUD Dr. Soetomo Surabaya periode 1 Januari 2017 – 31 Desember 2018 yang dibagi menjadi 2 kelompok berdasarkan ada atau tidaknya ekspresi reseptor estrogen. Parameter penilaian adalah jumlah persentase TIL area tumor invasif yang terpulas positif dengan antibodi IFNγ dan CTLA-4. Ekspresi IFNγ+ TIL didapatkan lebih tinggi pada subtipe luminal (p=0,001), sedangkan ekspresi CTLA-4+ TIL didapatkan lebih tinggi pada subtipe non-luminal (p=0,001). Analisis statistik menunjukkan adanya korelasi signifikan antara ekspresi IFNγ+ TIL dengan CTLA-4+ TIL (rs=-0,350, p=0,027). Salah satu sifat dari sel limfosit T kelelahan adalah mengekspresikan molekul inhibitor sistem imun antara lain CTLA-4 (Cytotoxic T-Cell Lymphocyte Associated Protein-4). CTLA-4 akan menekan fungsi sistem imun dan berdampak pada penurunan aktivitas IFN-γ yang merupakan salah satu molekul penting dalam imunitas anti-tumor sehingga terbentuklah lingkungan mikro yang imunosupresif dan pro-tumor. Hasil penelitian menunjukkan adanya perbedaan ekspresi IFNγ+ TIL (p=0,001) dan CTLA-4+ TIL (p=0,001) pada kedua kelompok yang secara bermakna berhubungan dengan subtipe molekuler karsinoma payudara (secara berurutan mendapatkan nilai (rs=-0,683, p=0,001 dan rs=0,501, p=0,001). Korelasi negatif antara IFNγ+ TIL dengan CTLA-4+ TIL menunjukkan adanya peran CTLA-4 sebagai molekul inhibisi terhadap sistem imun (rs=-0,350, p=0,027).Kata kunci                  : tumour infiltrating lymphocytes, IFNγ, CTLA-4, karsinoma payudara, subtipe molekuler luminalKorespondensi            :lingkan.parengkuan@gmail.com Universitas Muhammadiyah Surabaya 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Observational research with an cross-sectional approach application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2778 10.30651/jqm.v3i2.2778 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 2 (2019); 169-180 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 2 (2019); 169-180 2548-9526 2541-2272 10.30651/jqm.v3i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2778/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2781 2021-04-27T02:51:00Z qanunmedika:AR

Drug Hypersensitivity in Daily Practice Soegiarto, Gatot Immunology Medicine Drugs ABSTRACTAdverse drug reactions can affect up to 25% of outpatients and 10–20% of hospitalized patients. They are an important public health issue due to the potential of fatal outcomes. They are increasingly common in daily practice, but ascertaining whether the adverse reaction is a true allergic reaction to the drug is not easy. Drug hypersensitivity encompasses a spectrum of immunologically and non-immunologically-mediated reactions with varying mechanisms and clinical presentations. Factors associated with an increased risk of developing a drug hypersensitivity include patient-related factors, treatment regimen-related factors, and drug-related factors.  Diagnosis of drug hypersensitivity relies on a careful history and physical examination and, in some instances, in vivo and in vitro testing and drug provocation tests. The most effective strategy for the management of drug allergy is avoidance and discontinuation of the offending drug(s). Alternative medications with unrelated chemical structures should be given. Additional therapy is largely supportive which includes nutritional support, fluid replacement, and symptomatic which may include topical corticosteroids, oral antihistamines and, in severe cases, systemic corticosteroids. This article will discuss the classification of adverse reactions to drugs, professional steps that can be taken by a physician in prescribing drugs, minimizing the risk of adverse drug reactions, approach to diagnosis, and managing drug hypersensitivity cases in daily practice.Keywords: drug reaction, drug hypersensitivity, drug allergyCorrespondence to: gatotsby@yahoo.com ABSTRAKReaksi efek samping obat dapat mengenai sekitar 25% pasien rawat jalan dan 10-20% pasien rawat inap. Reaksi efek samping obat adalah masalah kesehatan masyarakat yang penting karena berpotensi fatal. Hal tersebut semakin umum dijumpai dalam praktek sehari-hari, tetapi memastikan apakah reaksi efek samping tersebut adalah reaksi alergi yang sebenarnya terhadap obat itu tidaklah mudah. Hipersensitivitas obat mencakup spektrum reaksi yang dimediasi secara imunologis dan non imunologis dengan berbagai mekanisme dan presentasi klinis. Faktor-faktor yang terkait dengan peningkatan risiko terjadinya hipersensitivitas obat meliputi faktor terkait pasien, faktor terkait regimen pengobatan, dan faktor terkait obat. Diagnosis hipersensitivitas obat bergantung pada anamnesis dan pemeriksaan fisik yang cermat dan, dalam beberapa kasus, tes in vivo dan in vitro dan tes provokasi obat. Strategi yang paling efektif untuk pengelolaan alergi obat adalah penghindaran dan penghentian obat-obatan tersebut. Obat-obatan alternatif dengan struktur kimia yang tidak terkait harus diberikan. Terapi terapi suportif yang mencakup dukungan nutrisi, penggantian cairan, dan gejala yang mungkin termasuk kortikosteroid topikal, antihistamin oral dan, dalam kasus yang parah, kortikosteroid sistemik dapat diberikan. Artikel ini akan membahas klasifikasi reaksi efek samping terhadap obat, langkah profesional yang dapat diambil oleh dokter dalam meresepkan obat, meminimalkan risiko reaksi efek samping obat, pendekatan untuk diagnosis, dan manajemen kasus hipersensitivitas obat dalam praktik sehari-hari.Kata kunci: Reaksi obat, hipersensitivitas obat, alergi obatKorespondensi: gatotsby@yahoo.com Universitas Muhammadiyah Surabaya 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion literature review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2781 10.30651/jqm.v3i2.2781 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 2 (2019); 93-111 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 2 (2019); 93-111 2548-9526 2541-2272 10.30651/jqm.v3i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2781/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2807 2021-04-27T02:51:00Z qanunmedika:AR

The Role Of Denosumab Utama, Raditya Pria Fajri, Hesty Rohmatul Denosumab RANKL osteoporosis treatment ABSTRACT  Osteoporosis is one of the most common chronic diseases. This condition makes bones in a person to become more porous and fragile, therefore greatly increase their risk of suffering a fracture. In Asia, the mortality rate that are associated with these fractures occurred between 10–20% of cases within a year.  Osteoporosis is a condition in which there is an imbalanced activity between osteoblast and osteoclast. Osteoblast and osteoclast are two types of bone cells that majorly involve in bone remodelling process. Osteoclasts adhere to the bone surface once it mature, after that osteoclast both produce and secrete chloride acid (HCl), which will acidify bones and dissolve the bone mineral. Receptor Activator of Nuclear Factor kappa B Ligand (RANKL) is one of the necessary  factors in bone remodelling process. It will activate and mature the osteoclast. Denosumab is a monoclonal antibody that will inhibit  the binding of RANKL to its receptor, decreasing osteoclastogenesis and bone-resorbing activity.  This inhibiting activity will theoretically increase the bone mass density in ones’ body, ergo will treat and prevent osteoporosis. Denosumab showed favourable effect on bone metabolism without having serious adverse events compared to control group. This paper reviews the clinical pharmacology, pharmacokinetic and pharmacodynamic properties, and tolerability in the denosumab in the management of osteoporosis.Keywords                   : Denosumab, RANKL, osteoporosis, treatmentCorrespondence to      : radityapu@gmail.comABSTRAK  Osteoporosis adalah salah satu jenis dari penyakit kronis yang sering terjadi. Penyakit ini menyebabkan tulang seseorang menjadi lebih berongga dan rapuh, kondisi ini meningkatkan risiko patah tulang pada orang-orang tersebut. Di Asia, mortality rate yang berhubungan dengan kejadian patah tulang ini berkisar antara  10 – 20% dalam satu tahun. Osteoporosis adalah suatu kondisi dimana terjadi ketidakseimbangan antara osteoblast dan osteoklas. Osteoblas dan osteoklas adalah dua tipe dari sel tulang yang berperan pada proses bone remodelling. Setelah matang, osteoklas akan menempel pada tulang untuk menghasilkan dan menyekresi HCl, yang dimana zat ini akan mengasamkan tulang dan meluruhkan mineral di tulang.  Receptor Activator of Nuclear Factor kappa B Ligand (RANKL) adalah salah satu faktor yang dibutuhkan dalam proses remodelling tulang. RANKL akan mematangkan dan mengaktifkan osteoklas. Denosumab adalah antibody monoclonal yang menghambat ikatan dari RANKL kepada reseptor dari RANKL, menurunkan proses osteoklasogenesis dan aktivitas penyerapan tulang. Secara teori proses ini akan meningkatkan massa dari tulang dan mencegah osteoporosis. Denosumab menunjukan efek yang sbaik pada metabolisme tulang tanpa menunjukkan efek samping yang serius. Makalah ini akan meninjau tentang farmakologi klinis, farmakodinamik , dan farmakokinetik, serta tolerabilitas dari denosumab dalam terapi osteoporosis.Kata kunci                  : Denosumab, RANKL, osteoporosis, treatment Korespondensi             : radityapu@gmail.com Universitas Muhammadiyah Surabaya 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Literature review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2807 10.30651/jqm.v3i2.2807 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 2 (2019); 113-122 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 2 (2019); 113-122 2548-9526 2541-2272 10.30651/jqm.v3i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2807/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2826 2021-04-27T02:51:00Z qanunmedika:AR

Sensitivity and Specificity Comparison Between APFEL, KOIVURANTA, and SINCLAIR Score As PONV Predictor In Post General Anesthesia Patient Gunawan, M Yusuf Utariani, Arie Maulydia, Maulydia Veterini, Anna Surgean PONV predictor score apfel score koivuranta score sinclair score general anesthesia ABSTRACTBackground: Post Operative Nausea Vomiting (PONV) are the two most common and unpleasant side effects after anesthesia and surgery. Without proper prophylactic administration, the PONV incidence is currently around 20% -30% in normal patients and 70% in high-risk patients (Butterworth et al., 2013). Recently, many PONV predictor scores have been used to determine the PONV severity and prophylactic administration. Objective: To compare the scores of Apfel, Koivuranta, and Sinclair as predictors of PONV in adult patients after general anesthesia at RSUD Dr. Soetomo. Methods: A cross-sectional study design conducted in 100 patients who underwent elective surgery under general anesthesia at RSUD Dr. Soetomo Surabaya. Patients who meet the criteria will be recorded in the clinical research form and being followed to evaluate the assessment using Apfel, Koivuranta, and Sinclair scores when the patient is in the recovery room and the ward. A diagnostic test is performed to assess the accuracy between these scores. Results: In this study, the prevalence of PONV after general anesthesia in elective surgery at GBPT RSUD Dr Soetomo Surabaya is 26%. The Apfel score obtained has a sensitivity value of 79.5%, a specificity of 45.9% with an AUC value of 0.701. The Koivuranta score has a sensitivity value of 96.2%, a specificity of 27% with an AUC value of 0.628. The Sinclair score has a sensitivity value of 73.1%, a specificity of 48.6% with an AUC value of 0.619. Conclusion: Apfel's score is more accurate PONV prediction score and has a simpler score determination variable. Keywords                   : PONV, predictor score, apfel score, koivuranta score, sinclair score, general anesthesia.  Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Experimental Study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2826 10.30651/jqm.v4i1.2826 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 69-76 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 69-76 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2826/pdf Copyright (c) 2020 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/2833 2021-04-27T02:51:00Z qanunmedika:AR

The clinical and histopathological aspect of the liver, lung, and kidney in Malaria Akil, Syafarinah Nur Hidayah Malaria organ dysfunction lung liver kidney histopathology Malaria is an infectious disease with worldwide distribution. The symptom ranges from asymptomatic to severe malaria that could cause mortality. Sequestration and rosetting in the capillaries of several organs in combination with the host inflammatory and immune response could cause multi-organ dysfunction including brain, liver, lung, kidney, etc. This review is to summarize the clinical and histopathological aspect of the disease, especially in lung, liver, and kidney. The clinical importance of severe malaria in the lung are acute lung injury or acute respiratory distress syndrome, jaundice in the liver, and acute kidney injury in the kidney. The histopathological change, in general, is the sequestration of infected erythrocytes in the capillaries of the organ. In the lung, the main changes are seen especially the septa. While in the liver, there are various changes including Kupffer cells hyperplasia, the proliferation of portal tract and bile duct, etc. In the kidney, the changes are in the glomerulus, tubules, and interstitial. Universitas Muhammadiyah Surabaya 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion literature review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/2833 10.30651/jqm.v3i2.2833 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 3 No. 2 (2019); 123-135 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 3 No 2 (2019); 123-135 2548-9526 2541-2272 10.30651/jqm.v3i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/2833/pdf Copyright (c) 2019 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/3083 2021-04-27T02:51:00Z qanunmedika:CR

Collecting Duct Carcinoma: A Rare Entity Djawa, Ferdinant Martinus Rahaju, Anny Setijo renal cell carcinoma collecting duct carcinoma urothelial carcinoma PAX8 p63 ABSTRACTCollecting duct carcinoma is a rare and highly aggressive subtype of renal cell carcinoma. The incidence rate is less than 1-2% of all renal tumors and usually, affect middle-aged adult, commonly in men. We reported a 76-year-old man complains of an intermittent painless gross hematuria, abdominal mass and left flank pain for approximately three months. The CT abdomen showed a slightly enhancing solid mass in the left kidney and para-aorta lymphadenopathy. Cut surfaces of the kidney showed a solid-cystic and ill-defined greyish-white tumor. Microscopically, tumor formed solid sheets and tubulopapillary structures lined by neoplastic cells, hobnailing nuclei, abnormal mitotic, and a desmoplastic stroma with lymphoplasmacytic infiltration, and the immunochemical profile were PAX8 (+) /p63 (-). Based on these findings, the diagnosis was a collecting duct carcinoma. This tumor arising from the collecting duct of Bellini in the renal medulla, accounts for less than 1-2% of all renal masses and important to be distinguished from other tumors due to differences in prognosis and therapeutic. Histopathological examination is needed to establish the diagnosis. A case of collecting duct carcinoma that occurred in a 76-year-old man has been reported. A definitive diagnosis can only be done with a detailed histopathological examination for patient management benefits.Keywords          : renal cell carcinoma, collecting duct carcinoma, urothelial carcinoma, PAX8, p63 Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion case report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3083 10.30651/jqm.v4i1.3083 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 129-136 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 129-136 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3083/pdf Copyright (c) 2020 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/3119 2021-04-27T02:51:01Z qanunmedika:AR

Comparison of clinical evaluation of post-operation patients of open reduction internal fixation (ORIF) plating proximal humerus using conventional methods and minimally invasive plate osteosynthesis (MIPO) in Surabaya Arafah, Musa Suroto, Heri Ramawan, Erwin proximal humeral fracture Minimal Invasive Plate Osteosynthesis (MIPO) Open Reduction Internal Fixation (ORIF) ABSTRACT There are several kinds of approaches in the installation of implants for proximal humerus therapy. At present, minimally invasive surgery is gaining in popularity; this is supported by increasingly good technological developments to optimal the postoperative outcome is more optimal than conventional methods. This study used an analytic retrospective design with samples of post-ORIF Plating MIPO and posted ORIF due to proximal humeral fracture. Evaluation using the instrument of VAS Score, ASES Score, and measurement of range of motion. Statistical tests showed that there was a significant difference in the VAS score at the first evaluation (p = 0.002); the last review was not significant. In ASES Score, abduction, flexion, and external rotation, there were significant differences during the first and last evaluations. Adduction, extension, and internal rotation have no significance. The method of minimally invasive plate osteosynthesis (MIPO) on proximal humeral operative fracture therapy had a better clinical outcome and operating time than post-ORIF plating with conventional methods. As well, the MIPO method on proximal humeral fracture operative therapy based on radiological features has the same union rates compared to post ORIF plating with conventional methods. The method of minimally invasive plate osteosynthesis (MIPO) in operative therapy of neer 2 and 3 proximal humeral fracture has a better clinical outcome than conventional methods.Keywords: proximal humeral fracture, Minimal Invasive Plate Osteosynthesis (MIPO), Open Reduction Internal Fixation (ORIF)Correspondence to: musa_shi911@yahoo.com    Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3119 10.30651/jqm.v4i2.3119 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 165-170 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 165-170 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3119/pdf Copyright (c) 2020 Qanun Medika - Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/3142 2021-04-27T02:51:01Z qanunmedika:CR

Characteristics of complaints and functional outcomes of conservatively treated clavicle fractures in Dr. Soetomo general hospital: A case series Wirashada, Brilliant Citra Roychan, Maghrizal Wardhana, Teddy Heri Clavicle fractures shoulder pain conservative clavicle. ABSTRACT  Shoulder pain is a major complaint of patients with clavicle fractures as a result of trauma. At present most clavicle fracture treatments are performed surgery, although conservative therapy can produce the same results. This report aimed to show whether there were complaints of shoulder pain or disability in patients who have suffered clavicle fractures treated conservatively. There were fifteen patients with clavicle fractures at Dr. Soetomo Surabaya from January to July 2015, consisting of 14 male and one female patient. Data was taken from medical records, patient clinical records, home visits, physical examinations, SPADI questionnaires, and Quick DASH for patients. The results of SPADI questionnaire were varied; there were eight patients (53%) with an output of 0%, one patient (7%) each with a score of 0.63%, 1.25%, 5.90%, 7.13%, 8.50%, 9.90%, and a score of 10.50%. The results of calculating the Quick DASH questionnaire score also varied. There were ten patients (67%) with a score of 0, three patients (20%) with a score of 2.27, one patient (7%) with a score of 13.6, and one patient (6%) with a score of 6.81. In conclusion: (1) From the evaluation of 15 patients, there were no complaints of pain and disability in the shoulder joint. (2) From the evaluation of the results of the calculation of the SPADI questionnaire and Quick DASH, there were no significant complaints of shoulder joint pain and disability. (3) The conservative treatment of closed fractures on the clavicle can still be a reliable choice of treatment. Keywords                 : Clavicle fractures, shoulder pain, conservative clavicle.Correspondence to: brijurnalqanun@gmail.com   Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Case Report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3142 10.30651/jqm.v5i1.3142 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 153-161 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 153-161 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3142/pdf Copyright (c) 2021 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

oai:journal.um-surabaya.ac.id:article/3322 2021-04-27T02:51:00Z qanunmedika:AR

Relationships Between Body Mass Index with Cholelithiasis Thamrin, Husin Marthalitasari, Nadieda Ayu Prajitno, Subur body mass index cholelithiasis gallstone AbstractGallstones formed due to imbalance of bile components, excessive/ high level of cholesterol, nor bilirubin. Obesity was a condition where body mass index (BMI) was excess, which can cause health problems such as an increase of cholesterol, triglycerides, insulin levels, and blood pressure. There’s growing attention to cholelithiasis in Indonesia, but there wasn’t any data on the prevalence due to the limited amount of study related to cholelithiasis and BMI. This study aimed to analyze the relationship between BMI and cholelithiasis in Dr. Soetomo General Hospital. An analytical descriptive study with the case-control design was conducted, and the data were collected from medical records. The sample was 124 patients from the internal outpatient clinic Dr. Soetomo General Hospital. The data were analyzed using a t-test 2 independent sample. The ratio between female and male patients was 3:1, mean of age was 36-45 years, 45.2% had weight range from 61-70 kg, 51.2% had height range 150-159 cm, the BMI from patient with cholelithiasis specifically 45.3% on at-risk scale and 40% on obese I, the result showed p-value 0.089 (p>0.05), which means that there was no significant differences with the BMI from patients with cholelithiasis and without cholelithiasis. In conclusion, BMI could not be used as a parameter to determine the occurrence of cholelithiasis on an individual.Keywords: body mass index, cholelithiasis, gallstone Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion An analytical descriptive study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3322 10.30651/jqm.v4i1.3322 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 43-49 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 43-49 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3322/pdf Copyright (c) 2020 Husin Thamrin, Nadieda Ayu Marthalitasari

oai:journal.um-surabaya.ac.id:article/3397 2021-04-27T02:51:00Z qanunmedika:AR

Relationship between Smoking and Quality Of Life on Patient’s with Chronic Obstructive Pulmonary Disease In Dr.Reksodiwiryo Padang Hospital Hasni, Dita Safitri, Jely Dewi, Nadia Purnama Warlem, Nilas copd quality of life smoking Abstract Chronic obstructive pulmonary disease (COPD) is a lung disease with the limitation of the airway, which is not completely reversible and is progressive. One of the risk factors of this disease is exposure to cigarette smoke for a long time. The purpose of this research is to know the relationship of smoking with the quality of life of chronic obstructive pulmonary disease patients at Dr. Reksodiwiryo Padang Hospital. This cross-sectional research has been implemented in February-May 2019 and involving 35 research subjects that meet inclusion and exclusion criteria. In this study, data was obtained that 97.1% of male gender research subjects, aged 60-69 years, 37.1%, 45.7% had moderate smoking status, poor quality of life 54.3% and there was a relationship with quality of life in Dr. Reksodiwiryo Padang Hospital (P-value < 0.05). In this research can be concluded that there is a smoking relationship with the quality of life patients of chronic abortive pulmonary disease patients in Dr. Reksodiwiryo Hospital, Padang.Keywords:            Smoking Status, quality of life, COPD.  Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion original article application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3397 10.30651/jqm.v4i1.3397 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 35-42 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 35-42 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3397/pdf Copyright (c) 2020 Dita Hasni

oai:journal.um-surabaya.ac.id:article/3402 2021-04-27T02:51:00Z qanunmedika:AR

Contamination of water and soil of rice fields with soil transmitted helminths as source of transmission to farmers in Grogol sub-district, Kediri district Munawaroh, Siti Arwati, Heny Wardhani, Puspa feses soil STH Water ABSTRACTSoil-transmitted helminths (STH) are the worms which transmitted through the soil. The people of Dusun Semen, Grogol, Kediri have a habit of defecating in the river. Farmers who work in direct contact with water and soil is possible to be infected with STH. The purpose of this study was to determine STH species in water, soils, and farmer's fecal samples. Water samples were collected from three spots of river A and B, soil samples from 43 rice fields, and fecal samples from 50 farmers. Water samples were examined by sedimentation, soil samples by floatation, and fecal samples by Kato-Katz method. The data were then analyzed by Chi square test. Out of 18 water samples, 12 samples (66.7%) were positive, consisted of 4 samples (22.2%) contained of Ascaris lumbricoides and 8 samples (44.4%) contained Trichuris trichiura. Total soil samples were 129, where 8 samples (6.2%) were positive for A. lumbricoides, and 10 samples (7.7%) for T. trichiura. Out of 50 villagers, only 39 gave the fecal samples, where 12 samples (31.0%) were positive consisted of 5 samples (12.8%) for A. lumbricoides, 8 samples (20.5%) for T.trichiura. In conclusion, the STH species found in the media of water, soil, and feces of farmers are the similar namely A. lumbricoides and T. trichiura. Positive farmer samples prove STH transmission from STH contaminated water and soil.Keyword: Water, soil, feces, soil transmitted helminths Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Experimental Study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3402 10.30651/jqm.v4i1.3402 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 51-58 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 51-58 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3402/pdf Copyright (c) 2020 SITI SITI MUNAWAROH

oai:journal.um-surabaya.ac.id:article/3426 2021-04-27T02:51:01Z qanunmedika:AR

Relationship of Prostate-Specific Antigen (PSA) and Prostate Volume in Patients with Biopsy Proven Benign Prostatic Hyperplasia (BPH) Fadila, Aulia Nur Rahaju, Anny Setijo Tarmono, Tarmono benign prostatic hyperplasia prostate specific antigen prostate volume Abstract  Benign prostatic hyperplasia (BPH) is one of the most common benign tumors in men with prevalence ranging from 50% for men in their 60s to 90% for men in their 80s. The researcher sought to determine the relationship of prostate-specific antigen (PSA) and prostate volume in patients with benign prostatic hyperplasia. This study was based on 33 cases of benign prostatic hyperplasia in the Department of Urology, RSUD Dr. Soetomo Surabaya that diagnosed by histopathology examination. Cases with malignancy, acute urinary retention and prostatitis were excluded. The variables of prostate-specific antigen and prostate volume were examined. The results of this study found that 33 men were enrolled with mean PSA 16,04 ng/ml and a mean prostate volume of 49,13 ml. Overall, 84,8% had PSA level >4 ng/ml and 90,9% had prostate volume >25 ml. Prostate-specific antigen has significant correlation with prostate volume (p=0,019; r=0,362). This study concluded that prostate-specific antigen and prostate volume showed a significant correlation. Keywords             : benign prostatic hyperplasia, prostate specific antigen, prostate volumeCorrespondence   : anny_sr@fk.unair.ac.id Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3426 10.30651/jqm.v4i2.3426 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 171-177 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 171-177 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3426/pdf Copyright (c) 2020 Aulia Nur Fadila

oai:journal.um-surabaya.ac.id:article/3478 2021-04-27T02:51:00Z qanunmedika:LR

Role Of Inhaled Nitric Oxides In Pregnancy With Eisenmenger Syndrome Anas, Muhammad Triastuti, Nenny Airlangga, Muhammad Perdana Inhalation Nitric Oxides Pregnancy Eisenmenger Syndrome ABSTRACTEisenmenger Syndrome (ES) is congenital heart disease with pulmonary hypertension and shunting turning from right to left. The resistance of pulmonary vascular more than 7.5 mmHg/L/min. The right ventricle and pulmonary artery always enlarge. During pregnancy, there will be hemodynamic changes that will affect the ES. It can be understood the possible dangers that can occur, like right heart failure; an increase in pulmonary arteries or the aggravation of pulmonary hypertension because there is no decrease in pulmonary resistance; A sudden decrease in venous return in supine hypotension syndrome can cause a relative increase in pulmonary arterial pressure so as to aggravate pulmonary hypertension and reverse shunting.Physiological effects of inhaled nitric oxide (INO) therapy cause selective pulmonary vasodilation: Hypoxia alveoli causes reversible vasoconstriction, thereby increasing pulmonary wedge pressure. INO can lower it. Moderate cardiac output and systematic arterial pressure are not affected; Selective in pulmonary because it is activated by hemoglobin; Selective vasodilation in the ventilated area, local hypoxia alveoli constricts the surrounding vascular tissue and redistributes blood flow to the ventilated lungs better and higher intraalveolar oxygen pressure. INO enhances this mechanism by increasing blood flow through a well-ventilated lung; Bronchodilators; Pulmonary surfactant, The combination of high concentrations of inspired oxygen and high concentrations of INO reduces the minimum surfactant surface tension.Keywords: Inhalation Nitric Oxides, Pregnancy, Eisenmenger Syndrome Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Literature Review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3478 10.30651/jqm.v4i1.3478 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 11-26 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 11-26 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3478/pdf Copyright (c) 2020 Muhammad Anas, Nenny Triastuti, Muhammad Perdana Airlangga

oai:journal.um-surabaya.ac.id:article/3532 2021-04-27T02:51:00Z qanunmedika:LR

Effectiveness of core stability exercise for knee joint osteoarthritis: A review Wisnubrata, Muhammad Deyu Zharfan, Rahmat Sayyid article review Abstract  Background: The knee joint is a weight-bearing support joint that often affected by osteoarthritis. Knee joint osteoarthritis is characterized by pain in a movement that disappears when resting, joint stiffness especially after prolonged resting or waking up, crepitations, and can be accompanied by synovitis with or without joint fluid effusion. If the patient was passive, did not do exercises, muscle atrophy can occur, which will worsen the stability and function of the joint. Other consequences that can disrupt daily activities to the most severe feature, such as an inability to walk.  Objective: To discuss the role of core stability exercise for pain reduction in osteoarthritis. Method: This type of study is a literature review. Result: The goals of core stability exercise include: increasing muscle strength, improving posture, reducing pain, increasing ability, and functional mobility in patients. The provision of core stability exercise has a relationship between core stability with hip, knee, and ankle. This is because all parts of the body are connected to each other, both directly and indirectly. If the core muscle is strong, the muscles of the hip, knee, and ankle will also be strong. Conclusion: Core stability exercise is potential in the management of knee osteoarthritisKeywords:            core stability exercise, joint, knee, osteoarthritis Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion literature review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3532 10.30651/jqm.v4i1.3532 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 1-9 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 1-9 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3532/pdf_1 Copyright (c) 2020 Muhammad Deyu Wisnubrata

oai:journal.um-surabaya.ac.id:article/3539 2021-04-27T02:51:01Z qanunmedika:AR

Sequestration of erythrocytes infected with Plasmodium berghei ANKA in BALB/c mice treated with goat bile Wardani, Kartika Arum Aini, Kholida Nur Arwati, Heny Sandhika, Willy Malaria parasitemia sequestration goat bile Abstract Sequestration of Plasmodium berghei ANKA-infected erythrocytes occurs in BALB/c mice as characteristic of  Plasmodium falciparum infection in humans. Animals’ bile has been widely used for centuries in Traditional Chinese Medicine. Goat bile has been used in healing infectious and non-infectious diseases; however, no report on the use of goat bile against malaria infection and sequestration. The purpose of this study was to analyze the correlation between parasitemia and sequestration in the liver of P.berghei ANKA-infected BALB/c mice treated with goat bile. This research was an in vivo experimental study using the post-test control group design. The male BALB/c mice aged ± 6 weeks, body weight 20-25 g were used. The mice were divided into five groups where Group 1-3 were mice treated with goat bile 25%, 50%, and 100%, respectively. Group 4-5 were negative (sterile water) and positive controls (DHP). Parasitemia was observed daily from each mouse and the number of sequestered infected erythrocytes on the endothelium of sinusoids. The data were analyzed using t independent test. Antimalarial activity of goat bile was shown by the lower parasitemia in goat bile-treated mice compared with the negative control. The average number of sequestration was goat bile concentration-dependent manner. The higher the concentration, the lower the number of sequestration. Sequestration was correlated with parasitemia (p=0,0001). Sequestration of P.berghei ANKA-infected erythrocytes correlated with parasitemia, and was goat bile concentration-dependent manner. Keywords: Malaria, parasitemia, sequestration, goat bileCorrespondence: arwatiheny@gmail.com Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion In vivo experimental study using the post-test control group design. application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3539 10.30651/jqm.v4i2.3539 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 179-186 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 179-186 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3539/pdf Copyright (c) 2020 KARTIKA ARUM WARDANI, KHOLIDA NUR AINI, HENY ARWATI, WILLY SANDHIKA

oai:journal.um-surabaya.ac.id:article/3540 2021-04-27T02:51:01Z qanunmedika:AR

Antimalarial activity of goat bile against Plasmodium berghei ANKA infection in BALB/c mice Aini, Kholida Nur Hapsari, Windya Tri Wardani, Kartika Arum Arwati, Heny Sandhika, Willy Goat bile parasitemia Plasmodium berghei ANKA ED50 Abstract Goat bile has been used by some Indonesian people to treat malaria and increase their stamina. This study aimed to prove whether goat bile toxic or not in BALB/c mice and to verify the antimalarial activity of goat bile at various concentrations in mice infected with Plasmodium berghei ANKA. Acute toxicity test was performed using twenty male BALB/c mice with an average body weight of 25 grams, which were divided into four groups. Mice were given 25%, 50%, and 100% goat bile, respectively, while negative control was given distilled water. Any change in weight, odor, color, agitation, appearance, color of urine and feces, coma, and death, were recorded. A different set of mice were infected with P. berghei ANKA. This study conducted using the posttest only control group design with four treatments and five replications. A four day-treatment of goat bile was given by oral gavage to find out its effect on parasitemia level. Infected mice were divided randomly into 4 groups, where the GBNeg group as negative control was given only distilled water. The GB25, GB50, and GB100 groups were treated with 25%, 50%, and 100% goat bile, respectively. The parasitemia was observed daily on Giemsa-stained tail blood smears of each mice. No death or other sign of toxicity was found in goat bile-treated mice. Goat bile showed anti-malarial activity. The parasitemia in all goat bile treated groups was lower compared with the negative control group. The ED50 of goat bile against the growth of parasite was 48,55 %. Goat bile is a potential source of new antimalarial therapies. Further investigations are recommended to yield new anti-malarial drug candidates. Keywords                :    Goat bile, parasitemia, Plasmodium berghei ANKA, ED50Correspondence     :    heny-a@fk.unair.ac.id Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion In vivo experimental study using the post-test control group design. application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3540 10.30651/jqm.v4i2.3540 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 187-194 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 187-194 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3540/pdf Copyright (c) 2020 KHOLIDA NUR AINI, WINDYA TRI HAPSARI, KARTIKA ARUM WARDANI, HENY ARWATI, WILLY SANDHIKA

oai:journal.um-surabaya.ac.id:article/3559 2021-04-27T02:51:01Z qanunmedika:AR

Thrombocyte Count in Male and Female Adult of Dengue Hemorrhagic Fever Patients Afgriyuspita, Lelyana Sih Arwati, Heny Kahar, Hartono research article AbstractThe trend of dengue virus infection in Indonesia has changed from children to older groups. Some studies suggested that different gender might affect the different progression of dengue infection, but its mechanism was unclear. This study analyzed the difference by evaluating the daily thrombocyte count pattern. An analytic observational study with a retrospective design was conducted using the secondary data collected from medical records in Dr. Soetomo General Hospital Surabaya during 2017-2018. The samples were adult patients in the age range of 18-55 years old with DHF but without comorbidity or coinfection. The total number of samples was 40 patients. The average of thrombocyte count in both male and female patients decreased since the 3rd day of illness and reached the lowest level on the 6th day of illness then increased on the 7th day but did not reach the normal range. Although the majority of thrombocyte count in females was lower than males, there was no significant difference in thrombocyte count pattern between them. Keyword: Adult, DHF, Thrombocyte, GenderCorrespondence : heny-a@fk.unair.ac.id Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Descriptive observational study (retsrospective design) application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3559 10.30651/jqm.v4i2.3559 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 195-202 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 195-202 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3559/pdf Copyright (c) 2020 Lelyana Sih Afgriyuspita, Heny Arwati, Hartono Kahar

oai:journal.um-surabaya.ac.id:article/3566 2021-04-27T02:51:00Z qanunmedika:AR

Wild tembelek plant (Lantana camara) as a potential bioactive natural product againts Streptococcus pyogenes in Indonesia Alfaray, Ricky Indra Faizun, Rafiqy Sa'adiy Yodianto, Lionardy Batsaikhan, Saruuljavkhlan Rezkitha, Yudith Annisa Ayu Antibacterial potential Lantana camara Streptococcus pyogenes Abstract  Infectious diseases are common problems in most countries. Streptococcus pyogenes is the infectious agent that causes diseases such as pharyngitis, impetigo, toxic shock syndrome, and necrotizing fasciitis. Tembelek (Lantana camara) is a wild plant that can easily be found in every ecosystem in Indonesia whether in nature or settlements and known as a plant that has an antibacterial effect but the knowledge about its potential against Streptococcus pyogenes in this past five years remain scant. The aim of this study was to determine the potentiality of Lantana camara leaves and flowers extract against Streptococcus pyogenes. In this experimental study, in vitro using Post-test Only Control Group Designed, has been done and confirmed by the Indonesian Institute of Sciences. Lantana camara leaves and flowers extracts were obtained by maceration using ethanol. The extracts were diluted into eight concentrations and their antibacterial activity against Streptococcus pyogenes was tested using the Kirby-Bauer disc then proceeded Minimum Inhibitory Concentration (MIC) test and phytochemical assay. The data processed using SPSS software version 22. The results showed that flowers extract had the most significant inhibition zone (11.85 ± 0.119 mm) compared with the leaves extract (9.54 ± 0.07 mm) at the highest tested concentration was 640 mg/ml. The MIC of both extracts was 250 mg/ml. Flavonoids, phenolic, steroids, and saponins were found in both extracts whereas, alkaloid was found only in flowers extract. In conclusion, the Tembelek plant has an antibacterial effect against Streptococcus pyogenes. Future study is needed related to its mechanism of antibacterial effect. Keywords                : Antibacterial potential, Lantana camara; Streptococcus pyogenes Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3566 10.30651/jqm.v4i1.3566 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 77-85 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 77-85 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3566/pdf Copyright (c) 2020 Ricky Indra Alfaray

oai:journal.um-surabaya.ac.id:article/3598 2021-04-27T02:51:01Z qanunmedika:AR

Electrocardiogram abnormality and Distance Covered during Six Minute Walk Test on Diabetes Mellitus Type 2 Mayasari, Ni Made Elva Permana, Adhi Fadilah, Yudi Amanda, Namira Diabetes mellitus type 2 ECG Six Minute Walk Test AbstractDiabetes Mellitus (DM) is a metabolic disease that has the characteristics of hyperglycemia that occurs due to abnormalities of insulin secretion, insulin action, or both. Macrovascular complications are often also referred to as secondary atherosclerosis due to DM, which can cause cerebral vascular disease, coronary arterial disease, and peripheral atrial disease. Diagnostic tools are needed for early detection in cardiovascular diseases which is accurate, inexpensive, comfortable, and available in almost health center. One of the diagnostic tools for early detection of cardiovascular diseases is an electrocardiogram (ECG). Six Minute Walk Test (SMWT) is a simple, objective, inexpensive, and efficient test to assess functional capacity and prognosis. This study aims to [nmem1] see whether there is a correlation between abnormalities of ECG and distance covered during SMWT in DM patients. This study was a cross-sectional study design from DM patients in the Polyclinic of the Muhammadiyah Hospital in Palembang. Forty patients with type 2 DM who fulfilled inclusion and exclusion criteria were selected using a consecutive sampling method. Twenty-seven patients have abnormal ECG, and only thirteen patients had distance covered during SMWT >300m. There is a correlation between abnormalities of ECG and distance covered during SMWT in DM patients with a significance value p = 0.011.Keywords: Diabetes Mellitus type 2, Eelectrocardiogram, Six Minute WalkingCorrespondence author: elva.maya@yahoo.com   Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion experimental study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3598 10.30651/jqm.v4i2.3598 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 203-208 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 203-208 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3598/pdf Copyright (c) 2020 Ni Made Elva Mayasari

oai:journal.um-surabaya.ac.id:article/3639 2021-04-27T02:51:00Z qanunmedika:CR

Anatomical and Sexual Functions at Post Neovagina operation on Mayer Rokitansky Kuster Hauser Syndrome (MRKH) Patients with Sigmoid ,Amnion and Conventional Methods in Dr. Soetomo Hospital Marlina, Uning Parathon, Hari Demas, Azami Yanuar, Jimmy Kristian, Iwan Neovagina MRKH sigmoid amnion anatomic function sexual function  ABSTRACT Background: The Mayer–Rokitansky–Kuster–Hauser (MRKH) syndrome is congenital malformation due to utero‐vaginal agenesis. For many years Dr Soetomo Hospital has been applying McIndoe technique using biomaterial amnion. Recently, in collaboration with digestive surgery, neovagina operation using sigmoid was performed. However, no data are available on the complications, anatomic, and functional results of the neovagina operation using sigmoid and amnion. Methods: MRKH patients who have performed neovagina operations from January 2011 to December 2014 were involved in this case review. The anatomical function was measured based on minimal vaginal length of more than 6 cm and width of 3 cm, while sexual performance is measured by Female Sexual Function Index (FSFI), which is above 23, and Female Sexual Distress Score Revised (FSDSR), whose score is < 11. Result: In 4 years period, there were 6 cases of MRKH underwent neovagina (1 used sigmoid and 5 used amnion) at Dr Soetomo Hospital. All of them had a satisfying anatomical and sexual function. Even though neovagina operation significantly reduces sexual distress, but it does not necessarily mean alleviate as seen by the high FSDSR score. Neovagina using amnion has faster operation time and cheaper with the same length of hospital stay than sigmoid neovagina. Sigmoid neovagina has a better vaginal length, lubrication and no need dilatation after operation, but it has higher complication risk. Conclusion: The Neovagina technique should be used at Soetomo Hospital depends on patient wishes and circumstances. For those who have strong financial support and are not willing to do manual dilatation, they should use the sigmoid neovagina, while those who are able to do manual dilatation, then the amnion neovagina is a good choice.Keywords: Neovagina, MRKH, sigmoid, amnion, anatomic function  Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion case report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3639 10.30651/jqm.v4i1.3639 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 103-110 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 103-110 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3639/pdf Copyright (c) 2020 Uning Marlina

oai:journal.um-surabaya.ac.id:article/3645 2021-04-27T02:51:01Z qanunmedika:AR

In Vitro Test: Antimicrobial Activity Potential From Ciplukan Fruit (Physalis minima L.) Extract in Methicillin-resistant Staphylococcus aureus (MRSA) IN VITRO TEST: Antimicrobial Activity Potential From Ciplukan Fruit (Physalis minima L.) Extract in Methicillin-resistant Staphylococcus aureus (MRSA) Mahyuddin, Muhammad Hanun Mustika, Arifa Prabowo, Gwenny Ichsan Kusumaningrum, Deby Physalis minima L. Antimicrobial Ciplukan Methicillin-resistant Staphylococcus aureus Withaferin A research article Abstract  In Indonesia, in 2006, the prevalence of infections due to MRSA was 23.5%. Physalis minima L. plants are known to have antimicrobial activity because they contain compounds withaferin A, which can induce programmed cell death. This research was to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Ciplukan (Physalis minima L.) extract in Methicillin-resistant Staphylococcus aureus (MRSA) bacteria. Dilution test with Mueller-Hinton broth medium used for measuring the minimum inhibitory concentration (MIC). Ciplukan  fruit extract was dissolved in distilled water, and poured into a test tube with a certain concentration (0.9 g/mL (90%); 0.3 g/mL (45%); 0.15 g/mL (22.5%); 0.075 g/mL (11.25%) and 0.0375 g/mL (5.625%). After being incubated for 24 hours, the bacteria in the test tube were plated on nutrient agar plates to determine the MBC. The MIC cannot be determined, because the medium in the dilution test tube is disturbed by the color of the extract so that turbidity cannot be observed. From the observations of the minimum bactericidal concentration, MBC of the Ciplukan (Physalis minima  L.) fruit extract against MRSA was in the P1 tube or equivalent to 0.9 g / ml (90%).Keywords             : Physalis minima L., Antimicrobial, Ciplukan, Methicillin-resistant Staphylococcus aureus, Withaferin ACorrespondence   : arifa-m@fk.unair.ac.id In Indonesia, in 2006 the prevalence of infections due to MRSA was 23.5%. Physalis minima L. plants are known to have antimicrobial activity because they contain compounds withaferin A which can induce programmed cell death. This research was to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Ciplukan (Physalis minima L.) extract in Methicillin-resistant Staphylococcus aureus (MRSA) bacteria. Dilution test with Mueller-Hinton broth medium used for measuring the minimum inhibitory concentration (MIC). Ciplukan  fruit extract was dissolved in distilled water, and poured into a test tube with a certain concentration (0.9 g/mL (90%); 0.3 g/mL (45%); 0.15 g/mL (22.5%); 0.075 g/mL (11.25%) and 0.0375 g/mL (5.625%). After being incubated for 24 hours, the bacteria in the test tube were plated on nutrient agar plates, to determine the MBC. The MIC cannot be determined, because the solution in the dilution test tube is disturbed by the color of the extract so that turbidity cannot be observed. From the observations of the minimum bactericidal concentration MBC of the Ciplukan (Physalis minima  L.) fruit extract against MRSA was in the P1 tube or equivalent to 0.9 g / ml (90%). Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Experimental Study Experimental Study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3645 10.30651/jqm.v4i2.3645 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 209-216 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 209-216 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3645/pdf Copyright (c) 2020 Muhammad Hanun Mahyuddin, Arifa Mustika, Gwenny Ichsan Prabowo

oai:journal.um-surabaya.ac.id:article/3678 2021-04-27T02:51:00Z qanunmedika:CR

Pregnancy with Myasthenia Gravis Dwi ariningtyas, Ninuk Irfana, Laily Pregnancy Myasthenia Gravis ABSTRACTMyasthenia Gravis (MG) is a serious autoimmune disease, but now can be treated. Symptoms include weakness and fatigue in voluntary muscles caused by an autoantibody reaction to nicotinic acetylcholine receptor (AChR) at the post synapse of the neuromuscular junction. Pregnancy can affect autoimmune diseases so that pregnancy can aggravate MG disease. On the other hand it is also reported that pregnancy does not affect and can even improve MG disease. In this article, We report a 27-year-old woman who was diagnosed with myasthenia gravis that having a pregnancy. Initially she had no problems with pregnancy. Patients underwent pregnancy by taking the drug Mestinon four times daily and roborant. But entering the 33rd-34th week, the examination results showed that the pregnancy experienced oligohydramnios and Intrauterine Growth Retardation (IUGR), it was probably caused by malnutrition. Then we decided to end the patient's pregnancy with a Caesarean section. The operation went well, born to a baby boy / 2450grams / Apgar Score 5-7. Observation for one week the mother's condition continued to improve. Diplopia and weaknesses also improve. Likewise the baby showed a healthy condition. The patient was discharged while still taking MG drugs that had been previously consumed. This case report showed that pregnancy worsened MG disease, but MG did not affect pregnancy.Keywords : Pregnancy, Myasthenia Gravis Universitas Muhammadiyah Surabaya 2020-01-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion case report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3678 10.30651/jqm.v4i1.3678 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020); 119-127 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020); 119-127 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3678/pdf Copyright (c) 2020 Ninuk Dwi ariningtyas

oai:journal.um-surabaya.ac.id:article/3857 2021-04-27T02:51:01Z qanunmedika:AR

Clinical and Functional Outcome of Cervical Degenerative Disc Disease after Operative Treatment at Dr. Soetomo General Hospital Surabaya In 2013-2018 Tumbelaka, Reyner Valiant Utomo, Dwikora Novembri Martiana, I Ketut cervical degenerative disc disease Neck Disability Index SF36 Backgrounds: Cervical degenerative disc disease is a pathological change in the cervical associated with the degenerative process. Surgery is one of the therapeutic modalities in cases of cervical degenerative disc disease. Post-surgical clinical outcomes are needed to evaluate the results of the actions that have been taken. Methods: This study is an observational retrospective study to evaluate clinical and functional outcomes using Neck Disability Index & SF36 on cervical degenerative disc disease before and after surgery at Dr. Soetomo Hospital Surabaya in 2013-2018. Data is processed using SPSS and compared using the T-test. Results: A total of 12 patients with details of 8 male patients and four female patients who met the inclusion and exclusion criteria in this study. There was a significant decrease in the average NDI score (p = 0.05) before surgery (47.33) compared with after surgery (15.58). There was a significant increase in the average SF36 score (p< 0.05) before surgery (50.75) compared to after surgery (88.16). Conclusions: There is an increase in clinical and functional outcomes in patients with cervical degenerative disc disease who undergo operative treatment. Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Retrospective Study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/3857 10.30651/jqm.v5i1.3857 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 69-75 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 69-75 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/3857/pdf Copyright (c) 2021 Reyner Valiant Tumbelaka, Dwikora Novembri Utomo, I Ketut Martiana

oai:journal.um-surabaya.ac.id:article/4168 2022-08-26T07:39:24Z qanunmedika:AR

The potential of ethanol extracts 96% mature Papaya fruit seeds (Carica papaya L) as anti-diarrhea medicine Suciati, Wilujeng Basuki, Sri Wahyu Mature papaya fruit seeds (Carica papaya L) stool weight fecal uptake diameter stool consistency Mature papaya fruit seeds (Carica papaya L.) reduce diarrhea because of phytochemical compounds. This study aimed to determine the potential of 96% ethanol extract of mature papaya fruit seeds as antidiarrhea. This study used experimental laboratory research with pre and post-test with control group design. The research subjects were 25 mice divided into 5 groups, KI group (negative control), KII (positive control) loperamide, and KIII-KIV-KV given treatment with a dose (200 mg; 400 mg; 800 mg). A decrease in diarrhea is known by observing the consistency of feces, stool weight, and stool diameter. Data were analyzed by the Kruskal Wallis test and the Mann Whitney Post Hoc test. The results of the consistency of feces in group K(I) were compared with groups of K(II), K(III), K(IV), K(V) p=0.046, 0.083, 0.014, and 0.014. In stool weight K(I) compared to K(II), K(III), K(IV), K(V) with p=0.053, 0.102, 0.016, and 0.053. In the observation of absorption diameter K(-) compared to K(+), KI(200), KII(400), KIII(800) the p=0.121, 0.0197, 0.051 and 0.21. In conclusion, the mature extract papaya fruit seeds can reduce diarrhea seen from the stool consistency in the group extract 400 and 800 mg/Kilograms body weight and fecal weight in the 400mg/Kilograms body weight extract group. Universitas Muhammadiyah Surabaya 2022-07-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Research Article application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4168 10.30651/jqm.v6i2.4168 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 6 No. 2 (2022): Journal Qanun Medika Vol 6 No 02 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 6 No 2 (2022): Journal Qanun Medika Vol 6 No 02 2548-9526 2541-2272 10.30651/jqm.v6i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4168/pdf Copyright (c) 2022 sri wahyu basuki

oai:journal.um-surabaya.ac.id:article/4206 2021-04-27T02:51:01Z qanunmedika:AR

Effects of Prebiotics, Probiotics, and Synbiotics on the Bodyweight, Blood Glucose, Triglyceride and TNF-α of Diet-induced Obesity Rats Octavia, Lenny Soelistijo, Soebagijo Adi Widodo, Agung Dwi Wahyu high fat diet prebiotics probiotics synbiotics meta-inflammation Abstract  High-fat diet leads to obesity-associated chronic low-grade inflammation. Prebiotics, probiotics, and synbiotics produced short-chain fatty acids (SCFA), bonded to G protein-coupled receptors (GPR)-41 and GPR-43 decreased triglyceride deposits in adipocytes and liver, decreased fatty acid oxidation, increased glucose regulation and insulin sensitivity thus reduced the risk of obesity and metabolic syndrome. This study conducted in order to evaluate the effects of prebiotics, probiotics, and synbiotics on the body weight, blood glucose, triglyceride, and TNF-α used rats model, which were fed by a high-fat diet. Thirty-eight 6-8 weeks old male rats were fed by high-fat diet for three weeks, then rats were randomly divided into four groups, high-fat diet (HFD), a high fat diet with prebiotics supplementation (HFD+ PRE), a high fat diet with probiotics supplementation (HFD+PRO), and high-fat diet with synbiotics supplementation (HFD+SYN) for three weeks. Blood samples and body weight were measured at the third and sixth week. There was no effect of prebiotics, probiotics, and synbiotics on body weight, triglyceride levels, blood glucose, and TNF-α in rats fed a high-fat diet compared to control. These results suggested that supplementations gave inconsistent results with other studies and needed further researches.Keywords             : high fat diet, prebiotics, probiotics, synbiotics, meta-inflammationCorrespondence   : soebagijo@yahoo.com Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion controlled trial application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4206 10.30651/jqm.v4i2.4206 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 247-254 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 247-254 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4206/pdf Copyright (c) 2020 Lenny Octavia

oai:journal.um-surabaya.ac.id:article/4258 2021-04-27T02:51:01Z qanunmedika:AR

Oxygen saturation among newborns in the first 10 hours of life to detect Critical Congenital Heart Disease - Ductus Dependent Wahab, Fatchul Rahman, Mahrus Abdul Ontoseno, Teddy Etika, Risa Utamayasa, Alit Hidayat, Taufiq Sarmanu, Sarmanu critical congenital heart disease oxygen saturation fingertip pulse oximetry diagnostic tests ABSTRACT Delay diagnosis of Critical Congenital Heart Disease (CHD) can be associated with sudden clinical deterioration and dangerous cardiovascular conditions. The oxygen saturation screening among newborns in the first 10 hours of life is essential for early detection of critical CHD. This study aims to prove that measuring oxygen saturation among newborns in the first 10 hours of life can detect critical CHD. This study is a diagnostic experimental with consecutive sampling subjects in the infant care unit of Dr. Soetomo Hospital, including all newborns with birth weight ≥ 1500 grams and oxygen saturation at ≥ 1 hour of age below 90%. The measurement of oxygen saturation uses fingertip pulse oximetry in the right hand and foot at the age of 10 hours. A "positive oxygen saturation" is defined as oxygen saturation ≤ 85% or different oxygen saturation ≥ 3%, while a "negative oxygen saturation" is when the oxygen saturation is 85% to 90% or different oxygen saturation is 3%. Echocardiography is performed for the gold standard. From November 2019 to January 2020, 11 newborns underwent an oxygen saturation examination. Five subjects (45.46%) in the category of positive oxygen saturation, echocardiographic showed all Critical CHD (100%). Six subjects (54.54%) with negative oxygen saturation category, echocardiographic results showed two critical CHD (33.34%) and four non-critical CHD (66.66%). Fisher's exact test p < 0.005 (α). The diagnostic oxygen saturation test among newborns at 10 hours of life shows ≤85%, all subject’s echocardiography (100%) shows detection of critical CHD, while saturation 85% to 90% has of 33.3% for detection of critical CHD. The sensitivity and specificity of oxygen saturation for early diagnosis of critical CHD are 100% and 67%, respectively. Keywords: critical congenital heart disease, oxygen saturation, fingertip pulse oximetry, diagnostic tests*Corresponding Author: wfatchul045@gmail.com Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Experimental Study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4258 10.30651/jqm.v4i2.4258 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 237-245 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 237-245 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4258/pdf Copyright (c) 2020 fatchul wahab, teddy ontoseno, risa etika, sarmanu sarmanu, mahrus abdul rahman, alit utamayasa, taufiq hidayat

oai:journal.um-surabaya.ac.id:article/4269 2021-04-27T02:51:01Z qanunmedika:AR

Pneumonia Degree Correlation in Children with Clean and Healthy Behavior (CHB) Setyarini, Tri Kartika Lahdji, Aisyah Fajri, Isna Zalwa Noor pneumonia CHB children Abstract  Pneumonia is an acute infection that affects the lung with symptoms of cough, shortness of breath, grunting, cyanosis, rhonchi, and infiltrates in thorax imaging. Based on The Integrated Management of Sick Children in handling Acute Respiratory Tract Infection program, pneumonia is classified as severe pneumonia, pneumonia and not pneumonia. One of the risk factors of pneumonia is the low level of Clean and Healthy Behavior (CHB). The purpose of this study was to determine the degree of pneumonia in children with clean and healthy behavior (CHB). The analytic observational study with cross-sectional method. The sample was conducted children under five years old diagnosed with pneumonia in the Children's Ward of Rachma Husada Hospital Bantul with due regard to inclusion and exclusion criteria. Sampling was carried out using consecutive techniques. The data was retrieved using secondary data (medical records) and observing CHB with questionnaire. The data was analyzed using fisher’s exact test. From 32 samples in this study, the majority of samples suffered from severe pneumonia (81.3%) and the most CHB indicators were the Intermediate category (50%). The result of bivariate analysis shows there was a correlation between the degree of pneumonia in children and the family’s CHB (p=0.01). There was a correlation between the degree of pneumonia in children and the clean and healthy behavior (CHB). Keywords             : pneumonia, CHB, childrenCorrespondence   : lahdjiaa@unimus.ac.id Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4269 10.30651/jqm.v4i2.4269 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 217-223 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 217-223 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4269/pdf Copyright (c) 2020 Aisyah Lahdji

oai:journal.um-surabaya.ac.id:article/4374 2021-04-27T02:51:01Z qanunmedika:AR

In vitro Alpha Lipoic Acid supplementation in freeze-dried human sperm: the impact on DNA fragmentation index Octarina, Rezia Pramesti, M. P. B. Dyah Agustinus, Agustinus research article Freeze-drying technique is an alternative method on sperm preservation. However, this process can results in DNA damage. Adding antioxidants before freezing can reduce the detrimental effects of ROS on spermatozoa. Alpha lipoic acid (ALA) is one of the potent antioxidant that can be used to protect the sperm DNA. This study was aimed to determine the effect of ALA supplementation before freeze-drying on the DNA fragmentation index (DFI) of human spermatozoa. Nine semen samples were collected and evaluated for DFI (O1) then divided into 3 groups; freeze-drying without ALA (O2), freeze-drying with ALA 1,25 mg (O3) and freeze-drying with ALA 2,5 mg (O4).All three groups were stored at 4oC for 1 week. Sperm DFI were evaluated before and after freeze-drying. The result of this study showed a significant increase in sperm DFI in all three groups after freeze-drying (p<0,05) when compared to DFI before freeze-drying (14,67 ±3,295). However there was no significant difference between O2 (26,90 ±9,180) and O4 (29,29 ±5,524) group where the supplementation of 2,5 mg ALA did not have significant effect on protecting the DNA of freeze-dried human spermatozoa. The highest DFI was in the O3 group (44,64 ±11,717). Therefore, ALA supplementation before freeze-drying does not have a significant effect on protecting the DNA of freeze-dried human spermatozoa. Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Experimental Study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4374 10.30651/jqm.v5i1.4374 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 125-132 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 125-132 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4374/pdf Copyright (c) 2021 Rezia Octarina, M. P. B. Dyah Pramesti, Agustinus Agustinus

oai:journal.um-surabaya.ac.id:article/4377 2021-04-27T02:51:01Z qanunmedika:AR

Collagen Type I and Type II Expression Evaluation on Cartilage Defect Regeneration Treated with Dwikora–Ferdiansyah–Lesmono–Purwati (DFLP) Scaffold Supplemented with Adipose–Derived Stem Cells (ASCs) or Secretome: An In-Vivo Study Perbowo, Adrianto Prasetyo Utomo, Dwikora Novembri Widhiyanto, Lukas Airlangga, Primadenny Ariesa Purwati, Purwati DFLP Scaffold Adipose-Derived Stem Cells (ASCs) Secretome Collagen Type I Collagen Type II Abstract Cell-based therapies such as Scaffold, stem cells, and secretome, are one of the alternatives to enhance the regeneration of hyaline-like cartilage in cases of cartilage defects. This study is an in-vivo experiment using animal models, in which we apply a composite of DFLP (Dwikora-Ferdiansyah-Lesmono-Purwati) Scaffold and Adipose-Derived Stem Cells (ASCs) or Secretome to an injury model on the distal femoral trochlea of New Zealand White Rabbits. The animals were divided into four groups: (1) control (K); (2) Scaffold only (S); (3) Scaffold + ASCs (SA); (4) Scaffold + Secretome (SS). Animals were terminated in the 12th week, and an immunohistochemistry (IHC) evaluation for Collagen type I and II were done. Statistical analysis shows that collagen type I IHC between groups shows no significant difference (p = 0.546). Collagen type II IHC shows significant difference between groups (p = 0,016). The findings in this study showed that Scaffold + ASCs group and Scaffold + Secretome have better collagen type II expression compared to the control group. DFLP Scaffold composite with ASCs or Secretome shows potential for cartilage regeneration therapy by increasing type II collagen expression as in hyaline-like cartilage which may be used for regenerative therapy for cartilage defects. Keywords             : DFLP Scaffold; Adipose-Derived Stem Cells (ASCs); Secretome; Collagen Type I; Collagen Type IICorrespondence    : ianperbowo@me.com Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Experimental Study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4377 10.30651/jqm.v4i2.4377 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 225-235 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 225-235 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4377/pdf Copyright (c) 2020 Adrianto Prasetyo Perbowo, Dwikora Novembri Utomo, Lukas Widhiyanto, Primadenny Ariesa Airlangga, Purwati Purwati

oai:journal.um-surabaya.ac.id:article/4378 2021-04-27T02:51:01Z qanunmedika:CR

Overlapping Primary and Secondary Syphilis in Human Immunodeficiency Virus (HIV) Patient Nahlia, Nurul Laili Setyowatie, Lita primary syphilis secondary syphilis HIV case report ABSTRACTCoinfection between syphilis and Human Immunodeficiency Virus (HIV) could have varied clinical manifestations. Overlapping of syphilis stages is accounted for 25% of cases, attributable to the defect of the cellular and humoral immune response. We reported 55 years old man who was sexually active since 25 years ago via genito-genital, genito-anal, genito-oral routes, had multiple sexual partners both male and female, seldom used condom, and always being the insertive. Dermatological examination revealed alopecia non-scarring, a painless solitary ulcer on the collum penis, also multiple erythematous macules, patches, and plaques all over the body. Spirochaeta sp. was found from the base of the ulcer with a darkfield microscope. Histopathology examination revealed secondary syphilis lesion. Venereal Disease Research Laboratory (VDRL) 1:16, Treponema Pallidum Haemagglutination test (TPHA) reactive, HIV Determine rapid test reactive, and CD4 (Cluster of Differentiation 4) T-cell count 111 cells/ µL. He was treated with a single dose of benzathine penicillin G 2,4 million units intramuscular and antiretroviral drugs. On sixth month evaluation, VDRL was non-reactive, and CD4 T-cell count 325 cells/µL. This case shows that overlapping clinical manifestations of primary and secondary syphilis on HIV patients could occur with a good general condition. Immediate treatment of antibiotics for syphilis and antiretroviral could improve the clinical and serological conditions.Keyword: primary syphilis, secondary syphilis, HIVCorrespondence: nurul.laili.nahlia@gmail.com Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Case report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4378 10.30651/jqm.v4i2.4378 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 265-272 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 265-272 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4378/pdf Copyright (c) 2020 Nurul Laili Nahlia, Lita Setyowatie

oai:journal.um-surabaya.ac.id:article/4469 2021-04-27T02:51:01Z qanunmedika:AR

Identification of Thalassemia Carrier in Anemic Pregnant Women at Puskesmas Kertapati Palembang: Comparison of Five Erythrocyte Indices Purwoko, Mitayani Erenkwot, Eriko anemia thalassemia pregnant woman erythrocyte index Anemia is a condition that is almost always found in pregnancy. Although a program of Fe tablets has been introduced during pregnancy, the prevalence of anemia during pregnancy is still high. This situation maybe caused by another risk factor of anemia such as Thalassemia. This study was aimed to investigate the presence of carrier Thalassemia in pregnant women at the Puskesmas Kertapati, Palembang, South Sumatera using erythrocyte indices. This was a cross-sectional study with a sample size of 68 subjects, taken by purposive sampling technique. Hemoglobin level of all subjects was measured by Easy touch GCHb and confirmed by Sysmex K21. Differences of hemoglobin between Easy Touch GCHb and Sysmex K21 were analyzed by impaired t-test used SPSS program. Other data were analyzed using descriptive statistic.The mean hemoglobin levels in subjects were 10.7 g/dl. There were 68 subjects have anemia according to Easy Touch GCHb  but only 30 subjects that confirmed positive anemia by Sysmex KX 21. T-test result gavep value <0.05 that isconsidered there was a statistically significant difference between Easy Touch GCHb and Sysmex KX 21 results(p=0.001). Calculations using the England-Fraser index, Mentzer, Sirdah, and Srivastava indicate that none of the research subjects had thalassemia carrier status. Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion cross sectional study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4469 10.30651/jqm.v5i1.4469 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 95-101 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 95-101 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4469/pdf Copyright (c) 2021 Mitayani Purwoko, Eriko Erenkwot

oai:journal.um-surabaya.ac.id:article/4508 2021-04-27T02:51:00Z qanunmedika:IND

Index and Acknowledgement Levani, Yelvi Index and Acknowledgement Universitas Muhammadiyah Surabaya 2020-03-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4508 10.30651/jqm.v4i1.4508 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 1 (2020) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 1 (2020) 2548-9526 2541-2272 10.30651/jqm.v4i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4508/pdf Copyright (c) 2020 Yelvi Levani

oai:journal.um-surabaya.ac.id:article/4593 2021-04-27T02:51:01Z qanunmedika:LR

Quality of life of cervical cancer patients Wulan, Mayang Yusop, Yuzana Binti Mohd Yusoff, Harmy Bin Mohamed Quality of life Cervical cancer Reproductive Organ Cancer ABSTRACT Cervical cancer is known as the highest cause of death after breast cancer. It is gynecological cancer contributing to the top cause of death in women. Sexual and reproductive issues can reduce the quality of life of women with cervical cancer. WHO defines the quality of life as an individual's perception in the cultural context and value system in which the individual experiences and is related to their goals, expectations, standards, and affairs. It gives the concept of an individual's physical health, psychological conditions, one's beliefs, social relationships, and one's involvement with something meaningful in their environment. This article will explain the definition, symptoms, and staging of cervical cancer, the definition of the quality of life, the meaning of excellence for the cervical cancer patient, and the facts that affect the quality of life.  Keywords           : quality of life, cervical cancer, reproductive organ cancerCorrespondence  : mayangwulan8@gmail.com  Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Literature Review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4593 10.30651/jqm.v4i2.4593 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 143-150 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 143-150 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4593/pdf_1 Copyright (c) 2020 mayang wulan

oai:journal.um-surabaya.ac.id:article/4594 2021-04-27T02:51:01Z qanunmedika:AR

Solanum betaceum Extract as a Protective on Spermatozoa Morphology of Mice Exposed to Lead Acetate Wirenviona, Rima I'tishom, Reny Khaerunnisa, Siti Riris, Anak Agung Istri Dalem Cinthya Susanti, Nurul Fatimah Wahidah, Nurul Jannatul Kustantina, Abadiyah Zakiah research article Environmental pollution is one of the factors that contribute to the decline in male fertility. Lead is one of six air pollutants harmful to the reproductive system. One parameter of infertility in men is an increase in reproductive function observed with decreased morphological abnormalities of spermatozoa. The purpose is to analyze the effect of giving various dosages of Solanum betaceum extract on spermatozoa morphology of mice exposed to lead acetate. This study was true experimental using a randomized post-test only control group design. The total sample was 40 male mice Balb/ C taken by simple random sampling technique. Treatment and maintenance of experimental animals for 35 days. Statistical tests showed there were significant differences with p-value 0.005. Solanum betaceum extract can be used as a protective to improve the normal morphology spermatozoa of mice that exposed to lead acetate. Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion experimental study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4594 10.30651/jqm.v5i1.4594 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 87-94 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 87-94 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4594/pdf Copyright (c) 2021 Rima Wirenviona

oai:journal.um-surabaya.ac.id:article/4693 2021-04-27T02:51:01Z qanunmedika:LR

Role of antioxidant to protect Leydig cells induced by reactive oxygen species: a literature review Cinthya Riris, Anak Agung Istri Dalem I'tishom, Reny Khaerunnisa, Siti literature review The Leydig cells play crucial role in steroidogenesis and spermatogenesis. Those processes need complex communication in hormonal and testicular to maintain male reproductive function. Abnormal condition induced by reactive oxygen species reduce cell viability through lipid peroxidation and apoptotic pathway. Antioxidant ameliorate ROS elevation and prevent cell damage. Specifically, Leydig cells are vulnerable to ROS exposure and decline its function in mediating spermatogenesis. Therefore, it is needed to improve Leydig cells viability within antioxidant supplementation. This study aimed to determine the protective effect of antioxidant on Leydig cells induced by reactive oxygen species. This type of study is a literature review. Various studies have been reviewed through critical appraisal tool Olsen-Baisch Scoring for integrated review. Furthermore, this study highlighted the importance of the mechanism of antioxidant as protective agent of Leydig cells. Supplementation of antioxidant with the correct administration, dosage, and duration is potential to balance reactive oxygen species level and protect Leydig cells.    Keywords             : Leydig cell, antioxidant, reactive oxygen species, infertility Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Literature review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4693 10.30651/jqm.v5i1.4693 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 49-60 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 49-60 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4693/pdf Copyright (c) 2021 Anak Agung Istri Dalem Cinthya Riris, Reny I'tishom, Siti Khaerunnisa

oai:journal.um-surabaya.ac.id:article/4757 2021-04-27T02:51:01Z qanunmedika:AR

The effectiveness of classic lecture and workshop as interventions to improve primary health care providers knowledge and skill on the management of pediatric emergencies: a case study Alfaray, Ricky Indra Zharfan, Rahmat Sayyid Kloping, Yudhistira Pradnyan Rezkitha, Yudith Annisa Ayu Faizun, Rafiqy Sa’adiy Batsaikhan, Saruuljavkhlan Muhajir, Ahmad Siddiq Presidiana, Bestya Rosyidah, Umaimah Chasanah, Khodijah Nidaul Aini, Delia Nur Fauzy, Naufal Musthofa, Kamal Firdaos, Nur Handayani, Samsriyaningsih primary health care workers classic lecture workshop knowledge skill Abstract A preliminary study showed that most health workers in primary health care (PHC) claimed that they need a refreshing course because of their lack of updated knowledge and skill. This study enrolled 27 primary healthcare workers recruited from the PHC. The intervention used were classic lectures and workshops. The knowledge was evaluated using a paper-based test and practice, while the skill was evaluated using a practice test. Multiple questions (pre-test and post-test) based on current emergency management for pediatric were used for paper-based evaluation. Semi-structured interviews were conducted to confirm the subject's perspective on the intervention. A paired t-test was used for evaluating the pre- and post-test results, which was confirmed by a triangulation approach. There was a significant difference between the pre- and post-test results (p<0.001), and 8 of 10 subjects can demonstrate the procedure learned correctly after the intervention. A total of 14 interviewed subjects stated great effectiveness of the intervention, with several limitations on applicability in daily clinical practice. Classic lecture and workshop as an intervention in health education effectively increase health workers' knowledge and skill in PHC. This study might help other rural areas PHC apply the same method so the professionalism and quality of health workers in PHC providers can be maintained.Keywords                : primary health care, classic lecture; workshop; knowledge; skillCorrespondence     : rickyindraalfaray@gmail.com Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion cross-sectional experimental study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4757 10.30651/jqm.v5i1.4757 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 133-143 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 133-143 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4757/pdf Copyright (c) 2021 Ricky Indra Alfaray

oai:journal.um-surabaya.ac.id:article/4775 2021-04-27T02:51:01Z qanunmedika:CR

Cardio-vocal Syndrome as a Complication Patient with Severe Mitral Regurgitation and Moderate Aortic Regurgitation with Pulmonary Hypertension Basworo, Adityo Subagjo, Agus Cardio-vocal syndrome Mitral regurgitation Aortic Regurgitation ABSTRACT  Hoarseness due to paralysis of vocal cord, as in Cardio-vocal syndrome, is caused by mechanical affection of left recurrent laryngeal nerve from enlarged cardiovascular structures. Mitral valve prolapse is rarely found to cause this syndrome. Case report presenting a 47 years old male visited the outpatient department with a clinical history of dyspnea and hoarseness since a year ago. Physical examination revealed late systolic murmur in apex and low-grade diastolic murmur in right second intercostal space. Echocardiography confirmed severe mitral regurgitation due to flail anterior mitral valve leaflet with severe left atrium dilatation (9.0 cm) and moderate aortic regurgitation due to mal-coaptation of aortic valves. Laryngoscopy revealed an immobile left vocal cord. He underwent successful double valve replacement after three months follow up the patient showed improvement of hoarseness. The incidence of Cardio-vocal syndrome in mitral valve disease varies from 0.6% to 5%. In cases diagnosed with thoracic disease, paralysis of the left vocal cord was reported 1.75 times more frequent than the right side. The aim of this case report is we have to aware that Cardio-vocal syndrome is a rare cause of vocal cord paralysis and should be considered as a differential diagnosis of hoarseness, particularly if the patient has a cardiac history. Comprehensive evaluation and prompt treatment may allow reversal of the damage to left recurrent laryngeal nerve. Permanent nerve damage can occur due to late diagnosis. Keywords             : Cardio-vocal syndrome, Mitral regurgitation, Aortic RegurgitationCorrespondence   : adityobasworo@gmail.com Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Case Report application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4775 10.30651/jqm.v5i1.4775 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 145-151 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 145-151 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4775/pdf Copyright (c) 2021 Adityo Basworo

oai:journal.um-surabaya.ac.id:article/4998 2021-04-27T02:51:01Z qanunmedika:LR

The Level of Effectiveness Use of Quinoline Drugs in COVID-19: A Literature Review Dermawan, M.Dedi Dermawan Laitupa, Afrita Amalia Putra, Muslim Andala Triastuti, Nenny Effectiveness Chloroquine Covid-19 ABSTRACT          Chloroquine is the first line of medicine in the treatment of malaria. Besides being antimalaria, the chloroquine also can be used as the anti-inflammation in the medicine of arthritis rheumatoid arthritis and lupus erythematosus discoid. Hydroxychloroquine sulfate is 4-aminoquinolin with hydroxylated chloroquine analog, having the same pharmacokinetic as chloroquine which is given orally in hydroxychloroquine sulfate form, processed by gastrointestinal absorption and very faster kidney elimination. The effectiveness of chloroquine and hydroxychloroquine towards COVID-19 in the in vitro experiment showed it could inhibit the duplication of the SARS-CoV-2 virus. The chloroquine function is to stop COVID-19 infection with (EC50) 1,13 μM and (CC50) larger than 100 μM. Meanwhile, the hydroxychloroquine function is to inhibit the attachment and entry of the virus into the host’s cell by enzymatic activation which is the lysosome acidification disorder and antigen presentation as the result of pH increase. Based on the clinical study, the 10 of 12 patients who have lopinavir/ritonavir therapy by virology, the chloroquine group showed RT-PCR negative on day 7, 10, and 14 in compare to lopinavir/ritonavir that showed RT-PCR negative on day 14. On the 9th day, 60% of the patients of chloroquine group showed the CT scan of Lungs image normal instead of the lopinavir/ritonavir at 25%. In the day 14 based on the CT test result, the pulmonary improvement increased twice rather than chloroquine group (Rate Ratio 2.21). It proved that the chloroquine role showed the result of the medicine has a significant effect by cleaning the virus or other clinical matters. The purpose of this literature review is to know the effectiveness quinoline class of drugs which is chloroquine and hydroxychloroquine in COVID-19 disease.Keywords: effectiveness, chloroquine, COVID-19Correspondence: dedydermawan555@gmail.com Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Literatur Review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4998 10.30651/jqm.v4i2.4998 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 151-163 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 151-163 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4998/pdf Copyright (c) 2020 M.Dedi Dermawan Dermawan, Afrita Laitupa Laitupa, Muslim Andala Andala

oai:journal.um-surabaya.ac.id:article/4999 2021-09-10T06:21:28Z qanunmedika:LR

Risk Factors for Diabetes Mellitus Patients Against Covid-19 Wulan, Jasmin Ananda Laitupa, Afrita Amalia Prahasanti, Kartika Risk factors Diabetes Mellitus Covid-19 ABSTRACTCovid-19 patients with Diabetes mellitus (DM) ranked third after hypertension and cardiovascular disease with an estimated 36% of all Covid-19 cases. These patients have a risk of experiencing a higher complication possibility since their metabolic disorder can cause hyperglycemia to the patient. It is showed that the number of deaths reached 7,3%, which is higher than non-diabetes. The increase of DM patients caused by stress factors may trigger the onset of glucose in blood sugar, and the glucose variability became abnormal. This circumstance may cause a glycemic increase that causes the predisposition intensification of susceptible affected by Covid-19. Good management is truly needed for DM patients affected by Covid-19. It is hoped to reduce the risk factor, such as preventing complications and increasing life quality by regular medical check to have a good prognosis. Some research showed that Covid-19 patients with DM are essential in ICU and need more treatment attention as they may experience Acute Respiratory Distress Syndrome (ARDS). Diabetes mellitus patients' treatment strategy is to manage the blood glucose level, especially in post-prandial glucose. This literature aims to know the degree of serious illness of Covid-19 patients by the comorbidity of DM in this pandemic event. Keywords: Covid-19, Sars-Cov-2, Diabetes Mellitus, risk factors,Correspondence: jasminananda@gmail.com Universitas Muhammadiyah Surabaya 2021-07-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Literature Review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/4999 10.30651/jqm.v5i2.4999 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 2 (2021) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 2 (2021) 2548-9526 2541-2272 10.30651/jqm.v5i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/4999/pdf Copyright (c) 2021 jasmin ananda wulan, Afrita amalia Laitupa, kartika prahasanti

oai:journal.um-surabaya.ac.id:article/5000 2021-04-27T02:51:01Z qanunmedika:AR

Medical students' perspectives about distance learning during early COVID 19 pandemic: a qualitative study Utama, Muhammad Reza Levani, Yelvi Paramita, Ayu Lidya research article distance learning COVID 19 undergraduate medical students UTAUT e-learning qualitative study Background: Medical education throughout the world has experienced major changes as a consequence of the presence of the COVID-19 pandemic. The Government of Indonesia has instructed physical distancing so that teaching and learning activities, including in the Faculty of Medicine, must be carried out at home with online methods to reduce the risk of COVID distribution. Objective: to explore undergraduate medical students’ perspectives towards distance learning during early COVID 19 pandemic at Muhammadiyah Surabaya University - Faculty of Medicine (MSU-FM), Indonesia. Methods: a qualitative study of students’ online survey responses had been done. Thematic analysis based on Unified Theory of Acceptance and Usage of Technolgy (UTAUT) constructs was done to ecplore students’ perspectives. Results: Students have a positive perspective related to performance expectancy of distance learning. This factor have been perceived as factor that support the behavior of the use of distance learning in order to increase cognitive involvement in the learning process. However, in this study, other factors conveyed by students limiting their optimal use of current distance learning platform. Conclusion: Students‘ user experiences must be developed and maintained continuously during this pandemic era. Longitudinal studies that investigate the long-term impact of various distance learning platforms‘ usage also need further study. Universitas Muhammadiyah Surabaya 2020-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Qualitative study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/5000 10.30651/jqm.v4i2.5000 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 4 No. 2 (2020); 255-264 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 4 No 2 (2020); 255-264 2548-9526 2541-2272 10.30651/jqm.v4i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/5000/pdf Copyright (c) 2020 Muhammad Reza Utama, Yelvi Levani, Ayu Lidya Paramita

oai:journal.um-surabaya.ac.id:article/5043 2021-04-27T02:51:02Z qanunmedika:LR

Roflumilast: A Review of Chronic Obstructive Pulmonary Disease (COPD) Treatment Octafia, Ita Sari, Dwi Octamy Wulandari, Novi Annisa, Sandra Wongkar, Linda Wahyuni Bahari, Ferdias Kurnia Farikhah, Faiz Firmansah, Moh Midhiawati, Erfin Herawati, Fauna COPD Roflumilast phosphodiesterase-4 inhibitor treatment Abstract Chronic Obstructive Pulmonary Disease (COPD) is a chronic airway inflammation with resulting progressive airflow limitation that has a high incidence, morbidity, and mortality. Roflumilast is an oral phosphodiesterase-4 inhibitor as a therapy to decrease the risk of COPD exacerbations in patients with moderate-severe COPD with a history of chronic bronchitis. Roflumilast can be given orally once daily as a single or combination drug. It can be used as COPD moderate-severe but also more beneficial as COPD mild treatment. The efficacy of Roflumilast can prevent exacerbations of repetition and can fixed lung function both in terms of FEV1 and vital capacity to force. The incidence of side effects, which are diarrhea and digestive disorders. The cost-effectiveness showed that Quality of life patient with Roflumilast is better than the group without additional. This paper aimed to review systematically Roflumilast as COPD treatment for the clinical application.Keywords                   : COPD, Roflumilast, phosphodiesterase-4 inhibitorCorrespondence          : fauna@staff.ubaya.ac.id Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion literature review application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/5043 10.30651/jqm.v5i1.5043 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 35-47 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 35-47 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/5043/pdf Copyright (c) 2021 ita octafia

oai:journal.um-surabaya.ac.id:article/5097 2021-04-27T02:51:01Z qanunmedika:AR

Effects of acupressure therapy period towards blood sugar level in type 2 diabetes mellitus patients at Lumajang acupressure clinic Illahika, Anung Putri Safira, Hean Acupressure period of therapy blood glucose level type two diabetes mellitus Abstract  Diabetes Mellitus is a worldwide metabolic disease and becomes a challenge for the health practitioner. Unfortunately, less than half of these diabetic individuals are aware of their conditions, and less than 1% of those receiving medical treatment achieve their therapeutic targets. Acupressure is an alternative method that is believed to be an effective way of treating diabetic patients with reducing symptoms and complications. This research aims to discover the effect of period acupressure therapy on blood sugar levels in type two diabetes mellitus patients in Lumajang Acupressure Clinic. It uses an observational analytic design with pre-test and post-test approach. It involved 36 participants who were split into two groups and contained 18 participants for each group. The first group received acupressure therapy for three weeks, while the second group received eight weeks. Both groups underwent acupressure at the San Yin Jiao (SP-6) acupoint for 20 minutes three times a week. All participants in both groups had their blood glucose checked before and after acupressure therapy. The results showed that the two groups were significantly different for the paired t-test and the independent t-test. The acupressure therapy period has an effect on decreasing blood sugar levels in type two diabetes mellitus patients at Lumajang acupressure clinic. Keywords             : Acupressure, the period of therapy, blood glucose level, type two diabetes mellitusCorrespondence   : Anungputri113@gmail.com Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Observational analitic design, pre-test and post-test approach application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/5097 10.30651/jqm.v5i1.5097 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 61-67 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 61-67 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/5097/pdf Copyright (c) 2021 Anung Putri Illahika

oai:journal.um-surabaya.ac.id:article/5177 2021-04-27T02:51:02Z qanunmedika:AR

Depression, anxiety, and stress levels in Denpasar community during the pandemic of Corona Virus Disease 2019 (COVID-19) Hartawan, I Gusti Ngurah Bagus Rai Mulya Sastrawan, I Gede Gita Parastan, Rovie Hikari Ani, Luh Seri Depression Anxiety Stress Denpasar Community COVID-19 The Government of Indonesia has started to implement a Large-Scale Social Limitation (PSBB) in cities and provinces in Indonesia to prevent the increasing of COVID-19 transmission. The Denpasar city as one of the cities that implemented a similar system. This study was aims to provide an overview of the levels of depression, anxiety, and stress in the Denpasar community during the COVID-19 pandemic. This study was an observational descriptive study with cross-sectional design. The data collection used Google forms that distributed online. There were 160 respondents participated in this study, dominated by women (56.9%), domiciled in South Denpasar (35.0%), living with family or relatives (85.6%), aged 18-25 years old (63.7%), had diploma or bachelor degree as their education background (55.0%), unmarried (66.3%), students (38.8%), and no income (44.4%). The results showed that respondents had 1-2 offspring (53.7%), did not experience layoffs (83.9%), and experienced a decrease in income (67.0%), dominant respondents experienced psychosocial disorders in the form of depression (51.2%) with a moderate degree (31.7%) and the anxiety (53.1%) with a mild degree (40.0%). Most respondents did not experience stress (53.1%). In conclusion, the characteristics of respondents' psychosocial disorders were moderate depression, mild anxiety, and did not stress. Universitas Muhammadiyah Surabaya 2021-01-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Observational descriptive study with cross-sectional design application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/5177 10.30651/jqm.v5i1.5177 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 1 (2021); 103-111 Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 1 (2021); 103-111 2548-9526 2541-2272 10.30651/jqm.v5i1 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/5177/pdf Copyright (c) 2021 I Gusti Ngurah Bagus Rai Mulya Hartawan, I Gede Gita Sastrawan

oai:journal.um-surabaya.ac.id:article/5191 2021-09-10T06:21:28Z qanunmedika:AR

Prevalence and risk factors of Ascaris lumbricoides infection in children of Manusak Village, Kupang District, East Nusa Tenggara Province, Indonesia Bria, Meliance Arwati, Heny Tantular, Indah Setyawati SoilTransmitted Helminth Ascaris lumbricoides children Kupang District ABSTRACT Worm infection is one of the health problems in all tropical countries, including Indonesia. The most frequent helminthiasis is the infection caused by the Soil-Transmitted Helminth. Primary school-age children are an age group that is susceptible to helminthiasis. Worm infections can cause a serious impact if left untreated with no clean and healthy lifestyle. This study was conducted to determine the prevalence and risk factors of STH in children of Manusak Village, East Kupang Subdistrict, Kupang District, East Nusa Tenggara Province, followed by the characterization of subjects. The analytic observational design with the cross-sectional study was applied to this research. Research subjects were 130 children aged 6-12 years old. The infection was diagnosed microscopically by the Katokatz method. Ascaris lumbricoides were the only species found infecting a total of 50 children (38.4%.). The distribution of ascariasis was higher in girls (30 or 23.08%) than in boys (20 or 15.38%), in children whose parents have no formal education (41 or 31.54%), and who their professions are a farmer. Poor hygiene and sanitation such as no washing hands with soap (27 or 20.77%) as well as the habit of not wearing footwear (47 or 36.2%) and bowel habit on the open areas (35 or 26.92%)  are the risks factors causing the high incidence of A. lumbricoides in the studied area. Enlightenment to the parents regarding good personal and environmental hygiene and sanitation along with chemotherapy from the government and related agencies is needed to achieve a durable reduction of the burden of ascariasis and other STH infection. Keywords                   : Soil Transmitted Helminth, Ascaris lumbricoides, children,                                      Kupang DistrictCorrespondence        : heny-a@fk.unair.ac.id Universitas Muhammadiyah Surabaya 2021-07-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Analytic observational design with cross sectional study application/pdf https://journal.um-surabaya.ac.id/qanunmedika/article/view/5191 10.30651/jqm.v5i2.5191 Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya; Vol. 5 No. 2 (2021) Qanun Medika - Jurnal Kedokteran FK UMSurabaya; Vol 5 No 2 (2021) 2548-9526 2541-2272 10.30651/jqm.v5i2 eng https://journal.um-surabaya.ac.id/qanunmedika/article/view/5191/pdf_2 Copyright (c) 2021 HENY ARWATI, Meliance Bria, INDAH SETYAWATI TANTULAR 4f87a4bfbda30fbf986a6d191bd6b41a