Effects of Ginger Extract (Zingiber officinale L) on Glycogen Levels Liver on Mice with Hyperglycaemia

Nenny Triastuti (1), Achmad Basori (2), Sunarni Zakaria (3)
(1) Dosen Fakultas Kedokteran Universitas Muhammadiyah Surabaya - Indonesia, Indonesia,
(2) Departemen Farmakologi dan Terapi Fakultas Kedokteran Universitas Airlangga Surabaya – Indonesia, Indonesia,
(3) Departemen Farmakologi dan Terapi Fakultas Kedokteran Universitas Airlangga Surabaya – Indonesia, Indonesia


This study aims to prove the effect of ginger extract on rat liver glycogen levels in hyperglycemic. The design of this study is the post-test only control group design with independent variables (free) include a high-fat diet, injections of streptozotocin, the ethanol extract of ginger doses of 300, 400, 500 mg / kg and the dependent variable (dependent) include blood glucose levels ( GTTO II), glycogen levels. Based on this study, the results of different test GTTO end shows significant differences between negative control group and a positive control, a positive control and P1. Besides, also, there is a significant difference between P1 to P2. This suggests that, dosing higher ginger extract can increase the amount of glycogen levels to near normal. Effect of ginger extract on levels of glycogen in the liver of mice were exposed to a high-fat diet and STZ

Full text article

Generated from XML file


ADA. (2016) Standards of Medical Care in Diabetes – 2016. American Diabetes Association.39, pp.1–112. Available from :http://doi.org/10.2337/dc14-S014 [accessed 01 March 2012].

Abdulrazaq, NB., Cho, MM., Win, N.,Zaman, R. and Rahman, MT. (2012) Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats. British J of Nutrition. 108(7) pp.1194-1201.

Adeniyi, PO and Sanusi, RA. (2014) Effect of ginger (Zingiber officinale) extracts on blood glucose in normal and steptozotocin-induced diabetic rats. Int J of Clinical Nutrition. 2(2), pp.32-35.

Akhani, SP., Vishwakarma, SL. and Goyal, RK. (2004) Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. J Pharm Pharmacol.. 56, pp.101–105.

Al-Amin, ZM., Thomson, M., Al Qattan, KK., Peltonen-Shalaby, R. and Ali, M. (2006) Anti diabetic and hypoglycemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. British J of Nutrition. 96, pp.660-666.

Asha, B., Krishnamurthy, KH. and Devaru, S. (2011). Evaluation of anti hyperglycaemic activity of Zingiber officinale (Ginger) in albino rats. J Chem Pharm Res. 3, pp.452–456.

Badreldin, HA., Gerald, B., Musbah, OT. et al. (2008) ‘Some phytochemical, pharmacolo-gical and toxicological pro-perties of ginger (Zingiber officinale L)’: a review of recent research. Food Chem Toxicol. 46, pp.409–420.

Cheng, D. (2012) Prevalence, Predisposition and Prevention of Type II Diabetes. Nutrition & Metabolism. 2, pp.29. [accessed 01 March 2012].

Jafri, S.A., Abass, S. and Qasim, M. (2011) Hypoglycemic effect of Ginger (Zingiber officinale) in alloxan-induced diabetic rats (Rattus norvagicus). Pakistan Veteri-nary J. 31(2), pp.160-162.

Meigs, JB. (2007) Association of Oxidative Stress, Insulin Resistance, and Diabetes Risk Phenotypes. Diabetes Care. 30(10).[accessed 01 March 2012]

Pessin, JE., Saltiel, AR. (2010) Signaling Pathways in Insulin Action: Molecular Targets of Insulin Resistance. J Clin Invest. 106(2) .[accessed 01 March 2012].

Shaw, JE., Sicree, RA., Zimmet, PZ. (2010) Global Estimates of The Prevalence of Diabetes for 2010 and 2030. Diabetes Research and Clinical Practice; 87, p.4-14. [accessed 01 March 2012].

Shulman, GI. (2012) Insulin Resistance. J Clin Invest. 106(2). [accessed 01 March 2012].

Son, MJ., Miura, Y. and Kazum, Y. (2014) Mechanism of anti diabetic effect of gingerol in cultured cultured cells and obese diabetic model mice Cytotechnology. Diabetes Research and Clinical Practice. 87, pp.15-20. [accessed 01 March 2012].

Sukalingam K., Ganesan K. and Gani SB. (2013) Hypoglycemic effect of 6-gingerol, an active principle of ginger in streptozotocin-induced diabetic rats. J Pharmaco and Toxico Studies. 1(2), pp.23-30.

Wu, C., Khan, SA., Peng, LJ. and Lange, AJ. (2006) Roles for fructose-2,6-bisphosphate in the control of fuel metabolism beyond its allosteric effects on glycolytic and gluconeogenic enzymes. Adv. Enzyme Regul. 46 (1) pp.72-78


Nenny Triastuti
nennytriastuti38@gmail.com (Primary Contact)
Achmad Basori
Sunarni Zakaria
Triastuti, N., Basori, A., & Zakaria, S. (2017). Effects of Ginger Extract (Zingiber officinale L) on Glycogen Levels Liver on Mice with Hyperglycaemia. Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya, 1(01). https://doi.org/10.30651/qm.v1i01.379

Article Details

No Related Submission Found