Relationship of genetic factors to the degree of Acne vulgaris as one of the predisposing factors in student Faculty of Medicine University of Muhammadiyah Malang

Dwi Nurwulan Pravitasari (1), Ratna Wulandari (2), Sri Adila Nurianiwati (3), M Yuliansyah Aldi Kurniawan (4), Raihan Fatihka Devi (5)
(1) Universitas Muhammadiyah Malang, Indonesia,
(2) Universitas Muhammadiyah Malang, Indonesia,
(3) ,
(4) ,


Acne vulgaris is a skin disease, a chronic inflammation that affects the poly sebaceous glands, especially on the face and neck. One of the endogenous causes that influence the occurrence of acne vulgaris is a genetic and hormonal predisposition. Family history of acne is one of the risk factors in family genetics associated with the onset of the disease, the difficulty of therapy, and the risk for relapse. This research aimed to explain the relationship between genetic factors to the degree of acne vulgaris as one of the predisposing factors. This research was observational analytic, using purposive sampling as the sampling method and collecting data using a cross-sectional questionnaire. Statistical analysis between variables shows that age was not related (p = 0,790), while gender was not related (p = 0,066), the father's genetic history was related (p = 0,001), and mother's genetic history was not related (p = 0,390). In conclusion, among the factors that were analyzed, the father's genetic history was the only one which has a relationship in aggravating the degree of acne vulgaris.

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Anaba, E. L., & Oaku, I. R. (2021). Adult female acne: A cross-sectional study of diet, family history, body mass index, and premenstrual flare as risk factors and contributors to severity. International Journal of Women’s Dermatology, 7(3).

Anyachukwu, C., Onyeso, O., & Ezema, C. (2018). Age, Body Mass and Physical Activity Determinants of Facial Acne Severity among Southern Nigerian Adolescents and Young Adults. West Indian Medical Journal.

Bansal, P., Sardana, K., Vats, G., Sharma, L., Garga, U., & Khurana, A. (2020). A prospective study examining trigger factors and hormonal abnormalities in adult female acne. Indian Dermatology Online Journal, 11(4).

Common, J. E. A., Barker, J. N., & van Steensel, M. A. M. (2019). What does acne genetics teach us about disease pathogenesis? In British Journal of Dermatology (Vol. 181, Issue 4).

Edalatkhah, H., Matin, E., & Ahari, S. S. (2017). Familial risk of acne vulgaris in 8-13 year-old females: A case-control study. Iranian Journal of Dermatology, 20(2).

Ghodsi, S. Z., Orawa, H., & Zouboulis, C. C. (2009).

Prevalence, severity, and severity risk factors of acne in high school pupils: A community-based study. Journal of Investigative Dermatology, 129(9).

Heng, A. H. S., Say, Y. H., Sio, Y. Y., Ng, Y. T., & Chew, F. T. (2021). Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis. BMC Medical Genomics, 14(1).

Melnik, B. C. (2016). Western diet-induced imbalances of FoxO1 and mTORC1 signalling promote the sebofollicular inflammasomopathy acne vulgaris. Experimental Dermatology, 25(2).

Šijak, D., Horvat, I., Sonicki, Z., Murat-Sušić, S., Husar, K., Skerlev, M., Marinović, B., & Mokos, Z. B. (2019). Correlation between family history and the age of onset of childhood acne in relation to sex and type of acne. Acta Dermatovenerologica Croatica, 27(2).

Sitohang, I. B. S., Fathan, H., Effendi, E., & Wahid, M. (2019). The susceptibility of pathogens associated with acne vulgaris to antibiotics. Medical Journal of Indonesia, 28(1).

Yang, J., Yang, H., Xu, A., & He, L. (2020). A Review of Advancement on Influencing Factors of Acne: An Emphasis on Environment Characteristics. In Frontiers in Public Health (Vol. 8).


Dwi Nurwulan Pravitasari (Primary Contact)
Ratna Wulandari
Sri Adila Nurianiwati
M Yuliansyah Aldi Kurniawan
Raihan Fatihka Devi
Author Biography

Dwi Nurwulan Pravitasari, Universitas Muhammadiyah Malang

Departemen Kulit dan Kelamin Fakultas Kedokteran Universitas Muhammadiyah Malang
Pravitasari, D. N., Wulandari, R., Nurianiwati, S. A., Aldi Kurniawan, M. Y., & Devi, R. F. (2023). Relationship of genetic factors to the degree of Acne vulgaris as one of the predisposing factors in student Faculty of Medicine University of Muhammadiyah Malang. Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya, 7(2).

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