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SARS-Cov-2 is the newest coronavirus caused Covid-19 which can infect human and pandemic, COVID-19 parameter testing can be done with serological tests used to detect antibody or antigen and also molecular test using PCR method. This research is aimed to compare the sensitivity and specificity between COVID-19 Ag rapid test and PCR test. This research is an analytical descriptive study with 421 samples were obtained from documentation study with probability systematic random sampling and by using secondary data taken from Laboratory Information System (LIS) at Siloam Hospitals Lippo Village Tangerang and the type of observational analytical research with cross sectional design. The analysis results show the sensitivity rate was 96.64%, specificity was 93.75%, PPV was 89.44%, NPV was 98.08%, LR (+) was 15.46, and LR (-) was 0.04. The conclusion of the research result, COVID-19 Ag rapid test is valid to be used as a diagnostic test because it has high rate of sensitivity and specificity according to WHO regulations. Â
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Referensi
- Altman, D, D. Machine, T.N. Bryant, M.J. Gardner. 2015. Statistic With Confidence. 2nd ed. BMJ Books. England, 106-109.
- Chaimayo, C., Kaewnaphan, B., Tanlieng, N. 2020. Rapid SARS-CoV-2 Antigen Detection Assay In Comparison With Real Time RT-PCR Assay For Laboratory Diagnosis of COVID-19 in Thailand. BMC Virology Journal, 17(177):7.
- Helmy, Y.A., Fawzy, M., Elaswad, A., Sobieh, A., Kenney, S.P., Shebata, A.A. 2020. The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment and Control. MDPI Journal of Clinical Medicine, 9(1225):3.
- King, J., Kosinsky-Collins, M., Sundberg, F. 2020. Structure and Organizarion of Coronaviruses. http://web.mit.edu/fnl/volume/324/king_etal.html. Diakses 12 Maret 2021.
- Burhan, E., Fathiyah, I., Agus, D.S., Tjandra, Y.A., Soedarsono, Teguh, R.S.., Yani, J.S., Rezki, T., Bintang, Y.M.S., R.R. Diah, H., Heidy, A. Perhimpunan Dokter Paru Indonesia. 2020. Pneumonia COVID-19. Diagnosis dan Penatalaksanaan di Indonesia. Januari. PDPI. Jakarta.
- Putri, E.R.M., Ardyanto, T.D.2020. Menempatkan Tes COVID-19 Pada Tempatnya. http://fk.unej.ac.id. Diakses 20 Juli 2021.
- Siswosudarmo, R. Departemen Obstetrika dan Ginekologi. 2017. Tes Diagnostik (Diagnostic Test). FK UGM. Yogyakarta.
- World Health Organization (WHO). 2021. http://www.who.int/emergencies/diseases/novel-coronavirus-2019. Diakses 14 Februari 2021.
- World Health Organization (WHO). 2020. Deteksi Antigen Dalam Diagnosis Infeksi SARS-CoV-2 Menggunakan Imunoasai Cepat. Panduan Interim 11 September 2020.
- Yusra, N.P. 2020. Pemeriksaan Laboratorium Pada Coronaviru Disease 2019 (COVID-19). Medica Hospitalia Journal of Clinical Medicine, 7(1A): 304-319
Referensi
Altman, D, D. Machine, T.N. Bryant, M.J. Gardner. 2015. Statistic With Confidence. 2nd ed. BMJ Books. England, 106-109.
Chaimayo, C., Kaewnaphan, B., Tanlieng, N. 2020. Rapid SARS-CoV-2 Antigen Detection Assay In Comparison With Real Time RT-PCR Assay For Laboratory Diagnosis of COVID-19 in Thailand. BMC Virology Journal, 17(177):7.
Helmy, Y.A., Fawzy, M., Elaswad, A., Sobieh, A., Kenney, S.P., Shebata, A.A. 2020. The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment and Control. MDPI Journal of Clinical Medicine, 9(1225):3.
King, J., Kosinsky-Collins, M., Sundberg, F. 2020. Structure and Organizarion of Coronaviruses. http://web.mit.edu/fnl/volume/324/king_etal.html. Diakses 12 Maret 2021.
Burhan, E., Fathiyah, I., Agus, D.S., Tjandra, Y.A., Soedarsono, Teguh, R.S.., Yani, J.S., Rezki, T., Bintang, Y.M.S., R.R. Diah, H., Heidy, A. Perhimpunan Dokter Paru Indonesia. 2020. Pneumonia COVID-19. Diagnosis dan Penatalaksanaan di Indonesia. Januari. PDPI. Jakarta.
Putri, E.R.M., Ardyanto, T.D.2020. Menempatkan Tes COVID-19 Pada Tempatnya. http://fk.unej.ac.id. Diakses 20 Juli 2021.
Siswosudarmo, R. Departemen Obstetrika dan Ginekologi. 2017. Tes Diagnostik (Diagnostic Test). FK UGM. Yogyakarta.
World Health Organization (WHO). 2021. http://www.who.int/emergencies/diseases/novel-coronavirus-2019. Diakses 14 Februari 2021.
World Health Organization (WHO). 2020. Deteksi Antigen Dalam Diagnosis Infeksi SARS-CoV-2 Menggunakan Imunoasai Cepat. Panduan Interim 11 September 2020.
Yusra, N.P. 2020. Pemeriksaan Laboratorium Pada Coronaviru Disease 2019 (COVID-19). Medica Hospitalia Journal of Clinical Medicine, 7(1A): 304-319