Aplikasi FT-IR ATR Spektroskopi untuk Identifikasi Parasetamol pada Jamu Sediaan Serbuk
Artikel Sidebar
-
Parasetamol, Serbuk Ramuan Tradisional, Identifikasi, FTIR-ATR
Abstrak
Parasetamol dengan rumus kimia N-(4-Hydroxyphenyl) acetamide adalah bahan kimia obat yang diduga ditambahkan secara illegal kedalam obat tradisional.  Metode analisis yang sederhana, cepat dan akurat diperlukan untuk pengendalian keberadaan bahan kimia obat yang ditambahkan pada obat tradisional. Identifikasi parasetamol dilakukan dengan mengunakan FTIR-ATR pada bilangan gelombang 650 to 2000 cm-1 dan profil yang dihasilkan dibandingkan dengan standar parasetamol. Hasil penelitian menunjukkan adanya serapan yang karakteristik pada standar parasetamol daerah finger print pada bilangan gelombang 1650 cm-1 yang menunjukkan C=O amida ulur; 1610 cm-1 (C=C aromatis ulur); 1650 cm-1 (N-H amida tekuk); 1500 cm-1 (C-H aromatis ulur) dan bilangan gelombang 830 cm-1 (=C-H aromatis ulur). Berdasarkan hasil analisis diperoleh bahwa tidak terdapat parasetamol pada sampel A dan sampel B dan terdapat parasetamol pada sampel C yang ditunjukkan dengan kemiripan profil  dengan parasetamol standar dan adanya gugus karakteristik yang menunjukkan parasetamol.Â
Artikel teks lengkap
Referensi
Conformational and vibrational reassessment of solid paracetamol. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2017; 183: 431–438.
BPOM-RI, 2021, https:// drive . google . com / file /d/1Rxus9R7_R2AjtxrCkMj7SqAFymGdkK7q/view accessed, 20 September 2022
Custers D, Canfyn M, Courselle P, De Beer JO, Apers S, Deconinck E.2014. Headspace–gas chromatographic fingerprints to discriminate and classify counterfeit medicine. Talanta.123: 78–88.
Custers D, Cauwenbergh T, Bothy JL, Courselle P, De Beer JO, Apers E et al. 2015. ATR-FTIR spectroscopy and chemometrics: An interesting tool to discriminate and characterize counterfeit medicines. J. Pharm. Biomed. Anal. 112: 181–189.
Degardin K, Roggo Y, Margot P.2014. Understanding and fighting the medicine counterfeit market. J. Pharm. Biomed. Anal. 87: 167–175.
Dumarey M, van Nederkassel AM, Stanimirova I, Daszykowski M, Bensaid F, Lees M, et al. 2009. Recognizing paracetamol formulations with the same synthesis pathway based on their trace-enriched chromatographic impurity profiles. Anal. Chim. Acta. 655:43–51.
Gorog S.2015 Identification in drug quality control and drug research. TrAC Trends Anal. Chem.; 69: 114–122.
Graham L, John O., Sangeeta T. 2018. Quantitative screening of the pharmaceutical ingradient for the rapid of identification of substandard and falsified medicine using reflectance infrared spectroscopy. Plos one. 1-17. Mallah MA,
Hayun., Baitha P., Manggadani., Nurul amalina. 2017. Determination of sibutramine adulterated in herbal slimming products using TLC Densitometric Method. Indonesian Journal Pharm, 27(1).pp 15-21
Kwok K, Taylor LS. 2012. Analysis of the packaging enclosing a counterfeit pharmaceutical tablet using Raman microscopy and two-dimensional correlation spectroscopy. Vib. Spectrosc; 61: 176–182.
Lebel P, Gagnon J, Furtos A, Waldron KC. 2014. A rapid, quantitative liquid chromatography-mass spectrometry screening method for 71 active and 11 natural erectile dysfunction ingredients present in potentially adulterated or counterfeit products. J. Chromatogr. A. 1343:143–151.
Mallah MA, Sherazi STH, Bhanger MI, Mahesar SA, Bajeer MA. A rapid Fourier-transform infrared (FTIR) spectroscopic method for direct quantification of paracetamol content in solid pharmaceutical formulations. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2015; 141: 64–70.
Panusa A, Multari G, Incarnato G, Gagliardi L. 2007. High-performance liquid chromatography analysis of anti-inflammatory pharmaceuticals with ultraviolet and electrospray-mass spectrometry detection in suspected counterfeit homeopathic medicinal products. J. Pharm. Biomed. Anal. 43:1221–1227.
Russo G, Barbato F, Grumetto L. 2016. A validated LC/UV method for the determination of four adulterating drugs in herbal slimming capsules. J. Pharm. Biomed. Anal. 117: 436–445.
Sacre´ PY, Deconinck E, De Beer T, Courselle P, Vancauwenberghe R, Chiap P, et al. 2010.Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines. J. Pharm. Biomed. Anal. 53: 445–453.
Sammons HM, Choonara I. 2017. Substandard medicines: a greater problem than counterfeit medicines. BMJ Paediatrics.
Sherazi STH, Bhanger MI, Mahesar SA, Bajeer MA. A rapid Fourier-transform infrared (FTIR) spectroscopic method for direct quantification of paracetamol content in solid pharmaceutical formulations. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2015; 141: 64–70.
Silvestre V, Mboula VM, Jouitteau C, Akoka S, Robins RJ, Remaud G.S. 2009. Isotopic 13C NMR spectrometry to assess counterfeiting of active pharmaceutical ingredients: site-specific 13C content of aspirin and paracetamol. J. Pharm. Biomed. Anal. 50: 336–341.
Sukkar E. 2014. Taking stock of counterfeit medicines. Pharm. J. 292: 570.
Tambunan, E. Y. B. 2020. Penetapan kadar campuran parasetamol dan ibuprofen dalam sediaan tablet secara spektrofotometri inframerah (FTIR). Skripsi Universitas Sumatera utara. Medan
Wilczyński S. 2015.The use of dynamic thermal analysis to distinguish between genuine and counterfeit drugs. Int. J. Pharm. 2015; 490: 16–21.
Penulis
Penulis tetap memegang hak atas karyanya dan memberikan hak publikasi pertama kepada jurnal ini yang secara simultan karya tersebut dilisensikan di bawah: Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)