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MSG causes many side effects on the body, but MSG has long been used as a food flavor that can bring tastes (umami) and play a role in strengthening the taste. The chemical structure of MSG is no different from Glutamic Acid (glutamate), it is one of the 20 amino acids that make up proteins in the body. So the use of MSG needs to be discontinued to prevent kidney damage due to continued consumption of MSG, two research were conducted to determine the effect of discharging of MSG consumption by being given tomato juice (1) and discharged without treatment (2), the second study was seen from the histology picture of rats wistar mouse.
Methods were experimental with post test only control group design. The research (1) used 15 wistar rats divided into three groups: group I without treatment (pellet AD II and drinking water), group II was given MSG for 14 days and group III was given tomato juice and MSG for 14 days. The study (2) used 27 rats divided by 9 groups. The sample is selected by simple random sampling method. The mice were then gradually turned off on the 29th, 43rd and 57th days. There was no significant difference in mean number of normal and damaged proximal tubules in all treatment groups. The renal histologic features in the treatment group I (MSG) and the treatment group II (MSG and tomato juice) showed normal glomeruli, tubular epithelial tubules, and lumen tubular narrowing whereas in mice discharged without treatment there was no apparent difference between the two MSG Giving groups damage to proximal tubules and renal corpusculum and regeneration after 14 days of discontinuation of MSG. Conclusions from these two experiments occurred damage to the renal tubules
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Keywords: MSG, Kidney, Wistar Rat
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Referensi
- Abu-Taweel GM et al, (2014) – Cognitive and biochemical effects of monosodium glutamate and aspartame, administered individually and in combination in male albino mice.
- Aulia Candra et al (2015) Gambaran Histologis Korteks Ginjal Tikus (Rattus norvegicus) Pasca Penghentian Pajanan Monosudium Glutamat per Oral Jurnal Cerebellum. Volume 1 Nomor 3. Agustus. Jurnal Cerebellum.
- Desy Togatorop et al (2016) Gambaran histologik ginjal tikus Wistar yang diberikan jus tomat setelah diinduksi dengan monosodium glutamat , Volume 4, Nomor 2, Juli-Desember Jurnal e-Biomedik (eBm)
- Eweka et al (2011) – Histochemical Studies of the Effects of Monosodium Glutamate on the Liver of Adult Wistar Rats.
- FDA (not updated) (2012) – Questions and Answers on Monosodium glutamate (MSG)
- Gani, Y dan Munir, W. 1992. Pengaruh tamoxifen terhadap struktur ginjal dan hipofisa mencit (Mus Musculus). Jurnal Matematika dan Pengetahuan Alam 2(1):50.
- Guyton, A. C & Hall, J. E. 2007. Buku Ajar Fisiologi Kedokteran. Edisi 11. Jakarta: Penerbit Buku Kedokteran EGC.
- Horvath et al (2013) – Exposure to Enriched Environment Decreases Neurobehavioral Deficits Induced by Neonatal Glutamate Toxicity
- Indonesian Renal Registry (IRR).2013.5th Report of Indonesian Renal Registry
- Junqueira, L, C & Carneiro, J. 1991. Histologi Dasar Edisi 3. Jakarta: Penerbit Buku Kedokteran EGC.
- Syaifuddin. 2000. Fungsi Sistem Tubuh Manusia. Jakarta: Penerbit Widya Medika: hlm. 218-219.
- Sloane, E. 2003. Anatomi dan Fisiologi Untuk Pemula. Jakarta: Penerbit Buku Kedokteran EGC.
- Tambajong, J. 1995. Sinopsis Histologi. Jakarta: Penerbit Buku Kedokteran ECG: hlm. 163.
- United States Renal Data System. 2014. 2014 USRDS Annual Data Report, Volume 2: End-Stage Renal Disease.
- World Health Organization. USRDS Anual Data Report. US.2013.
- Wibowo, D.S & Widjaja, P. 2009. Anatomi Tubuh Manusia. Jakarta: Penerbit Graha: hlm. 42.
Referensi
Abu-Taweel GM et al, (2014) – Cognitive and biochemical effects of monosodium glutamate and aspartame, administered individually and in combination in male albino mice.
Aulia Candra et al (2015) Gambaran Histologis Korteks Ginjal Tikus (Rattus norvegicus) Pasca Penghentian Pajanan Monosudium Glutamat per Oral Jurnal Cerebellum. Volume 1 Nomor 3. Agustus. Jurnal Cerebellum.
Desy Togatorop et al (2016) Gambaran histologik ginjal tikus Wistar yang diberikan jus tomat setelah diinduksi dengan monosodium glutamat , Volume 4, Nomor 2, Juli-Desember Jurnal e-Biomedik (eBm)
Eweka et al (2011) – Histochemical Studies of the Effects of Monosodium Glutamate on the Liver of Adult Wistar Rats.
FDA (not updated) (2012) – Questions and Answers on Monosodium glutamate (MSG)
Gani, Y dan Munir, W. 1992. Pengaruh tamoxifen terhadap struktur ginjal dan hipofisa mencit (Mus Musculus). Jurnal Matematika dan Pengetahuan Alam 2(1):50.
Guyton, A. C & Hall, J. E. 2007. Buku Ajar Fisiologi Kedokteran. Edisi 11. Jakarta: Penerbit Buku Kedokteran EGC.
Horvath et al (2013) – Exposure to Enriched Environment Decreases Neurobehavioral Deficits Induced by Neonatal Glutamate Toxicity
Indonesian Renal Registry (IRR).2013.5th Report of Indonesian Renal Registry
Junqueira, L, C & Carneiro, J. 1991. Histologi Dasar Edisi 3. Jakarta: Penerbit Buku Kedokteran EGC.
Syaifuddin. 2000. Fungsi Sistem Tubuh Manusia. Jakarta: Penerbit Widya Medika: hlm. 218-219.
Sloane, E. 2003. Anatomi dan Fisiologi Untuk Pemula. Jakarta: Penerbit Buku Kedokteran EGC.
Tambajong, J. 1995. Sinopsis Histologi. Jakarta: Penerbit Buku Kedokteran ECG: hlm. 163.
United States Renal Data System. 2014. 2014 USRDS Annual Data Report, Volume 2: End-Stage Renal Disease.
World Health Organization. USRDS Anual Data Report. US.2013.
Wibowo, D.S & Widjaja, P. 2009. Anatomi Tubuh Manusia. Jakarta: Penerbit Graha: hlm. 42.