Factors Related To The Incidence Of Cancer Chemotherapeutic Agent Extravasation
Abstrak
Introduction: The objective of this study is to analyze factors such as vein conditions, type of medication/ chemotherapeutic agent, volume of chemotherapeutic agent and their relationship with chemotherapy drug extravasation incidences. Method: This study uses cross sectional observational analytic design with purposive sampling. The sample of this study is 70 cancer patients undergoing chemotherapy in hospitals. Inclusive criteria include patients ages 18-65 in their first to fifth cycle of chemotherapy. The instrument used is observation form and the hospital's standard operational procedures for administering chemotherapy drugs. Results: The study shows that there are no relationship between vein condition, type of medication/ chemotherapeutic agent and volume of chemotherapeutic agent with extravasation. Most veins were still in good condition while undergoing chemotherapy. The length of time for administering chemotherapy were mostly <24 hours, which contributed to the reduced risk for extravasation even though the type of medication used were irritants and vesicants, with drug volume of 100 – 1000mL. The incidence of extravasation that were immediately observed during chemotherapy occurred 7.14% of the time, possibly due to the use of infusion pump that helped nurses in anticipating leakage outside the veins early on. Conclusion: Vein conditions, duration of chemotherapy drug exposure, type and volume of medication given were not related statistically. However the occurrence of extravasation explained that there are other contributing factors that have yet to be studied.Â
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Keywords: extravasation, cancer chemotherapeutic agent
Referensi
American Cancer Society. (2013). Chemoterapy What it is, how it helps. www. cancer.org
Dahlan, M. Sopiyudin. (2010). Besar sampel dan cara pengambilan sampel dalam penelitian kedokteran dan kesehatan. Jakarta: Salemba Medika
Dougherty, L and Catherine O. (2011). Advanced practice in the management of extravasation. Cancer nursing practice. 10 (5) 16 - 22
Geddie, P. (2007). Out Cones of Oncology Nursing Critical. Oncology Nursing Forum 34, no. 2:478
Gonzalez, T. (2013). Chemoterapy extravasations: prevention, identification, management and documentation. Clinical Journal of Oncology Nursing. Volume 17, Number 1, page 61-66
Lewis, S. (2010). Medical Surgical Nursing: Assessment and management of clinical problem. 8th Edition. Mosby: Elsevier Science
Marelli, TM. (2008). Buku saku dokumentasi keperawatan. Jakarta: EGC
Miller, G. (2008). Pencegahan dan pengobatan penyakit kanker. Jakarta: Prestasi Pustaka
Mouridsen, et.al. (2007). Treatment of anthracycline extravasation with Savene (dexrazoxane). Annals of Oncology 18(3): 546-550
Mubarak, C. (2013). Faktor risiko yang mempengaruhi kejadian extravasasi kemoterapi intravena perifer di RSUP Dr. Sardjito Yogyakarta Tahun 2011-2013. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63348&obyek_id=4
Oestreicher, P. (2007). Can you recognize the risk factors for the vesicant extravasation?. ONS Connect. 22, 1, 22 – 23
Otto. SE. (2005). Keperawatan onkologi. Jakarta: EGC
Polit & Beck. (2006). Essentials of nursing research: methods, appraisal, and utilization. 6th ed. Philadelphia: Lippincott Williams & Wilkins.
Sakaida, E. et. al. (2014). Incidence, risk factors and treatment outcomes of extravasation of cytotoxic agents in an outpatient chemotherapy clinic. Japanese Journal of Clinical Oncology. 44(2) 168 – 171
Salunke, et.al. (2015). Post chemotherapy extravasation injuries: hypogastric flap for reconstruction of wounds over dorsum of hand. Journal of Cancer Research and Therapeutics. Vol.11, Issue 4, 835 - 839
Schulmeister, L. (2007). Managing vesicant extravasations. The Oncologist. 13, 284 – 288
Smith, L. (2009). National Patient Safety Goal #13: Patients' Active Involvement in Their Own Care: Preventing Chemotherapy Extravasation. Clinical Journal of Oncology Nursing, 13(2), 233-234
World Health Organization. (2015). Media centre: Cancer. http://www.who.int/mediacentre/factsheets/fs297/en/#
Yulia, T. (2012). Gambaran tingkat pengetahuan pasien tentang pengobatan kemoterapi di rumah sakit kanker Dharmais. http://lontar.ui.ac.id